{"id":"https://openalex.org/W2576215864","doi":"https://doi.org/10.1182/blood.v118.21.821.821","title":"Induction of a Novel Population of CD8+ Foxp3+ Regulatory T Cells During Graft Versus Host Disease","display_name":"Induction of a Novel Population of CD8+ Foxp3+ Regulatory T Cells During Graft Versus Host Disease","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2576215864","doi":"https://doi.org/10.1182/blood.v118.21.821.821","mag":"2576215864"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v118.21.821.821","doi":"https://doi.org/10.1182/blood.v118.21.821.821","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.821.821","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058759825","display_name":"Amy J. Beres","orcid":"https://orcid.org/0000-0003-4653-0368","observed_orcids":["https://orcid.org/0000-0003-4653-0368"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Beres","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076043614","display_name":"Dipica Haribhai","orcid":"https://orcid.org/0009-0005-3274-7410","observed_orcids":["https://orcid.org/0009-0005-3274-7410"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipica Haribhai","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080427253","display_name":"Chelsea Tessler-Verville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea Tessler-Verville","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051142807","display_name":"Patrick Gonyo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Gonyo","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034542132","display_name":"Martin J. Hessner","orcid":"https://orcid.org/0000-0001-9941-0314","observed_orcids":["https://orcid.org/0000-0001-9941-0314"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Hessner","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049539341","display_name":"Calvin B. Williams","orcid":"https://orcid.org/0000-0002-5492-8475","observed_orcids":["https://orcid.org/0000-0002-5492-8475"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calvin Williams","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076881385","display_name":"William R. Drobyski","orcid":"https://orcid.org/0000-0001-7121-6499","observed_orcids":["https://orcid.org/0000-0001-7121-6499"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Drobyski","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30809758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"118","issue":"21","first_page":"821","last_page":"821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8140000104904175},{"id":"https://openalex.org/keywords/induced-regulatory-t-cells","display_name":"induced regulatory T cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mhc-disparity","display_name":"MHC disparity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.6869999766349792},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.5419999957084656},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cd4-treg","display_name":"CD4+ Treg","score":0.46299999952316284},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.4970000088214874},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.8587085604667664},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6617717742919922},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.661501407623291},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6535770297050476},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5972509980201721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.565702497959137},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5286862254142761},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5182811617851257},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30219900608062744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.262182354927063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1316017210483551},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v118.21.821.821","doi":"https://doi.org/10.1182/blood.v118.21.821.821","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.821.821","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131161334","https://openalex.org/W2980110178","https://openalex.org/W2979323966","https://openalex.org/W3176994599","https://openalex.org/W2100911633","https://openalex.org/W1973251402","https://openalex.org/W32423716","https://openalex.org/W2105970563","https://openalex.org/W2573031606","https://openalex.org/W2579784346"],"abstract_inverted_index":{"Abstract":[0,1],"821":[2],"Regulatory":[3],"T":[4,59,87,168,250,353,390,425,443,691,698],"cells":[5,60,88,117,169,251,354,403,426,444,461,496,527,568,679],"defined":[6],"as":[7,172,174,412,434,660],"CD4+":[8,46,203,215,351,385,413,490,587,665],"and":[9,64,115,136,144,154,179,199,225,290,309,322,332,337,350,360,370,384,432,451,525,555,631,694],"expressing":[10],"the":[11,25,34,41,82,95,151,214,229,262,288,358,407,556,603,625,650],"transcription":[12,626],"factor":[13],"Foxp3":[14,63,130,559],"have":[15,671],"been":[16,75,582,662],"shown":[17],"to":[18,39,129,149,183,202,464,473,484,528,536,543,552,570,579,601,688,713],"play":[19],"a":[20,54,244,268,313,326,474,509,571,620,673],"pivotal":[21],"role":[22,43,83],"in":[23,49,77,89,103,186,196,205,299,312,342,372,381,396,430,469,478,488,499,501,541,561,585,607,610,624,640,641,644,704],"mitigating":[24],"severity":[26],"of":[27,36,44,57,84,97,157,220,237,248,264,270,284,293,306,362,395,406,460,468,558,566,606,627,658,676,711],"graft":[28],"versus":[29,609,643],"host":[30],"disease":[31],"(GVHD).":[32],"In":[33,531,667],"course":[35],"studies":[37,102,277,378,598,670],"designed":[38],"define":[40,150],"functional":[42],"various":[45],"Treg":[47,216,652],"populations":[48,222],"GVHD":[50,90,188,307,364,438,540,705],"biology,":[51],"we":[52,100,273],"identified":[53,672],"novel":[55,674],"population":[56,73,193,653,675,700],"CD8+":[58,85,158,166,249,265,294,329,344,348,383,423,441,471,503,533,547,612,646,677],"that":[61,122,165,213,239,341,380,401,485,520,617,649,680,701],"expressed":[62,404],"were":[65,110,138,170,296,310,346,355,445,497,505,599],"induced":[66,226,429,463,682],"early":[67,173,683],"during":[68,160,684],"this":[69,72,98],"disease.":[70],"While":[71],"has":[74,581,661],"reported":[76,663],"patients":[78],"with":[79,112,281,447,487],"autoimmune":[80],"disorders,":[81],"Foxp3+":[86,167,349,352,424,678],"is":[91,210,218,232,702],"unknown.":[92],"To":[93,259,339,420,492],"delineate":[94],"significance":[96],"observation,":[99],"performed":[101,274,600],"which":[104,209,481],"lethally":[105,516],"irradiated":[106,517],"Balb/c":[107,518],"[H-2d]":[108],"mice":[109,121,254,365,519,538],"transplanted":[111,545],"bone":[113],"marrow":[114],"spleen":[116,359,526],"from":[118,252,357,539],"C57BL/6J":[119],"[H-2b]":[120],"carried":[123],"an":[124,300],"EGFP":[125],"reporter":[126],"gene":[127,604],"linked":[128],"(Foxp3EGFP).":[131],"Tissues":[132],"(spleen,":[133],"lung,":[134],"liver":[135,361],"colon)":[137],"harvested":[139],"5,":[140],"7,":[141],"10,":[142],"14":[143],"21":[145],"days":[146,176,367],"post":[147,177,368],"transplantation":[148,178,369],"temporal":[152],"kinetics":[153],"absolute":[155,200,291],"numbers":[156,201],"Tregs":[159,204,224,238,266,295,345,386,414],"acute":[161],"GVHD.":[162,530],"We":[163],"observed":[164,486],"detectable":[171],"five":[175],"persisted":[180],"for":[181,437,453,584,664],"up":[182,234],"three":[184,317],"weeks":[185],"all":[187],"target":[189],"tissues.":[190],"This":[191,549],"cell":[192,391,409,513,692,699],"was":[194,267,482,550,619],"present":[195],"similar":[197,275,578,656],"percentages":[198],"these":[206,402,457,495,567,669],"tissue":[207],"sites":[208],"noteworthy":[211],"given":[212],"pool":[217,231],"comprised":[219],"two":[221],"(natural":[223],"Tregs)":[227],"whereas":[228],"CD8":[230,398],"made":[233],"almost":[235],"exclusively":[236],"are":[240,462,681,686],"induced,":[241],"since":[242],"only":[243,316],"very":[245],"small":[246],"percentage":[247],"normal":[253],"(<1.0%)":[255],"constitutively":[256],"express":[257],"Foxp3.":[258],"determine":[260,421,493],"whether":[261,494],"induction":[263],"function":[269],"MHC":[271,285,333],"disparity,":[272],"transplant":[276],"using":[278],"murine":[279],"models":[280],"varying":[282],"degrees":[283],"incompatibility.":[286],"Notably,":[287],"relative":[289],"number":[292],"much":[297],"lower":[298],"MHC-matched,":[301],"minor":[302],"antigen":[303],"mismatched":[304],"model":[305,314],"[B6\u2192Balb.B],":[308],"absent":[311],"where":[315],"amino":[318],"acids":[319],"distinguish":[320],"donor":[321,336],"recipient":[323],"[B6\u2192bm1],":[324],"indicating":[325],"correlation":[327],"between":[328,335],"iTreg":[330],"generation":[331],"disparity":[334],"host.":[338],"confirm":[340],"vivo-induced":[343,611],"suppressive,":[347],"sorted":[356],"B6\u2192Balb/c":[363],"six":[366],"examined":[371],"standard":[373,475],"MLC":[374,476],"suppression":[375,480,659],"assays.":[376],"These":[377],"revealed":[379,400,616],"vivo-derived":[382],"equally":[387],"suppressed":[388],"alloreactive":[389,690],"responses.":[392],"Phenotypic":[393],"analysis":[394,615],"vivo-differentiated":[397],"iTregs":[399,472,504,534,588],"many":[405],"same":[408],"surface":[410],"molecules":[411],"(e.g.":[415,629],"GITR,":[416],"CD25,":[417],"CD103,":[418],"CTLA-4).":[419],"if":[422],"could":[427],"be":[428],"vitro":[431,608],"used":[433],"adoptive":[435],"therapy":[436],"prevention,":[439],"purified":[440],"Foxp3EGFP\u2013":[442],"cultured":[446],"anti-CD3/CD28":[448],"antibodies,":[449],"TGF-\u03b2":[450],"IL-2":[452],"3":[454],"days.":[455],"Under":[456],"conditions,":[458],"\u223c30%":[459],"become":[465],"Foxp3+.":[466],"Addition":[467],"vitro-differentiated":[470,489,502,586],"resulted":[477],"potent":[479],"equivalent":[483],"Tregs.":[491,613,666],"suppressive":[498],"vivo,":[500],"adoptively":[506],"transferred":[507],"at":[508],"1:1":[510],"Treg:":[511],"effector":[512],"ratio":[514],"into":[515],"also":[521],"received":[522],"B6.PL":[523],"BM":[524],"induce":[529],"vitro-derived":[532],"failed":[535],"protect":[537],"comparison":[542],"animals":[544],"without":[546],"iTregs.":[548],"attributable":[551],"reduced":[553],"survival":[554],"loss":[557],"expression":[560],"vivo.":[562],"Furthermore,":[563],"approximately":[564],"30\u201350%":[565],"reverted":[569],"proinflammatory":[572],"phenotype":[573],"characterized":[574],"by":[575],"IFN-\u03b3":[576],"secretion,":[577],"what":[580],"described":[583],"(Beres":[589],"et":[590],"al,":[591],"Clin":[592],"Can":[593],"Res,":[594],"2011).":[595],"Finally,":[596],"microarray":[597],"compare":[602],"signatures":[605],"Ontological":[614],"there":[618],"3\u201316":[621],"fold":[622],"increase":[623],"cytokine":[628],"IL-10)":[630],"cytotoxic":[632],"(granzyme":[633],"A,":[634],"perforin,":[635],"granzyme":[636],"B)":[637],"pathway":[638],"genes":[639],"vivo":[642],"vitro-induced":[645],"Tregs,":[647],"suggesting":[648],"former":[651],"may":[654],"employ":[655],"mechanisms":[657],"summary,":[668],"GVHD,":[685],"able":[687],"suppress":[689],"responses,":[693],"constitute":[695],"another":[696],"regulatory":[697],"operative":[703],"biology.":[706],"Disclosures:":[707],"No":[708],"relevant":[709],"conflicts":[710],"interest":[712],"declare.":[714]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-26T00:00:00"}