{"id":"https://openalex.org/W2580337443","doi":"https://doi.org/10.1111/liv.13376","title":"Simeprevir and daclatasvir for 12 or 24 weeks in treatment\u2010na\u00efve patients with hepatitis C virus genotype 1b and advanced liver disease","display_name":"Simeprevir and daclatasvir for 12 or 24 weeks in treatment\u2010na\u00efve patients with hepatitis C virus genotype 1b and advanced liver disease","publication_year":2017,"publication_date":"2017-01-30","ids":{"openalex":"https://openalex.org/W2580337443","doi":"https://doi.org/10.1111/liv.13376","mag":"2580337443","pmid":"https://pubmed.ncbi.nlm.nih.gov/28135777"},"language":"en","primary_location":{"id":"doi:10.1111/liv.13376","doi":"https://doi.org/10.1111/liv.13376","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13376","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089037721","display_name":"Christophe H\u00e9zode","orcid":"https://orcid.org/0000-0002-6762-8033","observed_orcids":["https://orcid.org/0000-0002-6762-8033"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christophe H\u00e9zode","raw_affiliation_strings":["Department of Hepatology and Gastroenterology H\u00f4pital Henri Mondor Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France"],"raw_orcid":"https://orcid.org/0000-0002-6762-8033","affiliations":[{"raw_affiliation_string":"Department of Hepatology and Gastroenterology H\u00f4pital Henri Mondor Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France","institution_ids":["https://openalex.org/I197681013","https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056539843","display_name":"Piero Luigi Almasio","orcid":"https://orcid.org/0000-0003-0406-8494","observed_orcids":["https://orcid.org/0000-0003-0406-8494","https://orcid.org/0000-0003-1167-0723"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero L. Almasio","raw_affiliation_strings":["Gastroenterology and Hepatology Unit, Di.Bi.M.I.S, University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Unit, Di.Bi.M.I.S, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113578199","display_name":"Stefan Bourgeois","orcid":"https://orcid.org/0000-0002-1088-0430","observed_orcids":["https://orcid.org/0000-0002-1088-0430"]},"institutions":[{"id":"https://openalex.org/I4210150429","display_name":"Ziekenhuisnetwerk Antwerpen Stuivenberg","ror":"https://ror.org/05dpzfc16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210150429","https://openalex.org/I4405261247"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stefan Bourgeois","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, ZNA Campus Stuivenberg, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, ZNA Campus Stuivenberg, Antwerp, Belgium","institution_ids":["https://openalex.org/I4210150429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079850830","display_name":"Peter Buggisch","orcid":"https://orcid.org/0000-0002-3076-3960","observed_orcids":["https://orcid.org/0000-0002-3076-3960"]},"institutions":[{"id":"https://openalex.org/I4210122495","display_name":"Asklepios Klinik St. Georg","ror":"https://ror.org/0387raj07","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210122495"]},{"id":"https://openalex.org/I4210130427","display_name":"Institute for Interdisciplinary Medicine","ror":"https://ror.org/03tr83233","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210130427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Buggisch","raw_affiliation_strings":["Institute for Interdisciplinary Medicine at the Asklepios Klinik St. Georg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Interdisciplinary Medicine at the Asklepios Klinik St. Georg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210122495","https://openalex.org/I4210130427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061814401","display_name":"Ashley S Brown","orcid":"https://orcid.org/0000-0002-3167-7087","observed_orcids":["https://orcid.org/0000-0002-3167-7087"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I4210106957","display_name":"St Mary's Hospital","ror":"https://ror.org/01aysdw42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210106957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ashley Brown","raw_affiliation_strings":["Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK","institution_ids":["https://openalex.org/I153355300","https://openalex.org/I4210106957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689613","display_name":"M. Diago","orcid":"https://orcid.org/0000-0002-8583-2433","observed_orcids":["https://orcid.org/0000-0002-8583-2433"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Moises Diago","raw_affiliation_strings":["Digestive Department, Valencia Hospital, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Department, Valencia Hospital, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008225974","display_name":"Yves Horsmans","orcid":"https://orcid.org/0000-0002-5779-2454","observed_orcids":["https://orcid.org/0000-0002-5779-2454"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Horsmans","raw_affiliation_strings":["Department of Gastroenterology, Louvain Catholic University, Louvain, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Louvain Catholic University, Louvain, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058614665","display_name":"Lawrence Serfaty","orcid":"https://orcid.org/0000-0003-3055-5579","observed_orcids":["https://orcid.org/0000-0003-3055-5579"]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lawrence Serfaty","raw_affiliation_strings":["Department of Hepatology H\u00f4pital Saint\u2010Antoine  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology H\u00f4pital Saint\u2010Antoine  Paris France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109886580","display_name":"Feren\u00e7 Szalay","orcid":"https://orcid.org/0000-0003-2771-7362","observed_orcids":["https://orcid.org/0000-0003-2771-7362"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Ferenc Szalay","raw_affiliation_strings":["1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004667227","display_name":"Giovanni Battista Gaeta","orcid":"https://orcid.org/0000-0003-1573-6224","observed_orcids":["https://orcid.org/0000-0003-1573-6224"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni B. Gaeta","raw_affiliation_strings":["Infectious Diseases, Department of Internal and Specialized Medicine, Second University of Naples, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Department of Internal and Specialized Medicine, Second University of Naples, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030635582","display_name":"Ram\u00f3n Planas","orcid":"https://orcid.org/0000-0002-0886-604X","observed_orcids":["https://orcid.org/0000-0002-0886-604X"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210153460","display_name":"Hospital Universitari Germans Trias i Pujol","ror":"https://ror.org/04wxdxa47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210153460"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ramon Planas","raw_affiliation_strings":["Hepatology Unit Hospital Germans Trias I Pujol and CIBERehd, Badalona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatology Unit Hospital Germans Trias I Pujol and CIBERehd, Badalona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210153460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692586","display_name":"Michael Schlag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schlag","raw_affiliation_strings":["Janssen-Cilag, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen-Cilag, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002507814","display_name":"Isabelle Lonjon\u2010Domanec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Lonjon\u2010Domanec","raw_affiliation_strings":["Janssen Pharmaceuticals, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Pharmaceuticals, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017909182","display_name":"Edmund V Ekoka Omoruyi","orcid":"https://orcid.org/0009-0006-5893-3630","observed_orcids":["https://orcid.org/0009-0006-5893-3630"]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Edmund Omoruyi","raw_affiliation_strings":["Janssen Infectious Diseases BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Infectious Diseases BVBA, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108414829","display_name":"Ralph A. DeMasi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph DeMasi","raw_affiliation_strings":["Janssen Research & Development LLC Titusville NJ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research & Development LLC Titusville NJ USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045504446","display_name":"Stefan Zeuzem","orcid":"https://orcid.org/0000-0002-0845-6833","observed_orcids":["https://orcid.org/0000-0002-0845-6833"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Zeuzem","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, J.W. Goethe University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, J.W. Goethe University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5089037721"],"corresponding_institution_ids":["https://openalex.org/I197681013","https://openalex.org/I3019246885","https://openalex.org/I4210130325"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.7667,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70131348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"37","issue":"9","first_page":"1304","last_page":"1313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simeprevir","display_name":"simeprevir","score":0.9789999723434448},{"id":"https://openalex.org/keywords/daclatasvir","display_name":"daclatasvir","score":1.0},{"id":"https://openalex.org/keywords/hcv-genotype-1b","display_name":"HCV genotype 1b","score":0.9160000085830688},{"id":"https://openalex.org/keywords/advanced-liver-disease","display_name":"advanced liver disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.8960000276565552},{"id":"https://openalex.org/keywords/viral-breakthrough","display_name":"viral breakthrough","score":0.7699999809265137},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.652999997138977},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5960000157356262},{"id":"https://openalex.org/keywords/ns5a-resistance-associated-substitutions","display_name":"NS5A resistance-associated substitutions","score":0.7519999742507935},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2776979040","wikidata":"https://www.wikidata.org/wiki/Q5207712","display_name":"Daclatasvir","level":5,"score":0.9404700994491577},{"id":"https://openalex.org/C2778986448","wikidata":"https://www.wikidata.org/wiki/Q7517689","display_name":"Simeprevir","level":5,"score":0.9196802377700806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8587720394134521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7625497579574585},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6762940883636475},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6396955847740173},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6147380471229553},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6029320359230042},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5257055163383484},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.519240140914917},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4218497574329376},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.41822415590286255},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.41658687591552734},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.38716229796409607},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24396491050720215},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.20547455549240112},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.15354964137077332}],"mesh":[{"descriptor_ui":"D000069616","descriptor_name":"Simeprevir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069616","descriptor_name":"Simeprevir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000072230","descriptor_name":"Sustained Virologic Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1111/liv.13376","doi":"https://doi.org/10.1111/liv.13376","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13376","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},{"id":"pmid:28135777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28135777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver international : official journal of the International Association for the Study of the Liver","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:dial.uclouvain.be:boreal:202822","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/202822","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liver International, Vol. 37, no.9, p. 1304-1313 (2017)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/387236","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/387236","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unipa.it:10447/415822","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10447/415822","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repo.lib.semmelweis.hu:123456789/7269","doi":null,"is_oa":false,"landing_page_url":"http://repo.lib.semmelweis.hu//handle/123456789/7269","pdf_url":null,"source":{"id":"https://openalex.org/S4306402199","display_name":"Semmelweis University Repository (Semmelweis University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I101202996","host_organization_name":"Semmelweis University","host_organization_lineage":["https://openalex.org/I101202996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337601","display_name":"Janssen Pharmaceuticals","ror":"https://ror.org/03qd7mz70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W754726257","https://openalex.org/W1621802947","https://openalex.org/W1660090100","https://openalex.org/W1888988496","https://openalex.org/W1954015314","https://openalex.org/W1989504822","https://openalex.org/W1996309817","https://openalex.org/W2010316858","https://openalex.org/W2067182451","https://openalex.org/W2106081736","https://openalex.org/W2112024536","https://openalex.org/W2127189337","https://openalex.org/W2133036275","https://openalex.org/W2143244227","https://openalex.org/W2166323995","https://openalex.org/W2209281674","https://openalex.org/W2216865272","https://openalex.org/W2241552982","https://openalex.org/W2290229326","https://openalex.org/W2292010270","https://openalex.org/W2292090508","https://openalex.org/W2414493501"],"related_works":["https://openalex.org/W2523651751","https://openalex.org/W1888988496","https://openalex.org/W2778790736","https://openalex.org/W2555009932","https://openalex.org/W2209281674","https://openalex.org/W7120310832","https://openalex.org/W2338758709","https://openalex.org/W2808222920","https://openalex.org/W2883029661","https://openalex.org/W2408930139"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"We":[3],"investigated":[4],"the":[5,92,106,168],"efficacy":[6,97],"and":[7,24,138,150,187,224,239],"safety":[8],"of":[9,108,113,148,155,170,243],"simeprevir":[10],"plus":[11],"daclatasvir":[12],"in":[13,227,249],"treatment-na\u00efve":[14],"patients":[15,29,44,115,119,159,193,203,211,228],"with":[16,30,48,57,204,229],"chronic,":[17],"genotype":[18,233],"1b":[19,234],"hepatitis":[20,230],"C":[21,231],"virus":[22,232],"infection":[23],"advanced":[25,49,236],"liver":[26,237],"disease,":[27],"excluding":[28],"pre-defined":[31],"NS5A":[32],"resistance-associated":[33,61],"substitutions.":[34],"METHODS:":[35],"This":[36],"phase":[37],"II,":[38],"open-label,":[39],"single-arm,":[40],"multicentre":[41],"study":[42],"included":[43],"aged":[45,121],"\u226518":[46],"years":[47],"fibrosis":[50],"or":[51,59,78,90],"compensated":[52],"cirrhosis":[53],"(METAVIR":[54],"F3/4).":[55],"Patients":[56],"NS5A-Y93H":[58],"L31M/V":[60],"substitutions":[62],"at":[63,91,180],"screening":[64],"were":[65,116,120,176],"excluded.":[66],"Simeprevir":[67],"(150":[68],"mg)+daclatasvir":[69],"(60":[70],"mg)":[71],"once":[72],"daily":[73],"was":[74,99,225],"administered":[75],"for":[76,174],"12":[77,94,103,146,165],"24":[79,86,153],"weeks;":[80],"treatment":[81,149,184,213],"could":[82],"be":[83],"extended":[84],"to":[85,89,215],"weeks":[87,104,147,154,166,181],"prior":[88],"Week":[93],"visit.":[95],"Primary":[96],"endpoint":[98],"sustained":[100,162],"virological":[101,163],"response":[102,164],"after":[105,167],"end":[107,169],"treatment.":[109,156,171],"RESULTS:":[110],"A":[111],"total":[112],"106":[114],"treated;":[117],"27%":[118],">65":[122],"years,":[123],"39%":[124],"had":[125,128,136,140,194],"cirrhosis,":[126],"53%":[127],"estimated":[129],"glomerular":[130],"filtration":[131],"rate":[132],"30-89":[133],"mL/min,":[134],"14%":[135],"diabetes,":[137],"38%":[139],"arterial":[141],"hypertension.":[142],"Overall,":[143],"42/106":[144],"received":[145,152],"64/106":[151],"Ninety-seven":[157],"(92%)":[158],"achieved":[160],"a":[161,240],"The":[172],"reasons":[173],"failure":[175],"viral":[177,188,246],"breakthrough":[178,247],"(n=7)":[179],"4-16,":[182],"early":[183],"discontinuation":[185],"(n=1)":[186],"relapse":[189],"(n=1).":[190],"Seventy-four":[191],"(70%)":[192],"\u22651":[195,205],"adverse":[196,207,216],"event":[197],"during":[198],"treatment,":[199],"including":[200],"six":[201],"(6%)":[202],"serious":[206],"event.":[208],"Three":[209],"(3%)":[210],"discontinued":[212],"owing":[214],"events.":[217],"CONCLUSIONS:":[218],"Simeprevir+daclatasvir":[219],"demonstrated":[220],"strong":[221],"antiviral":[222],"activity":[223],"well-tolerated":[226],"infection,":[235],"disease":[238],"high":[241],"prevalence":[242],"comorbidities.":[244],"However,":[245],"occurred":[248],"seven":[250],"patients,":[251],"making":[252],"this":[253],"regimen":[254],"unsatisfactory.":[255]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-02-03T00:00:00"}