{"id":"https://openalex.org/W2581007336","doi":"https://doi.org/10.1182/blood.v116.21.646.646","title":"Chromatin Boundaries Require the Functional Cooperation Between hSET1 and NURF Complexes","display_name":"Chromatin Boundaries Require the Functional Cooperation Between hSET1 and NURF Complexes","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2581007336","doi":"https://doi.org/10.1182/blood.v116.21.646.646","mag":"2581007336"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.646.646","doi":"https://doi.org/10.1182/blood.v116.21.646.646","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.646.646","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100395648","display_name":"Li X","orcid":"https://orcid.org/0000-0003-1952-3445","observed_orcids":["https://orcid.org/0000-0003-1952-3445"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xingguo Li","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456667","display_name":"Shaohua Wang","orcid":"https://orcid.org/0000-0002-8899-3160","observed_orcids":["https://orcid.org/0000-0002-8899-3160"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaohua Wang","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100770218","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-9316-2521","observed_orcids":["https://orcid.org/0000-0002-9316-2521"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying Li","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA,","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019524510","display_name":"Yi Qiu","orcid":"https://orcid.org/0000-0002-3282-6072","observed_orcids":["https://orcid.org/0000-0002-3282-6072"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi Qiu","raw_affiliation_strings":["Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA,","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100616943","display_name":"Suming Huang","orcid":"https://orcid.org/0000-0002-4788-2085","observed_orcids":["https://orcid.org/0000-0002-4788-2085"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suming Huang","raw_affiliation_strings":["Shands Cancer Ctr. Biochemistry & Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shands Cancer Ctr. Biochemistry & Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019524510","https://openalex.org/A5100395648","https://openalex.org/A5100456667","https://openalex.org/A5100770218"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29788682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"646","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-insulators","display_name":"chromatin insulators","score":0.902999997138977},{"id":"https://openalex.org/keywords/bptf","display_name":"BPTF","score":0.9350000023841858},{"id":"https://openalex.org/keywords/usf1","display_name":"USF1","score":0.800000011920929},{"id":"https://openalex.org/keywords/histone-h3k4-methylation","display_name":"histone H3 lysine 4 methylation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/h3k9-dimethylation","display_name":"H3K9 dimethylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nucleosome-positioning","display_name":"nucleosome positioning","score":0.9010000228881836},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chromatin-silencing","display_name":"chromatin silencing","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8174524307250977},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.6971578598022461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6108092069625854},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.571670413017273},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5566243529319763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5410290360450745},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.5171434283256531},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.5028014183044434},{"id":"https://openalex.org/C212702","wikidata":"https://www.wikidata.org/wiki/Q178150","display_name":"Insulator (electricity)","level":2,"score":0.4568920135498047},{"id":"https://openalex.org/C92477616","wikidata":"https://www.wikidata.org/wiki/Q7119217","display_name":"PHD finger","level":5,"score":0.45618736743927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4333879351615906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16364970803260803},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10066333413124084},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.646.646","doi":"https://doi.org/10.1182/blood.v116.21.646.646","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.646.646","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.5299999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042447587","https://openalex.org/W2089200494","https://openalex.org/W2551366234","https://openalex.org/W2062875409","https://openalex.org/W2017006362","https://openalex.org/W2561379194","https://openalex.org/W2585965951","https://openalex.org/W7099930825","https://openalex.org/W1483132716","https://openalex.org/W2151779515"],"abstract_inverted_index":{"Abstract":[0,1],"646":[2],"Chromatin":[3,19],"modification":[4],"and":[5,47,68,113,119,127,199,228,255,269],"remodeling":[6,122,257],"activities":[7],"play":[8],"a":[9,87,108,148,155,163,209,216,223,246],"central":[10],"role":[11],"in":[12,16,73,154,194,249],"organizing":[13,69],"nuclear":[14],"functions":[15],"eukaryotic":[17],"genome.":[18],"domains":[20],"with":[21,111],"characteristic":[22],"epigenetic":[23],"marks":[24],"are":[25,130],"organized":[26],"by":[27,66,137,172,178],"chromatin":[28,63,121,143,166,239,256,266],"insulator.":[29],"The":[30,168],"chicken":[31,75],"b-globin":[32,76],"insulator,":[33],"5\u2032HS4,":[34],"is":[35,80,176],"an":[36,179],"excellent":[37],"model":[38],"system":[39],"to":[40,133,139,188,213,262,270,283],"study":[41],"how":[42,83],"insulator":[43,61,84,136,197,240],"maintains":[44],"gene":[45],"function":[46,94],"prevents":[48],"the":[49,74,92,99,134,141,173,186,189,195,205,234,264,272],"encroachment":[50,273],"of":[51,95,146,150,158,170,181,207,218,225,236,274,281],"repressive":[52,201],"heterochromatin.":[53,276],"We":[54,103],"showed":[55],"previously":[56],"that":[57,105,161,184],"USF1/2":[58],"bound":[59],"5\u2032HS4":[60,135,265],"mediates":[62],"barrier":[64,159,171,219,267],"activity":[65,160,268],"recruiting":[67],"active":[70,142],"histone":[71,116,251],"modifications":[72],"locus.":[77],"However,":[78],"it":[79],"not":[81,214],"clear":[82],"establishes":[85],"such":[86],"barrier.":[88],"To":[89],"further":[90],"understand":[91],"physical":[93],"USF1,":[96],"we":[97],"purified":[98],"USF1-associated":[100],"protein":[101],"complexes.":[102],"found":[104],"USF1":[106,138],"forms":[107],"multiprotein":[109],"complex":[110,258],"hSET1":[112,126,254],"NURF":[114,128,151,259],"exhibiting":[115],"H3K4":[117,210,226],"methyltransferase":[118],"ATP-dependent":[120],"activities,":[123],"respectively.":[124],"Both":[125],"complexes":[129],"specifically":[131],"recruited":[132],"retain":[140],"structure.":[144],"Knock-down":[145],"BPTF,":[147],"component":[149],"complex,":[152],"resulted":[153],"rapid":[156],"loss":[157,169,217,224],"protects":[162],"transgene":[164],"from":[165],"silencing.":[167],"BPTF":[174,237],"knock-down":[175],"accompanied":[177],"alternation":[180],"nucleosome":[182,187,190],"positioning":[183],"expands":[185],"free":[191],"linker":[192],"region":[193],"HS4":[196],"site":[198],"increases":[200],"H3K9":[202],"dimethylation.":[203],"Furthermore,":[204],"suppression":[206],"hSET1,":[208],"methyltransferase,":[211],"leads":[212],"only":[215],"activity,":[220],"but":[221],"also":[222],"dimethylation":[227],"H3K9/K14":[229],"acetylation,":[230],"as":[231,233],"well":[232],"recruitment":[235],"at":[238],"sites.":[241],"Thus,":[242],"our":[243],"data":[244],"reveal":[245],"molecular":[247],"mechanism":[248],"which":[250],"modifying":[252],"enzyme":[253],"collaborate":[260],"together":[261],"maintain":[263],"prevent":[271],"adjacent":[275],"Disclosures:":[277],"No":[278],"relevant":[279],"conflicts":[280],"interest":[282],"declare.":[284]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-02-03T00:00:00"}
