{"id":"https://openalex.org/W2571194574","doi":"https://doi.org/10.1182/blood.v110.11.2471.2471","title":"Identification of Survival Critical Genomic Gains or Losses in Myeloma (MM) Using Array-Comparative Genomic Hybridization (aCGH).","display_name":"Identification of Survival Critical Genomic Gains or Losses in Myeloma (MM) Using Array-Comparative Genomic Hybridization (aCGH).","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2571194574","doi":"https://doi.org/10.1182/blood.v110.11.2471.2471","mag":"2571194574"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.2471.2471","doi":"https://doi.org/10.1182/blood.v110.11.2471.2471","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2471.2471","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066282840","display_name":"Wee Joo Chng","orcid":"https://orcid.org/0000-0003-2578-8335","observed_orcids":["https://orcid.org/0000-0003-2578-8335"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wee J. Chng","raw_affiliation_strings":["Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073201968","display_name":"Tae-Hoon Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Hoon Chung","raw_affiliation_strings":["TGen, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TGen, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085850492","display_name":"Jonathan J. Keats","orcid":"https://orcid.org/0000-0003-4375-7399","observed_orcids":["https://orcid.org/0000-0003-4375-7399"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan J. Keats","raw_affiliation_strings":["Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066225086","display_name":"Angela S. Baker","orcid":"https://orcid.org/0000-0001-9482-4286","observed_orcids":["https://orcid.org/0000-0001-9482-4286"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Baker","raw_affiliation_strings":["TGen, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TGen, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004436275","display_name":"Peter Leif Bergsagel","orcid":"https://orcid.org/0000-0003-1523-7388","observed_orcids":["https://orcid.org/0000-0003-1523-7388"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Leif Bergsagel","raw_affiliation_strings":["Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080927178","display_name":"John David Carpten","orcid":"https://orcid.org/0000-0002-6862-2821","observed_orcids":["https://orcid.org/0000-0002-6862-2821"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Carpten","raw_affiliation_strings":["TGen, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TGen, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003015868","display_name":"Rafa\u00ebl Fonseca","orcid":"https://orcid.org/0000-0002-5938-3769","observed_orcids":["https://orcid.org/0000-0002-5938-3769"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael Fonseca","raw_affiliation_strings":["Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35445693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"2471","last_page":"2471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6179999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.746999979019165},{"id":"https://openalex.org/keywords/deletion-hotspots","display_name":"deletion hotspots","score":0.8460000157356262},{"id":"https://openalex.org/keywords/high-dose-therapy","display_name":"high-dose therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/total-therapy","display_name":"total therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chromosome-13q-deletion","display_name":"chromosome 13q deletion","score":0.43700000643730164},{"id":"https://openalex.org/keywords/chromosome-17p-deletion","display_name":"chromosome 17p deletion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/chromosome-18q-deletion","display_name":"chromosome 18q deletion","score":0.671999990940094},{"id":"https://openalex.org/keywords/chromosome-11q-deletion","display_name":"chromosome 11q deletion","score":0.6119999885559082},{"id":"https://openalex.org/keywords/chromosome-14q-deletion","display_name":"chromosome 14q deletion","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.8185445070266724},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.668969988822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5071876049041748},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.49504485726356506},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4800485372543335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3813847303390503},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.27854764461517334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25432121753692627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25417906045913696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24412235617637634},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.08302578330039978}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.2471.2471","doi":"https://doi.org/10.1182/blood.v110.11.2471.2471","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2471.2471","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061982070","https://openalex.org/W1484057906","https://openalex.org/W1977262284","https://openalex.org/W2003242428","https://openalex.org/W1975185235","https://openalex.org/W4211065811","https://openalex.org/W4255453824","https://openalex.org/W2013824969","https://openalex.org/W2063205700","https://openalex.org/W2116701921"],"abstract_inverted_index":{"Abstract":[0],"Genetic":[1],"abnormalities":[2,39,433,465],"are":[3,403,434,447,457],"important":[4,448],"in":[5,42,51,78,210,370],"the":[6,61,87,94,110,135,159,206,211,227,243,273,278,284,354,360,418,422],"pathobiology":[7],"of":[8,20,46,89,109,124,137,141,145,153,191,208,246,275,330,337,363,374,383,390,399,405,443,459],"myeloma":[9],"and":[10,23,114,130,219,240,267,277,301,325,340,407],"established":[11],"prognostic":[12,361],"factors.":[13],"High-density":[14],"aCGH":[15,48,75],"allow":[16],"global":[17],"unbiased":[18],"detection":[19],"genomic":[21,34,138,338,444],"gains":[22,308,339],"losses.":[24],"In":[25,70,416],"this":[26],"study,":[27],"we":[28],"attempt":[29],"to":[30,178,242,312,327],"identify":[31],"survival":[32,41,251,314,347,365,385],"critical":[33,366,386],"aberrations":[35],"by":[36,173,283,393],"correlating":[37],"aCGH-defined":[38],"with":[40,56,83,151,315,345,348,378,463],"2":[43,107,355],"different":[44,414],"cohorts":[45],"patients.":[47],"was":[49,103,171,198,253,281,290],"performed":[50,77],"64":[52],"MM":[53,80,391],"patients":[54,81,376],"treated":[55,82,119,377],"high":[57,379,397],"dose":[58,380],"therapy":[59,85],"from":[60,86,186],"Mayo":[62],"Clinic":[63],"using":[64,93,158,272,368],"Agilent\u2019s":[65],"44k":[66],"DNA":[67],"microarray":[68],"genechip.":[69],"addition,":[71,417],"a":[72,121,142,262],"publicly":[73],"available":[74],"dataset":[76,373],"67":[79],"total":[84],"University":[88],"Arkansas":[90],"Medical":[91],"School":[92],"lower":[95],"density":[96],"Agilent":[97],"22k":[98],"chip":[99],"(Human":[100],"1A":[101],"v2)":[102],"also":[104],"analyzed.":[105],"Base":[106],"logarithms":[108],"ratios":[111],"between":[112,128,255,353],"red":[113],"green":[115],"intensities":[116],"(log-ratios)":[117],"were":[118,149,202,233,333,342],"as":[120,292],"primary":[122],"measure":[123],"copy":[125,228],"number":[126,207,229,398],"ratio":[127],"tumor":[129],"normal":[131],"samples.":[132],"To":[133],"detect":[134],"regions":[136,188,336,442,456],"aberration,":[139],"values":[140,176],"sliding":[143,238,248,288],"window":[144,239,289],"15":[146,182],"consecutive":[147],"log-ratios":[148,185,209],"compared":[150],"those":[152],"an":[154,371,427],"artificial":[155],"\u2018reference\u2019":[156],"chromosome":[157,214,423,431],"Wilcoxon":[160,192],"rank":[161,194],"sum":[162],"test.":[163,286],"The":[164,217,250,287],"reference":[165,213],"chromosome,":[166],"constructed":[167],"for":[168,226,236],"each":[169,237],"sample,":[170],"assembled":[172,212],"collecting":[174],"log-ratio":[175],"close":[177],"zero.":[179],"For":[180],"this,":[181],"randomly":[183],"sampled":[184],"autosomal":[187],"whose":[189,307],"p-value":[190,318],"signed":[193],"test":[195,317],"against":[196],"0":[197],"larger":[199],"than":[200],"0.05":[201],"recursively":[203],"accepted":[204],"until":[205],"reached":[215],"1000.":[216],"p-values":[218],"their":[220],"corresponding":[221,247,321],"false":[222],"discovery":[223],"rates":[224],"(q-values)":[225],"gain":[230],"or":[231,260,294,309,396],"loss":[232,425],"calculated":[234],"independently":[235],"assigned":[241],"center":[244],"position":[245],"window.":[249],"difference":[252],"examined":[254],"samples":[256,268,332],"that":[257,269,446,454,466],"had":[258,270],"gained":[259,293],"lost":[261,295],"chromosomal":[263],"region":[264],"(sliding":[265],"window)":[266],"not":[271],"method":[274],"Kaplan-Meier":[276],"statistical":[279],"significance":[280,362],"assessed":[282],"log-rank":[285,316],"identified":[291,440],"if":[296],"P-value":[297],"<":[298,303,319,323],"10":[299],"\u22124":[300],"Q-value":[302],"10[suo]-3.":[304],"Sliding":[305],"windows":[306],"losses":[310,341],"led":[311],"poor":[313],"0.5,":[320,324],"q-value":[322],"happened":[326],"\u2265":[328],"10%":[329],"all":[331],"retained.":[334],"Several":[335],"significantly":[343,413],"associated":[344],"poorer":[346,468],"5":[349],"deletion":[350],"hotspots":[351],"common":[352],"datasets":[356],"(Table).":[357],"We":[358],"validated":[359],"these":[364,384,400,455],"loci":[367,387],"FISH":[369],"independent":[372,404],"169":[375],"therapy.":[381],"Clustering":[382],"revealed":[388],"clusters":[389],"characterized":[392],"low,":[394],"intermediate":[395],"abnormalities,":[401],"which":[402],"ploidy":[406],"translocations":[408],"subtypes.":[409],"These":[410],"subgroups":[411],"have":[412,467],"survival.":[415],"clustering":[419],"analysis":[420],"suggests":[421],"13":[424],"is":[426,452],"early":[428],"event":[429],"whereas":[430],"1":[432,475,480],"late":[435],"events.":[436],"Our":[437],"strategy":[438],"therefore":[439],"novel":[441],"aberration":[445],"prognostically.":[449],"However,":[450],"it":[451],"likely":[453],"manifestation":[458],"genomically":[460],"unstable":[461],"tumors":[462],"complex":[464],"prognosis.":[469],"Chr":[470],"Start":[471],"End":[472],"Length":[473],"Cytoband":[474],"74,137,824":[476],"75,972,544":[477],"1,834,720":[478],"p31.1":[479],"62,433,123":[481],"84,792,809":[482],"22,359,686":[483],"p31.3":[484],"\u2013":[485,492,499,506],"p22.3":[486],"20":[487,494,501],"4,100,452":[488],"6,189,410":[489],"2,088,958":[490],"p13":[491,505],"p12.3":[493,498],"6,717,170":[495],"13,142,205":[496],"6,425,035":[497],"p12.1":[500],"4,708,668":[502],"10,566,333":[503],"5,857,665":[504],"p12.2":[507]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
