{"id":"https://openalex.org/W2576394304","doi":null,"title":"An update on clinical trials of targeted therapies in thyroid cancer","display_name":"An update on clinical trials of targeted therapies in thyroid cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2576394304","mag":"2576394304"},"language":"en","primary_location":{"id":"pmh:oai:czasopisma.viamedica.pl:article/38275","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/view/38275","pdf_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/download/38275/26908","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncology in Clinical Practice; Vol 10, No 2 (2014); 121-130","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/download/38275/26908","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077475730","display_name":"Sigurd\u00eds Haraldsd\u00f3ttir","orcid":"https://orcid.org/0000-0002-5050-3699","observed_orcids":["https://orcid.org/0000-0002-5050-3699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sigurd\u00eds Haraldsd\u00f3ttir","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5050-3699","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035552610","display_name":"Manisha H. Shah","orcid":"https://orcid.org/0000-0002-6453-2044","observed_orcids":["https://orcid.org/0000-0002-6453-2044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manisha H. Shah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6453-2044","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7646,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.93853032,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"121","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7269999980926514},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.7110000252723694},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vandetanib","display_name":"vandetanib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cabozantinib","display_name":"cabozantinib","score":0.9729999899864197},{"id":"https://openalex.org/keywords/radioiodine-refractory-thyroid-cancer","display_name":"radioiodine-refractory thyroid cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8999999761581421},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9129999876022339},{"id":"https://openalex.org/keywords/multidisciplinary-care","display_name":"multidisciplinary care","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9411700963973999},{"id":"https://openalex.org/C2780333294","wikidata":"https://www.wikidata.org/wiki/Q7914515","display_name":"Vandetanib","level":4,"score":0.9095197916030884},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8118096590042114},{"id":"https://openalex.org/C2781064419","wikidata":"https://www.wikidata.org/wiki/Q795057","display_name":"Cabozantinib","level":3,"score":0.7925770282745361},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6878923177719116},{"id":"https://openalex.org/C2780120053","wikidata":"https://www.wikidata.org/wiki/Q3493538","display_name":"Medullary thyroid cancer","level":4,"score":0.665793240070343},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.6364206075668335},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6048733592033386},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5835939049720764},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5711727142333984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5487684011459351},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43815261125564575},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:czasopisma.viamedica.pl:article/38275","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/view/38275","pdf_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/download/38275/26908","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncology in Clinical Practice; Vol 10, No 2 (2014); 121-130","raw_type":null},{"id":"mag:2576394304","doi":null,"is_oa":false,"landing_page_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/download/38275/26908","pdf_url":null,"source":{"id":"https://openalex.org/S2737348819","display_name":"Oncology in Clinical Practice","issn_l":"2450-1654","issn":["2450-1654","2450-6478"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-100","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Oncology in Clinical Practice","raw_type":null}],"best_oa_location":{"id":"pmh:oai:czasopisma.viamedica.pl:article/38275","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/view/38275","pdf_url":"https://journals.viamedica.pl/oncology_in_clinical_practice/article/download/38275/26908","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncology in Clinical Practice; Vol 10, No 2 (2014); 121-130","raw_type":null},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2576394304.pdf","grobid_xml":"https://content.openalex.org/works/W2576394304.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027331882","https://openalex.org/W2563853024","https://openalex.org/W4417333353","https://openalex.org/W2471706669","https://openalex.org/W2050425302","https://openalex.org/W2311220203","https://openalex.org/W3008601482","https://openalex.org/W3114714629","https://openalex.org/W184653811","https://openalex.org/W3046155501"],"abstract_inverted_index":{"Purpose":[0],"of":[1,53,60,138,165],"review.":[2],"Several":[3],"new":[4,192],"targeted":[5,141,166],"therapies":[6,82,105,132,142,168],"with":[7,76,130,187],"multikinase":[8],"inhibitors":[9],"targeting":[10],"vascular":[11],"endothelial":[12],"growth":[13],"factor":[14],"(VEGF),":[15],"rearranged":[16,79],"during":[17,80],"transfection":[18],"and":[19,40,71,78,84,95,171,185],"v-raf":[20],"murine":[21],"sarcoma":[22],"viral":[23],"oncogene":[24],"homolog":[25],"B1":[26],"pathways":[27],"have":[28,88,191],"been":[29],"tested":[30],"in":[31,45,64,68,86,98,158,169,173,181],"clinical":[32],"trials":[33,75],"for":[34,145,152],"radioiodine-refractory":[35],"differentiated":[36],"thyroid":[37,42,153],"cancer":[38,43],"(DTC)":[39],"medullary":[41],"(MTC)":[44],"the":[46,54,99,174,182],"past":[47,100,175],"10":[48],"years.":[49,102],"Recent":[50],"findings.":[51],"Results":[52],"fi":[55,183],"rst":[56],"phase":[57,73],"III":[58,74],"trial":[59],"VEGF-targeted":[61],"therapy":[62,116,194],"(sorafenib)":[63],"DTC":[65,170],"were":[66],"presented":[67],"June":[69],"2013,":[70],"two":[72],"VEGF":[77],"transfection-targeted":[81],"(vandetanib":[83],"cabozantinib)":[85],"MTC":[87,172],"led":[89],"to":[90,111,118,134],"approval":[91],"by":[92],"US":[93],"Food":[94],"Drug":[96],"Administration":[97],"2":[101],"Whereas":[103],"such":[104,131],"increase":[106],"median":[107],"progression-free":[108],"survival":[109,121],"compared":[110],"placebo,":[112],"there":[113],"is":[114,143,155,178],"no":[115],"proven":[117],"improve":[119],"overall":[120],"yet.":[122],"Signifi":[123],"cant":[124],"potential":[125],"adverse":[126],"event":[127],"risks":[128],"associated":[129],"need":[133],"be":[135],"recognized.":[136],"Dissemination":[137],"knowledge":[139],"about":[140],"critical":[144],"various":[146],"medical":[147],"specialists":[148],"as":[149],"patient":[150],"care":[151],"cancers":[154],"best":[156],"delivered":[157],"a":[159],"multidisciplinary":[160],"setting.":[161],"Summary.":[162],"Successful":[163],"development":[164],"systemic":[167],"5":[176],"years":[177],"incredibly":[179],"exciting":[180],"eld":[184],"patients":[186],"advanced":[188],"DTC/MTC":[189],"now":[190],"standard-of-care":[193],"options.":[195]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2017-01-26T00:00:00"}