{"id":"https://openalex.org/W2571998636","doi":"https://doi.org/10.1007/s10930-017-9696-z","title":"Phosphorylation: Implications in Cancer","display_name":"Phosphorylation: Implications in Cancer","publication_year":2017,"publication_date":"2017-01-20","ids":{"openalex":"https://openalex.org/W2571998636","doi":"https://doi.org/10.1007/s10930-017-9696-z","mag":"2571998636","pmid":"https://pubmed.ncbi.nlm.nih.gov/28108801"},"language":"en","primary_location":{"id":"doi:10.1007/s10930-017-9696-z","doi":"https://doi.org/10.1007/s10930-017-9696-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-017-9696-z","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115590741","display_name":"Vishakha Singh","orcid":"https://orcid.org/0000-0001-8307-3659","observed_orcids":["https://orcid.org/0000-0001-8307-3659"]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishakha Singh","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004535349","display_name":"Mahendra Ram","orcid":"https://orcid.org/0000-0002-3911-8271","observed_orcids":["https://orcid.org/0000-0002-3911-8271"]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mahendra Ram","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India. mahendrak92@gmail.com","Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India. mahendrak92@gmail.com","institution_ids":["https://openalex.org/I205478545"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084383371","display_name":"Rajesh Kumar","orcid":"https://orcid.org/0000-0002-0211-7195","observed_orcids":["https://orcid.org/0000-0002-0211-7195"]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Kumar","raw_affiliation_strings":["Department of Livestock Products Technology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Livestock Products Technology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103759033","display_name":"Raju Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raju Prasad","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112563614","display_name":"Birendra Kumar Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Birendra Kumar Roy","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101240514","display_name":"Kaushal Singh","orcid":"https://orcid.org/0000-0002-0524-0324","observed_orcids":["https://orcid.org/0000-0002-0524-0324"]},"institutions":[{"id":"https://openalex.org/I205478545","display_name":"Birsa Agricultural University","ror":"https://ror.org/03a7ksb41","country_code":"IN","type":"education","lineage":["https://openalex.org/I205478545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kaushal Kumar Singh","raw_affiliation_strings":["Department of Pathology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ranchi Veterinary College, BAU, Kanke, Ranchi, Jharkhand, 834006, India","institution_ids":["https://openalex.org/I205478545"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004535349"],"corresponding_institution_ids":["https://openalex.org/I205478545"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":1.3136,"has_fulltext":false,"cited_by_count":361,"citation_normalized_percentile":{"value":0.8025824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"36","issue":"1","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.15320000052452087,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.09709999710321426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.675000011920929},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cadherin-catenin-complex","display_name":"cadherin-catenin complex","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/erk-inhibitor","display_name":"ERK inhibitor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5752823352813721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5154989361763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5026857852935791},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4990861415863037},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4721817076206207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44230079650878906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.440054714679718},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43505120277404785},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4201065003871918},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.41590166091918945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07267603278160095}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10930-017-9696-z","doi":"https://doi.org/10.1007/s10930-017-9696-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-017-9696-z","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},{"id":"pmid:28108801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28108801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The protein journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W152231097","https://openalex.org/W1500780819","https://openalex.org/W1501199419","https://openalex.org/W1504315082","https://openalex.org/W1564058497","https://openalex.org/W1591443723","https://openalex.org/W1762366815","https://openalex.org/W1904672267","https://openalex.org/W1937607074","https://openalex.org/W1964504843","https://openalex.org/W1966091813","https://openalex.org/W1981665139","https://openalex.org/W1982244057","https://openalex.org/W1989844987","https://openalex.org/W1991845461","https://openalex.org/W1995492336","https://openalex.org/W1997835441","https://openalex.org/W1999441881","https://openalex.org/W2006690126","https://openalex.org/W2007042842","https://openalex.org/W2010670456","https://openalex.org/W2011732151","https://openalex.org/W2011826559","https://openalex.org/W2013334458","https://openalex.org/W2020459598","https://openalex.org/W2034269086","https://openalex.org/W2042629507","https://openalex.org/W2043794217","https://openalex.org/W2046056065","https://openalex.org/W2051506850","https://openalex.org/W2052690509","https://openalex.org/W2055878807","https://openalex.org/W2065725840","https://openalex.org/W2074018262","https://openalex.org/W2074688366","https://openalex.org/W2076015888","https://openalex.org/W2076718655","https://openalex.org/W2078960019","https://openalex.org/W2079056345","https://openalex.org/W2102648794","https://openalex.org/W2105484422","https://openalex.org/W2107023082","https://openalex.org/W2109261845","https://openalex.org/W2111642458","https://openalex.org/W2113999599","https://openalex.org/W2118873545","https://openalex.org/W2121745326","https://openalex.org/W2123365645","https://openalex.org/W2124076790","https://openalex.org/W2125242999","https://openalex.org/W2134043419","https://openalex.org/W2142026383","https://openalex.org/W2147921405","https://openalex.org/W2155679637","https://openalex.org/W2157942810","https://openalex.org/W2164590607","https://openalex.org/W2168165195","https://openalex.org/W2171137597","https://openalex.org/W2409039558","https://openalex.org/W2561540427","https://openalex.org/W3102875255","https://openalex.org/W4213141530","https://openalex.org/W4294413394"],"related_works":["https://openalex.org/W2553465681","https://openalex.org/W2976406941","https://openalex.org/W1998014006","https://openalex.org/W1963529180","https://openalex.org/W2635415917","https://openalex.org/W205949964","https://openalex.org/W2574246591","https://openalex.org/W1513895168","https://openalex.org/W1974404912","https://openalex.org/W7202345074"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":65},{"year":2024,"cited_by_count":70},{"year":2023,"cited_by_count":47},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-01-26T00:00:00"}