{"id":"https://openalex.org/W2575803525","doi":"https://doi.org/10.18632/oncotarget.14585","title":"The IgH locus 3\u2032 cis-regulatory super-enhancer co-opts AID for allelic transvection","display_name":"The IgH locus 3\u2032 cis-regulatory super-enhancer co-opts AID for allelic transvection","publication_year":2017,"publication_date":"2017-01-10","ids":{"openalex":"https://openalex.org/W2575803525","doi":"https://doi.org/10.18632/oncotarget.14585","mag":"2575803525","pmid":"https://pubmed.ncbi.nlm.nih.gov/28088785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5355067"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.14585","doi":"https://doi.org/10.18632/oncotarget.14585","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.14585","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14585&path%5B%5D=46538","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14585&path%5B%5D=46538","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025280061","display_name":"Sandrine Le Noir","orcid":"https://orcid.org/0000-0002-2297-4186","observed_orcids":["https://orcid.org/0000-0002-2297-4186"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sandrine Le Noir","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018643276","display_name":"Brice Laffleur","orcid":"https://orcid.org/0000-0003-2904-9345","observed_orcids":["https://orcid.org/0000-0003-2904-9345"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Brice Laffleur","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037574721","display_name":"Claire Carrion","orcid":"https://orcid.org/0000-0003-3221-6319","observed_orcids":["https://orcid.org/0000-0003-3221-6319"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Carrion","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043525645","display_name":"Armand Garot","orcid":"https://orcid.org/0000-0002-4517-339X","observed_orcids":["https://orcid.org/0000-0002-4517-339X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Armand Garot","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056930658","display_name":"Sandrine Lecardeur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Lecardeur","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061875124","display_name":"Eric Pinaud","orcid":"https://orcid.org/0000-0001-7405-9273","observed_orcids":["https://orcid.org/0000-0001-7405-9273"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Pinaud","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063574799","display_name":"Yves Denizot","orcid":"https://orcid.org/0000-0003-0143-5543","observed_orcids":["https://orcid.org/0000-0003-0143-5543"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Denizot","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083464518","display_name":"Jane A. Skok","orcid":"https://orcid.org/0000-0002-4145-1516","observed_orcids":["https://orcid.org/0000-0002-4145-1516"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Skok","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051446250","display_name":"Michel Cogn\u00e9","orcid":"https://orcid.org/0000-0002-8519-4427","observed_orcids":["https://orcid.org/0000-0002-8519-4427"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210132523","display_name":"Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9rations","ror":"https://ror.org/02zh2vx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118469","https://openalex.org/I4210132523","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Cogn\u00e9","raw_affiliation_strings":["UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 7276 CNRS and Universit\u00e9 de Limoges: Contr\u00f4le de la R\u00e9ponse Immune B et Lymphoprolif\u00e9ration, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018643276","https://openalex.org/A5025280061"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210132523","https://openalex.org/I65806277"],"apc_list":null,"apc_paid":null,"fwci":0.6531,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.63372458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"8","first_page":"12929","last_page":"12940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igh-locus","display_name":"IGH locus","score":0.6919999718666077},{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.8849999904632568},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.8460000157356262},{"id":"https://openalex.org/keywords/3-regulatory-region","display_name":"3' regulatory region","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain","display_name":"immunoglobulin heavy chain","score":0.6290000081062317},{"id":"https://openalex.org/keywords/biallelic-expression","display_name":"biallelic expression","score":0.5440000295639038},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8079074025154114},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.786175549030304},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.6779385209083557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6345099210739136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6174835562705994},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5667518377304077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36259111762046814},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18465521931648254},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17966559529304504},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.12665042281150818}],"mesh":[{"descriptor_ui":"D000098830","descriptor_name":"AICDA (Activation-Induced Cytidine Deaminase)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017578","descriptor_name":"Immunoglobulin Class Switching","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024509","descriptor_name":"3' Flanking Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058501","descriptor_name":"Enzyme-Linked Immunospot Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.14585","doi":"https://doi.org/10.18632/oncotarget.14585","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.14585","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14585&path%5B%5D=46538","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4242745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5355067","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5355067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5355067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:28088785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28088785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01567757v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-01567757","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1949-2553","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.14585","doi":"https://doi.org/10.18632/oncotarget.14585","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.14585","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14585&path%5B%5D=46538","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6957832408","display_name":"Role of Ig and BCR class in the cell interaction supporting immune memory and impact for immune pathology","funder_award_id":"ANR-16-CE15-0019","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2575803525.pdf","grobid_xml":"https://content.openalex.org/works/W2575803525.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W182737502","https://openalex.org/W1562404955","https://openalex.org/W1635346580","https://openalex.org/W1813376539","https://openalex.org/W1930093851","https://openalex.org/W1982232574","https://openalex.org/W1989556124","https://openalex.org/W2002395443","https://openalex.org/W2004271214","https://openalex.org/W2009614918","https://openalex.org/W2016448166","https://openalex.org/W2020637967","https://openalex.org/W2026664902","https://openalex.org/W2038842399","https://openalex.org/W2048049150","https://openalex.org/W2055456397","https://openalex.org/W2058973843","https://openalex.org/W2067746648","https://openalex.org/W2076142853","https://openalex.org/W2077665121","https://openalex.org/W2093021355","https://openalex.org/W2108847679","https://openalex.org/W2110146990","https://openalex.org/W2114866946","https://openalex.org/W2114930786","https://openalex.org/W2116147219","https://openalex.org/W2116785079","https://openalex.org/W2132808863","https://openalex.org/W2153506782","https://openalex.org/W2157808247","https://openalex.org/W2162801478","https://openalex.org/W2164278804","https://openalex.org/W2175327158","https://openalex.org/W2262605787","https://openalex.org/W2327756257","https://openalex.org/W2437539949","https://openalex.org/W4235854794"],"related_works":["https://openalex.org/W2114930786","https://openalex.org/W3127716597","https://openalex.org/W182737502","https://openalex.org/W1998644010","https://openalex.org/W4392532657","https://openalex.org/W2093021355","https://openalex.org/W7097825604","https://openalex.org/W2909945298","https://openalex.org/W1964193772","https://openalex.org/W2038814117"],"abstract_inverted_index":{"//":[0,83],"Sandrine":[1,18],"Le":[2],"Noir":[3],"1,*":[4,8],",":[5,9,13,17,21,25,29,206],"Brice":[6],"Laffleur":[7],"Claire":[10],"Carrion":[11],"1":[12,16,20,24,28,36,37],"Armand":[14],"Garot":[15],"Lecardeur":[19],"Eric":[22],"Pinaud":[23],"Yves":[26],"Denizot":[27],"Jane":[30],"Skok":[31],"2":[32,55],"and":[33,41,133,164,166,188,218,229],"Michel":[34,80],"Cogn\u00e9":[35],"UMR":[38],"7276":[39],"CNRS":[40],"Universit\u00e9":[42],"de":[43,46],"Limoges:":[44],"Contr\u00f4le":[45],"la":[47],"R\u00e9ponse":[48],"Immune":[49],"B":[50],"et":[51],"Lymphoprolif\u00e9ration,":[52],"Limoges,":[53],"France":[54],"Department":[56],"of":[57,63,127,179,211,254],"Pathology,":[58],"New":[59,65],"York":[60],"University":[61],"School":[62],"Medicine,":[64],"York,":[66],"NY,":[67],"USA":[68],"*":[69],"These":[70],"authors":[71],"have":[72,116],"contributed":[73],"equally":[74],"to":[75,214,225],"this":[76],"work":[77],"Correspondence":[78],"to:":[79],"Cogn\u00e9,":[81],"email:":[82],"Keywords":[84],":":[85,94,99,104],"super-enhancer;":[86],"alleles;":[87],"transvection;":[88],"nuclear":[89],"positioning;":[90],"gene":[91],"regulation":[92],"Received":[93],"December":[95],"20,":[96],"2016":[97],"Accepted":[98],"January":[100],"01,":[101],"2017":[102,107],"Published":[103],"February":[105],"21,":[106],"Abstract":[108],"Immunoglobulin":[109],"heavy":[110],"chain":[111],"(":[112],"IgH":[113,145,215,256],")":[114],"alleles":[115],"ambivalent":[117],"relationships:":[118],"they":[119],"feature":[120,253],"both":[121,142],"allelic":[122],"exclusion,":[123],"ensuring":[124],"monoallelic":[125],"expression":[126,178],"a":[128,170,237,251],"single":[129],"immunoglobulin":[130],"(Ig)":[131],"allele,":[132],"frequent":[134],"inter-allelic":[135,216,232],"class-switch":[136],"recombination":[137],"(CSR)":[138],"reassembling":[139],"genes":[140],"from":[141],"alleles.":[143],"The":[144],"locus":[146],"3\u2019":[147],"regulatory":[148],"region":[149],"(3\u2019RR)":[150],"includes":[151],"several":[152],"transcriptional":[153],"cis":[154],"-enhancers":[155],"promoting":[156],"activation-induced":[157],"cytidine":[158],"deaminase":[159],"(AID)-dependent":[160],"somatic":[161],"hypermutation":[162],"(SHM)":[163],"CSR,":[165],"altogether":[167],"behaves":[168],"as":[169,250],"strong":[171],"super-enhancer.":[172,258],"It":[173],"can":[174],"also":[175,208],"promote":[176],"deregulated":[177],"translocated":[180],"oncogenes":[181],"during":[182],"lymphomagenesis.":[183],"Besides":[184],"these":[185],"rare,":[186],"illegitimate":[187],"pathogenic":[189],"interactions,":[190],"we":[191],"now":[192,248],"show":[193],"that":[194],"under":[195],"physiological":[196],"conditions,":[197],"the":[198,220,255],"3\u2019RR":[199,257],"super-enhancer":[200,221],"supports":[201],"not":[202],"only":[203],"legitimate":[204],"cis-":[205],"but":[207,242],"trans-":[209],"recruitment":[210],"AID,":[212],"contributing":[213],"proximity":[217],"enabling":[219],"on":[222],"one":[223],"allele":[224],"stimulate":[226],"biallelic":[227],"SHM":[228],"CSR.":[230],"Such":[231],"activating":[233],"interactions":[234],"define":[235],"transvection,":[236],"phenomenon":[238],"well-known":[239],"in":[240,245],"drosophila":[241],"rarely":[243],"observed":[244],"mammalian":[246],"cells,":[247],"appearing":[249],"unique":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-26T00:00:00"}
