{"id":"https://openalex.org/W2578464978","doi":"https://doi.org/10.1038/bjc.2016.454","title":"MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma","display_name":"MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma","publication_year":2017,"publication_date":"2017-01-12","ids":{"openalex":"https://openalex.org/W2578464978","doi":"https://doi.org/10.1038/bjc.2016.454","mag":"2578464978","pmid":"https://pubmed.ncbi.nlm.nih.gov/28081549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5344289"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.2016.454","doi":"https://doi.org/10.1038/bjc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2016.454","pdf_url":"https://www.nature.com/articles/bjc2016454.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/bjc2016454.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067987805","display_name":"Nuno Padr\u00e3o","orcid":"https://orcid.org/0000-0002-8368-2806","observed_orcids":["https://orcid.org/0000-0002-8368-2806"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nuno Andr\u00e9 Padr\u00e3o","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018710327","display_name":"Sara Monteiro\u2010Reis","orcid":"https://orcid.org/0000-0002-2193-2793","observed_orcids":["https://orcid.org/0000-0002-2193-2793"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Monteiro-Reis","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088712531","display_name":"Jorge Torres-Ferreira","orcid":"https://orcid.org/0000-0003-1347-7951","observed_orcids":["https://orcid.org/0000-0003-1347-7951"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Torres-Ferreira","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056641693","display_name":"Lu\u00eds Antunes","orcid":"https://orcid.org/0000-0002-3098-0711","observed_orcids":["https://orcid.org/0000-0002-3098-0711"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Antunes","raw_affiliation_strings":["Department of Epidemiology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061567609","display_name":"Lu\u00eds B. Le\u00e7a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Le\u00e7a","raw_affiliation_strings":["Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091393635","display_name":"Diana Montezuma","orcid":"https://orcid.org/0000-0001-9551-4589","observed_orcids":["https://orcid.org/0000-0001-9551-4589"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Diana Montezuma","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jo\u00e3o Ramalho-Carvalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Ramalho-Carvalho","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paula C Dias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula C Dias","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017221057","display_name":"Paula Monteiro","orcid":"https://orcid.org/0000-0002-3482-2307","observed_orcids":["https://orcid.org/0000-0002-3482-2307"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Monteiro","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001156104","display_name":"Jorge Oliveira","orcid":"https://orcid.org/0000-0001-7838-7493","observed_orcids":["https://orcid.org/0000-0001-7838-7493"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Oliveira","raw_affiliation_strings":["Department of Urology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057879270","display_name":"Rui Henrique","orcid":"https://orcid.org/0000-0003-3171-4666","observed_orcids":["https://orcid.org/0000-0003-3171-4666"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Henrique","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS) - University of Porto, Rua de Jorge Viterbo Ferreira n.\u00ba 228, Porto 4050-313, Portugal","Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS) - University of Porto, Rua de Jorge Viterbo Ferreira n.\u00ba 228, Porto 4050-313, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]},{"raw_affiliation_string":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042199157","display_name":"C\u00e1rmen Jer\u00f3nimo","orcid":"https://orcid.org/0000-0003-4186-5345","observed_orcids":["https://orcid.org/0000-0003-4186-5345"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Carmen Jer\u00f3nimo","raw_affiliation_strings":["Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS) - University of Porto, Rua de Jorge Viterbo Ferreira n.\u00ba 228, Porto 4050-313, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group - Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr Ant\u00f3nio Bernardino de Almeida, Porto 4200-072, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639"]},{"raw_affiliation_string":"Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS) - University of Porto, Rua de Jorge Viterbo Ferreira n.\u00ba 228, Porto 4050-313, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042199157"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405256639","https://openalex.org/I4405263123"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.665,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.81139126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"116","issue":"5","first_page":"634","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.054499998688697815,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":1.0},{"id":"https://openalex.org/keywords/mir-663a","display_name":"miR-663a","score":1.0},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7599999904632568},{"id":"https://openalex.org/keywords/non-invasive-cancer-detection","display_name":"non-invasive cancer detection","score":0.8550000190734863},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.859000027179718},{"id":"https://openalex.org/keywords/prognostic-performance","display_name":"prognostic performance","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7446907758712769},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6750661134719849},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6613075137138367},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.6298025846481323},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.49492019414901733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4554256796836853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3925226032733917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36162781715393066},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2918173670768738},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2825813293457031},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.25754475593566895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21535494923591614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18097978830337524},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17239445447921753}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014571","descriptor_name":"Urologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014571","descriptor_name":"Urologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019459","descriptor_name":"Urothelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/bjc.2016.454","doi":"https://doi.org/10.1038/bjc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2016.454","pdf_url":"https://www.nature.com/articles/bjc2016454.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4732453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5344289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5344289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5344289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:28081549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28081549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/bjc.2016.454","doi":"https://doi.org/10.1038/bjc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2016.454","pdf_url":"https://www.nature.com/articles/bjc2016454.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1578237752","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3789609402","display_name":"Role of VIM in Epithelial Mesenchymal Transition (EMT) in urothelial cancer","funder_award_id":"SFRH/BD/112673/2015","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G807149165","display_name":"MICRORNAS REGULATION OF CHROMATIN STRUCTURE IN PROSTATE CANCER","funder_award_id":"SFRH/BD/71293/2010","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2578464978.pdf","grobid_xml":"https://content.openalex.org/works/W2578464978.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1514970182","https://openalex.org/W1980525903","https://openalex.org/W1994524037","https://openalex.org/W2006521013","https://openalex.org/W2014946489","https://openalex.org/W2022957119","https://openalex.org/W2044584395","https://openalex.org/W2048547624","https://openalex.org/W2051577701","https://openalex.org/W2062594882","https://openalex.org/W2064792105","https://openalex.org/W2070602415","https://openalex.org/W2074977069","https://openalex.org/W2081379168","https://openalex.org/W2084120869","https://openalex.org/W2090129171","https://openalex.org/W2095682420","https://openalex.org/W2106787323","https://openalex.org/W2124756133","https://openalex.org/W2128580887","https://openalex.org/W2130346031","https://openalex.org/W2132907440","https://openalex.org/W2135810600","https://openalex.org/W2142158646","https://openalex.org/W2151781453","https://openalex.org/W2159142738","https://openalex.org/W2162674813","https://openalex.org/W2163587546","https://openalex.org/W2171141475","https://openalex.org/W2205275114","https://openalex.org/W2343075537","https://openalex.org/W2403689221","https://openalex.org/W2408369464","https://openalex.org/W2917837889","https://openalex.org/W3177100542","https://openalex.org/W4211118805","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2585955452","https://openalex.org/W7140221416","https://openalex.org/W4413574861","https://openalex.org/W4402561862","https://openalex.org/W3182716340","https://openalex.org/W2006761669","https://openalex.org/W2062594882","https://openalex.org/W4285726824","https://openalex.org/W4406834357","https://openalex.org/W2064361523"],"abstract_inverted_index":{"BACKGROUND:":[0],"Urothelial":[1],"carcinoma":[2],"(UC)":[3],"is":[4],"the":[5,10,53,131,176],"most":[6],"common":[7],"cancer":[8],"affecting":[9],"urinary":[11],"system,":[12],"worldwide.":[13],"Lack":[14],"of":[15,56,65,115,157],"accurate":[16],"early":[17],"detection":[18],"tools":[19],"entails":[20],"delayed":[21],"diagnosis,":[22],"precluding":[23],"more":[24],"efficient":[25],"and":[26,37,67,92,97,107,146],"timely":[27],"treatment.":[28],"In":[29,129],"a":[30,179],"previous":[31],"study,":[32],"we":[33,51],"found":[34],"that":[35],"miR-129-2":[36,66],"miR-663a":[38,68],"were":[39,69,100,118],"differentially":[40],"methylated":[41],"in":[42,59,76,87,121,150,164],"UC":[43,77,91,122,137,163],"compared":[44,125],"with":[45,126,143,168],"other":[46,93,139,169],"genitourinary":[47,94,140],"tract":[48,141],"malignancies.":[49,95],"Here,":[50],"evaluated":[52,101],"diagnostic":[54],"performance":[55],"those":[57],"microRNAs":[58,117],"urine.":[60],"METHODS:":[61],"Promoter":[62,112],"methylation":[63,113,160],"levels":[64,114],"assessed,":[70],"using":[71],"real-time":[72],"quantitative":[73],"methylation-specific":[74],"PCR,":[75],"tissue":[78,123],"samples":[79,89,124],"(using":[80],"normal":[81,127],"urothelium":[82],"as":[83],"control)":[84],"and,":[85],"subsequently,":[86],"urine":[88],"from":[90,138],"Diagnostic":[96],"prognostic":[98],"performances":[99],"by":[102],"receiver":[103],"operator":[104],"characteristics":[105],"curve":[106],"survival":[108],"analyses,":[109],"respectively.":[110],"RESULTS:":[111],"both":[116],"significantly":[119],"higher":[120],"urothelium.":[128],"urine,":[130,165],"assay":[132,181],"was":[133],"able":[134],"to":[135,182],"distinguish":[136],"carcinomas":[142],"87.7%":[144],"sensitivity":[145],"84%":[147],"specificity,":[148],"resulting":[149],"85.85%":[151],"overall":[152],"accuracy.":[153],"CONCLUSIONS:":[154],"This":[155,173],"panel":[156],"miRNAs":[158],"promoter":[159],"accurately":[161],"detects":[162],"comparing":[166],"well":[167],"promising":[170],"epigenetic-based":[171],"biomarkers.":[172],"may":[174],"constitute":[175],"basis":[177],"for":[178],"non-invasive":[180],"detect":[183],"UC.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-01-26T00:00:00"}