{"id":"https://openalex.org/W2580214973","doi":null,"title":"Effects of marijuana on peripheral and central nervous immune markers in marijuana smokers and HIV-infected subjects","display_name":"Effects of marijuana on peripheral and central nervous immune markers in marijuana smokers and HIV-infected subjects","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2580214973","mag":"2580214973"},"language":"en","primary_location":{"id":"pmh:oai:scholarspace.manoa.hawaii.edu:10125/101414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10125/101414","pdf_url":"http://hdl.handle.net/10125/101414","source":{"id":"https://openalex.org/S4306401722","display_name":"ScholarSpace (University of Hawaii at Manoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I117965899","host_organization_name":"University of Hawai\u02bbi at M\u0101noa","host_organization_lineage":["https://openalex.org/I117965899"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10125/101414","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003234168","display_name":"Sody Mweetwa Munsaka","orcid":"https://orcid.org/0000-0002-6917-3888","observed_orcids":["https://orcid.org/0000-0002-6917-3888"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sody Munsaka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6917-3888","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003234168"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabis","display_name":"cannabis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cannabis-use","display_name":"cannabis use","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6190000176429749},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6740000247955322},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.6690000295639038},{"id":"https://openalex.org/keywords/r5-tropic-hiv","display_name":"CCR5-tropic HIV","score":0.699999988079071},{"id":"https://openalex.org/keywords/cannabinoid-receptor-antagonists","display_name":"cannabinoid receptor antagonists","score":0.4050000011920929},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.3959999978542328},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.33799999952316284},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6554766893386841},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5794589519500732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5782586336135864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5681118965148926},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5578052997589111},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4860685169696808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17305225133895874}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarspace.manoa.hawaii.edu:10125/101414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10125/101414","pdf_url":"http://hdl.handle.net/10125/101414","source":{"id":"https://openalex.org/S4306401722","display_name":"ScholarSpace (University of Hawaii at Manoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I117965899","host_organization_name":"University of Hawai\u02bbi at M\u0101noa","host_organization_lineage":["https://openalex.org/I117965899"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2580214973","doi":null,"is_oa":false,"landing_page_url":"https://scholarspace.manoa.hawaii.edu/bitstream/10125/101414/1/Munsaka_Sody_r.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarspace.manoa.hawaii.edu:10125/101414","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10125/101414","pdf_url":"http://hdl.handle.net/10125/101414","source":{"id":"https://openalex.org/S4306401722","display_name":"ScholarSpace (University of Hawaii at Manoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I117965899","host_organization_name":"University of Hawai\u02bbi at M\u0101noa","host_organization_lineage":["https://openalex.org/I117965899"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1558475619","display_name":"Imaging Studies in Neurotoxicity and Neurodevelopment","funder_award_id":"U54NS056883","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1869832807","display_name":"Neuroimaging and Mentoring in Drug Abuse Research","funder_award_id":"K24DA016170","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F3078854275","display_name":"Fulbright Program","ror":null},{"id":"https://openalex.org/F4320306113","display_name":"U.S. Department of State","ror":"https://ror.org/03vvynj75"},{"id":"https://openalex.org/F4320310804","display_name":"University of Hawai'i","ror":"https://ror.org/03tzaeb71"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2580214973.pdf","grobid_xml":"https://content.openalex.org/works/W2580214973.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W152800299","https://openalex.org/W308087137","https://openalex.org/W1479742935","https://openalex.org/W1607901775","https://openalex.org/W1639216532","https://openalex.org/W1656832641","https://openalex.org/W1738483406","https://openalex.org/W1967735252","https://openalex.org/W1974642601","https://openalex.org/W1975258429","https://openalex.org/W1982510591","https://openalex.org/W1989073099","https://openalex.org/W1994253900","https://openalex.org/W2016384657","https://openalex.org/W2024653583","https://openalex.org/W2024720933","https://openalex.org/W2035126438","https://openalex.org/W2047044941","https://openalex.org/W2048487686","https://openalex.org/W2060843720","https://openalex.org/W2063955495","https://openalex.org/W2075243425","https://openalex.org/W2117553644","https://openalex.org/W2122483069","https://openalex.org/W2135475275","https://openalex.org/W2136798984","https://openalex.org/W2141208208","https://openalex.org/W2155020462","https://openalex.org/W2165627434","https://openalex.org/W2314461521"],"related_works":["https://openalex.org/W2772739184","https://openalex.org/W7165560696","https://openalex.org/W2971830776","https://openalex.org/W7162541773","https://openalex.org/W3134206166","https://openalex.org/W1994083049","https://openalex.org/W2074076338","https://openalex.org/W2789742968","https://openalex.org/W7161150198","https://openalex.org/W4391676651"],"abstract_inverted_index":{"Marijuana":[0],"can":[1],"lower":[2,45],"cellular":[3],"immune":[4,28,71,116],"responses":[5],"and":[6,23,35,48,69,79,87,104,115,118,144,171,181,188,201,217,249,266,275,277,281,290,302,307,326],"inhibit":[7],"inflammation.":[8],"The":[9,149,162,253,296],"goal":[10],"of":[11,19,82,197,255,262,299],"this":[12],"dissertation":[13],"was":[14,64,90,153,228,244],"to":[15,66,345],"examine":[16],"the":[17,54,80,195,260,288,324,333],"effects":[18],"marijuana":[20,32,37,43,256,320,340],"on":[21,186,204,332],"peripheral":[22],"central":[24],"nervous":[25],"system":[26],"(CNS)":[27],"markers":[29,72,117],"in":[30,53,57,73,158,194,210,213,218,222,231,241,287,293,305,323,336],"current":[31],"users":[33,38,220,233,248],"(MJ)":[34],"HIV-infected":[36],"(HIV+MJ).":[39],"We":[40],"hypothesized":[41],"that":[42,339],"would":[44],"cell":[46],"activation":[47,60,70],"reduce":[49],"inflammatory":[50,198,300],"cytokine":[51],"secretion":[52],"CNS.":[55,327],"An":[56],"vitro":[58],"monocyte":[59,151],"model":[61],"using":[62,76,121],"lipopolysaccharide":[63,139],"developed":[65],"assess":[67],"baseline":[68],"healthy":[74],"individuals":[75],"flow":[77,122],"cytometry":[78],"kinetics":[81],"HIV":[83,175,250,346],"infection":[84],"between":[85,246],"activated":[86,150,163,303,334],"non-activated":[88,177],"monocytes":[89,141,164,178,187,207,304,335],"studied.":[91],"Peripheral":[92],"blood":[93],"mononuclear":[94],"cells":[95],"were":[96,109,119,134,184,192,208,283],"isolated":[97],"from":[98,125],"HIV+MJ,":[99],"HIV+":[100,214],"subjects":[101,127,215,224,236,251],"(HIV+),":[102],"MJ":[103,219,232,291,308,317,337],"sero-negative":[105],"controls":[106],"(SN).":[107],"Cells":[108],"stained":[110],"for":[111],"cannabinoid":[112],"receptors":[113,183],"(CB)":[114],"analyzed":[120],"cytometry.":[123],"Cytokines":[124],"age-matched":[126],"who":[128],"provided":[129],"cerebral":[130],"spinal":[131],"fluid":[132],"(CSF)":[133],"measured":[135],"by":[136,155],"Luminex.":[137],"After":[138],"stimulation,":[140],"increased":[142,167],"CD16":[143,199],"CD69":[145],"surface":[146],"expression":[147,169,196,227,243,268,331],"(p<0.05).":[148,161,179],"phenotype":[152],"supported":[154],"an":[156],"increase":[157],"TNF-\u03b1":[159],"production":[160],"also":[165],"had":[166],"CCR5":[168,202,226,242,330],"(p=0.05)":[170],"bound":[172],"more":[173],"R5-tropic":[174],"than":[176,212,221,234,292],"CB1":[180],"CB2":[182],"found":[185,245],"significant":[189],"group":[190],"differences":[191],"observed":[193],"(p<0.0001)":[200],"(p<0.003)":[203],"monocytes.":[205],"CD14+CD16+":[206,263],"higher":[209,230,286,297,329],"HIV+MJ":[211,247,289,306],"(p=0.0054),":[216],"SN":[223,235],"(p<0.0001).":[225],"significantly":[229,285],"(p<0.0001);":[237],"however,":[238],"no":[239],"difference":[240],"(p=0.4).":[252],"duration":[254],"use":[257,341],"correlated":[258],"with":[259,315],"levels":[261,298],"(r=0.53,":[264],"p<0.001)":[265],"CD14+CCR5+":[267],"(r=0.24,":[269],"p=0.049).":[270],"Inflammatory":[271],"cytokines":[272,301],"(fractalkine,":[273],"INF-\u03b12":[274],"IL-1\u03b1)":[276],"chemoattractants":[278],"(MCP-1,":[279],"IP-10":[280],"IL-8)":[282],"all":[284],"respective":[294],"controls.":[295],"groups,":[309],"as":[310,312],"well":[311],"their":[313],"correlation":[314],"lifetime":[316],"use,":[318],"suggest":[319],"induced":[321],"inflammation":[322],"periphery":[325],"Moreover,":[328],"suggests":[338],"may":[342],"render":[343],"susceptibility":[344],"infection.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-03T00:00:00"}
