{"id":"https://openalex.org/W2576155338","doi":"https://doi.org/10.1016/j.ymthe.2016.12.023","title":"Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells","display_name":"Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells","publication_year":2017,"publication_date":"2017-01-28","ids":{"openalex":"https://openalex.org/W2576155338","doi":"https://doi.org/10.1016/j.ymthe.2016.12.023","mag":"2576155338","pmid":"https://pubmed.ncbi.nlm.nih.gov/28143740","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5363191"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2016.12.023","doi":"https://doi.org/10.1016/j.ymthe.2016.12.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2016.12.023","pdf_url":"http://www.cell.com/article/S1525001617300047/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001617300047/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091563032","display_name":"Malika R. Hale","orcid":"https://orcid.org/0000-0002-0822-7141","observed_orcids":["https://orcid.org/0000-0002-0822-7141"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malika Hale","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074041574","display_name":"Taylor D. Mesojednik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Mesojednik","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083736612","display_name":"Guillermo S. Romano Ibarra","orcid":"https://orcid.org/0000-0003-4723-2055","observed_orcids":["https://orcid.org/0000-0003-4723-2055"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo S. Romano Ibarra","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063194527","display_name":"Jaya Sahni","orcid":"https://orcid.org/0000-0002-5373-6084","observed_orcids":["https://orcid.org/0000-0002-5373-6084"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaya Sahni","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442709","display_name":"Alison Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Bernard","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028866726","display_name":"Karen Sommer","orcid":"https://orcid.org/0000-0003-4370-4772","observed_orcids":["https://orcid.org/0000-0003-4370-4772"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Sommer","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063879916","display_name":"Andrew M. Scharenberg","orcid":"https://orcid.org/0000-0002-4292-6114","observed_orcids":["https://orcid.org/0000-0002-4292-6114"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Scharenberg","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA","Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","Department of Immunology, University of Washington, Seattle, WA 98101, USA","Department of Pediatrics, University of Washington, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027470095","display_name":"David J. Rawlings","orcid":"https://orcid.org/0000-0002-0810-1776","observed_orcids":["https://orcid.org/0000-0002-0810-1776","https://orcid.org/0000-0003-4370-4772"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Rawlings","raw_affiliation_strings":["Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA. Electronic address: drawling@uw.edu","Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","Department of Immunology, University of Washington, Seattle, WA 98101, USA","Department of Pediatrics, University of Washington, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA. Electronic address: drawling@uw.edu","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033119708","display_name":"Thor A. Wagner","orcid":"https://orcid.org/0000-0002-1520-268X","observed_orcids":["https://orcid.org/0000-0002-1520-268X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thor A. Wagner","raw_affiliation_strings":["Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA. Electronic address: thor.wagner@seattlechildrens.org","Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA","Department of Pediatrics, University of Washington, Seattle, WA 98101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA. Electronic address: thor.wagner@seattlechildrens.org","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027470095","https://openalex.org/A5033119708"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":8.1915,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.98586976,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"25","issue":"3","first_page":"570","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.12729999423027039,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.07720000296831131,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/broadly-neutralizing-monoclonal-antibodies","display_name":"broadly neutralizing monoclonal antibodies","score":0.9330000281333923},{"id":"https://openalex.org/keywords/envelope-glycoprotein","display_name":"envelope glycoprotein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/homology-directed-recombination","display_name":"homology-directed recombination","score":0.9440000057220459},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hiv-immunotherapy","display_name":"HIV immunotherapy","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7748706340789795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6533578634262085},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.617939829826355},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5428395867347717},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5272212028503418},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.519277811050415},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5109997987747192},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.47642287611961365},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.4632849097251892},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.4417727291584015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37053340673446655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32285094261169434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.258897602558136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14209607243537903},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.12540364265441895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023061","descriptor_name":"Gene Order","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ymthe.2016.12.023","doi":"https://doi.org/10.1016/j.ymthe.2016.12.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2016.12.023","pdf_url":"http://www.cell.com/article/S1525001617300047/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4212709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5363191","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5363191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5363191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmid:28143740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28143740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2016.12.023","doi":"https://doi.org/10.1016/j.ymthe.2016.12.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2016.12.023","pdf_url":"http://www.cell.com/article/S1525001617300047/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3612366744","display_name":"Engineering T-cells with optimized anti-HIV chimeric antigen receptors and CCR5 disruption as a strategy to target HIV-infected cells","funder_award_id":"R01AI118500","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4857206910","display_name":"University of Washington Medical Scientist Training Program","funder_award_id":"T32GM007266","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6305753049","display_name":"Cell and Gene Therapy for HIV Cure","funder_award_id":"UM1AI126623","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868680","display_name":"University of Washington/Fred Hutch Center for AIDS Research","funder_award_id":"P30AI027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893466","display_name":"Stem Cell and Transplantation Biology","funder_award_id":"U54DK106829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320316659","display_name":"bluebird bio","ror":"https://ror.org/04vaq9436"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2576155338.pdf"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1484226051","https://openalex.org/W1598217555","https://openalex.org/W1674854702","https://openalex.org/W1686812758","https://openalex.org/W1737344958","https://openalex.org/W1794017375","https://openalex.org/W1841220820","https://openalex.org/W1935345769","https://openalex.org/W1961668980","https://openalex.org/W1964586095","https://openalex.org/W1965528983","https://openalex.org/W1967517831","https://openalex.org/W1969796442","https://openalex.org/W1974488636","https://openalex.org/W1974872064","https://openalex.org/W1975094254","https://openalex.org/W1979818745","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1986574361","https://openalex.org/W1996083965","https://openalex.org/W1996459980","https://openalex.org/W1996684522","https://openalex.org/W2000211970","https://openalex.org/W2004458954","https://openalex.org/W2007607803","https://openalex.org/W2020977401","https://openalex.org/W2022770520","https://openalex.org/W2023068069","https://openalex.org/W2035813371","https://openalex.org/W2041080087","https://openalex.org/W2044870374","https://openalex.org/W2052749202","https://openalex.org/W2053763799","https://openalex.org/W2057567758","https://openalex.org/W2063485002","https://openalex.org/W2070086938","https://openalex.org/W2075106941","https://openalex.org/W2082708772","https://openalex.org/W2084390276","https://openalex.org/W2087179955","https://openalex.org/W2089242226","https://openalex.org/W2091856865","https://openalex.org/W2099146947","https://openalex.org/W2102300099","https://openalex.org/W2104607069","https://openalex.org/W2108422942","https://openalex.org/W2113236498","https://openalex.org/W2123273309","https://openalex.org/W2124058652","https://openalex.org/W2125524975","https://openalex.org/W2125927970","https://openalex.org/W2130011407","https://openalex.org/W2130399622","https://openalex.org/W2132297600","https://openalex.org/W2132626699","https://openalex.org/W2150633245","https://openalex.org/W2153520524","https://openalex.org/W2163775969","https://openalex.org/W2165497759","https://openalex.org/W2167155055","https://openalex.org/W2206690149","https://openalex.org/W2219506342","https://openalex.org/W2229738114","https://openalex.org/W2230199130","https://openalex.org/W2319657764","https://openalex.org/W2324845132","https://openalex.org/W2343897169","https://openalex.org/W2394566891","https://openalex.org/W2400154936","https://openalex.org/W2407240165","https://openalex.org/W2408097265","https://openalex.org/W2508439116"],"related_works":["https://openalex.org/W4315498885","https://openalex.org/W2599813933","https://openalex.org/W2567273477","https://openalex.org/W4388419735","https://openalex.org/W1841220820","https://openalex.org/W2972926173","https://openalex.org/W2546886586","https://openalex.org/W2394566891","https://openalex.org/W2968882288","https://openalex.org/W2565100518"],"abstract_inverted_index":{"The":[0],"treatment":[1],"or":[2],"cure":[3,173],"of":[4,38,56,82,90,99,111,143],"HIV":[5,49,91,123],"infection":[6],"by":[7,146],"cell":[8],"and":[9,24,80,152],"gene":[10,22,102,148],"therapy":[11],"has":[12,156],"been":[13],"a":[14,36,53],"goal":[15],"for":[16,35,47],"decades.":[17],"Recent":[18],"advances":[19],"in":[20,87,163,169],"both":[21],"editing":[23],"chimeric":[25],"antigen":[26],"receptor":[27],"(CAR)":[28],"technology":[29],"have":[30],"created":[31],"new":[32],"therapeutic":[33],"possibilities":[34],"variety":[37],"diseases.":[39],"Broadly":[40],"neutralizing":[41],"monoclonal":[42],"antibodies":[43],"(bNAbs)":[44],"with":[45,115],"specificity":[46],"the":[48,88,100,106,140,157,170],"envelope":[50],"glycoprotein":[51],"provide":[52],"promising":[54],"means":[55],"targeting":[57],"HIV-infected":[58,83,161,164],"cells.":[59],"Here":[60],"we":[61],"show":[62,77,95],"that":[63,96,122],"primary":[64],"human":[65],"T":[66,144],"cells":[67,86,145,162],"engineered":[68],"to":[69,132,159,172],"express":[70],"anti-HIV":[71],"CARs":[72],"based":[73],"on":[74],"bNAbs":[75],"(HIVCAR)":[76],"specific":[78],"activation":[79],"killing":[81],"versus":[84],"uninfected":[85],"absence":[89],"replication.":[92],"We":[93],"also":[94],"homology-directed":[97,147],"recombination":[98],"HIVCAR":[101,116],"expression":[103,117],"cassette":[104],"into":[105,139],"CCR5":[107,141],"locus":[108,142],"enhances":[109],"suppression":[110],"replicating":[112],"virus":[113],"compared":[114],"alone.":[118],"This":[119,154],"work":[120],"demonstrates":[121],"immunotherapy":[124],"utilizing":[125],"potent":[126],"bNAb-based":[127],"single-chain":[128],"variable":[129],"fragments":[130],"fused":[131],"second-generation":[133],"CAR":[134],"signaling":[135],"domains,":[136],"delivered":[137],"directly":[138],"editing,":[149],"is":[150],"feasible":[151],"effective.":[153],"strategy":[155],"potential":[158],"target":[160],"individuals,":[165],"which":[166],"might":[167],"help":[168],"effort":[171],"HIV.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-26T00:00:00"}