{"id":"https://openalex.org/W2579097633","doi":null,"title":"Molecular insights into mitochondrial transcription and its role in DNA replication","display_name":"Molecular insights into mitochondrial transcription and its role in DNA replication","publication_year":2016,"publication_date":"2016-12-07","ids":{"openalex":"https://openalex.org/W2579097633","mag":"2579097633"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/50132","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/50132","pdf_url":"http://hdl.handle.net/2077/50132","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/50132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030490991","display_name":"Viktor Posse","orcid":"https://orcid.org/0000-0003-4936-4967","observed_orcids":["https://orcid.org/0000-0003-4936-4967"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Viktor Posse","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4936-4967","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030490991"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna-replication","display_name":"mitochondrial DNA replication","score":0.7179999947547913},{"id":"https://openalex.org/keywords/mitochondrial-transcription","display_name":"mitochondrial transcription","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-rna-polymerase","display_name":"mitochondrial RNA polymerase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tfb2m","display_name":"TFB2M","score":1.0},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/early-termination","display_name":"early termination","score":0.5440000295639038},{"id":"https://openalex.org/keywords/rna-dna-hybrids","display_name":"RNA-DNA hybrids","score":0.7609999775886536},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rnase-h1","display_name":"RNase H1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/promoter-melting","display_name":"promoter melting","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6644892692565918},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5751998424530029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48576620221138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47108209133148193},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4396265745162964},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3752375543117523},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3719525635242462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26686805486679077},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.08042818307876587},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/50132","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/50132","pdf_url":"http://hdl.handle.net/2077/50132","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2579097633","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/handle/2077/50132","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/50132","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/50132","pdf_url":"http://hdl.handle.net/2077/50132","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2579097633.pdf","grobid_xml":"https://content.openalex.org/works/W2579097633.grobid-xml"},"referenced_works_count":167,"referenced_works":["https://openalex.org/W61586376","https://openalex.org/W179236238","https://openalex.org/W183349502","https://openalex.org/W1493170168","https://openalex.org/W1495825745","https://openalex.org/W1512483303","https://openalex.org/W1519160353","https://openalex.org/W1538004262","https://openalex.org/W1538077597","https://openalex.org/W1547309371","https://openalex.org/W1551996591","https://openalex.org/W1573889570","https://openalex.org/W1583445344","https://openalex.org/W1597095463","https://openalex.org/W1615790672","https://openalex.org/W1894198192","https://openalex.org/W1913038587","https://openalex.org/W1913284131","https://openalex.org/W1965642201","https://openalex.org/W1967154926","https://openalex.org/W1967798978","https://openalex.org/W1968197570","https://openalex.org/W1970381458","https://openalex.org/W1978422652","https://openalex.org/W1979275335","https://openalex.org/W1980242161","https://openalex.org/W1980714729","https://openalex.org/W1981161568","https://openalex.org/W1983569416","https://openalex.org/W1985890646","https://openalex.org/W1986575224","https://openalex.org/W1986877587","https://openalex.org/W1987147367","https://openalex.org/W1989026904","https://openalex.org/W1989840530","https://openalex.org/W1991112573","https://openalex.org/W1992477424","https://openalex.org/W1993401855","https://openalex.org/W1994755695","https://openalex.org/W1995169990","https://openalex.org/W1996052541","https://openalex.org/W1996097229","https://openalex.org/W1998974825","https://openalex.org/W2001054829","https://openalex.org/W2001294926","https://openalex.org/W2001801970","https://openalex.org/W2002841189","https://openalex.org/W2005928903","https://openalex.org/W2006967140","https://openalex.org/W2007153791","https://openalex.org/W2007323926","https://openalex.org/W2011000183","https://openalex.org/W2011073385","https://openalex.org/W2014254942","https://openalex.org/W2015700037","https://openalex.org/W2015897815","https://openalex.org/W2016800407","https://openalex.org/W2017284374","https://openalex.org/W2018448923","https://openalex.org/W2019422906","https://openalex.org/W2019636553","https://openalex.org/W2022664710","https://openalex.org/W2023029789","https://openalex.org/W2023941806","https://openalex.org/W2024590669","https://openalex.org/W2028198542","https://openalex.org/W2029738339","https://openalex.org/W2032913442","https://openalex.org/W2035257545","https://openalex.org/W2035356606","https://openalex.org/W2037389939","https://openalex.org/W2038411609","https://openalex.org/W2038571912","https://openalex.org/W2040390500","https://openalex.org/W2041850796","https://openalex.org/W2042111301","https://openalex.org/W2044487093","https://openalex.org/W2044715647","https://openalex.org/W2044897807","https://openalex.org/W2047475913","https://openalex.org/W2048599972","https://openalex.org/W2052124022","https://openalex.org/W2056004646","https://openalex.org/W2057695252","https://openalex.org/W2058244193","https://openalex.org/W2059453827","https://openalex.org/W2059713553","https://openalex.org/W2061266262","https://openalex.org/W2061294794","https://openalex.org/W2063296736","https://openalex.org/W2067322059","https://openalex.org/W2067405008","https://openalex.org/W2068565752","https://openalex.org/W2069240622","https://openalex.org/W2069525245","https://openalex.org/W2070079809","https://openalex.org/W2070739500","https://openalex.org/W2072687774","https://openalex.org/W2075195146","https://openalex.org/W2075542990","https://openalex.org/W2075583438","https://openalex.org/W2079167667","https://openalex.org/W2079640584","https://openalex.org/W2081360068","https://openalex.org/W2082187144","https://openalex.org/W2083748438","https://openalex.org/W2084581504","https://openalex.org/W2084927470","https://openalex.org/W2085796851","https://openalex.org/W2086328360","https://openalex.org/W2086372007","https://openalex.org/W2088585248","https://openalex.org/W2088635998","https://openalex.org/W2089556958","https://openalex.org/W2091701724","https://openalex.org/W2092578153","https://openalex.org/W2098419010","https://openalex.org/W2098992864","https://openalex.org/W2099352677","https://openalex.org/W2103776029","https://openalex.org/W2107273340","https://openalex.org/W2109291482","https://openalex.org/W2113216285","https://openalex.org/W2113959582","https://openalex.org/W2114625860","https://openalex.org/W2116541356","https://openalex.org/W2118397007","https://openalex.org/W2122126700","https://openalex.org/W2124457156","https://openalex.org/W2124982778","https://openalex.org/W2126354256","https://openalex.org/W2127327752","https://openalex.org/W2135853075","https://openalex.org/W2136592076","https://openalex.org/W2137999969","https://openalex.org/W2141163306","https://openalex.org/W2143604267","https://openalex.org/W2144567287","https://openalex.org/W2145220051","https://openalex.org/W2145723200","https://openalex.org/W2146482482","https://openalex.org/W2147821579","https://openalex.org/W2147828523","https://openalex.org/W2154834417","https://openalex.org/W2156061481","https://openalex.org/W2158065668","https://openalex.org/W2161116308","https://openalex.org/W2162006879","https://openalex.org/W2162114846","https://openalex.org/W2163356737","https://openalex.org/W2164228620","https://openalex.org/W2165960631","https://openalex.org/W2166393810","https://openalex.org/W2169230340","https://openalex.org/W2171830519","https://openalex.org/W2174383425","https://openalex.org/W2215582843","https://openalex.org/W2336578011","https://openalex.org/W2345074464","https://openalex.org/W2389281650","https://openalex.org/W2398140809","https://openalex.org/W2463555142","https://openalex.org/W2476107434","https://openalex.org/W2488521388","https://openalex.org/W2507486477","https://openalex.org/W2515162953","https://openalex.org/W3198823065"],"related_works":["https://openalex.org/W2899325243","https://openalex.org/W2128100990","https://openalex.org/W2137263881","https://openalex.org/W7215135274","https://openalex.org/W2093319492","https://openalex.org/W1901297520","https://openalex.org/W2769954814","https://openalex.org/W2784144573","https://openalex.org/W6940434519","https://openalex.org/W3210919120"],"abstract_inverted_index":{"The":[0,29,107],"mitochondrion":[1,30],"is":[2,84,92,142,161,181,186,208],"an":[3,231],"organelle":[4],"of":[5,13,15,26,44,50,73,88,109,127,132,154,197,216,228,239,251,266],"the":[6,11,16,24,45,56,71,129,138,158,182,189,198,214,217,226,237,263,271,280,306],"eukaryotic":[7],"cell":[8],"responsible":[9],"for":[10,163,221,230,253],"production":[12],"most":[14],"cellular":[17],"energy-carrying":[18],"molecule":[19,39],"adenosine":[20],"triphosphate":[21],"(ATP),":[22],"through":[23],"process":[25,72],"oxidative":[27,46],"phosphorylation.":[28],"contains":[31],"its":[32,62],"own":[33],"genome,":[34],"a":[35,80,102,151,209],"small":[36],"circular":[37],"DNA":[38,90],"(mtDNA),":[40],"encoding":[41],"essential":[42],"subunits":[43],"phosphorylation":[47],"system.":[48],"Initiation":[49,87],"mitochondrial":[51,57,89,199,254,307],"transcription":[52,64,74,98,124,139,164,241],"involves":[53],"three":[54],"proteins,":[55],"RNA":[58],"polymerase,":[59],"POLRMT,":[60],"and":[61,67,125,166,192,235,288],"two":[63],"factors,":[65],"TFAM":[66],"TFB2M.":[68],"Even":[69],"though":[70],"has":[75],"been":[76,115],"reconstituted":[77],"in":[78,144,169],"vitro,":[79],"full":[81],"molecular":[82],"understanding":[83],"still":[85],"missing.":[86],"replication":[91,110,126,255,308],"believed":[93],"to":[94,188,297],"be":[95,250,277,293,303],"primed":[96],"by":[97,279,295,305],"prematurely":[99],"terminated":[100,282],"at":[101,261],"sequence":[103],"known":[104,156],"as":[105,157],"CSBII.":[106],"mechanisms":[108],"initiation":[111,140,171,190],"have":[112,122],"however":[113],"not":[114],"fully":[116],"defined.":[117],"In":[118],"this":[119,133,201,267],"thesis":[120,134,202,268],"we":[121,135,148,177,203,269],"studied":[123],"mtDNA.\\nIn":[128],"first":[130],"part":[131,265],"demonstrate":[136,178,205,289],"that":[137,150,179,185,193,206,212,247,275,290,301],"machinery":[141],"recruited":[143,187],"discrete":[145],"steps.":[146],"Furthermore,":[147],"find":[149],"large":[152],"domain":[153],"POLRMT":[155,207,229],"N-terminal":[159],"extension":[160],"dispensable":[162],"initiation,":[165,256],"instead":[167],"functions":[168],"suppressing":[170],"events":[172],"from":[173],"non-promoter":[174],"DNA.":[175],"Additionally":[176],"TFB2M":[180],"last":[183,264],"factor":[184,219],"complex":[191],"it":[194,258],"induces":[195],"melting":[196],"promoters.\\nIn":[200],"also":[204,245],"non-processive":[210],"polymerase":[211],"needs":[213],"presence":[215],"elongation":[218],"TEFM":[220,224,248],"processive":[222],"transcription.":[223],"increases":[225],"affinity":[227],"elongation-like":[232],"RNA-DNA":[233,272],"template":[234],"decreases":[236],"probability":[238],"premature":[240],"termination.":[242],"Our":[243],"data":[244],"suggest":[246],"might":[249],"importance":[252],"since":[257],"affects":[259],"termination":[260],"CSBII.\\nIn":[262],"study":[270],"hybrids":[273],"(R-loops)":[274],"can":[276,292,302],"formed":[278],"CSBII":[281],"transcript.":[283],"We":[284],"characterize":[285],"these":[286],"R-loops":[287],"they":[291],"processed":[294],"RNaseH1":[296],"form":[298],"replicative":[299],"primers":[300],"used":[304],"machinery.":[309]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2017-01-26T00:00:00"}