{"id":"https://openalex.org/W2575431087","doi":"https://doi.org/10.1182/blood.v104.11.3577.3577","title":"PDE-4 Inhibitor Rolipram Prevents Hypoxia Induced Pulmonary Hypertension in Transgenic Sickle Cell Sad Mice.","display_name":"PDE-4 Inhibitor Rolipram Prevents Hypoxia Induced Pulmonary Hypertension in Transgenic Sickle Cell Sad Mice.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2575431087","doi":"https://doi.org/10.1182/blood.v104.11.3577.3577","mag":"2575431087"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.3577.3577","doi":"https://doi.org/10.1182/blood.v104.11.3577.3577","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3577.3577","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043729712","display_name":"Lucia De Franceschi","orcid":"https://orcid.org/0000-0001-7093-777X","observed_orcids":["https://orcid.org/0000-0001-7093-777X"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia De Franceschi","raw_affiliation_strings":["Dpt. of Clinical and Experimental Medicine, University of Verona, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dpt. of Clinical and Experimental Medicine, University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022596417","display_name":"Giorgio Malpeli","orcid":"https://orcid.org/0000-0002-2996-2903","observed_orcids":["https://orcid.org/0000-0002-2996-2903"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giorgio Malpeli","raw_affiliation_strings":["dept. of Pathology, Section of Anatomic Pathology, University of Verona, Italy, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dept. of Pathology, Section of Anatomic Pathology, University of Verona, Italy, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026162865","display_name":"Anne Janin","orcid":"https://orcid.org/0000-0002-9595-6261","observed_orcids":["https://orcid.org/0000-0002-9595-6261"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne Janin","raw_affiliation_strings":["lab. de Pathologie, INSERM 02 20, Hopital S Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"lab. de Pathologie, INSERM 02 20, Hopital S Louis, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003507376","display_name":"Aldo Scarpa","orcid":"https://orcid.org/0000-0003-1678-739X","observed_orcids":["https://orcid.org/0000-0003-1678-739X"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Aldo Scarpa","raw_affiliation_strings":["dept. of Pathology, Section of Anatomic Pathology, University of Verona, Italy, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dept. of Pathology, Section of Anatomic Pathology, University of Verona, Italy, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039241678","display_name":"Christhophe Leboeuf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christhophe Leboeuf","raw_affiliation_strings":["lab. de Pathologie, INSERM 02 20, Hopital S Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"lab. de Pathologie, INSERM 02 20, Hopital S Louis, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108619780","display_name":"Orah S. Platt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orah Platt","raw_affiliation_strings":["Labs of Medicine, Children\u2019 s Hospital, Harvard Medical SChool, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Labs of Medicine, Children\u2019 s Hospital, Harvard Medical SChool, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020887225","display_name":"Philippe Leboulch","orcid":"https://orcid.org/0000-0002-9196-0255","observed_orcids":["https://orcid.org/0000-0002-9196-0255"]},"institutions":[{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philippe Leboulch","raw_affiliation_strings":["Division of Health Sciences & Technology, MIT, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Sciences & Technology, MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210092658","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040679034","display_name":"Emmanuel Payen","orcid":"https://orcid.org/0000-0002-1329-2327","observed_orcids":["https://orcid.org/0000-0002-1329-2327"]},"institutions":[{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Emmanuel Payen","raw_affiliation_strings":["Division of Health Sciences & Technology, MIT, Cambridge, MA, USA","Lab of Hematopoietic Gene Therapy, Hopital S Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Sciences & Technology, MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210092658","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Lab of Hematopoietic Gene Therapy, Hopital S Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056396769","display_name":"Yves Beuzard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Yves Beuzard","raw_affiliation_strings":["Lab of Hematopoietic Gene Therapy, Hopital S Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Hematopoietic Gene Therapy, Hopital S Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029691139","display_name":"Carlo Brugnara","orcid":"https://orcid.org/0000-0001-8192-8713","observed_orcids":["https://orcid.org/0000-0001-8192-8713"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Brugnara","raw_affiliation_strings":["Labs of Medicine and Pathology, Children\u2019s Hospital, Harvard medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Labs of Medicine and Pathology, Children\u2019s Hospital, Harvard medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003507376","https://openalex.org/A5020887225","https://openalex.org/A5022596417","https://openalex.org/A5026162865","https://openalex.org/A5039241678","https://openalex.org/A5040679034","https://openalex.org/A5056396769"],"corresponding_institution_ids":["https://openalex.org/I119439378","https://openalex.org/I154526488","https://openalex.org/I4210092658","https://openalex.org/I4210144610","https://openalex.org/I63966007"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45937653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"3577","last_page":"3577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.18140000104904175,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rolipram","display_name":"rolipram","score":0.828000009059906},{"id":"https://openalex.org/keywords/phosphodiesterase-4-inhibitors","display_name":"phosphodiesterase-4 inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.906000018119812},{"id":"https://openalex.org/keywords/endothelin-1-receptor","display_name":"endothelin-1 receptor","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.5600000023841858},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.49900001287460327},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6686964631080627},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6238919496536255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.597122073173523},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5050874352455139},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4838660955429077},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.4624040722846985},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43993836641311646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43561193346977234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40056365728378296},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3381812870502472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11150792241096497},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.3577.3577","doi":"https://doi.org/10.1182/blood.v104.11.3577.3577","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3577.3577","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159690166","https://openalex.org/W2545218315","https://openalex.org/W857475424","https://openalex.org/W2789853097","https://openalex.org/W2117563227","https://openalex.org/W3174121021","https://openalex.org/W4410276006","https://openalex.org/W2922716216","https://openalex.org/W3143730869","https://openalex.org/W2161859232"],"abstract_inverted_index":{"Abstract":[0],"Pulmonary":[1],"hypertension":[2],"(PH)":[3],"is":[4,23],"one":[5],"of":[6,10,28,38,70,125,133,162,235,266,275,294,343],"the":[7,26,36,163,273,276,281,292,341,344,351,364],"major":[8],"causes":[9],"morbidity":[11],"and":[12,32,57,63,106,120,129,154,159,183,191,211,220,226,230,245,321,329,358,367],"mortality":[13],"for":[14,46],"young-adult":[15],"patients":[16],"with":[17,202,251,263],"sickle":[18,51,371],"cell":[19,52,372],"disease":[20],"(SCD).":[21],"Little":[22],"known":[24],"about":[25],"role":[27],"vaso-active":[29],"agents,":[30],"pro-inflammatory":[31],"pro-fibrotic":[33],"mediators":[34],"in":[35,40,49,68,104,204,255,268,283,303,370],"genesis":[37],"PH":[39,48,203,267,282,369],"SCD.":[41,269],"We":[42,270],"developed":[43],"a":[44,85,195,264],"model":[45,265],"studying":[47],"transgenic":[50],"SAD":[53,58,165,237,286,309],"mice.":[54,287],"Wild-type":[55],"(WT)":[56],"mice":[59,166,177,310],"aged":[60],"between":[61],"4":[62],"6":[64],"months":[65],"were":[66,102,178,249,261,301],"divided":[67],"groups":[69],"7":[71,94],"animals":[72],"each.":[73],"One":[74],"group":[75,87],"from":[76,88,311],"each":[77,89],"strain":[78,90],"served":[79],"as":[80],"control":[81],"under":[82],"normoxia,":[83],"while":[84],"second":[86],"was":[91,136,289],"exposed":[92,167],"to":[93,168],"days":[95],"hypoxia":[96,169,312],"(8%":[97],"oxygen).":[98],"The":[99,131,174],"following":[100],"parameters":[101],"evaluated":[103],"normoxic":[105],"hypoxic":[107,236,285],"groups:":[108],"lung":[109,199,314],"histopathology,":[110],"complete":[111],"blood":[112],"count,":[113,122],"reticulocytes,":[114],"bronchoalveolar":[115],"lavage":[116],"(BAL)":[117],"total":[118,209,319],"leokocyte":[119],"neutrophil":[121,212,225,322,335],"BAL":[123,208,216,318,326],"levels":[124],"IL-6,":[126],"IL-10,":[127],"IL-1\u03b2":[128,244],"TNF-\u03b1.":[130],"expression":[132,248,342],"nine":[134],"genes":[135],"examined":[137],"by":[138,297],"quantitative":[139],"RT-PCR.":[140],"These":[141,259,347],"included":[142],"endothelin-1":[143,145],"(ET-1),":[144],"receptor":[146],"(ET-1R),":[147],"cycloxygenase-2":[148],"(COX2),":[149],"NF-kBp65,":[150],"transforming-growth-factor-1\u03b2":[151],"(TGF-1\u03b2),":[152],"metalloproteinase-2":[153],"9":[155],"(MMP-2,":[156],"MMP-9),":[157],"IL-10":[158,246,330],"IL-1\u03b2.":[160],"Two":[161],"seven":[164,182,284],"died":[170],"at":[171,180,291],"day":[172,181],"fourth.":[173],"remaining":[175],"five":[176],"sacrified":[179],"showed:":[184],"a)":[185,307],"increased":[186,207,215,223],"pulmonary":[187],"arterial":[188],"wall":[189],"thickness":[190],"\u03b1-actin":[192],"staining,":[193],"suggesting":[194],"vascular":[196],"remodeling;":[197],"b)":[198,316],"injury":[200],"compatible":[201],"SCD;":[205],"c)":[206,324],"leukocyte":[210,320],"count;":[213,323,336],"d)":[214,332,337],"IL1\u03b2,":[217],"IL10,":[218],"IL6":[219],"TNF-\u03b1;":[221],"e)":[222],"peripheral":[224,334],"reticulocyte":[227],"counts,":[228],"hematocrit":[229],"hemoglobin":[231],"levels.":[232],"In":[233],"lungs":[234],"mice,":[238],"ET-1,":[239],"ET-1R,":[240],"TGF-1\u03b2,":[241],"MMP-2,":[242],"MMP-9,":[243],"gene":[247,257],"induced,":[250],"no":[252],"significant":[253],"changes":[254],"NF-Kbp65":[256],"expression.":[258],"data":[260,348],"consistent":[262],"then":[271],"assessed":[272],"effect":[274],"PDE-4":[277,352],"inhibitor":[278,353],"ROLIPRAM":[279,288,306,354],"on":[280,363],"administrated":[290],"dosage":[293],"30":[295],"mg/Kg/day":[296],"gavage.":[298],"No":[299],"deaths":[300],"observed":[302],"this":[304],"group.":[305],"protected":[308],"induced":[313],"injury;":[315],"decreased":[317,325],"IL-1\u03b2,":[327],"IL-6":[328],"levels;":[331],"reduced":[333],"normalized":[338],"and/or":[339],"modulated":[340],"hypoxia-induced":[345,365],"genes.":[346],"suggest":[349],"that":[350],"has":[355],"anti-inflammatory":[356],"properties":[357],"could":[359],"have":[360],"beneficial":[361],"effects":[362],"airway-remodeling":[366],"possibly":[368],"disease.":[373]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-26T00:00:00"}
