{"id":"https://openalex.org/W2580466901","doi":"https://doi.org/10.1038/ismej.2016.200","title":"Salivary mucins promote the coexistence of competing oral bacterial species","display_name":"Salivary mucins promote the coexistence of competing oral bacterial species","publication_year":2017,"publication_date":"2017-01-24","ids":{"openalex":"https://openalex.org/W2580466901","doi":"https://doi.org/10.1038/ismej.2016.200","mag":"2580466901","pmid":"https://pubmed.ncbi.nlm.nih.gov/28117832","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5437932"},"language":"en","primary_location":{"id":"doi:10.1038/ismej.2016.200","doi":"https://doi.org/10.1038/ismej.2016.200","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ismej.2016.200","pdf_url":"https://www.nature.com/articles/ismej2016200.pdf","source":{"id":"https://openalex.org/S149218730","display_name":"The ISME Journal","issn_l":"1751-7362","issn":["1751-7362","1751-7370"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/ismej2016200.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080495441","display_name":"Erica Shapiro Frenkel","orcid":"https://orcid.org/0009-0002-1039-2928","observed_orcids":["https://orcid.org/0009-0002-1039-2928"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Shapiro Frenkel","raw_affiliation_strings":["Biological Sciences in Dental Medicine, Harvard University , Cambridge, MA, USA","Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences in Dental Medicine, Harvard University , Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076155587","display_name":"Katharina Ribbeck","orcid":"https://orcid.org/0000-0001-8260-338X","observed_orcids":["https://orcid.org/0000-0001-8260-338X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katharina Ribbeck","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076155587"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":3675,"currency":"EUR","value_usd":4153},"apc_paid":null,"fwci":2.01,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.86441815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"1286","last_page":"1290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.2434999942779541,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-mucins","display_name":"salivary mucins","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oral-bacteria","display_name":"oral bacteria","score":0.6869999766349792},{"id":"https://openalex.org/keywords/bacterial-coexistence","display_name":"bacterial coexistence","score":0.7919999957084656},{"id":"https://openalex.org/keywords/interspecific-competition","display_name":"interspecific competition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.6330000162124634},{"id":"https://openalex.org/keywords/planktonic-growth","display_name":"planktonic growth","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dual-species-biofilms","display_name":"dual-species biofilms","score":0.7009999752044678},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.9584217071533203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8622154593467712},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.8329950571060181},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6255055665969849},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6178150773048401},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5984829664230347},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5100508332252502},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.41155192255973816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3479641377925873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.174754798412323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12475055456161499}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/ismej.2016.200","doi":"https://doi.org/10.1038/ismej.2016.200","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ismej.2016.200","pdf_url":"https://www.nature.com/articles/ismej2016200.pdf","source":{"id":"https://openalex.org/S149218730","display_name":"The ISME Journal","issn_l":"1751-7362","issn":["1751-7362","1751-7370"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4844995","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5437932","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5437932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5437932","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISME J","raw_type":"Text"},{"id":"pmid:28117832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28117832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/ismej.2016.200","doi":"https://doi.org/10.1038/ismej.2016.200","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ismej.2016.200","pdf_url":"https://www.nature.com/articles/ismej2016200.pdf","source":{"id":"https://openalex.org/S149218730","display_name":"The ISME Journal","issn_l":"1751-7362","issn":["1751-7362","1751-7370"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1148400999","display_name":null,"funder_award_id":"ES-002109","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3705494735","display_name":"The Role of Salivary Mucin in Preventing Cariogenic Streptococcus Biofilm Formation","funder_award_id":"1f30de024917-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3909382221","display_name":"MIT Center for Environmental Health Sciences","funder_award_id":"P30ES002109","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4056874268","display_name":null,"funder_award_id":"P30-ES002109","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G6382267131","display_name":"Mucin Glycans in the Regulation of Microbial Virulence","funder_award_id":"R01EB017755","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6673225952","display_name":null,"funder_award_id":"F30 DE024917","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000300833","display_name":null,"funder_award_id":"ES002109","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2580466901.pdf","grobid_xml":"https://content.openalex.org/works/W2580466901.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1779034727","https://openalex.org/W1964186648","https://openalex.org/W1986219050","https://openalex.org/W2020978031","https://openalex.org/W2030434248","https://openalex.org/W2032092088","https://openalex.org/W2032515852","https://openalex.org/W2047693198","https://openalex.org/W2067477145","https://openalex.org/W2070856482","https://openalex.org/W2102861863","https://openalex.org/W2110621364","https://openalex.org/W2121890764","https://openalex.org/W2131310780","https://openalex.org/W2139871778","https://openalex.org/W2141015679","https://openalex.org/W2147592252","https://openalex.org/W2162733558","https://openalex.org/W2164028009","https://openalex.org/W2175111362","https://openalex.org/W4252523298"],"related_works":["https://openalex.org/W3110179927","https://openalex.org/W2141015679","https://openalex.org/W4387765509","https://openalex.org/W2276960275","https://openalex.org/W2618125291","https://openalex.org/W4391577240","https://openalex.org/W3040312096","https://openalex.org/W7065209606","https://openalex.org/W2751799791","https://openalex.org/W2030434248"],"abstract_inverted_index":{"Mucus":[0],"forms":[1],"a":[2,38,142],"major":[3],"ecological":[4],"niche":[5],"for":[6],"microbiota":[7],"in":[8],"various":[9],"locations":[10],"throughout":[11],"the":[12,17,46,83,88,107,110,120,124,133],"human":[13,78],"body":[14],"such":[15],"as":[16],"gastrointestinal":[18],"tract,":[19],"respiratory":[20],"tract":[21],"and":[22,114],"oral":[23,95],"cavity.":[24],"The":[25],"primary":[26],"structural":[27],"components":[28],"of":[29,85,90,94,109,146],"mucus":[30,134],"are":[31],"mucin":[32,47,86],"glycoproteins,":[33],"which":[34],"crosslink":[35],"to":[36,81,102],"form":[37],"complex":[39],"polymer":[40],"network":[41],"that":[42,52,104,115,132],"surrounds":[43],"microbes.":[44],"Although":[45],"matrix":[48],"could":[49,136],"create":[50],"constraints":[51],"impact":[53],"inhabiting":[54],"microbes,":[55],"little":[56],"is":[57],"understood":[58],"about":[59],"how":[60],"this":[61,69,99],"key":[62],"environmental":[63],"factor":[64],"affects":[65],"interspecies":[66],"interactions.":[67],"In":[68],"study,":[70],"we":[71],"develop":[72],"an":[73],"experimental":[74],"model":[75,101],"using":[76],"gel-forming":[77],"salivary":[79],"mucins":[80,105,116],"understand":[82],"influence":[84,137],"on":[87],"viability":[89,139],"two":[91,111],"competing":[92,112],"species":[93],"bacteria.":[96],"We":[97],"use":[98],"dual-species":[100],"show":[103],"promote":[106],"coexistence":[108],"bacteria":[113],"shift":[117],"cells":[118],"from":[119],"mixed-species":[121],"biofilm":[122],"into":[123],"planktonic":[125],"form.":[126],"Taken":[127],"together,":[128],"these":[129],"findings":[130],"indicate":[131],"environment":[135],"bacterial":[138],"by":[140],"promoting":[141],"less":[143],"competitive":[144],"mode":[145],"growth.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}
