{"id":"https://openalex.org/W2578239678","doi":null,"title":"Temporal evaluation of an ex vivo bioreactor model of abdominal aortic aneurysm","display_name":"Temporal evaluation of an ex vivo bioreactor model of abdominal aortic aneurysm","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2578239678","mag":"2578239678"},"language":"en","primary_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:13918","doi":null,"is_oa":true,"landing_page_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","pdf_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034245479","display_name":"Emily R. Clark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emily R. Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034245479"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":1.0},{"id":"https://openalex.org/keywords/porcine-carotid-artery","display_name":"porcine carotid artery","score":0.8489999771118164},{"id":"https://openalex.org/keywords/arterial-remodeling","display_name":"arterial remodeling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6819999814033508},{"id":"https://openalex.org/keywords/uniaxial-tensile-test","display_name":"uniaxial tensile testing","score":0.796999990940094},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.7579326033592224},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6177738904953003},{"id":"https://openalex.org/C2780520971","wikidata":"https://www.wikidata.org/wiki/Q2264329","display_name":"Abdominal aorta","level":3,"score":0.5692145824432373},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5588379502296448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5093690156936646},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.48746681213378906},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.4839909076690674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42892542481422424},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3733710050582886},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36991992592811584},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3328849673271179},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.27228525280952454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2624669075012207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08616667985916138},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.whiterose.ac.uk:13918","doi":null,"is_oa":true,"landing_page_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","pdf_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2578239678","doi":null,"is_oa":false,"landing_page_url":"https://etheses.whiterose.ac.uk/13918/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.whiterose.ac.uk:13918","doi":null,"is_oa":true,"landing_page_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","pdf_url":"http://etheses.whiterose.ac.uk/13918/1/EmilyClark_Thesis2016.pdf","source":{"id":"https://openalex.org/S4306401585","display_name":"White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2578239678.pdf","grobid_xml":"https://content.openalex.org/works/W2578239678.grobid-xml"},"referenced_works_count":272,"referenced_works":["https://openalex.org/W38131634","https://openalex.org/W57916358","https://openalex.org/W84743294","https://openalex.org/W239602587","https://openalex.org/W278134811","https://openalex.org/W1488072854","https://openalex.org/W1491671746","https://openalex.org/W1501615986","https://openalex.org/W1587697394","https://openalex.org/W1603518308","https://openalex.org/W1605822561","https://openalex.org/W1622431244","https://openalex.org/W1628282901","https://openalex.org/W1707463934","https://openalex.org/W1769745300","https://openalex.org/W1876118674","https://openalex.org/W1886864374","https://openalex.org/W1897788786","https://openalex.org/W1936770188","https://openalex.org/W1964592337","https://openalex.org/W1965152163","https://openalex.org/W1965661486","https://openalex.org/W1965933207","https://openalex.org/W1966309110","https://openalex.org/W1967456218","https://openalex.org/W1967611844","https://openalex.org/W1969887141","https://openalex.org/W1969929083","https://openalex.org/W1970190103","https://openalex.org/W1971448058","https://openalex.org/W1971898007","https://openalex.org/W1971925839","https://openalex.org/W1972349762","https://openalex.org/W1974355899","https://openalex.org/W1974445311","https://openalex.org/W1976562969","https://openalex.org/W1976983083","https://openalex.org/W1978582021","https://openalex.org/W1978838038","https://openalex.org/W1978857673","https://openalex.org/W1979430873","https://openalex.org/W1980020427","https://openalex.org/W1981157406","https://openalex.org/W1981551394","https://openalex.org/W1982318528","https://openalex.org/W1983678692","https://openalex.org/W1983964976","https://openalex.org/W1984587485","https://openalex.org/W1985732223","https://openalex.org/W1985865240","https://openalex.org/W1985922835","https://openalex.org/W1987165350","https://openalex.org/W1987280936","https://openalex.org/W1987603011","https://openalex.org/W1988167553","https://openalex.org/W1989152927","https://openalex.org/W1989746297","https://openalex.org/W1990113206","https://openalex.org/W1990861235","https://openalex.org/W1991016293","https://openalex.org/W1991279168","https://openalex.org/W1991708925","https://openalex.org/W1993030094","https://openalex.org/W1993480392","https://openalex.org/W1993721409","https://openalex.org/W1995403412","https://openalex.org/W1995719512","https://openalex.org/W1996282226","https://openalex.org/W1996630410","https://openalex.org/W1996648522","https://openalex.org/W1996702326","https://openalex.org/W1997439732","https://openalex.org/W1999773490","https://openalex.org/W2000053231","https://openalex.org/W2000825997","https://openalex.org/W2002622272","https://openalex.org/W2004181539","https://openalex.org/W2005358475","https://openalex.org/W2005893093","https://openalex.org/W2010548149","https://openalex.org/W2011339859","https://openalex.org/W2012160048","https://openalex.org/W2013393085","https://openalex.org/W2015148040","https://openalex.org/W2015156312","https://openalex.org/W2015725632","https://openalex.org/W2016203569","https://openalex.org/W2018738609","https://openalex.org/W2020084616","https://openalex.org/W2021229522","https://openalex.org/W2021366186","https://openalex.org/W2022544791","https://openalex.org/W2024045849","https://openalex.org/W2024335159","https://openalex.org/W2025900960","https://openalex.org/W2027462241","https://openalex.org/W2028378081","https://openalex.org/W2028477410","https://openalex.org/W2028810337","https://openalex.org/W2029081881","https://openalex.org/W2030817861","https://openalex.org/W2030928343","https://openalex.org/W2031575410","https://openalex.org/W2032381326","https://openalex.org/W2033317461","https://openalex.org/W2033611394","https://openalex.org/W2034671758","https://openalex.org/W2034855849","https://openalex.org/W2036067687","https://openalex.org/W2036788356","https://openalex.org/W2037181102","https://openalex.org/W2037384386","https://openalex.org/W2038015971","https://openalex.org/W2038021740","https://openalex.org/W2038454445","https://openalex.org/W2039068212","https://openalex.org/W2041560313","https://openalex.org/W2043156676","https://openalex.org/W2045025698","https://openalex.org/W2045831731","https://openalex.org/W2046311960","https://openalex.org/W2047110284","https://openalex.org/W2047899902","https://openalex.org/W2048138263","https://openalex.org/W2048239536","https://openalex.org/W2048497399","https://openalex.org/W2049130497","https://openalex.org/W2049135617","https://openalex.org/W2050619507","https://openalex.org/W2051437231","https://openalex.org/W2052402508","https://openalex.org/W2053832395","https://openalex.org/W2054758930","https://openalex.org/W2054801276","https://openalex.org/W2055034760","https://openalex.org/W2055864356","https://openalex.org/W2057259121","https://openalex.org/W2058370346","https://openalex.org/W2058517835","https://openalex.org/W2059401552","https://openalex.org/W2061091803","https://openalex.org/W2061476870","https://openalex.org/W2063401487","https://openalex.org/W2064399578","https://openalex.org/W2065530999","https://openalex.org/W2066820321","https://openalex.org/W2068145120","https://openalex.org/W2069092564","https://openalex.org/W2069423108","https://openalex.org/W2069629141","https://openalex.org/W2070563373","https://openalex.org/W2070923130","https://openalex.org/W2071763658","https://openalex.org/W2074304438","https://openalex.org/W2075234146","https://openalex.org/W2077472932","https://openalex.org/W2081117740","https://openalex.org/W2082332064","https://openalex.org/W2082822668","https://openalex.org/W2083384470","https://openalex.org/W2083601199","https://openalex.org/W2083790949","https://openalex.org/W2084337122","https://openalex.org/W2084838040","https://openalex.org/W2085421725","https://openalex.org/W2085837709","https://openalex.org/W2086321931","https://openalex.org/W2088601069","https://openalex.org/W2089980004","https://openalex.org/W2090073018","https://openalex.org/W2090763398","https://openalex.org/W2090788017","https://openalex.org/W2092126087","https://openalex.org/W2092144064","https://openalex.org/W2094876228","https://openalex.org/W2095250024","https://openalex.org/W2096839116","https://openalex.org/W2102237590","https://openalex.org/W2103006958","https://openalex.org/W2103370821","https://openalex.org/W2105826816","https://openalex.org/W2107122524","https://openalex.org/W2108808942","https://openalex.org/W2112541717","https://openalex.org/W2112850450","https://openalex.org/W2112964143","https://openalex.org/W2114814938","https://openalex.org/W2115484826","https://openalex.org/W2116105773","https://openalex.org/W2116809022","https://openalex.org/W2119584795","https://openalex.org/W2120149146","https://openalex.org/W2120639656","https://openalex.org/W2120839177","https://openalex.org/W2121313897","https://openalex.org/W2121427612","https://openalex.org/W2121431419","https://openalex.org/W2121822802","https://openalex.org/W2122348272","https://openalex.org/W2122756945","https://openalex.org/W2123518040","https://openalex.org/W2125507532","https://openalex.org/W2126922182","https://openalex.org/W2126984992","https://openalex.org/W2127737230","https://openalex.org/W2128455103","https://openalex.org/W2128534413","https://openalex.org/W2129221272","https://openalex.org/W2131171515","https://openalex.org/W2131887858","https://openalex.org/W2135742242","https://openalex.org/W2135802281","https://openalex.org/W2136248852","https://openalex.org/W2137531080","https://openalex.org/W2138041199","https://openalex.org/W2138885149","https://openalex.org/W2140611701","https://openalex.org/W2141224774","https://openalex.org/W2143544907","https://openalex.org/W2146052423","https://openalex.org/W2147355064","https://openalex.org/W2147640802","https://openalex.org/W2149335377","https://openalex.org/W2149932046","https://openalex.org/W2152717709","https://openalex.org/W2153221979","https://openalex.org/W2154001085","https://openalex.org/W2154123067","https://openalex.org/W2154952881","https://openalex.org/W2156291142","https://openalex.org/W2156914728","https://openalex.org/W2157572390","https://openalex.org/W2157856015","https://openalex.org/W2159097149","https://openalex.org/W2161517314","https://openalex.org/W2161572158","https://openalex.org/W2163041161","https://openalex.org/W2164258641","https://openalex.org/W2166004158","https://openalex.org/W2166171562","https://openalex.org/W2166183981","https://openalex.org/W2166320116","https://openalex.org/W2166404845","https://openalex.org/W2166739553","https://openalex.org/W2168796958","https://openalex.org/W2168917423","https://openalex.org/W2168947486","https://openalex.org/W2172214297","https://openalex.org/W2172215671","https://openalex.org/W2207452496","https://openalex.org/W2213478767","https://openalex.org/W2217220297","https://openalex.org/W2222930627","https://openalex.org/W2263051185","https://openalex.org/W2272921018","https://openalex.org/W2289409406","https://openalex.org/W2293117303","https://openalex.org/W2298081206","https://openalex.org/W2320689805","https://openalex.org/W2323285201","https://openalex.org/W2358688435","https://openalex.org/W2395043331","https://openalex.org/W2396747242","https://openalex.org/W2406477783","https://openalex.org/W2428653926","https://openalex.org/W2436310127","https://openalex.org/W2441515673","https://openalex.org/W2575806582","https://openalex.org/W2601484520","https://openalex.org/W2979556210","https://openalex.org/W4256715862","https://openalex.org/W4296979652"],"related_works":["https://openalex.org/W2121313897","https://openalex.org/W4220929124","https://openalex.org/W2773009193","https://openalex.org/W3157071645","https://openalex.org/W2990606045","https://openalex.org/W4214559860","https://openalex.org/W2369053899","https://openalex.org/W2979301611","https://openalex.org/W2922216719","https://openalex.org/W2567762258"],"abstract_inverted_index":{"Abdominal":[0,33],"aortic":[1],"aneurysm":[2],"(AAA)":[3],"is":[4,20,47,87,584],"an":[5,48,109,125,296,385,493,496],"asymptomatic":[6],"dilatation":[7],"of":[8,28,55,73,89,103,117,130,167,176,186,191,224,251,264,272,289,298,305,339,394,399,413,433,445,453,462,473,510,535,591,597],"the":[9,25,29,31,44,53,70,74,79,83,171,187,210,225,236,249,252,273,276,290,306,340,350,356,364,368,372,420,429,434,457,476,484,511,516,520,529,588],"abdominal":[10],"aorta":[11],"which":[12,86,206,479,539,583],"ultimately":[13],"leads":[14],"to":[15,24,51,81,98,122,148,169,230,246,348,362,456,544,564,569,579],"rupture":[16],"without":[17,553],"intervention.":[18,602],"Rupture":[19],"typically":[21],"fatal.":[22],"Due":[23],"silent":[26],"nature":[27,54],"disease,":[30],"National":[32],"Aortic":[34],"Aneurysm":[35],"Screening":[36],"Programme":[37],"(NAAASP)":[38],"has":[39,105],"recently":[40],"been":[41,96,106],"implemented":[42],"in":[43,112,160,184,203,235,275,301,355,367,371,387,407,419,443,475,483,528],"UK.":[45],"It":[46,487],"unprecedented":[49],"opportunity":[50,598],"explore":[52],"early":[56,110,172,237,277,600],"AAA":[57,92,113,131,215,409,566,592],"development":[58],"and":[59,77,132,145,158,173,189,194,218,222,238,278,286,322,328,331,343,396,548],"uncover":[60],"new":[61],"targets":[62,582],"for":[63,164,220,267,325,381,599],"therapeutics.":[64],"\\nSmooth":[65],"muscle":[66],"cells":[67],"(SMCs)":[68],"are":[69,404],"principle":[71],"component":[72],"arterial":[75,192,532],"wall":[76],"have":[78,95],"ability":[80],"stabilise":[82],"pathological":[84],"remodelling":[85,509,533],"characteristic":[88,432],"AAA.":[90,177],"In":[91],"tissue,":[93],"SMCs":[94,104,208,221,274,307,424,438,567],"shown":[97],"be":[99,545,562,577],"dysfunctional.":[100],"Phenotypic":[101],"switching":[102],"reported":[107],"as":[108,261],"event":[111],"development.":[114],"\\nThe":[115,270],"aim":[116],"this":[118,268,491],"study":[119,197,202,360,556],"was":[120,139,244,258,295,308,334,346,416,480,488,492],"therefore":[121],"further":[123],"characterise":[124,134,248,565],"ex":[126],"vivo":[127],"porcine":[128,142],"model":[129,170,179,212,478,502,575],"temporally":[133,182],"SMC":[135,388,414,571],"phenotype.":[136,302,572],"The":[137,178,303,423,437,500,573],"approach":[138],"\\nto":[140],"harvest":[141],"carotid":[143],"arteries":[144],"subject":[146],"them":[147],"a":[149,161,200,262,299,337,470,595],"protease":[150,341,375,541],"pre-treatment.":[151,536,554],"\\nThey":[152],"were":[153,228,281,439],"then":[154,181,551],"cultured":[155],"under":[156],"flow":[157],"pressure":[159],"vascular":[162],"bioreactor":[163,344,379,530],"specified":[165],"periods":[166],"time":[168],"end":[174,517],"stage":[175,518],"\\nwas":[180],"characterised":[183,282],"terms":[185,444,461],"structure":[188,234,271],"function":[190,250,304],"tissue":[193,233,463],"SMCs.":[195,216,410],"This":[196,359],"directly":[198],"followed":[199,377],"previous":[201,369],"our":[204],"\\nlaboratory":[205],"validated":[207],"from":[209],"end-stage":[211,239,279,357,373,435,458,477],"with":[213],"human":[214,408],"\\nHistology":[217],"immunohistochemistry":[219],"components":[223],"extracellular":[226],"matrix":[227,326],"used":[229,245,578],"qualitatively":[231],"analyse":[232],"models.":[240],"Uniaxial":[241],"tensile":[242,523],"testing":[243,524],"\\nbiomechanically":[247],"tissue.":[253],"Whole":[254],"vessel":[255],"pressuredilation":[256],"analysis":[257,285],"also":[259,309,405,417,440,503],"evaluated":[260],"method":[263],"biomechanical":[265],"characterisation":[266],"model.":[269,358,422,436,459,486,521],"models":[280],"using":[283,311],"image":[284],"fluorescence":[287],"microscopy":[288],"actin":[291],"cytoskeleton.":[292],"\\nSMC":[293],"circularity":[294],"indication":[297],"change":[300],"assessed":[310],"proliferation":[312],"assays,":[313],"scratch":[314],"wound":[315],"migration":[316],"\\nassays,":[317],"senescence":[318,395,454],"associated":[319],"beta-galactosidase":[320],"assays":[321],"gelatin":[323],"zymography":[324],"metalloproteinase-2":[327],"9":[329],"(MMP-2":[330],"-9).":[332],"\\nIt":[333],"determined":[335],"that":[336,490,526,558],"combination":[338],"pre-treatment":[342,376,542],"culture":[345,380,527],"required":[347],"induce":[349],"phenotypic":[351,430],"switch":[352,431],"seen":[353,366],"previously":[354],"managed":[361],"reproduce":[363],"results":[365],"study;":[370],"model,":[374],"by":[378,515],"twelve":[382],"days":[383],"induced":[384],"increase":[386],"circularity,":[389],"impaired":[390],"proliferation,":[391],"elevated":[392],"levels":[393,398,452],"decreased":[397],"MMP":[400,446],"secretion.":[401],"These":[402],"characteristics":[403],"observed":[406,418],"\\nA":[411],"period":[412],"hyperproliferation":[415],"early-stage":[421,485,501,574],"had":[425,449,513],"not":[426,481,561],"yet":[427],"undergone":[428],"more":[441],"active":[442],"secretion":[447],"\\nand":[448],"much":[450],"lower":[451],"compared":[455],"\\nIn":[460],"structure,":[464],"Sirius":[465],"Red":[466],"histological":[467],"staining":[468],"revealed":[469,525],"periluminal":[471],"deposition":[472],"collagen":[474],"present":[482],"hypothesised":[489],"attempt":[494],"at":[495],"ECM":[497],"stabilisation":[498],"mechanism.":[499],"reached":[504],"aneurysmal":[505],"dimensions":[506],"but":[507],"inwards":[508],"artery":[512],"occurred":[514],"\\nof":[519],"\\nUniaxial":[522],"caused":[531],"regardless":[534],"Generally,":[537],"vessels":[538],"received":[540],"tended":[543],"thinner,":[546],"weaker":[547],"less":[549],"compliant":[550],"those":[552],"\\nThis":[555],"shows":[557],"it":[559],"may":[560,576],"appropriate":[563],"according":[568],"classical":[570],"\\nilluminate":[580],"potential":[581],"particularly":[585],"pertinent":[586],"given":[587],"recent":[589],"advent":[590],"screening,":[593],"providing":[594],"window":[596],"\\ntherapeutic":[601]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-26T00:00:00"}