{"id":"https://openalex.org/W2576584875","doi":"https://doi.org/10.1038/cr.2017.14","title":"Simultaneous enhancement of cellular and humoral immunity by the high salt formulation of Al(OH)3 adjuvant","display_name":"Simultaneous enhancement of cellular and humoral immunity by the high salt formulation of Al(OH)3 adjuvant","publication_year":2017,"publication_date":"2017-01-20","ids":{"openalex":"https://openalex.org/W2576584875","doi":"https://doi.org/10.1038/cr.2017.14","mag":"2576584875","pmid":"https://pubmed.ncbi.nlm.nih.gov/28106074","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5385609"},"language":"en","primary_location":{"id":"doi:10.1038/cr.2017.14","doi":"https://doi.org/10.1038/cr.2017.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cr.2017.14","pdf_url":"https://www.nature.com/articles/cr201714.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/cr201714.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100440788","display_name":"Min Luo","orcid":"https://orcid.org/0000-0002-6875-7945","observed_orcids":["https://orcid.org/0000-0002-6875-7945"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Luo","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707416","display_name":"Bin Shao","orcid":"https://orcid.org/0000-0002-0678-7372","observed_orcids":["https://orcid.org/0000-0002-0678-7372"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Shao","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077056483","display_name":"Jiayun Yu","orcid":"https://orcid.org/0000-0003-4569-3093","observed_orcids":["https://orcid.org/0000-0003-4569-3093"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-yun Yu","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418162","display_name":"Ting Liu","orcid":"https://orcid.org/0000-0003-1816-5551","observed_orcids":["https://orcid.org/0000-0003-1816-5551","https://orcid.org/0009-0000-7402-2817","https://orcid.org/0009-0002-5449-669X","https://orcid.org/0009-0005-6034-5101","https://orcid.org/0009-0007-4365-5444"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Liu","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015152606","display_name":"Xiao Liang","orcid":"https://orcid.org/0000-0003-0330-7027","observed_orcids":["https://orcid.org/0000-0003-0330-7027"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Liang","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103120278","display_name":"Lian Lu","orcid":"https://orcid.org/0000-0001-5707-2150","observed_orcids":["https://orcid.org/0000-0001-5707-2150"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Lu","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002925062","display_name":"Tinghong Ye","orcid":"https://orcid.org/0000-0002-3296-6753","observed_orcids":["https://orcid.org/0000-0002-3296-6753"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting-hong Ye","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076381011","display_name":"Zhiyao He","orcid":"https://orcid.org/0000-0001-7888-211X","observed_orcids":["https://orcid.org/0000-0001-7888-211X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-yao He","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029916604","display_name":"Hengyi Xiao","orcid":"https://orcid.org/0000-0003-3872-9203","observed_orcids":["https://orcid.org/0000-0003-3872-9203"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng-yi Xiao","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000511598","display_name":"Xiawei Wei","orcid":"https://orcid.org/0000-0002-6513-6422","observed_orcids":["https://orcid.org/0000-0002-6513-6422"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia-wei Wei","raw_affiliation_strings":["Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]},{"raw_affiliation_string":"Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000511598"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.8315,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67565474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"27","issue":"4","first_page":"586","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aluminum-hydroxide-adjuvant","display_name":"aluminum hydroxide adjuvant","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.9610000252723694},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.8679999709129333},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.9599999785423279},{"id":"https://openalex.org/keywords/protein-vaccine","display_name":"protein vaccine","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.800000011920929},{"id":"https://openalex.org/keywords/cross-presentation","display_name":"cross-presentation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7720000147819519},{"id":"https://openalex.org/keywords/igg-isotypes","display_name":"IgG isotypes","score":0.5009999871253967},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.8264951705932617},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.7999584674835205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7934921979904175},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.6754964590072632},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6486074328422546},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.5903553366661072},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49269822239875793},{"id":"https://openalex.org/C2991991741","wikidata":"https://www.wikidata.org/wiki/Q188025","display_name":"Salt lake","level":3,"score":0.4429793357849121},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3970506489276886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08168718218803406},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C109007969","wikidata":"https://www.wikidata.org/wiki/Q749565","display_name":"Structural basin","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000277","descriptor_name":"Adjuvants, Pharmaceutic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000536","descriptor_name":"Aluminum Hydroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012492","descriptor_name":"Salts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/cr.2017.14","doi":"https://doi.org/10.1038/cr.2017.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cr.2017.14","pdf_url":"https://www.nature.com/articles/cr201714.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4252036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5385609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28106074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28106074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell research","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:5385609","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5385609/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/cr.2017.14","doi":"https://doi.org/10.1038/cr.2017.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cr.2017.14","pdf_url":"https://www.nature.com/articles/cr201714.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3396537242","display_name":"\u78f7\u8102\u9170\u4e1d\u6c28\u9178\u8c03\u63a7\u80bf\u7624\u5fae\u73af\u5883\u5185\u5de8\u566c\u7ec6\u80deM2\u578b\u6781\u5316\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"81602492","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5532428116","display_name":null,"funder_award_id":"2016YFA0201402","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2576584875.pdf","grobid_xml":"https://content.openalex.org/works/W2576584875.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1990954596","https://openalex.org/W2029884055","https://openalex.org/W2036606290","https://openalex.org/W2048253455","https://openalex.org/W2067749638","https://openalex.org/W2107140931","https://openalex.org/W2111975769","https://openalex.org/W2112837750","https://openalex.org/W2119954265","https://openalex.org/W2154911070","https://openalex.org/W2170240282","https://openalex.org/W4233777048"],"related_works":["https://openalex.org/W2049284422","https://openalex.org/W4402726366","https://openalex.org/W2059512105","https://openalex.org/W4401820107","https://openalex.org/W146717125","https://openalex.org/W4399874384","https://openalex.org/W1548884443","https://openalex.org/W2560638286","https://openalex.org/W2340651629","https://openalex.org/W2890423549"],"abstract_inverted_index":{"Adjuvants":[0],"play":[1,1461],"essential":[2],"roles":[3,1240],"in":[4,19,48,213,218,286,321,443,449,461,539,551,582,601,636,664,678,694,699,751,793,892,1012,1065,1078,1171,1195,1217,1241,1261,1316,1363,1397,1427,1465,1476,1490,1531,1572,1645,1667,1676,1691,1702,1718,1729,1771,1789,1961,2006,2024],"vaccination":[5,50,99,942,970,979],"by":[6,118,137,344,358,427,483,500,518,569,629,683,732,848,920,960,1050,1293,1310,1457,1577,1617,1837,1862,1920,1944,2001],"enhancing":[7],"and/or":[8],"shaping":[9],"antigen-specific":[10,1102,1469],"immune":[11,38,61,95,110,201,889,1320,1569,1677,1742,1769,1918,1928],"responses":[12,96,148,304,311,1243,1321],"1":[13,350,596,760,828],".":[14,41,54,76,130,150,185,451,493,506,528,541,584,638,740,782,795,1323],"They":[15],"are":[16],"commonly":[17],"used":[18,47,1326],"every":[20,879],"type":[21],"of":[22,59,65,72,80,133,143,173,182,189,192,197,209,231,266,294,301,338,353,362,395,415,477,496,532,537,564,574,580,621,625,667,675,727,737,754,790,851,867,886,902,909,936,943,952,989,999,1068,1101,1116,1147,1153,1161,1179,1193,1214,1253,1256,1266,1273,1287,1296,1307,1319,1350,1356,1381,1393,1424,1436,1454,1468,1480,1501,1523,1568,1596,1601,1612,1637,1654,1664,1720,1751,1755,1848,1865,1906,1916,1940,1977,1988,2017,2027,2034],"vaccines,":[23,26],"e.g.,":[24],"cancer":[25,37],"which":[27,1459,1964],"have":[28,44,167,203,1239],"been":[29,45,164,205],"proved":[30],"to":[31,89,108,121,140,157,166,222,253,1097,1238,1244,1341,1809,1937,1969,2014],"be":[32,116,223,1291,1747,1934,1966,1997],"a":[33,63,228,239,272,519,611,772,797,835,855,899,1051,1150,1297,1360,1432,1462,1634,1748,1898,1952],"promising":[34],"approach":[35],"for":[36,51,472,512,558,595,650,661,759,814,857,1335,2040],"therapy":[39,1535],"2":[40,589,651,745],"Aluminum-based":[42],"adjuvants":[43,67,85,217,2039],"widely":[46],"human":[49],"decades":[52],"3":[53,235,296,340,364,372,473,735,822,858,863,868,880,1908],"Despite":[55],"the":[56,78,87,103,141,171,187,195,200,245,250,264,267,283,291,322,335,346,359,405,408,416,444,456,535,554,562,577,604,626,632,665,679,702,711,752,755,787,831,896,929,934,950,987,997,1013,1030,1066,1080,1099,1105,1117,1127,1145,1177,1212,1251,1254,1257,1284,1294,1317,1336,1398,1401,1425,1443,1466,1475,1481,1486,1494,1502,1513,1524,1549,1566,1573,1578,1594,1613,1618,1662,1668,1674,1681,1703,1730,1752,1764,1768,1806,1827,1849,1853,1863,1874,1886,1914,1926,1938,1947,1957,1993,2003,2025,2032],"robust":[57],"induction":[58,935,1100,1467,1915],"antibody-mediated":[60],"responses,":[62,111],"limitation":[64],"aluminum-based":[66],"is":[68,154,1991,2011],"their":[69],"weak":[70],"stimulation":[71,120,1246],"cell-mediated":[73,937],"immunity":[74,343,357,1652,1974],"4":[75],"Thus,":[77],"development":[79,172,2033],"safe,":[81,2012],"stable":[82],"and":[83,93,125,161,179,199,243,249,308,355,413,419,422,458,503,561,608,653,767,769,817,915,1004,1022,1140,1158,1181,1189,1200,1202,1222,1230,1383,1390,1409,1561,1606,1686,1694,1724,1784,1826,1832,1842,1845,1868,1900,1930,1941,1975,1985,2008,2016,2031,2036],"effective":[84,1434,1610,2038],"with":[86,215,238,282,389,463,553,588,603,642,656,701,716,744,763,811,821,945,969,971,980,1033,1122,1126,1370,1420,1512,1541,1830],"ability":[88,1192],"enhance":[90,933,1098,1452,1925],"both":[91,1220],"humoral":[92,342,356,374,1917],"cellular":[94,354,437,1242,1651,1927,1973],"during":[97,1400],"clinical":[98],"remains":[100,221],"challenging.":[101],"As":[102,1233,1740],"major":[104,1749],"antigen-presenting":[105],"cells":[106,113,517,721,729,827,891,957,1041,1073,1330,1387,1589,1592,1608,1690,1728,1782],"(APCs)":[107],"initiate":[109],"dendritic":[112],"(DCs)":[114],"can":[115,932,1347,1450],"triggered":[117],"environmental":[119],"elicit":[122],"different":[123,393,812,852],"phenotypes":[124],"functions":[126,196],"5":[127,381,668,779],",":[128,177,1248,1759,1963],"6":[129,521,825,871],"Moreover,":[131,1025,1208,1412],"cross-presentation":[132,693,1306,1349,1453,1943],"extracellular":[134,1308,1455],"protein":[135,219,1223],"antigens":[136,1437,1456],"DCs":[138,198,538,544,581,585,630,639,696,713,741,1162,1194,1218,1311,1346,1373,1382],"contributes":[139],"generation":[142,476],"cytotoxic":[144],"T":[145,720,728,956,1026,1108,1329,1386,1588,1604,1657,1689,1697,1727,1980],"lymphocyte":[146],"(CTL)":[147],"7":[149,843,1322],"Sodium":[151],"chloride":[152],"(NaCl)":[153],"closely":[155,1935],"related":[156,1936],"our":[158,1169],"daily":[159],"lives":[160],"has":[162,1312],"recently":[163],"found":[165,940,1774],"potential":[168],"effects":[169,1995],"on":[170,194,861,1176],"autoimmune":[174],"diseases":[175],"8":[176],"9":[178],"specific":[180,436],"states":[181],"macrophages":[183,917,1786],"10":[184,643,707,806,824,870],"However,":[186],"impacts":[188],"high":[190,210,240,1075,1094,1142,1184,1209,1274,1344,1371,1428,1448,1579,1801,1833,1879],"concentrations":[191,394,531,557,573,607,705,758,1178],"salt":[193,211,241,368,433,689,1076,1095,1143,1185,1210,1275,1449,1483,1504,1580,1705,1732,1904,1949],"system":[202],"not":[204,983],"studied.":[206],"The":[207,258,475,494,507,673,725,874,883,907,1264,1353,1520,1982],"use":[208],"formulation":[212,230,293,337,361,785,885,931,1636,1666,1902,1950,2010],"combination":[214],"aluminum":[216,232,1831],"vaccines":[220,813,853,2007],"explored.":[224],"Here":[225],"we":[226,926,1249,1325,1473,1582,1672,1760,1896],"developed":[227],"new":[229,930],"hydroxide":[233],"(Al(OH)":[234],")":[236],"adjuvant":[237,256,284,1994],"concentration":[242,289,369,620,690,1152,1876,2005],"utilized":[244],"OVA":[246,399,467,594,750,962,1046,1081,1418],"model":[247,324,799,837,1016,1085,1489,1960],"antigen":[248,252,578,692,1190,1942],"HBsAg":[251,323,1014,1083],"evaluate":[254],"its":[255],"effect.":[257],"serum":[259,410,1550],"ELISA":[260,504],"results":[261,317,1008,1631],"showed":[262,1359,1551,1609],"that":[263,334,941,1093,1416,1447,1633,1775,1800,1992],"increase":[265,1064,1115,1362,1717],"total":[268,417],"IgG":[269,418,420],"level":[270,1119],"reached":[271,1877],"peak":[273],"at":[274,598,1219],"3.6%":[275],"NaCl":[276,288,396,533,556,575,606,622,660,704,757,947,982,1035,1124,1151,1526,1543,1620,1875,2004],"(":[277,312,325,378,803,840,973,1001,1017,1055,1086,1130,1163,1197,1225,1277,1301,1374,1404,1438,1516,1556,1622,1707,1734,1793],"Figure":[278,313,328,349,974,1002,1020,1056,1089,1133,1166,1198,1205,1228,1280,1302,1375,1407,1439,1517,1559,1625,1710,1737,1794],"1A":[279,314],").":[280,315,330,976,1006,1024,1058,1135,1207,1232,1282,1304,1377,1411,1441,1519,1563,1627,1712,1739,1796,1893],"Compared":[281],"prepared":[285],"regular":[287],"(0.9%),":[290],"high-salt":[292,336,360,884,1635,1665,1765],"Al(OH)":[295,339,363,371,1907],"mildly":[297],"improved":[298,1999],"OVA-induced":[299],"production":[300],"IgG1-associated":[302],"Th2":[303,347],"rather":[305],"than":[306,1885],"IgG2a-":[307],"IgG2b-associated":[309],"Th1":[310,1072],"Similar":[316,1007],"were":[318,384,425,441,453,510,549,586,640,681,697,714,742,809,846,918,1009,1236,1388,1821,1855],"also":[319,995,1010,1714],"observed":[320,1389,1715,1822],"Supplementary":[326,1018,1087,1131,1164,1203,1226,1278,1405,1557,1623,1708,1735,1889],"information,":[327,1019,1088,1132,1165,1204,1227,1279,1406,1558,1624,1709,1736,1890],"S1A":[329],"These":[331,1797],"data":[332,1445],"suggest":[333,1632],"enhances":[341,370],"stimulating":[345],"response.":[348],"Simultaneous":[351],"enhancement":[352],"adjuvant.":[365],"(A)":[366],"High":[367,530,572,619,688],"adjuvant-induced":[373],"immunity.":[375,438,938],"C57BL/6":[376,439,547,801],"mice":[377,440,548,802,839,944,1031,1333,1539,1792,1825,1828,1854],"n":[379,804,841],"=":[380,805,842],"per":[382,400,807,844],"group)":[383,808,845],"vaccinated":[385],"subcutaneously":[386,820,865],"three":[387,815],"times":[388,816,1883],"OVA/Al":[390,791,887,972,1128,1638],"complex":[391,1505],"containing":[392,706],"(5":[397],"\u03bcg":[398],"mouse).":[401],"Seven":[402],"days":[403,736],"after":[404,734,830,864,1074,1120,1271,1680],"third":[406,832,897],"immunization,":[407],"mouse":[409],"was":[411,481,498,567,730,877,905,1061,1113,1395,1528],"collected":[412],"levels":[414,674,1224],"subclasses":[421],"IgG1":[423],"titer":[424],"determined":[426,482,1836],"ELISA.":[428,684],"(B":[429],"-":[430,686],"E)":[431],"OVA/Al/high":[432,1482,1503,1704,1731,1948],"vaccine":[434,792,1015,1084,1484,1498,1527,1621,1639,1766,1803,2029],"induces":[435,691],"immunized":[442,810,1032,1540,1829],"same":[445,508],"way":[446],"as":[447,958,1048,1835,1860,1878,1880],"described":[448],"A":[450],"Lymphocytes":[452,1537],"isolated":[454,545],"from":[455,546,722,1029,1331,1538,1912],"spleen":[457],"further":[459,1529,1660,1761,1924],"incubated":[460,587],"vitro":[462,540,583,637,1172,1196],"CD8":[464,478,718,911,954,990,1327,1364,1384,1602,1648,1695,1725,1970],"+":[465,479,719,912,955,991,1070,1107,1328,1365,1385,1585,1587,1603,1649,1656,1693,1696,1723,1726,1971,1979],"-specific":[466],"257\u2013264":[468,490,963],"peptides":[469],"(10":[470],"\u03bcg/ml)":[471],"days.":[474,881],"CTLs":[480],"FCM":[484,501,733,1354],"using":[485,1485],"PE-conjugated":[486,961],"H-2K":[487,1337],"b":[488,966,1338],"/OVA":[489,1339],"tetramer":[491,967],"(B)":[492],"expression":[495,563,1213],"IFN-\u03b3":[497],"examined":[499,1138,1474],"(C)":[502],"(D)":[505],"lymphocytes":[509,1027,1605,1777],"tested":[511],"CTL-mediated":[513,1650,1972],"cytotoxicity":[514,1038],"against":[515,1039,1956],"E.G7-OVA":[516,826,872,1040,1487,1958],"standard":[520,1052],"h":[522,560,597,652,663],"51":[523],"Cr":[524],"release":[525,1286],"assay":[526,1054],"(E)":[527],"(F)":[529],"promote":[534,576],"maturation":[536,565,1188],"Bone":[542],"marrow-derived":[543],"cultured":[550,698],"medium":[552,602,700],"indicated":[555,605,703,756],"48":[559,662],"markers":[566],"analyzed":[568,609,919],"FCM.":[570,921],"(G)":[571],"uptake":[579,1191],"\u03bcg/ml":[590,708,746],"Alexa":[591,747],"Fluor":[592,748],"488-labeled":[593,749],"37":[599],"\u00b0C":[600],"under":[610,771,1856],"fluorescent":[612],"microscope.":[613,776],"Scale":[614,777],"bars,":[615,778],"20":[616],"\u03bcm.":[617],"(H)":[618],"promotes":[623,1211],"secretion":[624,998,1392],"pro-inflammatory":[627,676],"cytokines":[628,677,1216,1289],"through":[631,1593,1647],"p38":[633,1267,1298],"MAPK":[634,1234,1258,1268],"pathway":[635,1260],"pretreated":[641],"\u03bcM":[644,669],"SB203580":[645,1300],"(SB)":[646],"or":[647,658,671,1082,1496,1590],"DMSO":[648],"(DM)":[649],"then":[654,818],"treated":[655,743,847],"0.9%":[657],"1.5%":[659],"presence":[666,753],"SB":[670],"DM.":[672],"supernatant":[680],"measured":[682,878],"(I":[685],"J)":[687],"DCs.":[695,1148,1945],"OVA.":[709,1352],"Then":[710],"stimulated":[712],"co-cultured":[715],"CFSE-labeled":[717],"OT-I":[723,1332],"mice.":[724,1491],"proliferation":[726,1367],"assessed":[731,927,1673],"co-culture":[738,1369,1402],"(I)":[739],"h,":[761],"stained":[762],"rabbit":[764],"anti-LMP2/Cy3":[765],"antibody":[766],"DAPI,":[768],"visualized":[770],"confocal":[773,1413],"laser":[774],"scanning":[775],"\u03bcm":[780],"(J)":[781],"(K)":[783],"High-salt":[784],"potentiates":[786],"antitumor":[788,1478,1521,1554,1574,1614,1643,1670,1813,1954],"effect":[789,1479,1522,1555,1615,1644,1932,1955],"vivo":[794,1477,1646,1962],"In":[796,834,977,1492,1894],"prophylactic":[798,1495],"(left),":[800],"challenged":[819],"\u00d7":[823,869],"week":[829,856],"immunization.":[833,1682],"therapeutic":[836,1497,2041],"(right),":[838],"subcutaneous":[849],"injection":[850,1595],"once":[854],"weeks":[859],"starting":[860],"day":[862],"introduction":[866],"cells.":[873,1658,1981],"tumor":[875,893,903,1488,1507,1546,1744,1756,1807,1959],"volume":[876],"(L)":[882],"diminished":[888],"suppressive":[890,1743],"microenvironment.":[894],"After":[895],"treatment,":[898],"single-cell":[900],"suspension":[901],"tissues":[904],"prepared.":[906],"percentages":[908,1067,1719],"infiltrating":[910],"lymphocytes,":[913],"MDSCs":[914],"M2":[916,1785],"Full":[922],"size":[923],"image":[924],"Next,":[925,1472],"whether":[928,1139,1343,1763],"We":[939,1136,1713,1773],"OVA/Al/3.6%":[946,981,1034,1123,1525,1542,1619,1790],"dramatically":[948,985],"increased":[949,986,996,1156,1270,1285,1701],"frequency":[951,988],"OVA-specific":[953],"detected":[959,1396],"-bound":[964],"H-2k":[965],"compared":[968,1125,1511],"1B":[975],"addition,":[978],"only":[984],"INF-\u03b3-producing":[992,1071],"CTLs,":[993,1103],"but":[994],"INF-\u03b3":[1000],"1C":[1003],"1D":[1005],"obtained":[1011],"S1B":[1021],"S1C":[1023],"derived":[1028],"exhibited":[1036,1640,1951],"higher":[1037,1884],"(a":[1042,1422],"cell":[1043,1159,1570,1678,1698],"line":[1044],"expressing":[1045],"peptides)":[1047],"revealed":[1049,1415],"51Cr-release":[1053],"1E":[1057],"Notably,":[1059],"there":[1060,1112],"no":[1062,1114,1552,1818],"significant":[1063,1819,1953],"CD4":[1069,1106,1584,1655,1692,1722,1978],"treatment":[1077,1276],"either":[1079,1493],"S1D":[1090],"),":[1091,1168],"indicating":[1092],"helped":[1096],"bypassing":[1104],"helper":[1109],"arm.":[1110],"Also,":[1111,1378],"IL-4":[1118],"immunization":[1121,1500],"group":[1129,1706,1733],"S1E":[1134],"next":[1137],"how":[1141],"influences":[1144],"activation":[1146,1939],"Since":[1149],"1.8%":[1154],"caused":[1155],"apoptosis":[1157],"death":[1160],"S1J":[1167],"subsequent":[1170],"experiments":[1173],"mainly":[1174],"focused":[1175],"1.2%":[1180],"1.5%.":[1182],"Interestingly,":[1183],"significantly":[1186,1269,1451,1700,1788,1998],"promoted":[1187],"1F":[1199],"1G":[1201],"S1F":[1206],"inflammatory":[1215,1288],"mRNA":[1221],"S1G":[1229],"S1H":[1231],"pathways":[1235],"reported":[1237],"stress":[1245],"11":[1247],"explored":[1250],"possibility":[1252],"involvement":[1255],"signaling":[1259],"DC":[1262],"activation.":[1263],"phosphorylation":[1265],"hours":[1272],"S1I":[1281],"Furthermore,":[1283],"could":[1290,1923,1996],"abolished":[1292],"addition":[1295],"inhibitor":[1299],"1H":[1303],"Efficient":[1305],"proteins":[1309],"an":[1313,1532,1641,1716,1741],"important":[1314],"role":[1315,1464,1663],"initiation":[1318],"Here,":[1324],"(specific":[1334],"complex)":[1340],"test":[1342],"salt-stimulated":[1345],"perform":[1348],"soluble":[1351],"analysis":[1355],"CFSE":[1357],"fluorescence":[1358],"2-fold":[1361],"T-cell":[1366],"upon":[1368],"salt-treated":[1372,1429],"1I":[1376],"more":[1379,1417,1433,1509,1811,2037],"clusters":[1380],"enhanced":[1391,1642],"IL-2":[1394],"supernatants":[1399],"process":[1403],"S1K":[1408],"S1L":[1410],"microscopy":[1414],"co-localized":[1419],"LMP2":[1421],"marker":[1423],"immunoproteasome)":[1426],"DCs,":[1430,1458],"suggesting":[1431],"processing":[1435],"1J":[1440],"Collectively,":[1442],"above":[1444],"indicate":[1446,1799],"might":[1460,1746,1965],"critical":[1463],"CTL":[1470],"activity.":[1471],"model,":[1499],"inhibited":[1506,1545],"growth":[1508],"effectively":[1510,1544],"other":[1514],"groups":[1515],"1K":[1518],"studied":[1530],"adoptive":[1533],"cellular/serum":[1534],"model.":[1536],"growth,":[1547],"while":[1548],"apparent":[1553],"S1M":[1560],"S1N":[1562],"To":[1564,1659],"investigate":[1565],"function":[1567],"subsets":[1571,1679],"activity":[1575],"elicited":[1576],"formulation,":[1581],"depleted":[1583],"/CD8":[1586],"NK":[1591,1607],"monoclonal":[1597],"antibodies.":[1598],"Only":[1599],"depletion":[1600],"abrogation":[1611],"induced":[1616],"S1O":[1626],"Taken":[1628],"together,":[1629],"these":[1630],"independent":[1653,1976],"study":[1661,1990],"strong":[1669],"effect,":[1671],"changes":[1675],"Both":[1683],"central":[1684],"memory":[1685,1688],"effector":[1687],"populations":[1699],"S1P":[1711,1738],"splenic":[1721],"microenvironment":[1745,1770,1808],"determinant":[1750],"poor":[1753],"outcome":[1754],"immunotherapy":[1757],"12":[1758],"investigated":[1762],"alters":[1767],"tumors.":[1772],"tumor-infiltrating":[1776],"increased,":[1778],"whereas":[1779],"myeloid-derived":[1780],"suppressor":[1781],"(MDSCs)":[1783],"decreased":[1787],"NaCl-treated":[1791],"1L":[1795],"observations":[1798],"salt-containing":[1802],"may":[1804,1933,2022],"alter":[1805],"favor":[1810],"potent":[1812],"effects.":[1814],"For":[1815],"safety":[1816],"assessment,":[1817],"differences":[1820],"between":[1823],"normal":[1824,1887,1921],"salt,":[1834],"appearance,":[1838],"body":[1839],"weight,":[1840],"fecal":[1841],"urinary":[1843],"excretion,":[1844],"H&E":[1846],"staining":[1847],"vital":[1850],"organs.":[1851],"All":[1852],"good":[1857],"physiological":[1858],"conditions":[1859],"shown":[1861],"monitoring":[1864],"heart":[1866],"rate":[1867],"mean":[1869],"arterial":[1870],"pressure,":[1871],"even":[1872],"when":[1873],"14.4%":[1881],"(16":[1882],"osmolality;":[1888],"Table":[1891],"S1":[1892],"conclusion,":[1895],"discovered":[1897],"novel":[1899],"safe":[1901],"(high":[1903],"formulation)":[1905],"adjuvant,":[1909],"which,":[1910],"aside":[1911],"maintaining":[1913],"response":[1919],"Al-adjuvant,":[1922],"response;":[1929],"this":[1931,1989],"Consequently,":[1946],"largely":[1967],"due":[1968],"most":[1983],"interesting":[1984],"surprising":[1986],"finding":[1987],"simply":[2000],"altering":[2002],"such":[2009],"easy":[2013],"prepare,":[2015],"low":[2018],"cost.":[2019],"This":[2020],"concept":[2021],"assist":[2023],"design":[2026],"broad":[2028],"formulations":[2030],"safer":[2035],"uses.":[2042]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-26T00:00:00"}
