{"id":"https://openalex.org/W2575315561","doi":"https://doi.org/10.1371/journal.pone.0170076","title":"Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells","display_name":"Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells","publication_year":2017,"publication_date":"2017-01-11","ids":{"openalex":"https://openalex.org/W2575315561","doi":"https://doi.org/10.1371/journal.pone.0170076","mag":"2575315561","pmid":"https://pubmed.ncbi.nlm.nih.gov/28076410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5226839"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0170076","doi":"https://doi.org/10.1371/journal.pone.0170076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170076","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170076&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170076&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088567236","display_name":"Kenneth W. Adams","orcid":"https://orcid.org/0000-0003-4844-2046","observed_orcids":["https://orcid.org/0000-0003-4844-2046"]},"institutions":[{"id":"https://openalex.org/I17856709","display_name":"Bridgewater State University","ror":"https://ror.org/02x3skf39","country_code":"US","type":"education","lineage":["https://openalex.org/I17856709"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth W. Adams","raw_affiliation_strings":["Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4844-2046","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, United States of America","institution_ids":["https://openalex.org/I17856709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032202723","display_name":"Sergey Kletsov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17856709","display_name":"Bridgewater State University","ror":"https://ror.org/02x3skf39","country_code":"US","type":"education","lineage":["https://openalex.org/I17856709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Kletsov","raw_affiliation_strings":["Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, United States of America","institution_ids":["https://openalex.org/I17856709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064211571","display_name":"Ryan J. Lamm","orcid":"https://orcid.org/0000-0002-9158-654X","observed_orcids":["https://orcid.org/0000-0002-9158-654X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Lamm","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073800746","display_name":"Jessica S. Elman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica S. Elman","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006248486","display_name":"Steven Mullenbrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Mullenbrock","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":null,"display_name":"Geoffrey M. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey M. Cooper","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088567236"],"corresponding_institution_ids":["https://openalex.org/I17856709"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.5505,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.80093977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"e0170076","last_page":"e0170076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.40799999237060547,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.40799999237060547,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.11829999834299088,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egr-transcription-factors","display_name":"Egr transcription factors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.8420000076293945},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.42399999499320984},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.7570000290870667},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2780600689","wikidata":"https://www.wikidata.org/wiki/Q14864821","display_name":"EGR1","level":4,"score":0.8629193902015686},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7811887264251709},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.743683934211731},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7131893634796143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6377429366111755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6242380738258362},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.615892231464386},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6054337024688721},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.5639507174491882},{"id":"https://openalex.org/C2910670019","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum Response Element","level":5,"score":0.5634931325912476},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5611415505409241},{"id":"https://openalex.org/C2779555244","wikidata":"https://www.wikidata.org/wiki/Q409638","display_name":"Immediate early gene","level":4,"score":0.4974844753742218},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4417969584465027},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4368338882923126},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.4253826141357422},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32710111141204834},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2836626172065735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2635801434516907},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.24364277720451355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20405718684196472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1275424063205719}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0170076","doi":"https://doi.org/10.1371/journal.pone.0170076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170076","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170076&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:28076410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28076410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5226839","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5226839/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:vc.bridgew.edu:biol_fac-1073","doi":null,"is_oa":false,"landing_page_url":"https://vc.bridgew.edu/biol_fac/73","pdf_url":null,"source":{"id":"https://openalex.org/S2764422806","display_name":"Journal of international women's studies","issn_l":"1539-8706","issn":["1539-8706"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310315793","host_organization_name":"Bridgewater State University","host_organization_lineage":["https://openalex.org/P4310315793"],"host_organization_lineage_names":["Bridgewater State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Sciences Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4694657aa41d476897bb4514f675c79f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4694657aa41d476897bb4514f675c79f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 1, p e0170076 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4544293","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Role_for_Egr1_in_the_Transcriptional_Program_Associated_with_Neuronal_Differentiation_of_PC12_Cells/4544293","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0170076","doi":"https://doi.org/10.1371/journal.pone.0170076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170076","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170076&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1083046901","display_name":"Regulation of apoptosis by PI 3-kinase/Akt signaling","funder_award_id":"R01CA018689","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5286041622","display_name":null,"funder_award_id":"RO1 CA18689","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320311871","display_name":"Bridgewater State University","ror":"https://ror.org/02x3skf39"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2575315561.pdf","grobid_xml":"https://content.openalex.org/works/W2575315561.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W1486848541","https://openalex.org/W1490481380","https://openalex.org/W1526977916","https://openalex.org/W1561692645","https://openalex.org/W1592769050","https://openalex.org/W1597241698","https://openalex.org/W1803513118","https://openalex.org/W1821495885","https://openalex.org/W1868814633","https://openalex.org/W1873848645","https://openalex.org/W1935382092","https://openalex.org/W1964304127","https://openalex.org/W1965726907","https://openalex.org/W1966630774","https://openalex.org/W1970587959","https://openalex.org/W1971022786","https://openalex.org/W1972307828","https://openalex.org/W1974837024","https://openalex.org/W1976731473","https://openalex.org/W1978669073","https://openalex.org/W1984767179","https://openalex.org/W1984871200","https://openalex.org/W1985207318","https://openalex.org/W1989480480","https://openalex.org/W1991703596","https://openalex.org/W1994611219","https://openalex.org/W1998109615","https://openalex.org/W1999877624","https://openalex.org/W2000045473","https://openalex.org/W2000099917","https://openalex.org/W2001163784","https://openalex.org/W2004174427","https://openalex.org/W2006141036","https://openalex.org/W2006345574","https://openalex.org/W2009096648","https://openalex.org/W2010791130","https://openalex.org/W2014569682","https://openalex.org/W2016280793","https://openalex.org/W2020108005","https://openalex.org/W2020616048","https://openalex.org/W2021496076","https://openalex.org/W2024219555","https://openalex.org/W2028934778","https://openalex.org/W2029742330","https://openalex.org/W2030347572","https://openalex.org/W2041415111","https://openalex.org/W2048619491","https://openalex.org/W2050374121","https://openalex.org/W2054254513","https://openalex.org/W2060645936","https://openalex.org/W2061203824","https://openalex.org/W2062867942","https://openalex.org/W2067659919","https://openalex.org/W2067798937","https://openalex.org/W2071148558","https://openalex.org/W2071798310","https://openalex.org/W2072329780","https://openalex.org/W2072416078","https://openalex.org/W2072493946","https://openalex.org/W2078518864","https://openalex.org/W2078955619","https://openalex.org/W2080270890","https://openalex.org/W2081150698","https://openalex.org/W2082640307","https://openalex.org/W2082776443","https://openalex.org/W2082895851","https://openalex.org/W2087427828","https://openalex.org/W2090755410","https://openalex.org/W2091611885","https://openalex.org/W2096221719","https://openalex.org/W2097495301","https://openalex.org/W2111220502","https://openalex.org/W2116044769","https://openalex.org/W2117540633","https://openalex.org/W2122674384","https://openalex.org/W2123398106","https://openalex.org/W2123995229","https://openalex.org/W2125403403","https://openalex.org/W2127558032","https://openalex.org/W2131430973","https://openalex.org/W2136387223","https://openalex.org/W2144189667","https://openalex.org/W2144263195","https://openalex.org/W2145599313","https://openalex.org/W2145926386","https://openalex.org/W2148738605","https://openalex.org/W2150703568","https://openalex.org/W2151642254","https://openalex.org/W2155696186","https://openalex.org/W2158692390","https://openalex.org/W2160014402","https://openalex.org/W2162591320","https://openalex.org/W2167921759","https://openalex.org/W2258332806","https://openalex.org/W2320983896","https://openalex.org/W2338205519","https://openalex.org/W2429721485","https://openalex.org/W7097773031"],"related_works":["https://openalex.org/W1984871200","https://openalex.org/W2808227067","https://openalex.org/W3016528415","https://openalex.org/W2037713546","https://openalex.org/W3016921796","https://openalex.org/W1997084864","https://openalex.org/W1911828269","https://openalex.org/W2092841616","https://openalex.org/W2362406265","https://openalex.org/W2123398106"],"abstract_inverted_index":{"PC12":[0,28],"cells":[1,29],"are":[2,187,221],"a":[3,62,84,106,158],"well-established":[4],"model":[5],"to":[6,78,89,95,131,141,210,232,243,248],"study":[7,64],"how":[8],"differences":[9],"in":[10,27,35,53,76,93,109,139,208,241],"signal":[11],"transduction":[12],"duration":[13],"can":[14],"elicit":[15],"distinct":[16],"cell":[17],"behaviors.":[18],"Epidermal":[19],"growth":[20,40],"factor":[21,41],"(EGF)":[22],"activates":[23,43],"transient":[24,90,149],"ERK":[25,46,74,91,192,239],"signaling":[26,47,75,92,240],"that":[30,48,70,72,98,146,186,218,229],"lasts":[31,49],"30-60":[32],"min,":[33],"which":[34,52],"turn":[36],"promotes":[37],"proliferation;":[38],"nerve":[39],"(NGF)":[42],"more":[44],"sustained":[45,73,191,207,238],"4-6":[50],"h,":[51],"turns":[54],"induces":[55,80],"neuronal":[56],"differentiation.":[57],"Data":[58],"presented":[59],"here":[60],"extend":[61],"previous":[63],"by":[65,237,246],"Mullenbrock":[66],"et":[67],"al.":[68],"(2011)":[69],"demonstrated":[71],"response":[77,94,140,209,242],"NGF":[79,147,211],"preferential":[81,111,133,250],"expression":[82,112,134,197,251],"of":[83,113,126,135,151,161,182,201,252],"69-member":[85],"gene":[86,137],"set":[87,138],"compared":[88],"EGF":[96,213],"and":[97,103,168,198],"the":[99,110,117,123,132,136,183,215,233,249],"transcription":[100,127],"factors":[101,128],"AP-1":[102],"CREB":[104],"play":[105],"major":[107],"role":[108],"several":[114],"genes":[115,185,204,255],"within":[116,214],"set.":[118],"Here,":[119],"we":[120],"examined":[121],"whether":[122],"Egr":[124,153],"family":[125,154],"also":[129],"contributes":[130,231],"NGF.":[142],"Our":[143],"data":[144,225],"demonstrate":[145],"causes":[148],"induction":[150,160],"all":[152],"member":[155],"transcripts,":[156],"but":[157],"corresponding":[159],"protein":[162],"was":[163],"detected":[164],"for":[165],"only":[166],"Egr1":[167,179,196,230],"2.":[169],"Chromatin":[170],"immunoprecipitation":[171],"experiments":[172],"provided":[173],"clearest":[174],"evidence":[175,228],"that,":[176],"after":[177],"induction,":[178],"binds":[180],"12":[181],"69":[184],"preferentially":[188,222],"expressed":[189],"during":[190],"signaling.":[193],"In":[194],"addition,":[195],"binding":[199],"upstream":[200],"its":[202,219,253],"target":[203,254],"were":[205],"both":[206],"versus":[212],"same":[216],"timeframe":[217],"targets":[220],"expressed.":[223],"These":[224],"thus":[226],"provide":[227],"transcriptional":[234],"program":[235],"activated":[236],"NGF,":[244],"specifically":[245],"contributing":[247],"identified":[256],"here.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-26T00:00:00"}
