{"id":"https://openalex.org/W2580205151","doi":null,"title":"A Putative Cytosolic Saxitoxin Binding Protein in Frog Myocardium","display_name":"A Putative Cytosolic Saxitoxin Binding Protein in Frog Myocardium","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2580205151","mag":"2580205151"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/67597","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2142/67597","pdf_url":null,"source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110036447","display_name":"Donald D. Doyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donald D. Doyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110036447"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23484128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.12219999730587006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saxitoxin","display_name":"saxitoxin","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytosolic-proteins","display_name":"cytosolic proteins","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.5389999747276306},{"id":"https://openalex.org/keywords/saxitoxin-binding","display_name":"saxitoxin binding","score":0.515999972820282},{"id":"https://openalex.org/keywords/sodium-channel-inhibition","display_name":"sodium channel inhibition","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2777646408","wikidata":"https://www.wikidata.org/wiki/Q412694","display_name":"Saxitoxin","level":3,"score":0.8624905347824097},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.575843334197998},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.5523583889007568},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48033443093299866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4318528175354004},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.426118940114975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3449251055717468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29644718766212463},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.19762465357780457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18983373045921326},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/67597","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2142/67597","pdf_url":null,"source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2580205151","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/67597","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068019408","https://openalex.org/W2003562604","https://openalex.org/W1500395113","https://openalex.org/W2052733393","https://openalex.org/W4319940297","https://openalex.org/W1519901250","https://openalex.org/W2094688884","https://openalex.org/W2045312771","https://openalex.org/W4407500118","https://openalex.org/W2216511242"],"abstract_inverted_index":{"Approximately":[0],"20%":[1],"of":[2,12,27,36,44,47,87,108,130,141,177,194],"the":[3,10,13,28,45,48,69,75,88,96,101,119,124],"protein":[4],"in":[5,68,91,118,136,153,165,183,186,200],"sarcolemma":[6],"vesicles":[7,29,120],"prepared":[8],"from":[9,202],"hearts":[11],"North":[14],"American":[15],"frog":[16],"Rana":[17],"pipiens":[18,19],"is":[20,77,121,148,158],"solubilized":[21],"by":[22,54,95,171,211],"a":[23,31,144],"96":[24],"hour":[25],"dialysis":[26],"against":[30],"low":[32],"ionic":[33],"strength":[34],"solution":[35],"ethylene-diaminetetraacetic":[37],"acid":[38],"(EDTA)":[39],"at":[40,79],"pH":[41],"8.5.":[42],"All":[43],"polypeptides":[46],"vesicle":[49],"proteins":[50,90,169],"which":[51],"are":[52,66,134,181,188],"resolvable":[53],"sodium":[55],"dodecylsulfate":[56],"polyacrylamide":[57],"gel":[58,213],"electrophoresis":[59],"(SDS-PAGE)":[60],"using":[61],"7.5%":[62],"acrylamide":[63],"disc":[64],"gels":[65,102,180],"found":[67,135,182],"aqueous":[70],"supernatant":[71],"(F1":[72],"fraction)":[73],"when":[74,209],"dialysate":[76],"centrifuged":[78],"100,000":[80],"xg":[81],"for":[82],"1.5":[83],"hours.":[84],"The":[85,104,196],"yield":[86],"individual":[89],"F1":[92,137,187],"as":[93],"revealed":[94],"stained":[97],"polypeptide":[98],"bands":[99],"on":[100],"varies.":[103],"total":[105],"enzymatic":[106],"activity":[107,157],"alkaline":[109],"phosphatase":[110],"and":[111,128],"(Na('+)":[112],"+":[113],"K('+))-ATPase":[114],"(ouabain":[115],"sensitive)":[116],"measured":[117,210],"retained":[122],"throughout":[123],"EDTA":[125],"treatment.":[126],"15%":[127],"7%":[129],"their":[131],"vesicular":[132],"activities":[133],"respectively.":[138],"Total":[139,155],"binding":[140],"Saxitoxin":[142],"(STX),":[143],"Na('+)-channel":[145],"specific":[146],"neurotoxin,":[147],"only":[149,159],"25%":[150],"retained,":[151,161],"6%":[152],"F1.":[154,166,184],"5'-nucleotidase":[156],"5%":[160],"less":[162],"than":[163],"1%":[164],"Sugar":[167],"containing":[168],"detectable":[170],"periodic":[172],"acid-Schiff":[173],"base":[174],"(PAS)":[175],"staining":[176],"non-detergent":[178,212],"(buffer)":[179],"Proteins":[185],"associated":[189],"with":[190],"an":[191],"appreciable":[192],"amount":[193],"phospholipid.":[195],"protein-phospholipid":[197],"complexes":[198],"range":[199],"size":[201],"about":[203],"50,000":[204],"to":[205],"several":[206],"million":[207],"daltons":[208],"electrophoresis.":[214]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-02-03T00:00:00"}