{"id":"https://openalex.org/W2581095077","doi":"https://doi.org/10.1182/blood.v114.22.812.812","title":"Hematopoiesis of Human Induced Pluripotent Stem Cells Derived From Blood Cells of Healthy Donors and Patients with the JAK2-V617F Somatic Mutation.","display_name":"Hematopoiesis of Human Induced Pluripotent Stem Cells Derived From Blood Cells of Healthy Donors and Patients with the JAK2-V617F Somatic Mutation.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2581095077","doi":"https://doi.org/10.1182/blood.v114.22.812.812","mag":"2581095077"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.812.812","doi":"https://doi.org/10.1182/blood.v114.22.812.812","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.812.812","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013773397","display_name":"Zhaohui Ye","orcid":"https://orcid.org/0000-0001-5272-9168","observed_orcids":["https://orcid.org/0000-0001-5272-9168","https://orcid.org/0000-0001-8470-5267"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhaohui Ye","raw_affiliation_strings":["Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023463201","display_name":"Huichun Zhan","orcid":"https://orcid.org/0000-0002-0359-0371","observed_orcids":["https://orcid.org/0000-0002-0359-0371"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huichun Zhan","raw_affiliation_strings":["Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102747646","display_name":"Prashant Mali","orcid":"https://orcid.org/0000-0002-3383-1287","observed_orcids":["https://orcid.org/0000-0002-3383-1287"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prashant Mali","raw_affiliation_strings":["Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065107767","display_name":"Sarah N. Dowey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah Dowey","raw_affiliation_strings":["Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112235286","display_name":"Donna Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna Williams","raw_affiliation_strings":["Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoon-Young Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoon-Young Jang","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067716685","display_name":"Chi Van Dang","orcid":"https://orcid.org/0000-0002-4031-2522","observed_orcids":["https://orcid.org/0000-0002-4031-2522"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Van Dang","raw_affiliation_strings":["Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017159299","display_name":"Jerry L. Spivak","orcid":"https://orcid.org/0000-0003-0169-5388","observed_orcids":["https://orcid.org/0000-0003-0169-5388"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Spivak","raw_affiliation_strings":["Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076437910","display_name":"Alison R. Moliterno","orcid":"https://orcid.org/0000-0002-8673-4317","observed_orcids":["https://orcid.org/0000-0002-8673-4317"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison R Moliterno","raw_affiliation_strings":["Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090661712","display_name":"Linzhao Cheng","orcid":"https://orcid.org/0000-0001-7052-0296","observed_orcids":["https://orcid.org/0000-0001-7052-0296"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Linzhao Cheng","raw_affiliation_strings":["Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013773397","https://openalex.org/A5065107767","https://openalex.org/A5067716685","https://openalex.org/A5090661712","https://openalex.org/A5102747646","https://openalex.org/A5112235286"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32385067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"22","first_page":"812","last_page":"812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9660000205039978},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9919999837875366},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.7979999780654907},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5410000085830688},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.777999997138977},{"id":"https://openalex.org/keywords/patient-specific-cell-therapy","display_name":"patient-specific cell therapy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7326443195343018},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7030901908874512},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6792221069335938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5977700352668762},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5582360029220581},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5300911068916321},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.49662405252456665},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.48667556047439575},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4818626344203949},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4689621031284332},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.4672166109085083},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.46332141757011414},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4293903410434723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3370988965034485},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.19002392888069153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1622428297996521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.812.812","doi":"https://doi.org/10.1182/blood.v114.22.812.812","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.812.812","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995718960","https://openalex.org/W6887981786","https://openalex.org/W2739179787","https://openalex.org/W1990398429","https://openalex.org/W2549889409","https://openalex.org/W2469584285","https://openalex.org/W2108209546","https://openalex.org/W2007779995","https://openalex.org/W2021758930","https://openalex.org/W2594463253"],"abstract_inverted_index":{"Abstract":[0,1],"812":[2],"Human":[3],"induced":[4],"pluripotent":[5,325],"stem":[6,49,147],"(iPS)":[7],"cells":[8,12,36,43,60,79,115,129,148,160,169,179,314,319,326,351,363,387,428,451,472,524,535,545,549,560,578,585],"derived":[9,127,561,614],"from":[10,116,315,340,447,526,546,557,562,579,615],"somatic":[11,171,235,463],"hold":[13],"promise":[14],"to":[15,41,57,68,143,157,166,176,193,287,431,497,509,516,555,574,644],"develop":[16],"novel":[17,624],"patient-specific":[18],"cell":[19,87,106,336,442,489,590,612],"therapies":[20],"and":[21,26,30,65,83,118,180,208,225,244,248,266,299,320,330,348,373,378,390,397,407,424,481,592,617],"research":[22],"models":[23,284],"for":[24,149,271,327,399,596,626],"inherited":[25,636],"acquired":[27,183,233,460,634],"diseases.":[28],"We":[29],"others":[31],"previously":[32,341],"reprogrammed":[33],"human":[34,47,317,334,361,500,610],"adherent":[35,46],"such":[37,186,292],"as":[38,95,187,293,412,494,553],"postnatal":[39,316],"fibroblasts":[40],"iPS":[42,105,128,168,313,335,362,441,471,488,534,559,584,611],"that":[44,61,80,91,173,273],"resemble":[45],"embryonic":[48],"(hES)":[50],"cells.":[51,418,468,565],"It":[52],"is":[53,161,238],"also":[54,438,445,567],"highly":[55],"desirable":[56],"reprogram":[58,158],"blood":[59,77,146,159,178,318,347,449,467,630],"are":[62,81,89,174,212,285],"easily":[63],"accessible":[64],"less":[66],"exposed":[67],"environmental":[69],"mutagens.":[70],"The":[71,197,232,251,355,469],"large":[72],"numbers":[73],"of":[74,98,112,126,216,222,242,246,253,263,297,312,323,352,359,370,384,402,434,452,520,628,642],"umbilical":[75],"cord":[76,343],"(CB)":[78],"collected":[82],"stored":[84],"in":[85,109,130,182,191,230,240,256,465,478,538],"multiple":[86],"banks":[88],"examples":[90],"could":[92,491],"be":[93,492],"used":[94,493,503,537],"a":[96,122,140,213,376,495,569,588,593,623],"source":[97,591],"either":[99,633],"autologous":[100],"or":[101,229,635],"allogeneic":[102],"but":[103],"histo-compatible":[104,145],"lines.":[107],"As":[108],"vitro":[110],"expansion":[111,125],"hematopoietic":[113,135,328,356,394,403,427,513,521,542,619],"stem/progenitor":[114],"CB":[117],"adult":[119,345],"sources":[120],"remains":[121],"challenge,":[123],"unlimited":[124],"combination":[131,601],"with":[132,455,602,632],"further":[133],"optimized":[134],"differentiation":[136,329,357,374,507,620],"methods":[137],"should":[138],"provide":[139,587,622],"vital":[141],"alternative":[142],"amplify":[144],"blood/BM":[150],"transplantation":[151],"purposes.":[152],"More":[153],"critically,":[154],"the":[155,177,269,304,310,321,386,400,461,474,504,517,547,558,575,580,603],"ability":[156],"essential":[162,205],"if":[163,485],"one":[164,530],"wishes":[165],"generate":[167],"containing":[170,473],"mutations":[172,302],"restricted":[175],"found":[181],"hematological":[184],"disorders,":[185],"myeloproliferative":[188,456],"disorders":[189,457],"(MPDs),":[190],"order":[192],"investigate":[194],"their":[195,466],"pathogenesis.":[196,306,599],"BCR/ABL-negative":[198],"MPDs,":[199],"which":[200],"include":[201],"polycythemia":[202],"vera":[203],"(PV),":[204],"thrombocythemia":[206],"(ET)":[207],"primary":[209,576],"myelofibrosis":[210],"(PMF),":[211],"heterogeneous":[214],"group":[215],"diseases":[217,631],"characterized":[218],"by":[219,366,392],"increased":[220,518],"proliferation":[221],"erythroid,":[223],"megakaryocytic":[224],"myeloid":[226,406],"lineages":[227],"alone":[228],"combination.":[231],"common":[234],"mutation":[236,255,464,475],"JAK2-V617F":[237,298,462],"present":[239],">95%":[241],"PV,":[243],"\u223c50%":[245],"ET":[247],"PMF":[249],"patients.":[250],"discovery":[252],"this":[254,277,539],"2005":[257],"has":[258,267],"significantly":[259],"improved":[260,368],"our":[261],"understanding":[262],"MPD":[264,305,487,598],"mechanisms":[265],"intensified":[268],"search":[270],"drug(s)":[272],"may":[274],"effectively":[275],"inhibit":[276],"aberrant":[278],"kinase":[279],"activation.":[280],"However,":[281],"new":[282],"disease":[283,331],"needed":[286],"answer":[288],"questions":[289],"it":[290],"raised":[291],"how":[294],"gene":[295,570,604],"dosages":[296],"other":[300],"pre-disposing":[301],"affect":[303],"Here":[307],"we":[308,413,502,607],"report":[309],"derivation":[311],"potential":[322,358],"these":[324,360,486],"modeling.":[332],"Multiple":[333,440],"lines":[337,443,490,613],"were":[338,388,410,437,444,536],"generated":[339,446],"frozen":[342],"blood,":[344],"peripheral":[346,448],"marrow":[349],"CD34+":[350,450,564,577],"healthy":[353],"donors.":[354],"was":[364],"examined":[365],"an":[367],"method":[369],"EB":[371],"formation":[372],"under":[375],"feeder-":[377],"serum-free":[379,506],"condition.":[380],"After":[381],"two":[382,453],"weeks":[383],"treatment,":[385],"harvested":[389],"analyzed":[391],"both":[393],"colony-forming":[395],"assays":[396],"FACS":[398,420],"presence":[401],"markers.":[404],"Both":[405],"erythroid":[408],"colonies":[409],"detected":[411],"have":[414],"observed":[415],"using":[416],"hES":[417],"By":[419],"analysis,":[421],"CD45+":[422],"(27%-64%)":[423],"CD43+":[425],"(36%-60%)":[426],"co-expressing":[429],"undetectable":[430],"intermediate":[432],"levels":[433],"CD34":[435],"marker":[436],"observed.":[439],"patients":[454,616],"(MPDs)":[458],"who":[459],"MPD-derived":[470],"appeared":[476],"normal":[477,563],"phenotypes,":[479],"karyotype":[480],"pluripotency.":[482],"To":[483],"determine":[484],"model":[496,595,625],"study":[498],"abnormal":[499],"hematopoiesis,":[501],"same":[505],"protocol":[508],"direct":[510],"them":[511],"into":[512],"lineages.":[514],"Similar":[515],"erythropoiesis":[519,552],"progenitor":[522,543],"(CD34+)":[523],"isolated":[525],"PV":[527,581],"patients,":[528],"including":[529],"subject":[531],"whose":[532],"blood-derived":[533],"study,":[540],"re-differentiated":[541],"(CD34+CD45+)":[544],"PV-iPS":[548],"showed":[550,568],"enhanced":[551],"compared":[554],"those":[556],"They":[566],"expression":[571],"pattern":[572],"similar":[573],"patient.":[582],"These":[583],"thus":[586],"renewable":[589],"prospective":[594],"investigating":[597],"In":[600],"targeting":[605],"technology":[606],"recently":[608],"described,":[609],"subsequent":[618],"technologies":[621],"investigations":[627],"various":[629],"mutations.":[637],"Disclosures:":[638],"No":[639],"relevant":[640],"conflicts":[641],"interest":[643],"declare.":[645]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-03T00:00:00"}