{"id":"https://openalex.org/W2578255366","doi":"https://doi.org/10.1182/blood.v110.11.264.264","title":"Evidence for an Environmental Influence Leading to the Development of JAK2V617F-Positive Polycythemia Vera: A Molecular Epidemiological Study.","display_name":"Evidence for an Environmental Influence Leading to the Development of JAK2V617F-Positive Polycythemia Vera: A Molecular Epidemiological Study.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2578255366","doi":"https://doi.org/10.1182/blood.v110.11.264.264","mag":"2578255366"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.264.264","doi":"https://doi.org/10.1182/blood.v110.11.264.264","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.264.264","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Hoffman","raw_affiliation_strings":["Mount Sinai School of Medicine and MPD Research Alliance & Consortium, New York, NY, USA","University of Illinois, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine and MPD Research Alliance & Consortium, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033704013","display_name":"Mingjiang Xu","orcid":"https://orcid.org/0000-0002-7063-6253","observed_orcids":["https://orcid.org/0000-0002-7063-6253"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingjiang Xu","raw_affiliation_strings":["Mount Sinai School of Medicine and MPD Research Alliance & Consortium, New York, NY, USA","University of Illinois, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine and MPD Research Alliance & Consortium, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"University of Illinois, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024666997","display_name":"Paul I. Roda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul I. Roda","raw_affiliation_strings":["North Eastern Medical Oncology, Hazelton, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Eastern Medical Oncology, Hazelton, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080833158","display_name":"Aisha Obad Jumaan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199145359","display_name":"Agency for Toxic Substances and Disease Registry","ror":"https://ror.org/0045x2741","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I199145359"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aisha Jumaan","raw_affiliation_strings":["The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA","institution_ids":["https://openalex.org/I199145359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089983989","display_name":"Brian E. Lewis","orcid":"https://orcid.org/0000-0003-1636-432X","observed_orcids":["https://orcid.org/0000-0003-1636-432X"]},"institutions":[{"id":"https://openalex.org/I199145359","display_name":"Agency for Toxic Substances and Disease Registry","ror":"https://ror.org/0045x2741","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I199145359"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Lewis","raw_affiliation_strings":["The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA","institution_ids":["https://openalex.org/I199145359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076658707","display_name":"Carol A. Gotway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Gotway","raw_affiliation_strings":["Centers for Disease Control & Prevention, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control & Prevention, Atlanta, GA, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012326420","display_name":"Vincent Y. Seaman","orcid":"https://orcid.org/0000-0002-6518-4598","observed_orcids":["https://orcid.org/0000-0002-6518-4598"]},"institutions":[{"id":"https://openalex.org/I199145359","display_name":"Agency for Toxic Substances and Disease Registry","ror":"https://ror.org/0045x2741","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I199145359"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Seaman","raw_affiliation_strings":["The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA","institution_ids":["https://openalex.org/I199145359"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.155,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61427082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"110","issue":"11","first_page":"264","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14169","display_name":"Public Health and Environmental Issues","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/environmental-exposure","display_name":"environmental exposure","score":0.6869999766349792},{"id":"https://openalex.org/keywords/superfund-sites","display_name":"Superfund sites","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hazardous-waste-recycling","display_name":"hazardous waste recycling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/disease-clusters","display_name":"disease clusters","score":0.4950000047683716},{"id":"https://openalex.org/keywords/spatial-scan-statistic","display_name":"spatial scan statistic","score":0.5080000162124634},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.8040000200271606},{"id":"https://openalex.org/keywords/molecular-epidemiology","display_name":"molecular epidemiology","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6645066738128662},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5802503228187561},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.47301676869392395},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.44485750794410706},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4423188865184784},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.4287322461605072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32922595739364624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.264.264","doi":"https://doi.org/10.1182/blood.v110.11.264.264","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.264.264","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079656497","https://openalex.org/W130814372","https://openalex.org/W2578839706","https://openalex.org/W2285026922","https://openalex.org/W4206337447","https://openalex.org/W2066457878","https://openalex.org/W2003054658","https://openalex.org/W2993058114","https://openalex.org/W2275079856","https://openalex.org/W2306705894"],"abstract_inverted_index":{"Abstract":[0],"Polycythema":[1],"vera":[2],"(PV)":[3],"is":[4,36,408],"a":[5,62,92,102,145,153,180,189,213,268,278,310,314,447],"chronic":[6],"myeloproliferative":[7],"disorder":[8],"(MPD)":[9],"associated":[10],"with":[11,148,342],"an":[12,374,502,505],"acquired":[13],"mutation":[14],"(JAK2V617F)":[15],"in":[16,25,60,67,136,239,290,325,421,430,442,457,465,480],"over":[17],"90%":[18],"of":[19,23,45,50,65,78,95,104,118,138,163,182,193,212,223,252,283,293,300,313,333,346,353,361,368,381,438,450,454,461,469,477,486,491,514],"patients.":[20],"The":[21,98,131,207,351],"incidence":[22,485],"PV":[24,66,107,132,164,285,302,334,385,462],"the":[26,42,48,51,68,76,139,161,168,194,204,210,240,248,253,257,291,294,306,326,358,365,369,379,384,422,431,436,451,458,470,475,484,489,496,512],"US,":[27],"based":[28,143,388],"on":[29,144,389],"national":[30,401],"cancer":[31,112,393],"registry":[32,113,394,425,471],"data":[33],"from":[34,218],"2001\u201303,":[35],"0.9":[37],"persons/105population/year.":[38],"In":[39],"Oct.":[40],"2006,":[41],"PA":[43],"Dept.":[44],"Health":[46],"requested":[47],"assistance":[49],"Agency":[52,235],"for":[53,129,160,179,200,364,495,501],"Toxic":[54],"Substances":[55],"and":[56,84,114,125,175,250,271,357,392,400,511],"Disease":[57],"Registry":[58],"(ATSDR)":[59],"confirming":[61],"suspected":[63],"cluster":[64,270],"3":[69,295],"counties":[70,90,296],"(Carbon,":[71],"Luzerne,":[72],"&":[73],"Schuylkill)":[74],"surrounding":[75],"borough":[77],"Tamaqua,":[79],"home":[80,211],"to":[81,122,246,287,344,378,398],"multiple":[82],"Superfund":[83,197],"National":[85],"Priorities":[86],"Listing":[87],"sites.":[88],"These":[89],"have":[91,418],"total":[93,103,452],"population":[94],"\u223c527,000":[96],"individuals.":[97],"ATSDR":[99],"investigation":[100,444,493],"identified":[101,264,304,441],"131":[105],"possible":[106],"cases,":[108,117,395],"including":[109,320],"97":[110],"state":[111,399],"34":[115],"self-reported":[116],"which":[119,473],"72":[120],"agreed":[121],"be":[123,404],"interviewed":[124,140],"63":[126],"were":[127,226,303,335,338,428],"tested":[128],"JAK2V617F.":[130],"diagnosis":[133,162,181,460],"was":[134,209,244,463],"confirmed":[135,415,439,464],"38":[137],"participants":[141],"(53%)":[142],"JAK2V617F+":[146,301,515],"assay":[147,155],"granulocytes":[149],"(37":[150],"cases)":[151],"or":[152,348],"JAK2V617F\u2212":[154],"but":[156,243],"satisfying":[157],"WHO":[158],"criteria":[159,177],"(1":[165],"case).":[166],"Of":[167],"37":[169],"cases":[170,299,370,416,426,440,456],"who":[171,323],"met":[172],"both":[173,390],"clinical":[174],"molecular":[176],"(JAK2V617F+)":[178],"PV,":[183],"18":[184],"(49%)":[185],"had":[186,277],"resided":[187],"within":[188,274,305],"13":[190],"mile":[191],"radius":[192],"McAdoo":[195],"Associates":[196],"Site":[198],"(MASS)":[199],">5":[201],"years":[202],"during":[203],"period":[205],"1970\u201395.":[206],"MASS":[208],"hazardous":[214],"waste":[215],"recycling":[216],"business":[217],"1975\u201379":[219],"where":[220],"large":[221],"quantities":[222],"toxic":[224],"chemicals":[225,254],"dumped":[227],"directly":[228],"into":[229,256],"old":[230],"mine":[231],"shafts.The":[232],"Environmental":[233],"Protection":[234],"completed":[236],"surface":[237],"remediation":[238],"early":[241],"90\u2019s,":[242],"unable":[245],"determine":[247],"extent":[249],"fate":[251],"poured":[255],"mine.":[258],"A":[259],"spatial":[260],"scan":[261],"statistical":[262,362],"analysis":[263,479],"this":[265,275,443,492],"area":[266,276,308],"as":[267,413,427,506],"significant":[269,499],"individuals":[272,288,322],"living":[273],"4.5":[279],"times":[280],"greater":[281],"risk":[282],"developing":[284],"compared":[286],"residing":[289],"remainder":[292],"(p<0.001).":[297],"4":[298],"described":[307],"along":[309],"2-mile":[311],"stretch":[312],"single":[315],"street":[316],"containing":[317],"70":[318],"homes,":[319],"2":[321],"lived":[324],"same":[327],"dwelling.":[328],"No":[329],"familial":[330],"inheritance":[331],"patterns":[332],"documented,":[336],"nor":[337],"any":[339],"correlations":[340],"noted":[341],"regards":[343],"type":[345],"employment":[347],"recreational/leisure":[349],"activities.":[350],"lack":[352],"traditional":[354],"epidemiological":[355,481],"explanations":[356],"high":[359],"degree":[360],"certainty":[363],"geographical":[366],"association":[367,503],"strongly":[371],"suggests":[372],"that":[373,410],"external":[375,509],"influence":[376],"led":[377],"development":[380,513],"PV.":[382,516],"Since":[383],"rates":[386,402],"are":[387],"self-identified":[391],"direct":[396],"comparisons":[397],"can\u2019t":[403],"made.":[405],"However,":[406],"it":[407],"likely":[409],"at":[411],"least":[412],"many":[414],"would":[417],"been":[419],"found":[420,429],"61":[423],"\u201cmissing\u201d":[424],"20":[432],"\u201cself-reporting\u201d":[433],"cases.":[434],"Thus,":[435],"number":[437,453],"should":[445],"represent":[446],"conservative":[448],"estimate":[449],"actual":[455],"registry.The":[459],"less":[466],"than":[467],"half":[468],"participants,":[472],"highlights":[474],"utility":[476],"JAK2V617F":[478],"studies":[482],"evaluating":[483],"MPD.":[487],"Finally,":[488],"results":[490],"provide,":[494],"first":[497],"time,":[498],"evidence":[500],"between":[504],"yet":[507],"uncharacterized":[508],"stimulus":[510]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-01-26T00:00:00"}