{"id":"https://openalex.org/W2573661568","doi":null,"title":"Pooling of two randomized Phase III clinical trials of ciclosporin 1 mg/mL cationic emulsion (CsA CE) as a treatment for severe keratitis in patients with dry eye disease (DED)","display_name":"Pooling of two randomized Phase III clinical trials of ciclosporin 1 mg/mL cationic emulsion (CsA CE) as a treatment for severe keratitis in patients with dry eye disease (DED)","publication_year":2016,"publication_date":"2016-09-26","ids":{"openalex":"https://openalex.org/W2573661568","mag":"2573661568"},"language":"en","primary_location":{"id":"mag:2573661568","doi":null,"is_oa":true,"landing_page_url":"https://epub.ub.uni-muenchen.de/46041/index.html","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://epub.ub.uni-muenchen.de/46041/index.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006622188","display_name":"Eli\ufeffsa\ufeffbeth M. Messmer","orcid":"https://orcid.org/0000-0003-1299-3882","observed_orcids":["https://orcid.org/0000-0003-1299-3882"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eli\ufeffsa\ufeffbeth M. Messmer","raw_affiliation_strings":["Department of Ophthalmology, Ludwig Maximilian University Munich, M\u00fcnchen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1299-3882","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ludwig Maximilian University Munich, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035478404","display_name":"Andrea Leonardi","orcid":"https://orcid.org/0000-0002-7246-8580","observed_orcids":["https://orcid.org/0000-0002-7246-8580"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Leonardi","raw_affiliation_strings":["Department of Neuroscience Ophthalmology Unit University of Padua Padua Italy"],"raw_orcid":"https://orcid.org/0000-0002-7246-8580","affiliations":[{"raw_affiliation_string":"Department of Neuroscience Ophthalmology Unit University of Padua Padua Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041463616","display_name":"Mourad Amrane","orcid":"https://orcid.org/0000-0001-7661-5755","observed_orcids":["https://orcid.org/0000-0001-7661-5755"]},"institutions":[{"id":"https://openalex.org/I4210098896","display_name":"Santen (France)","ror":"https://ror.org/00z4cj158","country_code":"FR","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210098896"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mourad Amrane","raw_affiliation_strings":["Santen SAS, Evry, France"],"raw_orcid":"https://orcid.org/0000-0001-7661-5755","affiliations":[{"raw_affiliation_string":"Santen SAS, Evry, France","institution_ids":["https://openalex.org/I4210098896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110602157","display_name":"Dahlia Ismail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098896","display_name":"Santen (France)","ror":"https://ror.org/00z4cj158","country_code":"FR","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210098896"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dahlia Ismail","raw_affiliation_strings":["Santen SAS, Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santen SAS, Evry, France","institution_ids":["https://openalex.org/I4210098896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012252844","display_name":"Francisco C. Figueiredo","orcid":"https://orcid.org/0000-0002-5876-288X","observed_orcids":["https://orcid.org/0000-0002-5876-288X"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francisco C. Figueiredo","raw_affiliation_strings":["Royal Victoria Infirmary , Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Victoria Infirmary , Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049275848","display_name":"Christophe Baudouin","orcid":"https://orcid.org/0000-0003-1743-6698","observed_orcids":["https://orcid.org/0000-0003-1743-6698","https://orcid.org/0000-0002-2006-5384"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1340951533","display_name":"Institut de la Vision","ror":"https://ror.org/000zhpw23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1340951533","https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Baudouin","raw_affiliation_strings":["UPMC University, Paris 6, Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1743-6698","affiliations":[{"raw_affiliation_string":"UPMC University, Paris 6, Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1340951533","https://openalex.org/I154526488","https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.3087,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65856194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"57","issue":"12","first_page":"2871","last_page":"2871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cationic-emulsion","display_name":"cationic emulsion","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pooled-analysis","display_name":"pooled analysis","score":0.5149999856948853},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2779528694","wikidata":"https://www.wikidata.org/wiki/Q367700","display_name":"Ciclosporin","level":3,"score":0.7166368961334229},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.5732881426811218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5512017011642456},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.52326500415802},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4890340268611908},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.47950249910354614},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4217715859413147},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29712826013565063},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.29445862770080566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24073782563209534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18715834617614746},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10682812333106995},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07132256031036377}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2573661568","doi":null,"is_oa":true,"landing_page_url":"https://epub.ub.uni-muenchen.de/46041/index.html","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":{"id":"mag:2573661568","doi":null,"is_oa":true,"landing_page_url":"https://epub.ub.uni-muenchen.de/46041/index.html","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2568630575","https://openalex.org/W2790390467","https://openalex.org/W2942781595","https://openalex.org/W2286112668","https://openalex.org/W2790880597","https://openalex.org/W2995233405","https://openalex.org/W7164511865","https://openalex.org/W2520447099","https://openalex.org/W2802525514","https://openalex.org/W2362856052"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-01-26T00:00:00"}