{"id":"https://openalex.org/W2574800639","doi":"https://doi.org/10.1001/jamaoncol.2016.6020","title":"Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era","display_name":"Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era","publication_year":2017,"publication_date":"2017-01-17","ids":{"openalex":"https://openalex.org/W2574800639","doi":"https://doi.org/10.1001/jamaoncol.2016.6020","mag":"2574800639","pmid":"https://pubmed.ncbi.nlm.nih.gov/28097324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5464982"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2016.6020","doi":"https://doi.org/10.1001/jamaoncol.2016.6020","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2016.6020","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2597279/jamaoncology_bell_2017_oi_160093.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2597279/jamaoncology_bell_2017_oi_160093.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077260727","display_name":"Erica Hlavin Bell","orcid":"https://orcid.org/0000-0001-7488-4695","observed_orcids":["https://orcid.org/0000-0001-7488-4695"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Hlavin Bell","raw_affiliation_strings":["Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785984","display_name":"Stephanie L. Pugh","orcid":"https://orcid.org/0000-0002-5977-8912","observed_orcids":["https://orcid.org/0000-0002-5977-8912"]},"institutions":[{"id":"https://openalex.org/I4210162619","display_name":"NRG Oncology","ror":"https://ror.org/050draa26","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. Pugh","raw_affiliation_strings":["NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I4210162619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109481620","display_name":"Joseph Paul McElroy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. McElroy","raw_affiliation_strings":["The Ohio State University Center for Biostatistics, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Center for Biostatistics, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064627876","display_name":"Mark R. Gilbert","orcid":"https://orcid.org/0000-0003-2556-9722","observed_orcids":["https://orcid.org/0000-0003-2556-9722"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Gilbert","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038585908","display_name":"Minesh P. Mehta","orcid":"https://orcid.org/0000-0002-4812-5713","observed_orcids":["https://orcid.org/0000-0002-4812-5713"]},"institutions":[{"id":"https://openalex.org/I14285509","display_name":"University of Maryland Medical System","ror":"https://ror.org/04fkqna53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minesh Mehta","raw_affiliation_strings":["University of Maryland Medical Systems, Baltimore, Maryland (during trial)6now with Miami Cancer Institute, Coral Gables, Florida","University of Maryland Medical Systems, Baltimore, Maryland (during trial)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Medical Systems, Baltimore, Maryland (during trial)6now with Miami Cancer Institute, Coral Gables, Florida","institution_ids":["https://openalex.org/I14285509"]},{"raw_affiliation_string":"University of Maryland Medical Systems, Baltimore, Maryland (during trial)","institution_ids":["https://openalex.org/I14285509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081489838","display_name":"Alexander C. Klimowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexander C. Klimowicz","raw_affiliation_strings":["University of Calgary, Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080487628","display_name":"Anthony M. Magliocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Magliocco","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068526964","display_name":"Markus Bredel","orcid":"https://orcid.org/0000-0002-1436-2526","observed_orcids":["https://orcid.org/0000-0002-1436-2526","https://orcid.org/0000-0002-7828-0984"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Bredel","raw_affiliation_strings":["University of Alabama, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013779863","display_name":"Pierre A. J. T. Robe","orcid":"https://orcid.org/0000-0001-7845-6196","observed_orcids":["https://orcid.org/0000-0001-7845-6196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Robe","raw_affiliation_strings":["Utrecht Cancer Center, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht Cancer Center, Utrecht, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110848785","display_name":"Anca\u2010L. Grosu","orcid":"https://orcid.org/0000-0003-2255-2255","observed_orcids":["https://orcid.org/0000-0003-2255-2255"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anca-L. Grosu","raw_affiliation_strings":["University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053052330","display_name":"Roger Stupp","orcid":"https://orcid.org/0000-0002-5483-3118","observed_orcids":["https://orcid.org/0000-0002-5483-3118"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger Stupp","raw_affiliation_strings":["University Hospital Zurich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Zurich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026088869","display_name":"Walter John Curran","orcid":"https://orcid.org/0000-0002-7552-4453","observed_orcids":["https://orcid.org/0000-0002-7552-4453"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Curran","raw_affiliation_strings":["Emory University, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038929244","display_name":"Aline Paix\u00e3o Becker","orcid":"https://orcid.org/0000-0002-8695-810X","observed_orcids":["https://orcid.org/0000-0002-8695-810X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aline P. Becker","raw_affiliation_strings":["Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001650692","display_name":"Andrea L. Salavaggione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L. Salavaggione","raw_affiliation_strings":["Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051948022","display_name":"Jill S. Barnholtz\u2010Sloan","orcid":"https://orcid.org/0000-0001-6190-9304","observed_orcids":["https://orcid.org/0000-0001-6190-9304"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill S. Barnholtz-Sloan","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290790","display_name":"Kenneth Aldape","orcid":"https://orcid.org/0000-0001-5119-7550","observed_orcids":["https://orcid.org/0000-0001-5119-7550"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Aldape","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032789191","display_name":"Deborah T. Blumenthal","orcid":"https://orcid.org/0000-0002-8868-0148","observed_orcids":["https://orcid.org/0000-0002-8868-0148"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Deborah T. Blumenthal","raw_affiliation_strings":["Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067520533","display_name":"Paul D. Brown","orcid":"https://orcid.org/0000-0003-0022-4533","observed_orcids":["https://orcid.org/0000-0003-0022-4533"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Brown","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113586530","display_name":"Jon Glass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Glass","raw_affiliation_strings":["Thomas Jefferson University Hospital, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Jefferson University Hospital, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2799360765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741202","display_name":"Lu\u00eds Souhami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Luis Souhami","raw_affiliation_strings":["McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University Health Centre, Montreal, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091435105","display_name":"R. Jeffrey Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803061204","display_name":"Intermountain Medical Center","ror":"https://ror.org/009c06z12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Jeffrey Lee","raw_affiliation_strings":["Intermountain Medical Center, Murray, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intermountain Medical Center, Murray, Utah","institution_ids":["https://openalex.org/I2803061204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089928649","display_name":"David G Brachman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162453","display_name":"Arizona Oncology","ror":"https://ror.org/05c1xy536","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brachman","raw_affiliation_strings":["Arizona Oncology Services Foundation, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Oncology Services Foundation, Tucson, Arizona","institution_ids":["https://openalex.org/I4210162453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040507938","display_name":"John C. Fl\u00edckinger","orcid":"https://orcid.org/0000-0001-6900-1384","observed_orcids":["https://orcid.org/0000-0001-6900-1384"]},"institutions":[{"id":"https://openalex.org/I4210090793","display_name":"Shadyside Hospital","ror":"https://ror.org/00b4wat71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090793","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Flickinger","raw_affiliation_strings":["UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I4210090793","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057536092","display_name":"Minhee Won","orcid":"https://orcid.org/0000-0003-2214-282X","observed_orcids":["https://orcid.org/0000-0003-2214-282X"]},"institutions":[{"id":"https://openalex.org/I4210162619","display_name":"NRG Oncology","ror":"https://ror.org/050draa26","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minhee Won","raw_affiliation_strings":["NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I4210162619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018381770","display_name":"Arnab Chakravarti","orcid":"https://orcid.org/0000-0002-5392-8721","observed_orcids":["https://orcid.org/0000-0002-5392-8721"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arnab Chakravarti","raw_affiliation_strings":["Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center\u2013Arthur G. James Cancer Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":21,"corresponding_author_ids":["https://openalex.org/A5018381770"],"corresponding_institution_ids":["https://openalex.org/I2799885155"],"apc_list":null,"apc_paid":null,"fwci":4.7718,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.96563908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"3","issue":"6","first_page":"784","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recursive-partitioning","display_name":"recursive partitioning","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prognostic-risk-classification","display_name":"prognostic risk classification","score":0.699999988079071},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p-mtor","display_name":"p-mTOR","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.9200000166893005},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8669999837875366},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.32100000977516174},{"id":"https://openalex.org/keywords/prognostic-subgroups","display_name":"prognostic subgroups","score":0.5550000071525574},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.5619999766349792},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7975677251815796},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7740997672080994},{"id":"https://openalex.org/C137345334","wikidata":"https://www.wikidata.org/wiki/Q7303350","display_name":"Recursive partitioning","level":2,"score":0.7623211145401001},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6868442296981812},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6737405061721802},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6460291743278503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6137758493423462},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.5754344463348389},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5534487366676331},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5211917757987976},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.49535122513771057},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.46019864082336426},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.28473347425460815},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23074790835380554},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.22341975569725037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2075396478176117}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004812","descriptor_name":"Epidemiologic Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1001/jamaoncol.2016.6020","doi":"https://doi.org/10.1001/jamaoncol.2016.6020","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2016.6020","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2597279/jamaoncology_bell_2017_oi_160093.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmid:28097324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28097324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4928099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5464982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5464982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5464982","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"JAMA Oncol","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:neurosurgeryfp-1100","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/neurosurgeryfp/98","pdf_url":"https://jdc.jefferson.edu/neurosurgeryfp/98","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Neurosurgery Faculty Papers","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/355455","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/355455","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/206590","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/206590","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA Oncology (2017)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:scholarlycommons.baptisthealth.net:se-all-publications-3139","doi":null,"is_oa":false,"landing_page_url":"https://scholarlycommons.baptisthealth.net/cgi/viewcontent.cgi?article=3139&context=se-all-publications","pdf_url":null,"source":{"id":"https://openalex.org/S4377196589","display_name":"Scholarly Commons - Baptist Health South Florida (Baptist Health South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097785","host_organization_name":"Baptist Health South Florida","host_organization_lineage":["https://openalex.org/I4210097785"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Publications","raw_type":"text"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/355455","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/355455","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA Oncology, 3(6), 784. American Medical Association","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/355455","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/355455","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA oncology, 3(6), 784","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1001/jamaoncol.2016.6020","doi":"https://doi.org/10.1001/jamaoncol.2016.6020","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2016.6020","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2597279/jamaoncology_bell_2017_oi_160093.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2056007454","display_name":"Signal Transduction Pathways in Glioblastoma","funder_award_id":"R01CA108633","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2062632101","display_name":"Community Clinical Oncology Program","funder_award_id":"U10CA037422","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2525145985","display_name":"Therapeutic Exploitation of Mutant BRAF for Astrocytoma","funder_award_id":"R01CA169368","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2983694760","display_name":"NRG Oncology NCORP Research Base","funder_award_id":"UG1CA189867","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4319480698","display_name":"NRG Oncology Network Group Operations Center","funder_award_id":"U10CA180868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4531916530","display_name":"TOWARDS A REFINED MOLECULAR RECURSIVE PARTITIONING ANALYSIS MODEL FOR GLIOBLASTOM","funder_award_id":"RC2CA148190","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6487787252","display_name":"Radiation Therapy Oncology Group","funder_award_id":"U10CA021661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6701990775","display_name":null,"funder_award_id":"U10CA180850","funder_id":"https://openalex.org/F4320309374","funder_display_name":"Ohio State University"},{"id":"https://openalex.org/G6904013034","display_name":"OSU as Network Lead Academic Participating Site for the NCI NCTN","funder_award_id":"U10CA180850","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000885485","display_name":"NRG Oncology Biospecimen Bank","funder_award_id":"U24CA196067","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G982783723","display_name":"NRG Oncology - Statistical and Data Management Center","funder_award_id":"U10CA180822","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308542","display_name":"Brain Tumor Funders' Collaborative","ror":"https://ror.org/05ncfp318"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320313690","display_name":"Novocure","ror":"https://ror.org/018ec2p66"},{"id":"https://openalex.org/F4320333648","display_name":"Pharmacyclics","ror":"https://ror.org/03hm8w204"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2574800639.pdf","grobid_xml":"https://content.openalex.org/works/W2574800639.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W302923394","https://openalex.org/W1444168786","https://openalex.org/W1544392741","https://openalex.org/W1580788756","https://openalex.org/W1918200890","https://openalex.org/W1971772887","https://openalex.org/W1979300931","https://openalex.org/W1979773093","https://openalex.org/W1994497191","https://openalex.org/W2001660159","https://openalex.org/W2023996790","https://openalex.org/W2025183726","https://openalex.org/W2037789405","https://openalex.org/W2040878803","https://openalex.org/W2046371943","https://openalex.org/W2053154970","https://openalex.org/W2064214863","https://openalex.org/W2069228161","https://openalex.org/W2105100844","https://openalex.org/W2106421416","https://openalex.org/W2109816625","https://openalex.org/W2114012083","https://openalex.org/W2124537635","https://openalex.org/W2125096000","https://openalex.org/W2129296674","https://openalex.org/W2129925362","https://openalex.org/W2135947790","https://openalex.org/W2137868544","https://openalex.org/W2139984188","https://openalex.org/W2142635246","https://openalex.org/W2148977460","https://openalex.org/W2149407433","https://openalex.org/W2151808807","https://openalex.org/W2158370459","https://openalex.org/W2162640245","https://openalex.org/W2167823712","https://openalex.org/W2170553105","https://openalex.org/W2231000545","https://openalex.org/W2327897736","https://openalex.org/W2414199735","https://openalex.org/W2505636500","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W4256183008","https://openalex.org/W4293529598"],"related_works":["https://openalex.org/W2602325446","https://openalex.org/W2070662794","https://openalex.org/W7064899764","https://openalex.org/W2890825928","https://openalex.org/W7049066766","https://openalex.org/W2528213132","https://openalex.org/W2260957749","https://openalex.org/W2596022208","https://openalex.org/W2158370459","https://openalex.org/W2605455581"],"abstract_inverted_index":{"IMPORTANCE:":[0],"There":[1],"is":[2],"a":[3,6,59,236],"need":[4],"for":[5,13,50,243,274,278,299,388],"more":[7],"refined,":[8],"molecularly":[9],"based":[10,26,337],"classification":[11],"model":[12,31,99,124,339,372,382],"glioblastoma":[14],"(GBM)":[15],"in":[16,56,131,344,358,401,422],"the":[17,23,84,102,117,213,244,334,353,378,410,416],"temozolomide":[18,396,430],"era.":[19],"OBJECTIVE:":[20],"To":[21,82,211],"refine":[22,212],"existing":[24,118,214,335],"clinically":[25,336],"recursive":[27],"partitioning":[28],"analysis":[29,93,208],"(RPA)":[30],"by":[32,58,75],"incorporating":[33],"molecular":[34,61],"variables.":[35],"DESIGN,":[36],"SETTING,":[37],"AND":[38,141,367],"PARTICIPANTS:":[39],"NRG":[40,345],"Oncology":[41,346],"RTOG":[42,119,347,380],"0525":[43],"specimens":[44],"(n":[45,136,363],"=":[46,137,168,177,186,196,364],"452)":[47],"were":[48,94,200,233,250],"analyzed":[49],"protein":[51,72,89,198,217,260,285],"biomarkers":[52,90,218],"representing":[53],"key":[54],"pathways":[55],"GBM":[57,391,425],"quantitative":[60],"microscopy-based":[62],"approach":[63],"with":[64,220,265,302,333,390,393,424,427],"semiquantitative":[65],"immunohistochemical":[66],"validation.":[67],"Prognostic":[68],"significance":[69,351],"of":[70,101,111,209,228,318,328,352,419],"each":[71],"was":[73,126,262,355,398],"examined":[74],"single-marker":[76,92,206],"and":[77,113,188,230,270,323,340,383,395,397,429,431],"multimarker":[78],"Cox":[79],"regression":[80],"analyses.":[81],"reclassify":[83],"prognostic":[85,297,330,350,420],"risk":[86],"groups,":[87],"significant":[88,204,216],"on":[91,205],"incorporated":[95,234],"into":[96,235],"an":[97,132,359,402],"RPA":[98,123,338,381,408],"consisting":[100,317],"same":[103],"clinical":[104,221,434],"variables":[105,222],"(age,":[106,223],"Karnofsky":[107,224],"Performance":[108,225],"Status,":[109,226],"extent":[110,227],"resection,":[112,229],"neurologic":[114],"function)":[115,232],"as":[116],"RPA.":[120],"The":[121,314,349,406],"new":[122,237,245,370],"(NRG-GBM-RPA)":[125],"confirmed":[127,357],"using":[128],"traditional":[129],"immunohistochemistry":[130],"independent":[133,360,403],"data":[134,361,404],"set":[135,362],"176).":[138,365],"MAIN":[139],"OUTCOMES":[140],"MEASURES:":[142],"Overall":[143],"survival":[144],"(OS).":[145],"RESULTS:":[146],"In":[147],"452":[148],"specimens,":[149],"MGMT":[150,259,267,284,303,319,341,384],"(hazard":[151],"ratio":[152],"[HR],":[153],"1.81;":[154],"95%":[155,164,173,182,192,289,308],"CI,":[156,165,174,183,193,290,309],"1.37-2.39;":[157],"P":[158,167,176,185,195,280,292,311],"<":[159,281,293,312],".001),":[160],"survivin":[161],"(HR,":[162,171,180,190,287,306],"1.36;":[163],"1.04-1.76;":[166],".02),":[169,178],"c-Met":[170,321],"1.53;":[172],"1.06-2.23;":[175],"pmTOR":[179],"0.76;":[181],"0.60-0.97;":[184],".03),":[187],"Ki-67":[189],"1.40;":[191],"1.10-1.78;":[194],".007)":[197],"levels":[199],"found":[201],"to":[202,412,414,432],"be":[203],"multivariate":[207],"OS.":[210],"RPA,":[215],"together":[219],"neurological":[231],"model.":[238],"Of":[239],"166":[240],"patients":[241,389,423],"used":[242],"NRG-GBM-RPA":[246,316,354,371],"model,":[247],"97":[248],"(58.4%)":[249],"male":[251],"(mean":[252],"[SD]":[253],"age,":[254],"55.7":[255],"[12.0]":[256],"years).":[257],"Higher":[258],"level":[261],"significantly":[263],"associated":[264],"decreased":[266],"promoter":[268,304,342,385],"methylation":[269,305,343],"vice":[271],"versa":[272],"(1425.1":[273],"methylated":[275],"vs":[276],"1828.0":[277],"unmethylated;":[279],".001).":[282,313],"Furthermore,":[283],"expression":[286],"1.84;":[288],"1.38-2.43;":[291],".001)":[294],"had":[295],"greater":[296,326],"value":[298],"OS":[300,329],"compared":[301,332],"1.77;":[307],"1.28-2.44;":[310],"refined":[315],"protein,":[320,322],"age":[324],"revealed":[325],"separation":[327],"classes":[331],"0525.":[348],"subsequently":[356],"CONCLUSIONS":[366],"RELEVANCE:":[368],"This":[369],"improves":[373],"outcome":[374],"stratification":[375],"over":[376],"both":[377],"current":[379],"methylation,":[386],"respectively,":[387],"treated":[392,426],"radiation":[394,428],"biologically":[399],"validated":[400],"set.":[405],"revised":[407],"has":[409],"potential":[411],"contribute":[413],"improving":[415],"accurate":[417],"assessment":[418],"groups":[421],"influence":[433],"decision":[435],"making.":[436],"TRIAL":[437],"REGISTRATION:":[438],"clinicaltrials.gov":[439],"Identifier:":[440],"NCT00304031.":[441]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-01-26T00:00:00"}