{"id":"https://openalex.org/W2579064583","doi":"https://doi.org/10.1111/febs.14013","title":"Specific Arabidopsis thaliana malic enzyme isoforms can provide anaplerotic pyruvate carboxylation function in Saccharomyces cerevisiae","display_name":"Specific Arabidopsis thaliana malic enzyme isoforms can provide anaplerotic pyruvate carboxylation function in Saccharomyces cerevisiae","publication_year":2017,"publication_date":"2017-01-11","ids":{"openalex":"https://openalex.org/W2579064583","doi":"https://doi.org/10.1111/febs.14013","mag":"2579064583","pmid":"https://pubmed.ncbi.nlm.nih.gov/28075062"},"language":"en","primary_location":{"id":"doi:10.1111/febs.14013","doi":"https://doi.org/10.1111/febs.14013","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.14013","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14013","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012817004","display_name":"Mariana Beatriz Badia","orcid":"https://orcid.org/0000-0001-7981-8910","observed_orcids":["https://orcid.org/0000-0001-7981-8910"]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mariana Beatriz Badia","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069488232","display_name":"Robert Mans","orcid":"https://orcid.org/0000-0002-5311-1404","observed_orcids":["https://orcid.org/0000-0002-5311-1404"]},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Mans","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073714510","display_name":"Alicia V. Lis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Alicia V. Lis","raw_affiliation_strings":["Biochemical Engineering Institute Saarland University Saarbr\u00fccken Germany","Department of Biotechnology, Delft University of Technology, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Engineering Institute Saarland University Saarbr\u00fccken Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000824036","display_name":"Marcos Ariel Tronconi","orcid":"https://orcid.org/0000-0001-9568-7818","observed_orcids":["https://orcid.org/0000-0001-9568-7818"]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcos Ariel Tronconi","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010578071","display_name":"Cintia Luc\u00eda Arias","orcid":"https://orcid.org/0000-0002-2546-0877","observed_orcids":["https://orcid.org/0000-0002-2546-0877"]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cintia Luc\u00eda Arias","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027596879","display_name":"Ver\u00f3nica Graciela Maurino","orcid":"https://orcid.org/0000-0002-3124-1451","observed_orcids":["https://orcid.org/0000-0002-3124-1451"]},"institutions":[{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Graciela Maurino","raw_affiliation_strings":["Plant Molecular Physiology and Biotechnology Group Institute of Developmental and Molecular Biology of Plants Cluster of Excellence on Plant Sciences (CEPLAS) Heinrich\u2010Heine\u2010Universit\u00e4t D\u00fcsseldorf Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Molecular Physiology and Biotechnology Group Institute of Developmental and Molecular Biology of Plants Cluster of Excellence on Plant Sciences (CEPLAS) Heinrich\u2010Heine\u2010Universit\u00e4t D\u00fcsseldorf Germany","institution_ids":["https://openalex.org/I4210126213","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034843334","display_name":"Carlos Santiago Andreo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Carlos Santiago Andreo","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065046101","display_name":"Mar\u00eda F. Drincovich","orcid":"https://orcid.org/0000-0003-4897-3285","observed_orcids":["https://orcid.org/0000-0003-4897-3285"]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Fabiana Drincovich","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088420553","display_name":"Antonius J. A. van Maris","orcid":"https://orcid.org/0000-0001-5319-7511","observed_orcids":["https://orcid.org/0000-0001-5319-7511"]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL","SE"],"is_corresponding":true,"raw_author_name":"Antonius J. A. van Maris","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology, The Netherlands","Division of Industrial Biotechnology, School of Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Division of Industrial Biotechnology, School of Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018768826","display_name":"Mariel C. Gerrard Wheeler","orcid":"https://orcid.org/0000-0001-5232-5542","observed_orcids":["https://orcid.org/0000-0001-5232-5542"]},"institutions":[{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]},{"id":"https://openalex.org/I4210142727","display_name":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos","ror":"https://ror.org/040me2j46","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4141589","https://openalex.org/I4210107757","https://openalex.org/I4210123736","https://openalex.org/I4210142727","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Mariel Claudia Gerrard Wheeler","raw_affiliation_strings":["Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudios Fotosint\u00e9ticos y Bioqu\u00edmicos (CEFOBI) Universidad Nacional de Rosario Argentina","institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210142727"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018768826","https://openalex.org/A5088420553"],"corresponding_institution_ids":["https://openalex.org/I4141589","https://openalex.org/I4210135511","https://openalex.org/I4210142727","https://openalex.org/I86987016","https://openalex.org/I98358874"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.3036,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79442177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"284","issue":"4","first_page":"654","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadp-malic-enzyme","display_name":"NADP-malic enzyme","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nad-malic-enzyme","display_name":"NAD-malic enzyme","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pyruvate-carboxylation","display_name":"pyruvate carboxylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/anaplerosis","display_name":"anaplerosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.875},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9589999914169312},{"id":"https://openalex.org/keywords/malate-oxidation","display_name":"malate oxidation","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.8776918649673462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7604488134384155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6462254524230957},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.6451627016067505},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.6439902782440186},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.6277361512184143},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5239120721817017},{"id":"https://openalex.org/C2778957662","wikidata":"https://www.wikidata.org/wiki/Q6743424","display_name":"Malic enzyme","level":4,"score":0.49686649441719055},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.41163209080696106},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3851162791252136},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38085228204727173},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.32016438245773315},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1750119924545288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1691591441631317},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.09699487686157227}],"mesh":[{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008293","descriptor_name":"Malates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050538","descriptor_name":"Malate Dehydrogenase (NADP+)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050538","descriptor_name":"Malate Dehydrogenase (NADP+)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1111/febs.14013","doi":"https://doi.org/10.1111/febs.14013","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.14013","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14013","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:28075062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28075062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:24071","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/24071/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:americanae.aecid.es:3126684","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/50612","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/50612","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/50612","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:tudelft.nl:uuid:739f55d3-6ace-4d2b-97d5-457a94043aab","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:739f55d3-6ace-4d2b-97d5-457a94043aab","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:tud:oai:tudelft.nl:uuid:739f55d3-6ace-4d2b-97d5-457a94043aab","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:739f55d3-6ace-4d2b-97d5-457a94043aab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The FEBS Journal, 284(4)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/febs.14013","doi":"https://doi.org/10.1111/febs.14013","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.14013","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14013","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2579064583.pdf","grobid_xml":"https://content.openalex.org/works/W2579064583.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W331981547","https://openalex.org/W1136149187","https://openalex.org/W1480674700","https://openalex.org/W1483456869","https://openalex.org/W1767473373","https://openalex.org/W1775749144","https://openalex.org/W1921304878","https://openalex.org/W1921745712","https://openalex.org/W1981673913","https://openalex.org/W1988445317","https://openalex.org/W1991842384","https://openalex.org/W1993353532","https://openalex.org/W1994886068","https://openalex.org/W2001313672","https://openalex.org/W2002281803","https://openalex.org/W2035921852","https://openalex.org/W2039378889","https://openalex.org/W2039711608","https://openalex.org/W2041117835","https://openalex.org/W2043208429","https://openalex.org/W2046244942","https://openalex.org/W2047611334","https://openalex.org/W2049529573","https://openalex.org/W2050643560","https://openalex.org/W2056047887","https://openalex.org/W2058098679","https://openalex.org/W2064581967","https://openalex.org/W2072156052","https://openalex.org/W2077293542","https://openalex.org/W2081124819","https://openalex.org/W2084269752","https://openalex.org/W2085778086","https://openalex.org/W2088380315","https://openalex.org/W2092952815","https://openalex.org/W2096336948","https://openalex.org/W2099595662","https://openalex.org/W2101442503","https://openalex.org/W2102223554","https://openalex.org/W2102287393","https://openalex.org/W2103349249","https://openalex.org/W2109406269","https://openalex.org/W2117304629","https://openalex.org/W2117434037","https://openalex.org/W2121933175","https://openalex.org/W2124019798","https://openalex.org/W2124859343","https://openalex.org/W2131708560","https://openalex.org/W2135998024","https://openalex.org/W2138112807","https://openalex.org/W2141754479","https://openalex.org/W2147853672","https://openalex.org/W2151406110","https://openalex.org/W2165630230","https://openalex.org/W2471587466","https://openalex.org/W2494263218","https://openalex.org/W4239977205"],"related_works":["https://openalex.org/W2131708560","https://openalex.org/W2084269752","https://openalex.org/W2088380315","https://openalex.org/W7159939602","https://openalex.org/W2133494707","https://openalex.org/W7074205765","https://openalex.org/W2119408530","https://openalex.org/W2117434037","https://openalex.org/W2056005676","https://openalex.org/W2082069201"],"abstract_inverted_index":{"NAD(P)\u2010malic":[0],"enzyme":[1],"(NAD(P)\u2010ME)":[2],"catalyzes":[3],"the":[4,57,77,96,118,132,137,147,180,208,211,220],"reversible":[5],"oxidative":[6],"decarboxylation":[7],"of":[8,98,108,120,134,163,172,182,214,222],"malate":[9],"to":[10,62,83,196,219],"pyruvate,":[11],"CO2,":[12],"and":[13,15,86,115,126,142,165,203,225],"NAD(P)H":[14],"is":[16,35],"present":[17],"as":[18,74,76],"a":[19,80,205],"multigene":[20],"family":[21],"in":[22,54,69,95,159,201,228],"Arabidopsis":[23,32,71,167],"thaliana.":[24],"The":[25,105],"carboxylation":[26,49,154],"reaction":[27],"catalyzed":[28],"by":[29],"purified":[30],"recombinant":[31],"NADP\u2010ME":[33,153,192],"proteins":[34],"faster":[36],"than":[37],"those":[38],"reported":[39],"for":[40,56,207],"other":[41,138],"animal":[42],"or":[43],"plant":[44,229],"isoforms.":[45],"In":[46,60],"contrast,":[47],"no":[48],"activity":[50,155,176,213],"could":[51,144,156],"be":[52,157],"detected":[53],"vitro":[55],"NAD\u2010dependent":[58],"counterparts.":[59],"order":[61],"further":[63],"investigate":[64],"their":[65],"putative":[66],"carboxylating":[67,212],"role":[68,200],"vivo,":[70],"NAD(P)\u2010ME":[72],"isoforms,":[73],"well":[75],"NADP\u2010ME2del2":[78],"(with":[79],"decreased":[81],"ability":[82],"carboxylate":[84],"pyruvate)":[85],"NADP\u2010ME2R115A":[87],"(lacking":[88],"fumarate":[89],"activation)":[90],"versions,":[91],"were":[92],"functionally":[93],"expressed":[94],"cytosol":[97],"pyruvate":[99],"carboxylase\u2010negative":[100],"(Pyc\u2212)":[101],"Saccharomyces":[102],"cerevisiae":[103,123],"strains.":[104],"heterologous":[106],"expression":[107],"NADP\u2010ME1,":[109],"NADP\u2010ME2":[110,183],"(and":[111],"its":[112],"mutant":[113],"proteins),":[114],"NADP\u2010ME3":[116],"restored":[117],"growth":[119],"Pyc\u2212":[121,148],"S.":[122],"on":[124,131,210],"glucose,":[125],"this":[127,175],"capacity":[128],"was":[129,177],"dependent":[130],"availability":[133],"CO2.":[135],"On":[136],"hand,":[139],"NADP\u2010ME4,":[140],"NAD\u2010ME1,":[141],"NAD\u2010ME2":[143],"not":[145],"rescue":[146],"strains":[149],"from":[150],"C4":[151,223],"auxotrophy.":[152],"measured":[158],"leaf":[160],"crude":[161],"extracts":[162],"knockout":[164],"overexpressing":[166],"lines":[168],"with":[169,179],"modified":[170],"levels":[171],"NADP\u2010ME,":[173,215],"where":[174],"correlated":[178],"amount":[181],"transcript.":[184],"These":[185],"results":[186],"indicate":[187],"that":[188],"specific":[189],"A.":[190],"thaliana":[191],"isoforms":[193],"are":[194],"able":[195],"play":[197],"an":[198],"anaplerotic":[199],"vivo":[202],"provide":[204],"basis":[206],"study":[209],"which":[216],"may":[217],"contribute":[218],"synthesis":[221],"compounds":[224],"redox":[226],"shuttling":[227],"cells.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-26T00:00:00"}