{"id":"https://openalex.org/W2576244377","doi":null,"title":"Dietary Determinants of Age-Related Macular Degeneration","display_name":"Dietary Determinants of Age-Related Macular Degeneration","publication_year":2016,"publication_date":"2016-05-04","ids":{"openalex":"https://openalex.org/W2576244377","mag":"2576244377"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/27201715","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101544174","display_name":"Juan Wu","orcid":"https://orcid.org/0000-0002-1840-1895","observed_orcids":["https://orcid.org/0000-0002-1840-1895"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Juan Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1840-1895","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101544174"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":1.0},{"id":"https://openalex.org/keywords/dietary-carotenoids","display_name":"dietary carotenoids","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lutein","display_name":"lutein","score":0.8880000114440918},{"id":"https://openalex.org/keywords/zeaxanthin","display_name":"zeaxanthin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":0.7850000262260437},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":0.9459999799728394},{"id":"https://openalex.org/keywords/trans-fatty-acids","display_name":"trans fatty acids","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mayonnaise","display_name":"mayonnaise","score":0.9319999814033508},{"id":"https://openalex.org/keywords/intermediate-amd","display_name":"intermediate AMD","score":0.5989999771118164},{"id":"https://openalex.org/keywords/advanced-amd","display_name":"advanced AMD","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fruit-and-vegetable-intake","display_name":"fruit and vegetable intake","score":0.722000002861023},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.8740000128746033},{"id":"https://openalex.org/keywords/health-professionals-follow-up-study","display_name":"Health Professionals Follow-up Study","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8198100924491882},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4468994438648224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43652212619781494},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3988547623157501},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.36904722452163696},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3371308445930481},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.32259976863861084}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/27201715","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2576244377","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/27201715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/27201715","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2576244377.pdf","grobid_xml":"https://content.openalex.org/works/W2576244377.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1965361680","https://openalex.org/W2018298442","https://openalex.org/W2033902287","https://openalex.org/W2036127264","https://openalex.org/W2059063320","https://openalex.org/W2063337840","https://openalex.org/W2066068977","https://openalex.org/W2076375837","https://openalex.org/W2090189176","https://openalex.org/W2099756978","https://openalex.org/W2102984665","https://openalex.org/W2104421727","https://openalex.org/W2117957338","https://openalex.org/W2120021843","https://openalex.org/W2126558328","https://openalex.org/W2134187534","https://openalex.org/W2140626612","https://openalex.org/W2160226180","https://openalex.org/W2161126530","https://openalex.org/W2166829897","https://openalex.org/W2168506946","https://openalex.org/W2171753645"],"related_works":["https://openalex.org/W7099742861","https://openalex.org/W2184824787","https://openalex.org/W2611110267","https://openalex.org/W1534606983","https://openalex.org/W2126558328","https://openalex.org/W1970385641","https://openalex.org/W1900216307","https://openalex.org/W3168434391","https://openalex.org/W4401803069","https://openalex.org/W2119575236"],"abstract_inverted_index":{"Age-related":[0],"macular":[1],"degeneration":[2],"(AMD)":[3],"is":[4,235],"the":[5,23,28,35,44,56,66,85,94,105,121,162,198,227,241,269,307,323,342],"most":[6,67],"common":[7,100],"cause":[8],"of":[9,25,30,48,58,96,107,114,166,229,254,289,325,346],"irreversible":[10],"blindness":[11],"in":[12,22,27,43,102,187,278,283,332],"older":[13],"Americans.":[14],"There":[15,219],"has":[16,87],"been":[17,88],"a":[18,285],"long":[19],"standing":[20],"interest":[21],"role":[24],"diet":[26,326],"development":[29],"AMD.":[31,59,180,218],"As":[32],"early":[33],"as":[34,306],"first":[36],"National":[37],"Health":[38,123,126],"and":[39,50,61,81,98,125,282,327],"Nutrition":[40],"Examination":[41],"Survey":[42],"1970s,":[45],"higher":[46,252],"intakes":[47,95,133,165,185],"fruits":[49],"vegetables":[51],"were":[52,158,171,211],"inversely":[53,172,212],"correlated":[54],"with":[55,174,214,223,258,268],"prevalence":[57],"Carotenoids":[60],"omega3":[62,201,208,243],"fatty":[63,202,209,244],"acids":[64,210],"are":[65,303,312],"studied":[68,317],"dietary":[69,310],"factors":[70,311],"due":[71,321],"to":[72,104,160,314,322],"strong":[73],"biological":[74],"plausibility.":[75],"However,":[76],"evidence":[77,231],"from":[78,147,335],"epidemiologic":[79],"studies":[80,340],"clinical":[82],"trials":[83,302,320],"on":[84,183],"relations":[86],"inconsistent.":[89],"\\nChapter":[90,194],"I":[91],"prospectively":[92,196],"examined":[93],"lutein/zeaxanthin":[97],"other":[99],"carotenoids":[101,168],"relation":[103],"risk":[106],"AMD":[108,176,234,260],"over":[109],"more":[110],"than":[111,190],"two":[112,117],"decades":[113],"follow-up":[115],"among":[116],"large":[118,336],"US":[119],"cohorts,":[120],"Nurses\u2019":[122],"Study":[124],"Professionals":[127],"Follow-Up":[128],"Study.":[129],"We":[130,139,204,249],"assessed":[131],"nutrient":[132,192],"by":[134,318],"repeated":[135],"food":[136,148,287],"frequency":[137],"questionnaires.":[138],"also":[140,236],"computed":[141],"bioavailable":[142,167,184],"plasma":[143],"carotenoid":[144],"scores":[145],"directly":[146],"intake":[149,253],"using":[150],"validated":[151],"regression":[152],"models.":[153],"Cox":[154],"proportional":[155],"hazards":[156],"models":[157],"used":[159],"compute":[161],"associations.":[163],"Higher":[164],"(except":[169],"lycopene)":[170],"associated":[173,213,257],"advanced":[175,224,233],"but":[177,263],"not":[178,264],"intermediate":[179,217,259],"Analyses":[181],"based":[182],"resulted":[186],"stronger":[188],"associations":[189],"conventional":[191],"intakes.":[193],"II":[195],"evaluated":[197],"marine":[199],"long-chain":[200,207],"acids.":[203],"found":[205,250,277],"that":[206,251],"visually":[215],"significant":[216],"was":[220,256,276],"no":[221],"association":[222,297],"AMD;":[225],"however,":[226],"totality":[228],"current":[230],"for":[232],"discordant.\\nChapter":[237],"III":[238],"further":[239,299],"investigated":[240],"plant-derived":[242],"acids,":[245],"\u03b1-linolenic":[246],"acid":[247],"(ALA).":[248],"ALA":[255,275,293],"before":[261],"2002":[262],"after.":[265],"This":[266],"coincides":[267],"same":[270],"time":[271],"period":[272],"when":[273],"trans":[274,292],"our":[279],"participants\u2019":[280],"blood":[281],"mayonnaise,":[284],"primary":[286],"source":[288],"ALA.":[290],"Whether":[291],"mediates":[294],"this":[295,333],"positive":[296],"warrants":[298],"studies.\\nAlthough":[300],"randomized":[301,319],"usually":[304],"believed":[305],"\u201cgold":[308],"standard\u201d,":[309],"hard":[313],"be":[315],"adequately":[316],"complexities":[324],"disease":[328],"relations.":[329],"Thus,":[330],"findings":[331],"thesis":[334],"long-term":[337],"prospective":[338],"cohort":[339],"provide":[341],"next":[343],"best":[344],"form":[345],"evidence.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-26T00:00:00"}
