{"id":"https://openalex.org/W2575160849","doi":"https://doi.org/10.1080/17425247.2017.1285280","title":"Novel functionalization strategies to improve drug delivery from polymers","display_name":"Novel functionalization strategies to improve drug delivery from polymers","publication_year":2017,"publication_date":"2017-01-20","ids":{"openalex":"https://openalex.org/W2575160849","doi":"https://doi.org/10.1080/17425247.2017.1285280","mag":"2575160849","pmid":"https://pubmed.ncbi.nlm.nih.gov/28103740"},"language":"en","primary_location":{"id":"doi:10.1080/17425247.2017.1285280","doi":"https://doi.org/10.1080/17425247.2017.1285280","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2017.1285280","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070180973","display_name":"Emanuele Mauri","orcid":"https://orcid.org/0000-0002-6203-8405","observed_orcids":["https://orcid.org/0000-0002-6203-8405"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Mauri","raw_affiliation_strings":[",","Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045591592","display_name":"Simonetta Papa","orcid":"https://orcid.org/0000-0002-6062-649X","observed_orcids":["https://orcid.org/0000-0002-6062-649X"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simonetta Papa","raw_affiliation_strings":[",","Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090934399","display_name":"Maurizio Masi","orcid":"https://orcid.org/0000-0003-3457-4785","observed_orcids":["https://orcid.org/0000-0003-3457-4785"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Masi","raw_affiliation_strings":[",","Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004603208","display_name":"Pietro Veglianese","orcid":"https://orcid.org/0000-0002-0183-9428","observed_orcids":["https://orcid.org/0000-0002-0183-9428"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Veglianese","raw_affiliation_strings":[",","Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074581566","display_name":"Filippo Rossi","orcid":"https://orcid.org/0000-0003-2665-120X","observed_orcids":["https://orcid.org/0000-0003-2665-120X"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Filippo Rossi","raw_affiliation_strings":[",","Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074581566"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.1761,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.16666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"14","issue":"11","first_page":"1305","last_page":"1313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.4372999966144562,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-polymerization-modification","display_name":"post-polymerization modification","score":0.8579999804496765},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.4869999885559082},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.6840000152587891},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.6499999761581421},{"id":"https://openalex.org/keywords/polymer-drug-conjugates","display_name":"polymer-drug conjugates","score":0.6809999942779541},{"id":"https://openalex.org/keywords/release-kinetics","display_name":"release kinetics","score":0.7770000100135803},{"id":"https://openalex.org/keywords/complex-diseases","display_name":"complex diseases","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.7922302484512329},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6909131407737732},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6333754658699036},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5427276492118835},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.530555248260498},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.514546811580658},{"id":"https://openalex.org/C3020580240","wikidata":"https://www.wikidata.org/wiki/Q663272","display_name":"Expert opinion","level":2,"score":0.490968257188797},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46230852603912354},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.42308229207992554},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3481331467628479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27995362877845764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1859053373336792},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.1233169436454773},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.1130262017250061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10753610730171204},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/17425247.2017.1285280","doi":"https://doi.org/10.1080/17425247.2017.1285280","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2017.1285280","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},{"id":"pmid:28103740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28103740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug delivery","raw_type":"Journal Article"},{"id":"pmh:oai:re.public.polimi.it:11311/1033710","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11311/1033710","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W88713093","https://openalex.org/W241677491","https://openalex.org/W787328524","https://openalex.org/W1478059225","https://openalex.org/W1553174175","https://openalex.org/W1630018437","https://openalex.org/W1778592536","https://openalex.org/W1820230077","https://openalex.org/W1823902562","https://openalex.org/W1826508102","https://openalex.org/W1828270512","https://openalex.org/W1839516892","https://openalex.org/W1841920392","https://openalex.org/W1843302206","https://openalex.org/W1852131831","https://openalex.org/W1903724509","https://openalex.org/W1963743672","https://openalex.org/W1963853765","https://openalex.org/W1963918439","https://openalex.org/W1964681850","https://openalex.org/W1968372680","https://openalex.org/W1975880946","https://openalex.org/W1980517067","https://openalex.org/W1981012071","https://openalex.org/W1984899790","https://openalex.org/W1988238185","https://openalex.org/W1990447836","https://openalex.org/W1996998905","https://openalex.org/W1998015543","https://openalex.org/W2002447126","https://openalex.org/W2003503443","https://openalex.org/W2004123015","https://openalex.org/W2004641254","https://openalex.org/W2007499283","https://openalex.org/W2012937798","https://openalex.org/W2019081161","https://openalex.org/W2019555018","https://openalex.org/W2023412782","https://openalex.org/W2024663449","https://openalex.org/W2025658450","https://openalex.org/W2026364623","https://openalex.org/W2027432937","https://openalex.org/W2028582107","https://openalex.org/W2034902558","https://openalex.org/W2040922374","https://openalex.org/W2052004307","https://openalex.org/W2054607351","https://openalex.org/W2059950062","https://openalex.org/W2060320802","https://openalex.org/W2062487182","https://openalex.org/W2068572014","https://openalex.org/W2069922427","https://openalex.org/W2072750787","https://openalex.org/W2073256974","https://openalex.org/W2077300098","https://openalex.org/W2077964757","https://openalex.org/W2081583504","https://openalex.org/W2093073286","https://openalex.org/W2095016306","https://openalex.org/W2095029483","https://openalex.org/W2107883807","https://openalex.org/W2119405093","https://openalex.org/W2120293249","https://openalex.org/W2120915183","https://openalex.org/W2121892940","https://openalex.org/W2126848738","https://openalex.org/W2129210212","https://openalex.org/W2131071171","https://openalex.org/W2131226058","https://openalex.org/W2140588070","https://openalex.org/W2140595006","https://openalex.org/W2144591535","https://openalex.org/W2146298623","https://openalex.org/W2147388735","https://openalex.org/W2151326177","https://openalex.org/W2157139623","https://openalex.org/W2161612170","https://openalex.org/W2161842339","https://openalex.org/W2162742015","https://openalex.org/W2167988307","https://openalex.org/W2170977092","https://openalex.org/W2173114035","https://openalex.org/W2174284440","https://openalex.org/W2175611076","https://openalex.org/W2184967920","https://openalex.org/W2186832605","https://openalex.org/W2231813729","https://openalex.org/W2281500128","https://openalex.org/W2283047478","https://openalex.org/W2285815789","https://openalex.org/W2291574773","https://openalex.org/W2298714663","https://openalex.org/W2318194380","https://openalex.org/W2319866582","https://openalex.org/W2330726091","https://openalex.org/W2344949123","https://openalex.org/W2407317051","https://openalex.org/W2413607402","https://openalex.org/W2415067039","https://openalex.org/W2438292910","https://openalex.org/W2461207928","https://openalex.org/W2463185093","https://openalex.org/W2519053249","https://openalex.org/W2527786379","https://openalex.org/W2529561791","https://openalex.org/W4256503849"],"related_works":["https://openalex.org/W2953387227","https://openalex.org/W2047263803","https://openalex.org/W2026275607","https://openalex.org/W4383566787","https://openalex.org/W2291574773","https://openalex.org/W2969772938","https://openalex.org/W3174525833","https://openalex.org/W2186635179","https://openalex.org/W6967782958","https://openalex.org/W1971846101"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"utility":[2],"of":[3,8,57,71,74,85,96,130,147],"controlled":[4],"and":[5,16],"sustained":[6],"release":[7,66,97,143,167],"drugs":[9,101],"from":[10,102],"polymeric":[11,132],"systems,":[12],"both":[13],"bulk":[14],"(hydrogels)":[15],"colloids":[17],"(nanoparticles),":[18],"is":[19,37,78,144],"a":[20,94,103,122],"key":[21],"point":[22],"that":[23,150],"should":[24],"be":[25,111,152],"addressed.":[26],"Unfortunately,":[27],"classic":[28],"delivery":[29],"systems":[30],"are":[31],"essentially":[32],"driven":[33],"by":[34,68],"diffusion,":[35],"which":[36,60,91],"very":[38],"quick":[39],"due":[40],"to":[41,64,119,127,141],"the":[42,48,82,131,137,145,148,157,160,162,164,166],"high":[43],"concentration":[44],"gradient":[45],"present":[46],"in":[47,81,117],"body.":[49],"Area":[50],"covered:":[51],"This":[52,76],"review":[53],"provides":[54],"an":[55],"overview":[56],"functionalization":[58,73],"strategies":[59,116],"have":[61],"been":[62],"used":[63],"reduce":[65],"rates":[67],"taking":[69],"advantage":[70],"post-polymerization":[72,115],"polymers.":[75],"paradigm":[77],"extremely":[79],"useful":[80],"pharmacological":[83],"treatment":[84],"several":[86,114],"diseases,":[87,90],"particularly":[88],"multifactorial":[89],"may":[92],"require":[93],"variety":[95],"kinetics":[98],"for":[99],"different":[100],"single":[104],"device.":[105],"Expert":[106],"opinion:":[107],"Polymer":[108],"chains":[109],"can":[110],"functionalized":[112],"with":[113,121],"order":[118],"link,":[120],"cleavable":[123],"bond,":[124,163],"drug":[125,142],"molecules":[126],"reactive":[128],"points":[129],"network.":[133],"Following":[134],"this":[135],"strategy,":[136],"main":[138],"mechanism":[139],"related":[140],"breakage":[146],"link":[149],"could":[151],"opportunely":[153],"chosen":[154],"depending":[155],"on":[156],"medical":[158],"needs:":[159],"weaker":[161],"higher":[165],"rate.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-01-26T00:00:00"}