{"id":"https://openalex.org/W2580146426","doi":"https://doi.org/10.1002/jcp.25818","title":"SUMO\u2010modified insulin\u2010like growth factor 1 receptor (IGF\u20101R) increases cell cycle progression and cell proliferation","display_name":"SUMO\u2010modified insulin\u2010like growth factor 1 receptor (IGF\u20101R) increases cell cycle progression and cell proliferation","publication_year":2017,"publication_date":"2017-01-23","ids":{"openalex":"https://openalex.org/W2580146426","doi":"https://doi.org/10.1002/jcp.25818","mag":"2580146426","pmid":"https://pubmed.ncbi.nlm.nih.gov/28112398","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5518303"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.25818","doi":"https://doi.org/10.1002/jcp.25818","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.25818","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.25818","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.25818","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103180059","display_name":"Yingbo Lin","orcid":"https://orcid.org/0000-0001-7190-2261","observed_orcids":["https://orcid.org/0000-0001-7190-2261"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Yingbo Lin","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108125468","display_name":"Hongyu Liu","orcid":"https://orcid.org/0009-0002-6718-7976","observed_orcids":["https://orcid.org/0009-0002-6718-7976","https://orcid.org/0000-0001-5957-6993"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I79223203","display_name":"Guangdong Ocean University","ror":"https://ror.org/0462wa640","country_code":"CN","type":"education","lineage":["https://openalex.org/I79223203"]}],"countries":["CN","SE"],"is_corresponding":false,"raw_author_name":"Hongyu Liu","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","Laboratory of Aquatic Animal Nutrition Feed, Fisheries College, Guangdong Ocean University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Laboratory of Aquatic Animal Nutrition Feed, Fisheries College, Guangdong Ocean University, Zhanjiang, China","institution_ids":["https://openalex.org/I79223203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090874032","display_name":"Ahmed Waraky","orcid":"https://orcid.org/0000-0003-4635-021X","observed_orcids":["https://orcid.org/0000-0003-4635-021X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ahmed Waraky","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037384381","display_name":"Felix Haglund","orcid":"https://orcid.org/0000-0002-7015-3841","observed_orcids":["https://orcid.org/0000-0002-7015-3841"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Felix Haglund","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067957722","display_name":"Prasoon Agarwal","orcid":"https://orcid.org/0000-0003-1813-7606","observed_orcids":["https://orcid.org/0000-0003-1813-7606"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Prasoon Agarwal","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden","Department of Laboratory Medicine (LABMED) H5, Division of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Laboratory Medicine (LABMED) H5, Division of Clinical Immunology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052542248","display_name":"Helena Jernberg\u2010Wiklund","orcid":"https://orcid.org/0000-0002-9319-7986","observed_orcids":["https://orcid.org/0000-0002-9319-7986"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Helena Jernberg\u2010Wiklund","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081350746","display_name":"Dudi Warsito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dudi Warsito","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067670855","display_name":"Olle Larsson","orcid":"https://orcid.org/0000-0001-8173-2956","observed_orcids":["https://orcid.org/0000-0001-8173-2956"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle Larsson","raw_affiliation_strings":["Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, CCK R8: 04, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103180059"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":{"value":3500,"currency":"EUR","value_usd":3774},"fwci":3.4975,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93186101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"232","issue":"10","first_page":"2722","last_page":"2730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9890000224113464},{"id":"https://openalex.org/keywords/igf-1-signaling","display_name":"IGF-1 signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.44999998807907104},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.7315400242805481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.642060399055481},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6045065522193909},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5619187355041504},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5209547281265259},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5039312243461609},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4704044461250305},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4529808759689331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4351205825805664},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43147212266921997},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4196605086326599},{"id":"https://openalex.org/C2908605954","wikidata":"https://www.wikidata.org/wiki/Q25098752","display_name":"Insulin-Like Growth Factor Receptor","level":5,"score":0.41101276874542236},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3561258316040039},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3414947986602783},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33061912655830383},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3012685179710388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1386912763118744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11200779676437378}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017451","descriptor_name":"Receptors, Somatomedin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017451","descriptor_name":"Receptors, Somatomedin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017451","descriptor_name":"Receptors, Somatomedin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/jcp.25818","doi":"https://doi.org/10.1002/jcp.25818","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.25818","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.25818","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5518303","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5518303","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Physiol","raw_type":"Text"},{"id":"pmid:28112398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28112398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-334029","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334029","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/jcp.25818","doi":"https://doi.org/10.1002/jcp.25818","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.25818","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.25818","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3749610115","display_name":null,"funder_award_id":"31272673","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5071346759","display_name":null,"funder_award_id":"141232","funder_id":"https://openalex.org/F4320324250","funder_display_name":"Cancerf\u00f6reningen i Stockholm"},{"id":"https://openalex.org/G6958732680","display_name":null,"funder_award_id":"2014CB138600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8161390485","display_name":null,"funder_award_id":"#D0356401","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324250","display_name":"Cancerf\u00f6reningen i Stockholm","ror":"https://ror.org/00m8d6786"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2580146426.pdf","grobid_xml":"https://content.openalex.org/works/W2580146426.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1547298604","https://openalex.org/W1916328219","https://openalex.org/W1975736029","https://openalex.org/W1980492996","https://openalex.org/W1982416172","https://openalex.org/W2003340108","https://openalex.org/W2004087152","https://openalex.org/W2012940389","https://openalex.org/W2076860027","https://openalex.org/W2084361750","https://openalex.org/W2084471812","https://openalex.org/W2088977314","https://openalex.org/W2096081010","https://openalex.org/W2101493381","https://openalex.org/W2121058815","https://openalex.org/W2132915404","https://openalex.org/W2138853528","https://openalex.org/W2141516481","https://openalex.org/W2151577520","https://openalex.org/W2340992351","https://openalex.org/W2410413770","https://openalex.org/W2416643075"],"related_works":["https://openalex.org/W1975736029","https://openalex.org/W2752325851","https://openalex.org/W1542732723","https://openalex.org/W2084471812","https://openalex.org/W1980492996","https://openalex.org/W1982416172","https://openalex.org/W2998473867","https://openalex.org/W1766352301","https://openalex.org/W3143350395","https://openalex.org/W2758568440"],"abstract_inverted_index":{"Increasing":[0],"number":[1],"of":[2,8,34,72,95,102,173,185,190,196,206,220],"studies":[3,225],"have":[4],"shown":[5],"nuclear":[6,126],"localization":[7],"the":[9,61,164],"insulin-like":[10],"growth":[11],"factor":[12],"1":[13],"receptor":[14,62],"(nIGF-1R)":[15],"in":[16,26,112],"tumor":[17],"cells":[18],"and":[19,51,77,90,105,114,200,217],"its":[20],"links":[21],"to":[22,48,57,119,129,147,149,178,181,183,226],"adverse":[23],"clinical":[24],"outcome":[25],"various":[27],"cancers.":[28],"Any":[29],"obvious":[30],"cell":[31,49,150,221],"physiological":[32],"roles":[33],"nIGF-1R":[35],"have,":[36],"however,":[37],"still":[38],"not":[39,160],"been":[40],"disclosed.":[41],"Previously,":[42],"we":[43,68],"reported":[44],"that":[45,60,138,210,215],"IGF-1R":[46,96],"translocates":[47],"nucleus":[50],"modulates":[52],"gene":[53],"expression":[54,195,219],"by":[55,137],"binding":[56],"enhancers,":[58],"provided":[59],"is":[63,145],"SUMOylated.":[64],"In":[65],"this":[66],"study,":[67],"constructed":[69],"stable":[70],"transfectants":[71],"wild":[73],"type":[74],"IGF1R":[75,79],"(WT)":[76],"triple-SUMO-site-mutated":[78],"(TSM)":[80],"using":[81],"igf1r":[82],"knockout":[83],"mouse":[84],"fibroblasts":[85],"(R-).":[86],"Cell":[87],"clones":[88],"(R-WT":[89],"R-TSM)":[91],"expressing":[92],"equal":[93,111],"amounts":[94],"were":[97],"selected":[98],"for":[99],"experiments.":[100],"Phosphorylation":[101],"IGF-1R,":[103],"Akt,":[104],"Erk":[106],"upon":[107],"IGF-1":[108,169],"stimulation":[109,170],"was":[110,117],"R-WT":[113,152,174,191],"R-TSM.":[115,186],"WT":[116],"confirmed":[118],"enter":[120],"nuclei.":[121,151],"TSM":[122,139],"did":[123,159],"also":[124],"undergo":[125],"translocation,":[127],"although":[128],"a":[130],"lesser":[131],"extent.":[132],"This":[133,208],"may":[134],"be":[135],"explained":[136],"heterodimerizes":[140],"with":[141,193],"insulin":[142],"receptor,":[143],"which":[144,158],"known":[146],"translocate":[148],"proliferated":[153],"substantially":[154],"faster":[155],"than":[156],"R-TSM,":[157],"differ":[161],"significantly":[162],"from":[163,176],"empty":[165],"vector":[166],"control.":[167],"Upon":[168],"G1-S-phase":[171],"progression":[172,189],"increased":[175,194],"12":[177],"38%,":[179],"compared":[180],"13":[182],"20%":[184],"The":[187],"G1-S":[188],"correlated":[192],"cyclin":[197],"D1,":[198],"A,":[199],"CDK2,":[201],"as":[202,204],"well":[203],"downregulation":[205],"p27.":[207],"suggests":[209],"SUMO-IGF-1R":[211,229],"affects":[212],"upstream":[213],"mechanisms":[214,231],"control":[216],"coordinate":[218],"cycle":[222],"regulators.":[223],"Further":[224],"identify":[227],"such":[228],"dependent":[230],"seem":[232],"important.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}