{"id":"https://openalex.org/W2575684526","doi":"https://doi.org/10.1055/s-0036-1582592","title":"Annular Repair Using Cross-Linked High Density Collagen Gel Seeded with Fibrochondrocytes: In Vivo Outcomes of a Rodent Disc Study","display_name":"Annular Repair Using Cross-Linked High Density Collagen Gel Seeded with Fibrochondrocytes: In Vivo Outcomes of a Rodent Disc Study","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2575684526","doi":"https://doi.org/10.1055/s-0036-1582592","mag":"2575684526"},"language":"en","primary_location":{"id":"doi:10.1055/s-0036-1582592","doi":"https://doi.org/10.1055/s-0036-1582592","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0036-1582592","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1055/s-0036-1582592","source":{"id":"https://openalex.org/S2739034459","display_name":"Global Spine Journal","issn_l":"2192-5682","issn":["2192-5682","2192-5690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Global Spine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.sagepub.com/doi/pdf/10.1055/s-0036-1582592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021700763","display_name":"Brenton Henry Pennicooke","orcid":"https://orcid.org/0000-0002-4304-9141","observed_orcids":["https://orcid.org/0000-0002-4304-9141"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenton Pennicooke","raw_affiliation_strings":["Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112375728","display_name":"Yu Moriguchi","orcid":"https://orcid.org/0009-0000-4027-4688","observed_orcids":["https://orcid.org/0009-0000-4027-4688"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Moriguchi","raw_affiliation_strings":["Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083877008","display_name":"Brandon H. Borde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Borde","raw_affiliation_strings":["Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056431528","display_name":"Connor Berlin","orcid":"https://orcid.org/0000-0001-5090-1753","observed_orcids":["https://orcid.org/0000-0001-5090-1753"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Berlin","raw_affiliation_strings":["Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020603660","display_name":"Peter Grunert","orcid":"https://orcid.org/0000-0002-4647-547X","observed_orcids":["https://orcid.org/0000-0002-4647-547X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Grunert","raw_affiliation_strings":["Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087621922","display_name":"Lawrence J. Bonassar","orcid":"https://orcid.org/0000-0003-1094-6433","observed_orcids":["https://orcid.org/0000-0003-1094-6433"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Bonassar","raw_affiliation_strings":["Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110440920","display_name":"Roger H\u00e4rtl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger H\u00e4rtl","raw_affiliation_strings":["Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.18476057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"1_suppl","first_page":"s","last_page":"0036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annular-fibrosis","display_name":"annular fibrosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cross-linked-collagen","display_name":"cross-linked collagen","score":0.6309999823570251},{"id":"https://openalex.org/keywords/fibrochondrocytes","display_name":"fibrochondrocytes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nucleus-pulposus-regeneration","display_name":"nucleus pulposus regeneration","score":0.7770000100135803},{"id":"https://openalex.org/keywords/disc-height-index","display_name":"disc height index","score":0.546999990940094},{"id":"https://openalex.org/keywords/disc-herniation","display_name":"disc herniation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/athymic-rats","display_name":"athymic rats","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.7890221476554871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7280940413475037},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7019985914230347},{"id":"https://openalex.org/C2776008035","wikidata":"https://www.wikidata.org/wiki/Q3029776","display_name":"Discectomy","level":3,"score":0.5308718681335449},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45027580857276917},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4454541504383087},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4429522752761841},{"id":"https://openalex.org/C2778051963","wikidata":"https://www.wikidata.org/wiki/Q11773731","display_name":"Degenerative disc disease","level":3,"score":0.4259486794471741},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.42435771226882935},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4084108769893646},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.358684241771698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18183812499046326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16028925776481628},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.09930664300918579},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0036-1582592","doi":"https://doi.org/10.1055/s-0036-1582592","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0036-1582592","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1055/s-0036-1582592","source":{"id":"https://openalex.org/S2739034459","display_name":"Global Spine Journal","issn_l":"2192-5682","issn":["2192-5682","2192-5690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Global Spine Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:aae7f9bb3ece4895b9416e36738c49f3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aae7f9bb3ece4895b9416e36738c49f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Global Spine Journal, Vol 6 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1055/s-0036-1582592","doi":"https://doi.org/10.1055/s-0036-1582592","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0036-1582592","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1055/s-0036-1582592","source":{"id":"https://openalex.org/S2739034459","display_name":"Global Spine Journal","issn_l":"2192-5682","issn":["2192-5682","2192-5690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Global Spine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2575684526.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2258418812","https://openalex.org/W2471294161","https://openalex.org/W2529782472","https://openalex.org/W2845489947","https://openalex.org/W2314162216","https://openalex.org/W2328512381","https://openalex.org/W2578007985","https://openalex.org/W822158295","https://openalex.org/W2602300413","https://openalex.org/W2727844096"],"abstract_inverted_index":{"Introduction":[0],"Despite":[1],"alleviating":[2],"associated":[3,25],"neurological":[4],"symptoms,":[5],"discectomy":[6,23,514,644],"of":[7,29,67,90,103,169,203,207,245,311,320,333,343,350,357,382,398,403,415,424,488,519,550,575,590,595,597,617,641,649,719,752],"herniated":[8],"intervertebral":[9,599,720,756],"discs":[10,298],"(IVDs)":[11],"fails":[12],"to":[13,48,74,107,180,199,271,380,474,646],"repair":[14,77,102,209,446,670,751],"the":[15,50,65,86,100,101,129,182,201,227,243,341,373,383,396,399,401,413,416,420,429,435,443,517,593,639,647,750],"underlying":[16],"degenerative":[17,110],"process.":[18,422],"Persistent":[19],"annular":[20,76,105,208,417,445,462,753],"defect":[21,106],"post":[22],"is":[24],"with":[26,124,143,152,173,223,262,309,468],"increased":[27],"risk":[28],"reherniation,":[30],"progressive":[31],"IVD":[32],"degeneration,":[33],"and":[34,118,150,163,175,186,191,210,219,235,238,254,267,283,306,328,336,364,409,522,592,625],"chronic":[35,650],"low":[36,651],"back":[37,652],"pain.":[38],"1\u20137":[39],"Although":[40],"many":[41],"studies":[42,441],"have":[43,55],"previously":[44],"employed":[45,258],"cell":[46],"transplantation":[47],"regenerate":[49],"nucleus":[51,187],"pulposus":[52,188],"(NP),":[53],"few":[54,448],"focused":[56],"on":[57,442,619,724],"annulus":[58,695],"fibrosus":[59,696],"(AF)":[60],"repair.":[61,463],"Recently,":[62],"we":[63,84,257],"demonstrated":[64],"ability":[66],"riboflavin":[68],"crosslinked":[69,144,154,745],"high-density":[70,672,691,746],"collagen":[71,673,692,747],"gels":[72,352,359,394,693],"(HDC)":[73],"facilitate":[75],"in":[78,87,94,112,128,170,221,248,274,317,428,434,449,495,602,623,677,699,731,755,759],"vivo.":[79],"8,9":[80],"In":[81,439],"this":[82],"study,":[83],"assessed":[85],"vivo":[88,171,440,678,732,760],"efficacy":[89],"AF":[91],"fibrochondrocytes":[92,456],"seeded":[93],"a":[95,113,167,263,642,675],"gel":[96,325,748],"scaffold":[97],"at":[98,303,360,369,412],"enhancing":[99],"an":[104,125,730],"prevent":[108],"further":[109],"changes":[111,276],"post-puncture":[114],"rat-tail":[115,676],"model.":[116,679,703],"Material":[117],"Methods":[119],"38":[120],"athymic":[121],"rats,":[122],"punctured":[123],"18-gauge":[126],"needle":[127],"tail":[130,702],"disc,":[131],"were":[132,178,197,291,353],"divided":[133],"into":[134],"3":[135],"groups:":[136],"untreated":[137,297],"(":[138,146,156],"n":[139,147,157],"=":[140,148,158],"6),":[141],"injected":[142,151],"HDC":[145,155,324,393,460],"16),":[149],"fibrochondrocyte-laden":[153],"16).":[159],"At":[160],"1,":[161],"2,":[162],"5":[164],"weeks":[165,305],"postoperatively,":[166],"series":[168],"images":[172],"X-ray":[174],"7T":[176],"MRI":[177],"conducted":[179],"determine":[181],"disc":[183,212,249,321,334,490,543,552,600,721],"height":[184,250,335],"index":[185],"(NP)":[189],"size":[190,471],"hydration,":[192,256],"respectively.":[193],"8,10,11":[194],"Histological":[195],"assessments":[196,389],"performed":[198],"evaluate":[200],"viability":[202],"implanted":[204],"cells,":[205],"degree":[206],"secondary":[211],"degeneration.":[213],"The":[214,296,588,615],"study":[215,467,494,549],"was":[216,367,426],"approved":[217],"by":[218,226,313],"undertaken":[220],"accordance":[222],"guidelines":[224],"outlined":[225],"Hospital":[228],"for":[229,515,694,749],"Special":[230],"Surgery":[231],"Institutional":[232],"Animal":[233],"Care":[234],"Use":[236],"Committee":[237],"New":[239],"York":[240],"State.":[241],"For":[242],"analyses":[244],"continuous":[246],"outcomes":[247,511],"index,":[251],"NP":[252,255,301,307,337,347,377],"size,":[253],"linear":[259],"regression":[260],"models":[261],"generalized":[264],"estimating":[265],"equation":[266],"robust":[268],"standard":[269],"errors":[270],"estimate":[272],"differences":[273],"mean":[275],"from":[277],"baseline":[278],"controls":[279],"(discectomy)":[280],"across":[281],"displaced":[282],"stable":[284],"implantation":[285],"groups.":[286],"P":[287],"values":[288],"<":[289],"0.05":[290],"considered":[292],"statistically":[293],"significant.":[294],"Results":[295],"showed":[299],"substantial":[300],"herniation":[302],"two":[304],"absence":[308],"signs":[310],"degeneration":[312,596,722],"five":[314,344],"weeks,":[315],"resulting":[316],"40%":[318],"loss":[319],"height.":[322],"Both":[323],"groups,":[326],"cellular":[327,351,374],"acellular,":[329],"had":[330],"significant":[331],"retention":[332],"voxel":[338,348],"count":[339],"over":[340],"course":[342],"weeks.":[345],"Average":[346],"counts":[349],"higher":[354],"than":[355],"those":[356],"acellular":[358],"all":[361],"time":[362],"points":[363],"statistical":[365],"significance":[366],"achieved":[368],"1":[370],"week.":[371],"Only":[372],"group":[375],"restored":[376],"hydration":[378],"relative":[379],"that":[381,391,455],"adjacent":[384],"healthy":[385],"control.":[386],"Further":[387],"histological":[388],"indicate":[390],"while":[392],"influence":[395],"sealing":[397],"defect,":[400,418],"addition":[402],"cells":[404],"generates":[405],"abundant":[406],"tissue":[407],"growth":[408],"extracellular":[410],"matrices":[411],"site":[414],"accelerating":[419],"reparative":[421],"Disruption":[423],"endplate":[425],"observed":[427],"puncture":[430],"group,":[431],"but":[432],"not":[433],"treated":[436],"segments.":[437],"Conclusion":[438],"cell-based":[444],"are":[447,472],"number.":[450],"Our":[451],"preliminary":[452],"findings":[453],"suggest":[454],"can":[457],"potentially":[458],"improve":[459],"gel-based":[461],"A":[464,492,708],"long":[465],"term":[466],"sufficient":[469],"sample":[470],"necessary":[473],"confirm":[475],"these":[476],"results.":[477],"References":[478],"Bruske-Hohlfeld":[479],"I,":[480],"Merritt":[481],"JL,":[482],"Onofrio":[483],"BM,":[484],"et":[485,716,742],"al.":[486,717,743],"Incidence":[487],"lumbar":[489,513,542,567,620],"surgery.":[491],"population-based":[493],"Olmsted":[496],"County,":[497],"Minnesota,":[498],"1950-1979.":[499],"Spine":[500,578,605,628,680,734],"1990;15(1):31\u201335":[501],"Carragee":[502],"EJ,":[503,585],"Han":[504],"MY,":[505],"Suen":[506],"PW,":[507],"Kim":[508],"D.":[509],"Clinical":[510],"after":[512,566],"sciatica:":[516],"effects":[518],"fragment":[520],"type":[521],"anular":[523],"competence.":[524],"J":[525,704],"Bone":[526],"Joint":[527],"Surg":[528],"Am":[529],"2003;85-A(1):102\u2013108":[530],"Laus":[531],"M,":[532,559],"Bertoni":[533],"F,":[534],"Bacchini":[535],"P,":[536,658,685,711,737],"Alfonso":[537],"C,":[538,561],"Giunti":[539],"A.":[540],"Recurrent":[541],"herniation:":[544],"what":[545],"recurs?":[546],"(A":[547],"morphological":[548],"recurrent":[551],"herniation).":[553],"Chir":[554],"Organi":[555],"Mov":[556],"1993;78(3):147\u2013154":[557],"Barth":[558],"Weiss":[560],"Thom\u00e9":[562],"C.":[563],"Two-year":[564],"outcome":[565],"microdiscectomy":[568],"versus":[569],"microscopic":[570],"sequestrectomy:":[571],"part":[572],"1:":[573],"evaluation":[574],"clinical":[576],"outcome.":[577],"2008;33(3):265\u2013272":[579],"O'Connell":[580],"GD,":[581],"Malhotra":[582],"NR,":[583],"Vresilovic":[584],"Elliott":[586],"DM.":[587],"effect":[589,616],"nucleotomy":[591,618],"dependence":[594],"human":[598],"strain":[601],"axial":[603],"compression.":[604],"2011;36(21):1765\u20131771":[606],"Frei":[607],"H,":[608],"Oxland":[609],"TR,":[610,635],"Rathonyi":[611],"GC,":[612],"Nolte":[613],"LP.":[614],"spine":[621],"mechanics":[622],"compression":[624],"shear":[626],"loading.":[627],"2001;26(19):2080\u20132089":[629],"DePalma":[630],"MJ,":[631],"Ketchum":[632],"JM,":[633],"Saullo":[634],"Laplante":[636],"BL.":[637],"Is":[638],"history":[640],"surgical":[643],"related":[645],"source":[648],"pain?":[653],"Pain":[654],"Physician":[655],"2012;15(1):E53\u2013E58":[656],"Grunert":[657,684,710,736],"Borde":[659,682,738],"BH,":[660,739],"Hudson":[661,712],"KD,":[662,713],"Macielak":[663,714],"MR,":[664,715],"Bonassar":[665,688],"LJ,":[666],"H\u00e4rtl":[667,686],"R.":[668],"Annular":[669],"using":[671],"gel:":[674],"2014;39(3):198\u2013206":[681],"B,":[683],"R,":[687],"LJ.":[689],"Injectable,":[690],"repair:":[697],"An":[698,758],"vitro":[700],"rat":[701],"Biomed":[705],"Mater":[706],"Res":[707],"2015;103(8):2571\u20132581":[709],"Assessment":[718],"based":[723],"quantitative":[725],"magnetic":[726],"resonance":[727],"imaging":[728],"analysis:":[729],"study.":[733,761],"2014;39(6):E369\u2013E378":[735],"Towne":[740],"SB,":[741],"Riboflavin":[744],"defects":[754],"discs:":[757],"Acta":[762],"Biomater":[763],"2015;26:215\u2013224":[764]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-01-26T00:00:00"}