{"id":"https://openalex.org/W2569922319","doi":"https://doi.org/10.1371/journal.pone.0169259","title":"Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis","display_name":"Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis","publication_year":2016,"publication_date":"2016-12-30","ids":{"openalex":"https://openalex.org/W2569922319","doi":"https://doi.org/10.1371/journal.pone.0169259","mag":"2569922319","pmid":"https://pubmed.ncbi.nlm.nih.gov/28036377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5201288"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0169259","doi":"https://doi.org/10.1371/journal.pone.0169259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0169259","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169259&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169259&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020229957","display_name":"Caroline M. Li","orcid":"https://orcid.org/0000-0003-4091-3392","observed_orcids":["https://orcid.org/0000-0003-4091-3392"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caroline M. Li","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023066187","display_name":"Yunan Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunan Miao","raw_affiliation_strings":["Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044783834","display_name":"Robert G. Lingeman","orcid":"https://orcid.org/0000-0003-2737-1533","observed_orcids":["https://orcid.org/0000-0003-2737-1533"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Lingeman","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004481362","display_name":"Robert J. Hickey","orcid":"https://orcid.org/0000-0001-5099-8137","observed_orcids":["https://orcid.org/0000-0001-5099-8137"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Hickey","raw_affiliation_strings":["Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038795546","display_name":"Linda H. Malkas","orcid":"https://orcid.org/0000-0001-7624-8510","observed_orcids":["https://orcid.org/0000-0001-7624-8510"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda H. Malkas","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020229957"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.1732,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.63579804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"12","first_page":"e0169259","last_page":"e0169259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-replication-complex","display_name":"DNA replication complex","score":0.925000011920929},{"id":"https://openalex.org/keywords/free-flow-electrophoresis","display_name":"free-flow electrophoresis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-complex-purification","display_name":"protein complex purification","score":0.7329999804496765},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.777999997138977},{"id":"https://openalex.org/keywords/sv40-origin-of-replication","display_name":"SV40 origin of replication","score":0.7409999966621399},{"id":"https://openalex.org/keywords/t-antigen","display_name":"T antigen","score":0.9580000042915344},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dna-polymerase-delta","display_name":"DNA polymerase delta","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-polymerase-epsilon","display_name":"DNA polymerase epsilon","score":1.0},{"id":"https://openalex.org/keywords/replication-protein-a","display_name":"replication protein A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/replication-factor-c","display_name":"replication factor C","score":0.996999979019165},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.6866836547851562},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.6677604913711548},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.6548744440078735},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6548589468002319},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6516263484954834},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6444664001464844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.642051637172699},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.6407759189605713},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.6084954738616943},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.5680973529815674},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.47254014015197754},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.4509649872779846},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45080652832984924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2345874309539795},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.18618392944335938},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.14234435558319092},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.11337348818778992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06737402081489563},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000099272","descriptor_name":"Replisomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004256","descriptor_name":"DNA Polymerase I","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004257","descriptor_name":"DNA Polymerase II","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004258","descriptor_name":"DNA Polymerase III","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051716","descriptor_name":"Replication Protein A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051818","descriptor_name":"Replication Protein C","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0169259","doi":"https://doi.org/10.1371/journal.pone.0169259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0169259","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169259&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4129552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5201288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5201288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5201288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:28036377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28036377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:15303c2257cc4ab2a71c14e39497fffb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/15303c2257cc4ab2a71c14e39497fffb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 12, p e0169259 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4507508","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Partial_Purification_of_a_Megadalton_DNA_Replication_Complex_by_Free_Flow_Electrophoresis/4507508","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0169259","doi":"https://doi.org/10.1371/journal.pone.0169259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0169259","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169259&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G168079961","display_name":null,"funder_award_id":"P30CA03357 2","funder_id":"https://openalex.org/F4320310407","funder_display_name":"Beckman Research Institute, City of Hope"},{"id":"https://openalex.org/G5754489632","display_name":null,"funder_award_id":"RO1 CA121289","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8789692737","display_name":"A Structure/function Analysis of a Tumor Specific Protein","funder_award_id":"R01CA121289","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000889907","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA033572","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308906","display_name":"St. Baldrick's Foundation","ror":"https://ror.org/03h1gea69"},{"id":"https://openalex.org/F4320310407","display_name":"Beckman Research Institute, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2569922319.pdf","grobid_xml":"https://content.openalex.org/works/W2569922319.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W160349565","https://openalex.org/W202258085","https://openalex.org/W1565212447","https://openalex.org/W1579065797","https://openalex.org/W1658155341","https://openalex.org/W1963530308","https://openalex.org/W1964638981","https://openalex.org/W1966109883","https://openalex.org/W1971346573","https://openalex.org/W1982205851","https://openalex.org/W1984072871","https://openalex.org/W1987639811","https://openalex.org/W1996192549","https://openalex.org/W1998781040","https://openalex.org/W2003783127","https://openalex.org/W2009545612","https://openalex.org/W2010853485","https://openalex.org/W2015556811","https://openalex.org/W2029440030","https://openalex.org/W2035659472","https://openalex.org/W2038149991","https://openalex.org/W2039335261","https://openalex.org/W2041931294","https://openalex.org/W2044579687","https://openalex.org/W2050356929","https://openalex.org/W2050458733","https://openalex.org/W2059412686","https://openalex.org/W2060656834","https://openalex.org/W2061024091","https://openalex.org/W2068119233","https://openalex.org/W2077611642","https://openalex.org/W2079905392","https://openalex.org/W2082098973","https://openalex.org/W2086966742","https://openalex.org/W2103948578","https://openalex.org/W2121980126","https://openalex.org/W2126365697","https://openalex.org/W2135386829","https://openalex.org/W2138576404","https://openalex.org/W2157561719","https://openalex.org/W2162424511","https://openalex.org/W2162692975","https://openalex.org/W2164602875","https://openalex.org/W2168907205","https://openalex.org/W2297004666","https://openalex.org/W2334644310","https://openalex.org/W2397682226","https://openalex.org/W2418802286","https://openalex.org/W2471462939","https://openalex.org/W2509346396","https://openalex.org/W3149236675"],"related_works":["https://openalex.org/W1987639811","https://openalex.org/W2010853485","https://openalex.org/W202258085","https://openalex.org/W2082098973","https://openalex.org/W2050458733","https://openalex.org/W2044579687","https://openalex.org/W1974376374","https://openalex.org/W2071081804","https://openalex.org/W1998604681","https://openalex.org/W34257719"],"abstract_inverted_index":{"We":[0],"describe":[1],"a":[2,34,53,113,188],"gentle":[3],"and":[4,65,93,160,174],"rapid":[5],"method":[6],"to":[7,25,41],"purify":[8,26],"the":[9,27,46,56,66,84,98,132,181,200,210],"intact":[10],"multiprotein":[11,35,189],"DNA":[12,30,47,63,76,89,99,133,141,146,151,167,177,220],"replication":[13,48,64,90,100,156,161],"complex":[14,36,192],"using":[15,52],"free":[16],"flow":[17],"electrophoresis":[18],"(FFE).":[19],"In":[20],"particular,":[21],"we":[22],"applied":[23],"FFE":[24,183],"human":[28],"cell":[29,137],"synthesome,":[31,134],"which":[32,87],"is":[33,38,91],"that":[37],"fully":[39],"competent":[40],"carry-out":[42],"all":[43],"phases":[44],"of":[45,62,80,125,131],"process":[49],"in":[50,82,112,199],"vitro":[51],"plasmid":[54],"containing":[55,191,205],"simian":[57],"virus":[58],"40":[59],"(SV40)":[60],"origin":[61],"viral":[67],"large":[68],"tumor":[69],"antigen":[70,139],"(T-antigen)":[71],"protein.":[72],"The":[73],"isolated":[74],"native":[75,211],"synthesome":[77,168,221],"can":[78],"be":[79],"use":[81],"studying":[83],"mechanism":[85],"by":[86,118],"mammalian":[88],"carried-out":[92],"how":[94],"anti-cancer":[95],"drugs":[96],"disrupt":[97],"or":[101,224],"repair":[102],"process.":[103],"Partially":[104],"purified":[105],"extracts":[106],"from":[107,209],"HeLa":[108],"cells":[109],"were":[110,207],"fractionated":[111],"native,":[114],"liquid":[115],"based":[116],"separation":[117],"FFE.":[119],"Dot":[120],"blot":[121],"analysis":[122,216],"showed":[123],"co-elution":[124],"many":[126],"proteins":[127,169,223],"identified":[128,166,217],"as":[129],"part":[130],"including":[135],"proliferating":[136],"nuclear":[138],"(PCNA),":[140],"topoisomerase":[142],"I":[143],"(topo":[144],"I),":[145],"polymerase":[147,152,178],"\u03b4":[148],"(Pol":[149,154],"\u03b4),":[150],"\u025b":[153],"\u025b),":[155],"protein":[157,225],"A":[158],"(RPA)":[159],"factor":[162],"C":[163],"(RFC).":[164],"Previously":[165],"co-eluted":[170],"with":[171,194],"T-antigen":[172],"dependent":[173],"SV40":[175],"origin-specific":[176],"activity":[179],"at":[180],"same":[182],"fractions.":[184],"Native":[185],"gels":[186],"show":[187],"PCNA":[190,204],"migrating":[193],"an":[195],"apparent":[196],"relative":[197],"mobility":[198],"megadalton":[201],"range.":[202],"When":[203],"bands":[206],"excised":[208],"gel,":[212],"mass":[213],"spectrometric":[214],"sequencing":[215],"23":[218],"known":[219],"associated":[222],"subunits.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-01-13T00:00:00"}
