{"id":"https://openalex.org/W2570786147","doi":null,"title":"Can interactions between Bt proteins be predicted and how should effects on non-target organisms of GM crops with multiple Bt Proteins be assessed?","display_name":"Can interactions between Bt proteins be predicted and how should effects on non-target organisms of GM crops with multiple Bt Proteins be assessed?","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2570786147","mag":"2570786147"},"language":"en","primary_location":{"id":"pmh:oai:library.wur.nl:wurpubs/482766","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/can-interactions-between-bt-proteins-be-predicted-and-how-should-","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"External research report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.wur.nl/en/publications/can-interactions-between-bt-proteins-be-predicted-and-how-should-","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110346518","display_name":"A. De Schrijver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. De Schrijver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018210688","display_name":"Patrick DE CLERCQ","orcid":"https://orcid.org/0000-0003-0664-1602","observed_orcids":["https://orcid.org/0000-0003-0664-1602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick De Clercq","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0664-1602","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066336737","display_name":"K. Booij","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Booij","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021098392","display_name":"Ruud A. de Maagd","orcid":"https://orcid.org/0000-0001-7049-2029","observed_orcids":["https://orcid.org/0000-0001-7049-2029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruud A. de Maagd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7049-2029","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026343910","display_name":"Kees van Frankenhuyzen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kees van Frankenhuyzen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.24629999697208405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bt-proteins","display_name":"Bt proteins","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cry-proteins","display_name":"Cry proteins","score":0.718999981880188},{"id":"https://openalex.org/keywords/vip3aa","display_name":"Vip3Aa","score":0.9549999833106995},{"id":"https://openalex.org/keywords/non-target-invertebrates","display_name":"non-target invertebrates","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ecotoxicology","display_name":"ecotoxicology","score":0.7250000238418579},{"id":"https://openalex.org/keywords/bacillus-thuringiensis","display_name":"Bacillus thuringiensis","score":0.796999990940094},{"id":"https://openalex.org/keywords/insecticidal-proteins","display_name":"insecticidal proteins","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2779035793","wikidata":"https://www.wikidata.org/wiki/Q310467","display_name":"Bacillus thuringiensis","level":3,"score":0.8689364194869995},{"id":"https://openalex.org/C122172344","wikidata":"https://www.wikidata.org/wiki/Q1503477","display_name":"Genetically modified crops","level":4,"score":0.7242215871810913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6024810075759888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.596218466758728},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.5533961653709412},{"id":"https://openalex.org/C137580998","wikidata":"https://www.wikidata.org/wiki/Q235352","display_name":"Crop","level":2,"score":0.5408445596694946},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.5369477272033691},{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.479302316904068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39651310443878174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3527167737483978},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.27592015266418457},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.21093231439590454},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:library.wur.nl:wurpubs/482766","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/can-interactions-between-bt-proteins-be-predicted-and-how-should-","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"External research report"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/482766","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/can-interactions-between-bt-proteins-be-predicted-and-how-should-","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/report"},{"id":"mag:2570786147","doi":null,"is_oa":false,"landing_page_url":"http://library.wur.nl/WebQuery/wurpubs/482766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:library.wur.nl:wurpubs/482766","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/can-interactions-between-bt-proteins-be-predicted-and-how-should-","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"External research report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.800000011920929,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W1482595939","https://openalex.org/W1507759842","https://openalex.org/W1510897377","https://openalex.org/W1531023449","https://openalex.org/W1533532660","https://openalex.org/W1540538349","https://openalex.org/W1540636536","https://openalex.org/W1552202087","https://openalex.org/W1555307140","https://openalex.org/W1577206043","https://openalex.org/W1578126504","https://openalex.org/W1582369042","https://openalex.org/W1587545897","https://openalex.org/W1607892645","https://openalex.org/W1782983394","https://openalex.org/W1804502080","https://openalex.org/W1846073241","https://openalex.org/W1865053832","https://openalex.org/W1909004338","https://openalex.org/W1963524939","https://openalex.org/W1966207526","https://openalex.org/W1972069532","https://openalex.org/W1976661160","https://openalex.org/W1982421053","https://openalex.org/W1983976183","https://openalex.org/W1984799451","https://openalex.org/W1985707094","https://openalex.org/W1987326458","https://openalex.org/W1989276615","https://openalex.org/W1991213656","https://openalex.org/W1991333857","https://openalex.org/W1991374082","https://openalex.org/W1992280767","https://openalex.org/W1997136480","https://openalex.org/W1997511233","https://openalex.org/W1997552388","https://openalex.org/W1997998801","https://openalex.org/W1999197368","https://openalex.org/W1999427867","https://openalex.org/W1999972142","https://openalex.org/W2002479563","https://openalex.org/W2004127656","https://openalex.org/W2004630699","https://openalex.org/W2006594900","https://openalex.org/W2007458509","https://openalex.org/W2009411579","https://openalex.org/W2014564654","https://openalex.org/W2016764769","https://openalex.org/W2018137146","https://openalex.org/W2019504828","https://openalex.org/W2022087163","https://openalex.org/W2022292782","https://openalex.org/W2027203087","https://openalex.org/W2028306370","https://openalex.org/W2030996794","https://openalex.org/W2031388815","https://openalex.org/W2037008423","https://openalex.org/W2041152498","https://openalex.org/W2041194302","https://openalex.org/W2041200445","https://openalex.org/W2042000201","https://openalex.org/W2042277210","https://openalex.org/W2051007072","https://openalex.org/W2052336697","https://openalex.org/W2054238305","https://openalex.org/W2059580345","https://openalex.org/W2061431010","https://openalex.org/W2062867241","https://openalex.org/W2063227014","https://openalex.org/W2064673384","https://openalex.org/W2065585101","https://openalex.org/W2067393525","https://openalex.org/W2068076835","https://openalex.org/W2084455775","https://openalex.org/W2085550508","https://openalex.org/W2086458348","https://openalex.org/W2087579045","https://openalex.org/W2090340861","https://openalex.org/W2094043023","https://openalex.org/W2095966083","https://openalex.org/W2096719796","https://openalex.org/W2096847727","https://openalex.org/W2098161732","https://openalex.org/W2099095176","https://openalex.org/W2099315298","https://openalex.org/W2099607911","https://openalex.org/W2099866097","https://openalex.org/W2100716473","https://openalex.org/W2102117420","https://openalex.org/W2102626139","https://openalex.org/W2102845745","https://openalex.org/W2102981800","https://openalex.org/W2105212952","https://openalex.org/W2107034052","https://openalex.org/W2111097405","https://openalex.org/W2112543539","https://openalex.org/W2112865533","https://openalex.org/W2112923033","https://openalex.org/W2113515344","https://openalex.org/W2118266965","https://openalex.org/W2119750092","https://openalex.org/W2125354428","https://openalex.org/W2127774597","https://openalex.org/W2128806600","https://openalex.org/W2130873849","https://openalex.org/W2131000629","https://openalex.org/W2136519345","https://openalex.org/W2140674122","https://openalex.org/W2142823073","https://openalex.org/W2146447297","https://openalex.org/W2146568189","https://openalex.org/W2148150044","https://openalex.org/W2149322671","https://openalex.org/W2153257284","https://openalex.org/W2157267692","https://openalex.org/W2157618197","https://openalex.org/W2164834278","https://openalex.org/W2166236793","https://openalex.org/W2166505257","https://openalex.org/W2166874035","https://openalex.org/W2171314806","https://openalex.org/W2173522112","https://openalex.org/W2179586936","https://openalex.org/W2179773860","https://openalex.org/W2234574708","https://openalex.org/W2328013322","https://openalex.org/W2485202789","https://openalex.org/W2507150645","https://openalex.org/W2957963313"],"related_works":["https://openalex.org/W2136045726","https://openalex.org/W2190157907","https://openalex.org/W2999004537","https://openalex.org/W2152121500","https://openalex.org/W7100933058","https://openalex.org/W2269349421","https://openalex.org/W1913478764","https://openalex.org/W2793218990","https://openalex.org/W2140637490","https://openalex.org/W12488351"],"abstract_inverted_index":{"Genes":[0],"expressing":[1,66,114],"Bacillus":[2],"thuringiensis":[3],"(Bt)":[4],"toxins":[5,80],"have":[6,25,55],"been":[7,26,44,56,123],"incorporated":[8,45],"into":[9,46,179,261],"genetically":[10],"modified":[11],"(GM)":[12],"plants":[13,100,113],"to":[14,18,111,128,139,154,221],"render":[15],"these":[16,223],"resistant":[17],"certain":[19],"insect":[20,69],"pests.":[21],"Of":[22],"particular":[23,177],"interest":[24],"the":[27,35,38,50,132,195,203,207,219,239,247],"genes":[28],"encoding":[29,37],"Cry":[30],"(Crystal)":[31],"proteins,":[32,211],"but":[33,250],"also":[34],"gene":[36],"vegetative":[39],"insecticidal":[40],"protein":[41],"Vip3Aa":[42],"has":[43,122],"crop":[47],"plants.":[48],"Over":[49],"last":[51],"decennium,":[52],"GM":[53,64,99,112,166,192,232],"events":[54,65],"crossed":[57],"through":[58],"traditional":[59],"breeding,":[60],"resulting":[61],"in":[62,176,242],"stacked":[63],"several":[67],"Bt":[68,95,118,148,210,216,236],"resistance":[70],"genes.":[71],"Experiments":[72],"demonstrate":[73],"that":[74,92,185],"interactions":[75,93,146,160,214],"between":[76,94,147,215],"two":[77,141],"or":[78,84],"more":[79],"can":[81,145],"either":[82],"enhance":[83],"decrease":[85],"their":[86,105],"activity.":[87],"It":[88],"is":[89],"thus":[90],"possible":[91],"proteins":[96,149,217],"produced":[97],"by":[98,199],"occur":[101],"and":[102,152,201,218,225,254],"thereby":[103],"influence":[104],"effect":[106],"on":[107,159,206,212],"non-target":[108],"invertebrates":[109],"compared":[110],"just":[115],"a":[116,126,129,243,252],"single":[117],"gene.":[119],"This":[120],"report":[121],"drafted":[124],"as":[125],"response":[127],"call":[130],"of":[131,135,165,183,191,209,231],"Netherlands":[133],"Commission":[134],"Genetic":[136],"Modification":[137],"(COGEM)":[138],"address":[140],"main":[142],"questions:":[143],"(1)":[144],"be":[150],"predicted":[151],"(2)":[153],"what":[155],"extent":[156],"are":[157,186],"studies":[158],"relevant":[161,187],"for":[162,188,228],"risk/safety":[163,189,229],"assessment":[164,190,230],"crops.":[167,193],"The":[168],"questions":[169,196],"were":[170],"tackled":[171],"from":[172,251],"an":[173],"eco-toxicological":[174],"angle,":[175],"taking":[178],"account":[180,262],"those":[181],"types":[182],"information":[184,240],"Answering":[194],"was":[197,259],"done":[198],"reviewing":[200],"considering":[202],"current":[204],"knowledge":[205],"specificity":[208],"known":[213],"methods":[220],"assess":[222],"interactions,":[224],"available":[226],"guidance":[227],"crops":[233],"combining":[234],"multiple":[235],"proteins.":[237],"Also":[238],"reviewed":[241],"parallel":[244],"project":[245],"addressing":[246],"same":[248],"questions,":[249],"biochemical":[253],"toxicological":[255],"perspective":[256],"(Eco\u00bftat,":[257],"2014),":[258],"taken":[260],"when":[263],"formulating":[264],"conclusions.":[265]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2017-01-13T00:00:00"}
