{"id":"https://openalex.org/W2580248445","doi":null,"title":"A Randomized Clinical Trial Comparing the Efficacy of Melatonin and Amitriptyline in Migraine Prophylaxis of Children.","display_name":"A Randomized Clinical Trial Comparing the Efficacy of Melatonin and Amitriptyline in Migraine Prophylaxis of Children.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2580248445","mag":"2580248445","pmid":"https://pubmed.ncbi.nlm.nih.gov/29379562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760673"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5760673","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Child Neurol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112027846","display_name":"Razieh Fallah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Razieh Fallah","raw_affiliation_strings":["Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011563815","display_name":"Fatemeh Fazelishoroki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Fazelishoroki","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109277401","display_name":"Leila Sekhavat","orcid":"https://orcid.org/0000-0001-9516-6772","observed_orcids":["https://orcid.org/0000-0001-9516-6772"]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Leila Sekhavat","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223669574"],"apc_list":null,"apc_paid":null,"fwci":3.6146,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93593849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"47","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-migraine","display_name":"pediatric migraine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":1.0},{"id":"https://openalex.org/keywords/headache-frequency","display_name":"headache frequency","score":0.5099999904632568},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6439999938011169},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sleepiness","display_name":"sleepiness","score":0.7720000147819519},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9248179793357849},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.8089852333068848},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7992156147956848},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7712948322296143},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6608171463012695},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5094085335731506},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5037967562675476},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4613513946533203},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44323065876960754},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39392247796058655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3611891567707062}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5760673","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Child Neurol","raw_type":"Text"},{"id":"pmid:29379562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29379562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of child neurology","raw_type":"Journal Article"},{"id":"mag:2580248445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29379562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5760673","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5760673/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Child Neurol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328778","display_name":"Shahid Sadoughi University of Medical Sciences","ror":"https://ror.org/01zby9g91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2580248445.pdf","grobid_xml":"https://content.openalex.org/works/W2580248445.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W23388651","https://openalex.org/W1510176750","https://openalex.org/W1991277549","https://openalex.org/W2007513592","https://openalex.org/W2028975483","https://openalex.org/W2033170900","https://openalex.org/W2056570708","https://openalex.org/W2082983004","https://openalex.org/W2085179353","https://openalex.org/W2095466287","https://openalex.org/W2095863636","https://openalex.org/W2114520435","https://openalex.org/W2115479027","https://openalex.org/W2120263268","https://openalex.org/W2127246721","https://openalex.org/W2133631929","https://openalex.org/W2149737457","https://openalex.org/W2164465985","https://openalex.org/W2194612827","https://openalex.org/W2316628216","https://openalex.org/W2473237561","https://openalex.org/W2496847610","https://openalex.org/W3174319950","https://openalex.org/W4247292047"],"related_works":["https://openalex.org/W7219698543","https://openalex.org/W7217550915","https://openalex.org/W2194612827","https://openalex.org/W7164195685","https://openalex.org/W4311359177","https://openalex.org/W4394980222","https://openalex.org/W1966393124","https://openalex.org/W4400572929","https://openalex.org/W4311021417","https://openalex.org/W2540692073"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"aim":[2],"of":[3,14,38,54,88,95,103,117],"the":[4,10],"present":[5],"research":[6],"was":[7,43,99,135],"to":[8,50,66],"compare":[9],"effectiveness":[11],"and":[12,16,47,93,110,128,133,144,148],"tolerability":[13],"melatonin":[15,74,104,134,145],"amitriptyline":[17,70,118,138,155],"in":[18,45,86,101,115,123,126,130,150],"pediatric":[19,151],"migraine":[20,39,152],"prevention.":[21],"MATERIALS":[22],"&":[23],"METHODS:":[24],"In":[25],"a":[26,107,160],"parallel":[27],"single-blinded":[28],"randomized":[29],"clinical":[30],"trial,":[31],"5-15":[32],"yr":[33],"old":[34],"children":[35,132],"with":[36],"diagnosis":[37],"that":[40],"preventive":[41],"therapy":[42],"indicated":[44],"whom":[46],"were":[48,63,84,113],"referred":[49],"Pediatric":[51],"Neurology":[52],"Clinic":[53],"Shahid":[55],"Sadoughi":[56],"Medical":[57],"Sciences":[58],"University,":[59],"Yazd-Iran":[60],"from":[61],"2013-2014,":[62],"randomly":[64],"allocated":[65],"receive":[67],"1":[68],"mg/kg":[69,73],"or":[71],"0.3":[72],"for":[75],"three":[76,127],"consecutive":[77],"months.":[78],"RESULTS:":[79],"<":[80],"0.05).":[81],"Both":[82],"drugs":[83],"effective":[85,147,162],"reduction":[87],"monthly":[89],"frequency,":[90],"severity,":[91],"duration":[92],"disability":[94],"headache.":[96],"Daily":[97],"sleepiness":[98,122],"seen":[100,114],"7.5%":[102],"group":[105,119],"as":[106,159],"side":[108],"effect":[109],"adverse":[111],"events":[112],"22.5%":[116],"including":[120],"daily":[121],"four,":[124],"constipation":[125],"fatigue":[129],"two":[131],"safer":[136],"than":[137],"(value":[139],"=":[140],"0.04).":[141],"CONCLUSION:":[142],"Amitriptyline":[143],"are":[146],"safe":[149],"prophylaxis":[153],"but":[154],"can":[156],"be":[157],"considered":[158],"more":[161],"drug.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-02-03T00:00:00"}