{"id":"https://openalex.org/W257428869","doi":null,"title":"Regulation of telomerase activity in camptothecin-induced apoptosis of human leukemia HL-60 cells.","display_name":"Regulation of telomerase activity in camptothecin-induced apoptosis of human leukemia HL-60 cells.","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W257428869","mag":"257428869","pmid":"https://pubmed.ncbi.nlm.nih.gov/11501188"},"language":"en","primary_location":{"id":"pmid:11501188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101668000","display_name":"Jihong Jiang","orcid":"https://orcid.org/0000-0002-0830-1487","observed_orcids":["https://orcid.org/0000-0002-0830-1487"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J F Jiang","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061851021","display_name":"Weijun Liu","orcid":"https://orcid.org/0000-0002-4426-6148","observed_orcids":["https://orcid.org/0000-0002-4426-6148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029047259","display_name":"J Ding","orcid":"https://orcid.org/0009-0006-3362-6343","observed_orcids":["https://orcid.org/0009-0006-3362-6343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4082,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.63375079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"8","first_page":"759","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/human-telomerase-rna","display_name":"hTR","score":0.6050000190734863},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9552035331726074},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.8431656360626221},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.8145328760147095},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6936229467391968},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6466994881629944},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.5403189659118652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.533011257648468},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.4475230276584625},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4414348006248474},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.42228057980537415},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3597464859485626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.320778489112854},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2898602783679962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22200194001197815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11954328417778015},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11183080077171326}],"mesh":[{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019254","descriptor_name":"Genes, bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11501188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:257428869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3146185115","https://openalex.org/W2388925109","https://openalex.org/W2390883638","https://openalex.org/W2390025825","https://openalex.org/W2019054906","https://openalex.org/W2051450400","https://openalex.org/W2384283330","https://openalex.org/W2143608853","https://openalex.org/W2031547976","https://openalex.org/W2410570853"],"abstract_inverted_index":{"AIM:":[0],"To":[1,44],"explore":[2],"the":[3,63,107,141,154,161,165,168,182],"regulation":[4],"of":[5,12,19,66,111,119,127,135,140,164,167,185],"telomerase":[6,46,69,74,121,142,155,186],"activity":[7,99,143,156],"in":[8,89,102,117,144],"camptothecin":[9,25,95,108],"induced":[10,23,109],"apoptosis":[11,110],"human":[13],"leukemia":[14],"HL-60":[15,20,90,112,145],"cells.":[16,113],"METHODS:":[17],"Apoptosis":[18,34],"cells":[21,91,146],"was":[22,35,56,59,100,123,129,147,157],"by":[24,37],"(1":[26],"mg/L)":[27],"for":[28],"2,":[29],"4,":[30],"and":[31,40,82,93,153],"6":[32],"h.":[33],"determined":[36],"agarose":[38],"electrophoresis":[39],"flow":[41],"cytometry":[42],"analysis.":[43],"assess":[45],"activity,":[47],"a":[48,103],"PCR-based":[49],"telomeric":[50],"repeat":[51],"amplification":[52],"protocol":[53],"assay":[54],"(TRAP)":[55],"used.":[57],"RT-PCR":[58],"performed":[60],"to":[61,150],"examine":[62],"mRNA":[64,183],"levels":[65,163],"hTR":[67],"(human":[68,73],"RNA":[70],"component),":[71],"hEST2/hTERT":[72],"reverse":[75],"transcriptase),":[76],"TLP1/TP1":[77],"(telomerase":[78],"association":[79],"protein":[80],"1),":[81],"bcl-2":[83,128,178],"(B":[84],"cell":[85],"leukemia/lymphoma":[86],"2":[87],"gene)":[88],"before":[92],"after":[94],"treatment.":[96],"RESULTS:":[97],"Telomerase":[98],"decreased":[101],"time-dependent":[104],"manner":[105],"during":[106],"However,":[114],"no":[115],"difference":[116],"expression":[118,126],"each":[120],"subunit":[122],"detected,":[124],"while":[125],"progressively":[130],"down-regulated.":[131],"CONCLUSION:":[132],"These":[133],"lines":[134],"evidences":[136],"indicated":[137],"that":[138,177],"down-regulation":[139],"closely":[148],"related":[149],"camptothecin-induced":[151],"apoptosis,":[152],"not":[158,180],"blocked":[159],"at":[160],"transcriptional":[162],"genes":[166],"known":[169],"ribonucleoprotein":[170],"(RNP)":[171],"complex":[172],"components.":[173],"We":[174],"also":[175],"found":[176],"did":[179],"regulate":[181],"expressions":[184],"subunits":[187],"directly.":[188]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
