{"id":"https://openalex.org/W2571132007","doi":"https://doi.org/10.1016/j.ces.2016.12.065","title":"Biochemical engineering\u2019s grand adventure","display_name":"Biochemical engineering\u2019s grand adventure","publication_year":2017,"publication_date":"2017-01-07","ids":{"openalex":"https://openalex.org/W2571132007","doi":"https://doi.org/10.1016/j.ces.2016.12.065","mag":"2571132007"},"language":"en","primary_location":{"id":"doi:10.1016/j.ces.2016.12.065","doi":"https://doi.org/10.1016/j.ces.2016.12.065","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ces.2016.12.065","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0009250916307266-fx1_lrg.jpg","source":{"id":"https://openalex.org/S33892871","display_name":"Chemical Engineering Science","issn_l":"0009-2509","issn":["0009-2509","1873-4405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0009250916307266-fx1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024928000","display_name":"Henk J. Noorman","orcid":"https://orcid.org/0000-0001-8163-5814","observed_orcids":["https://orcid.org/0000-0001-8163-5814"]},"institutions":[{"id":"https://openalex.org/I127558574","display_name":"DSM (Netherlands)","ror":"https://ror.org/00k01kt20","country_code":"NL","type":"company","lineage":["https://openalex.org/I127558574"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Henk J. Noorman","raw_affiliation_strings":["DSM Biotechnology Center, Delft, The Netherlands","Department of Biotechnology, Technical University Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Biotechnology Center, Delft, The Netherlands","institution_ids":["https://openalex.org/I127558574"]},{"raw_affiliation_string":"Department of Biotechnology, Technical University Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090214575","display_name":"Joseph J. Heijnen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joseph J. Heijnen","raw_affiliation_strings":["Department of Biotechnology, Technical University Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Technical University Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024928000"],"corresponding_institution_ids":["https://openalex.org/I127558574","https://openalex.org/I98358874"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":{"value":4050,"currency":"USD","value_usd":4050},"fwci":3.1173,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.92896647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"170","issue":null,"first_page":"677","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13180","display_name":"Chemistry and Chemical Engineering","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"biochemical engineering","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bioprocess-design","display_name":"bioprocess design","score":0.9509999752044678},{"id":"https://openalex.org/keywords/conceptual-design","display_name":"conceptual design","score":0.9269999861717224},{"id":"https://openalex.org/keywords/downstream-purification","display_name":"downstream purification","score":0.8920000195503235},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.597000002861023},{"id":"https://openalex.org/keywords/bioeconomy","display_name":"bioeconomy","score":0.6169999837875366},{"id":"https://openalex.org/keywords/renewable-feedstocks","display_name":"renewable raw materials","score":0.7200000286102295},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.4860000014305115},{"id":"https://openalex.org/keywords/sustainability","display_name":"sustainability","score":0.5600000023841858},{"id":"https://openalex.org/keywords/bioproducts","display_name":"bioproducts","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6396424174308777},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.6205524206161499},{"id":"https://openalex.org/C66204764","wikidata":"https://www.wikidata.org/wiki/Q219416","display_name":"Sustainability","level":2,"score":0.49912452697753906},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.4955686330795288},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4921185374259949},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.4512993395328522},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.43730270862579346},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.43466657400131226},{"id":"https://openalex.org/C61664519","wikidata":"https://www.wikidata.org/wiki/Q864734","display_name":"Bioprocess engineering","level":2,"score":0.42296868562698364},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38263019919395447},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3683098554611206},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.32596588134765625},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3101074993610382},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16786375641822815},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ces.2016.12.065","doi":"https://doi.org/10.1016/j.ces.2016.12.065","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ces.2016.12.065","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0009250916307266-fx1_lrg.jpg","source":{"id":"https://openalex.org/S33892871","display_name":"Chemical Engineering Science","issn_l":"0009-2509","issn":["0009-2509","1873-4405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Science","raw_type":"journal-article"},{"id":"pmh:oai:tudelft.nl:uuid:3aeaa000-a9cd-4f91-927a-9688bc5242e4","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:3aeaa000-a9cd-4f91-927a-9688bc5242e4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:tud:oai:tudelft.nl:uuid:3aeaa000-a9cd-4f91-927a-9688bc5242e4","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:3aeaa000-a9cd-4f91-927a-9688bc5242e4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemical Engineering Science, 170","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ces.2016.12.065","doi":"https://doi.org/10.1016/j.ces.2016.12.065","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ces.2016.12.065","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0009250916307266-fx1_lrg.jpg","source":{"id":"https://openalex.org/S33892871","display_name":"Chemical Engineering Science","issn_l":"0009-2509","issn":["0009-2509","1873-4405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321012","display_name":"Technische Universiteit Delft","ror":"https://ror.org/02e2c7k09"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2571132007.pdf","grobid_xml":"https://content.openalex.org/works/W2571132007.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W164566635","https://openalex.org/W563559829","https://openalex.org/W1517848764","https://openalex.org/W1520839433","https://openalex.org/W1550965069","https://openalex.org/W1589168018","https://openalex.org/W1969690273","https://openalex.org/W1973042968","https://openalex.org/W1973220533","https://openalex.org/W1974033770","https://openalex.org/W1975471210","https://openalex.org/W1977493314","https://openalex.org/W1978032327","https://openalex.org/W1980802438","https://openalex.org/W1984920640","https://openalex.org/W1985781571","https://openalex.org/W1986584197","https://openalex.org/W1988585295","https://openalex.org/W1988730360","https://openalex.org/W1989508998","https://openalex.org/W1989919176","https://openalex.org/W1992157447","https://openalex.org/W2001357509","https://openalex.org/W2007558289","https://openalex.org/W2015245310","https://openalex.org/W2020843234","https://openalex.org/W2023136803","https://openalex.org/W2027618732","https://openalex.org/W2031944646","https://openalex.org/W2034609804","https://openalex.org/W2037569645","https://openalex.org/W2038727507","https://openalex.org/W2040353241","https://openalex.org/W2042707461","https://openalex.org/W2051143952","https://openalex.org/W2055740869","https://openalex.org/W2056228650","https://openalex.org/W2057010897","https://openalex.org/W2075762672","https://openalex.org/W2076149465","https://openalex.org/W2078022454","https://openalex.org/W2078472670","https://openalex.org/W2080428447","https://openalex.org/W2105845193","https://openalex.org/W2106411386","https://openalex.org/W2107262921","https://openalex.org/W2113487205","https://openalex.org/W2125902873","https://openalex.org/W2126579076","https://openalex.org/W2136090607","https://openalex.org/W2136536485","https://openalex.org/W2137018402","https://openalex.org/W2137544417","https://openalex.org/W2139192220","https://openalex.org/W2146952447","https://openalex.org/W2152644428","https://openalex.org/W2171463471","https://openalex.org/W2171996869","https://openalex.org/W2192908650","https://openalex.org/W2207762309","https://openalex.org/W2269971845","https://openalex.org/W2273877857","https://openalex.org/W2283311478","https://openalex.org/W2297918454","https://openalex.org/W2344136218","https://openalex.org/W2344431831","https://openalex.org/W2461617529","https://openalex.org/W2500740663","https://openalex.org/W2502699847","https://openalex.org/W4233565474"],"related_works":["https://openalex.org/W29094619","https://openalex.org/W2619628470","https://openalex.org/W2500987152","https://openalex.org/W7203605625","https://openalex.org/W7148630667","https://openalex.org/W2390382152","https://openalex.org/W386771429","https://openalex.org/W7203645757","https://openalex.org/W7221197491","https://openalex.org/W2055324842"],"abstract_inverted_index":{"Building":[0],"on":[1],"the":[2,18,28,31,56,80,100,119,130,135,147,151,156,176,181,185,235,271,285,295],"recent":[3],"revolution":[4],"in":[5,22,60,70,88,121,155,166,280,284],"molecular":[6],"biology,":[7],"enabling":[8,291],"a":[9,23,35,64,89,240],"wealth":[10],"of":[11,46,55,76,82,91,178,294],"bio-product":[12],"innovations":[13],"made":[14],"from":[15,37,207],"renewable":[16],"feedstocks,":[17],"biotechnology":[19],"field":[20,81],"is":[21,74,85,99,203,251],"transition":[24],"phase":[25],"to":[26,30,40,125,172,269],"bring":[27],"products":[29],"market.":[32],"This":[33,123],"requires":[34],"shift":[36],"natural":[38],"sciences":[39,42,237],"engineering":[41,84,236],"with":[43,118],"first":[44],"conception":[45],"new,":[47,223],"efficient":[48],"large-scale":[49],"bioprocess":[50,131,215],"designs,":[51],"followed":[52],"by":[53,63,67,111,253],"implementation":[54,288],"most":[57],"promising":[58],"design":[59,102,216,286],"practice.":[61],"Inspired":[62],"former":[65],"publication":[66],"O.":[68],"Levenspiel":[69],"1988,":[71],"an":[72,113],"outline":[73],"presented":[75],"main":[77],"challenges":[78],"that":[79,159,220,234],"biochemical":[83,259,281],"currently":[86],"facing,":[87],"context":[90],"major":[92],"global":[93],"sustainability":[94],"trends.":[95],"The":[96],"critical":[97],"stage":[98],"conceptual":[101,225],"phase.":[103],"Issues":[104],"can":[105,227],"best":[106],"be":[107,143,228],"addressed":[108],"and":[109,138,161,168,174,191,193,200,248,277,287],"overcome":[110],"adopting":[112],"attitude":[114],"where":[115,134,180,242],"one":[116],"begins":[117],"end":[120],"mind.":[122],"applies":[124],"three":[126,214],"principal":[127],"components:":[128],"1.":[129],"value":[132],"chain,":[133],"product":[136],"specifications":[137],"downstream":[139],"purification":[140],"schemes":[141],"should":[142],"set":[144],"before":[145],"defining":[146],"upstream":[148],"sections,":[149],"2.":[150],"time":[152],"perspective,":[153],"starting":[154],"future":[157],"assuming":[158],"feedstock":[160],"product-market":[162],"combinations":[163],"are":[164,218,238,264],"already":[165],"place":[167],"then":[169],"going":[170],"back":[171],"today,":[173],"3.":[175],"scale":[177],"operation,":[179],"industrial":[182],"operation":[183],"sets":[184],"boundaries":[186],"for":[187,274],"all":[188],"labscale":[189],"research":[190],"development,":[192],"not":[194],"vice":[195],"versa.":[196],"In":[197],"this":[198],"way,":[199],"ideal":[201,224],"process":[202],"defined":[204],"taking":[205],"constraints":[206],"anticipated":[208],"manufacturing":[209],"into":[210],"account.":[211],"For":[212,258],"illustration,":[213],"examples":[217],"provided,":[219],"show":[221],"how":[222],"designs":[226],"generated.":[229],"These":[230],"also":[231],"make":[232],"clear":[233],"undergoing":[239],"revolution,":[241],"bio-based":[243,296],"approaches":[244],"replace":[245],"fossil":[246],"routes,":[247],"gross":[249],"simplification":[250],"replaced":[252],"highly":[254],"detailed":[255],"computational":[256],"methods.":[257],"processes,":[260],"lifeline":[261],"modeling":[262],"frameworks":[263],"highlighted":[265],"as":[266],"powerful":[267],"means":[268],"reconcile":[270],"competing":[272],"needs":[273],"high":[275,278],"speed":[276],"quality":[279],"engineering,":[282],"both":[283],"stages,":[289],"thereby":[290],"significant":[292],"growth":[293],"economy.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-13T00:00:00"}
