{"id":"https://openalex.org/W2575401932","doi":null,"title":"Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data.","display_name":"Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data.","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2575401932","mag":"2575401932","pmid":"https://pubmed.ncbi.nlm.nih.gov/28392671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382966"},"language":"en","primary_location":{"id":"pmid:28392671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28392671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJCAI : proceedings of the conference","raw_type":"Journal Article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5382966/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039049453","display_name":"Zhaobin Kuang","orcid":"https://orcid.org/0000-0001-9295-4669","observed_orcids":["https://orcid.org/0000-0001-9295-4669"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaobin Kuang","raw_affiliation_strings":["University of Wisconsin-Madison","University of Wisconsin-Madison, #TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison, #TAB#","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110433162","display_name":"James Livingston Thomson","orcid":"https://orcid.org/0000-0003-1935-7395","observed_orcids":["https://orcid.org/0000-0003-1935-7395"]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Thomson","raw_affiliation_strings":["Morgridge Institute for Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079167360","display_name":"Michael D. Caldwell","orcid":"https://orcid.org/0000-0002-5525-0774","observed_orcids":["https://orcid.org/0000-0002-5525-0774"]},"institutions":[{"id":"https://openalex.org/I1315135799","display_name":"Marshfield Clinic","ror":"https://ror.org/025chrz76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315135799"]},{"id":"https://openalex.org/I4210092581","display_name":"Marshfield Clinic","ror":"https://ror.org/00etqq360","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210092581"]},{"id":"https://openalex.org/I4210138321","display_name":"Marshfield Clinic","ror":"https://ror.org/03zxy2q77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Caldwell","raw_affiliation_strings":["Marshfield Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshfield Clinic","institution_ids":["https://openalex.org/I1315135799","https://openalex.org/I4210092581","https://openalex.org/I4210138321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088183118","display_name":"Peggy L. Peissig","orcid":"https://orcid.org/0000-0003-4156-0189","observed_orcids":["https://orcid.org/0000-0003-4156-0189"]},"institutions":[{"id":"https://openalex.org/I1315135799","display_name":"Marshfield Clinic","ror":"https://ror.org/025chrz76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315135799"]},{"id":"https://openalex.org/I4210092581","display_name":"Marshfield Clinic","ror":"https://ror.org/00etqq360","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210092581"]},{"id":"https://openalex.org/I4210138321","display_name":"Marshfield Clinic","ror":"https://ror.org/03zxy2q77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Peissig","raw_affiliation_strings":["Marshfield Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshfield Clinic","institution_ids":["https://openalex.org/I1315135799","https://openalex.org/I4210092581","https://openalex.org/I4210138321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083447121","display_name":"Ron M. Stewart","orcid":"https://orcid.org/0000-0002-9041-1828","observed_orcids":["https://orcid.org/0000-0002-9041-1828"]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Stewart","raw_affiliation_strings":["Morgridge Institute for Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"last","author":{"id":null,"display_name":"David Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Page","raw_affiliation_strings":["University of Wisconsin-Madison","University of Wisconsin-Madison, #TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison, #TAB#","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4585,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.85796113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2016","issue":null,"first_page":"2521","last_page":"2528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.878000020980835},{"id":"https://openalex.org/keywords/longitudinal-observational-data","display_name":"longitudinal observational data","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fixed-effects-model","display_name":"fixed effects model","score":0.7239999771118164},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7110000252723694},{"id":"https://openalex.org/keywords/new-drug-indications","display_name":"new drug indications","score":0.6949999928474426},{"id":"https://openalex.org/keywords/high-dimensional-data","display_name":"high-dimensional data","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8462255001068115},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5579278469085693},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.5264554619789124},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5229654908180237},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.5026941299438477},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.4941144287586212},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4787518382072449},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.4512537717819214},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4318097233772278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4271731376647949},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3507481515407562},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2587999105453491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24252507090568542},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23669663071632385},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17435207962989807},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:28392671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28392671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJCAI : proceedings of the conference","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5382966","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5382966/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"IJCAI (U S)","raw_type":"Text"},{"id":"mag:2575401932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28392671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5382966","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5382966/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"IJCAI (U S)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5502554304","display_name":"The Center for Predictive Computational Phenotyping-1 Overall","funder_award_id":"U54AI117924","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5658521591","display_name":"Machine Learning for Identifying Adverse Drug Events","funder_award_id":"R01GM097618","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W297656647","https://openalex.org/W657476391","https://openalex.org/W1540764732","https://openalex.org/W1575333099","https://openalex.org/W1872037639","https://openalex.org/W1894966336","https://openalex.org/W1977777127","https://openalex.org/W1994213152","https://openalex.org/W1995691260","https://openalex.org/W2001344972","https://openalex.org/W2004320937","https://openalex.org/W2016914833","https://openalex.org/W2025861882","https://openalex.org/W2039131964","https://openalex.org/W2105050951","https://openalex.org/W2106033766","https://openalex.org/W2112946624","https://openalex.org/W2118259839","https://openalex.org/W2131996809","https://openalex.org/W2135046866","https://openalex.org/W2146883482","https://openalex.org/W2148228584","https://openalex.org/W2161256129","https://openalex.org/W2166293995","https://openalex.org/W2336057570","https://openalex.org/W3122369986","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2336057570","https://openalex.org/W2905487017","https://openalex.org/W3038273835","https://openalex.org/W4282932819","https://openalex.org/W3114294941","https://openalex.org/W2952959306","https://openalex.org/W3022308627","https://openalex.org/W2019707847","https://openalex.org/W3201002915","https://openalex.org/W2801988201"],"abstract_inverted_index":{"Computational":[0],"Drug":[1],"Repositioning":[2],"(CDR)":[3],"is":[4,64],"the":[5,39,58,77,93,101,125],"knowledge":[6],"discovery":[7],"process":[8],"of":[9,46,106],"finding":[10],"new":[11],"indications":[12],"for":[13,35,82],"existing":[14],"drugs":[15,83,108,123],"leveraging":[16],"heterogeneous":[17],"drug-related":[18],"data.":[19,72],"Longitudinal":[20],"observational":[21],"data":[22,33],"such":[23],"as":[24,114,116],"Electronic":[25],"Health":[26],"Records":[27],"(EHRs)":[28],"have":[29],"become":[30],"an":[31],"emerging":[32],"source":[34],"CDR.":[36],"To":[37],"address":[38],"high-dimensional,":[40],"irregular,":[41],"subject":[42],"and":[43,53],"time-heterogeneous":[44],"nature":[45],"EHRs,":[47],"we":[48,75],"propose":[49],"Baseline":[50],"Regularization":[51],"(BR)":[52],"a":[54,65],"variant":[55],"that":[56,84,100,109],"extend":[57],"one-way":[59],"fixed":[60],"effect":[61],"model,":[62],"which":[63],"standard":[66],"approach":[67],"to":[68,80],"analyze":[69],"small-scale":[70],"longitudinal":[71],"For":[73],"evaluation,":[74],"use":[76],"proposed":[78,102],"methods":[79,103],"search":[81],"can":[85,110],"lower":[86,111],"Fasting":[87],"Blood":[88],"Glucose":[89],"(FBG)":[90],"level":[91,113],"in":[92,124],"Marshfield":[94],"Clinic":[95],"EHR.":[96],"Experimental":[97],"results":[98],"suggest":[99],"are":[104],"capable":[105],"rediscovering":[107],"FBG":[112],"well":[115],"identifying":[117],"some":[118],"potential":[119],"blood":[120],"sugar":[121],"lowering":[122],"literature.":[126]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-26T00:00:00"}