{"id":"https://openalex.org/W2569685474","doi":"https://doi.org/10.1182/blood.v124.21.4369.4369","title":"Role of Hepatocyte Growth Factor in Endothelial-Dependent Hematopoietic Stem Cell Regeneration","display_name":"Role of Hepatocyte Growth Factor in Endothelial-Dependent Hematopoietic Stem Cell Regeneration","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2569685474","doi":"https://doi.org/10.1182/blood.v124.21.4369.4369","mag":"2569685474"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.4369.4369","doi":"https://doi.org/10.1182/blood.v124.21.4369.4369","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.4369.4369","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069689342","display_name":"Derek K. Zachman","orcid":"https://orcid.org/0000-0003-1433-8400","observed_orcids":["https://orcid.org/0000-0003-1433-8400"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek K Zachman","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870236","display_name":"Devorah C. Goldman","orcid":"https://orcid.org/0000-0002-5667-5600","observed_orcids":["https://orcid.org/0000-0002-5667-5600"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devorah C Goldman","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031536787","display_name":"Kimberly L. Hamlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly L Hamlin","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055510159","display_name":"Chandan Guha","orcid":"https://orcid.org/0000-0002-1906-2186","observed_orcids":["https://orcid.org/0000-0002-1906-2186"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandan Guha","raw_affiliation_strings":["Albert Einstein College Of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College Of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108391361","display_name":"WH Fleming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Fleming","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3535199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"124","issue":"21","first_page":"4369","last_page":"4369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-niche","display_name":"hematopoietic niche","score":0.7829999923706055},{"id":"https://openalex.org/keywords/arterial-endothelial-cells","display_name":"arterial endothelial cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/venous-endothelial-cells","display_name":"venous endothelial cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hgf-signaling","display_name":"HGF signaling","score":0.5379999876022339},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.781000018119812},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.5799999833106995},{"id":"https://openalex.org/keywords/irradiation","display_name":"irradiation","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.7922061085700989},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7063067555427551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7047537565231323},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6954146027565002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6079191565513611},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5853095054626465},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5811851620674133},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5220499038696289},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.49568331241607666},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4563688337802887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43982958793640137},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.4367332458496094},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3325861692428589},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12267449498176575},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08666065335273743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08045843243598938}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.4369.4369","doi":"https://doi.org/10.1182/blood.v124.21.4369.4369","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.4369.4369","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2752396002","https://openalex.org/W1993177032","https://openalex.org/W2979890605","https://openalex.org/W2613115673","https://openalex.org/W2038366805","https://openalex.org/W2979442529","https://openalex.org/W2057258796","https://openalex.org/W2565114390","https://openalex.org/W2036108191","https://openalex.org/W2416612047"],"abstract_inverted_index":{"Abstract":[0],"Hematopoiesis":[1],"is":[2],"tightly":[3],"regulated":[4],"by":[5,132,171,177],"the":[6,21,41,54,113,137,180,188,207],"niche":[7],"and":[8,23,66,152],"highly":[9],"sensitive":[10],"to":[11,70,103,118,163,169,193,235],"a":[12,67,220],"variety":[13],"of":[14,25,40,56,80,139,147,159,190,209,233],"genotoxic":[15],"stressors.":[16],"The":[17],"mechanisms":[18],"responsible":[19],"for":[20,49],"repair":[22],"regeneration":[24,167,205],"hematopoietic":[26,110,195],"stem":[27],"cells":[28,34,151,196],"(HSCs)":[29],"are":[30,36],"poorly":[31],"understood.":[32],"Endothelial":[33],"(ECs)":[35],"an":[37,77,210],"essential":[38],"component":[39],"bone":[42,149],"marrow":[43,150],"microenvironment":[44],"that":[45,93,107,217,225],"provide":[46],"regenerative":[47],"signals":[48,58],"HSCs":[50,97],"after":[51],"injury;":[52],"however,":[53],"identity":[55],"these":[57,214],"remain":[59],"largely":[60],"unknown.":[61],"We":[62],"utilized":[63],"RNA":[64],"sequencing":[65],"bioinformatics":[68],"approach":[69],"identify":[71],"hepatocyte":[72],"growth":[73],"factor":[74],"(HGF)":[75],"as":[76],"endothelial-derived":[78],"mediator":[79],"HSC":[81,142,204,227],"regeneration.":[82,228],"HGF":[83,121,126,140,160,191,202,218],"gene":[84],"expression":[85],"was":[86,127,161,175],"7.6-fold":[87],"higher":[88],"in":[89,129,141,206,223],"arterial-derived":[90],"ECs":[91,105,154,224],"(HAEC)":[92],"regenerate":[94],"functional":[95],"long-term":[96],"(CD150+LineageloSca1+Kit+":[98],"cells;":[99],"CD150+LSK":[100,165],"cells)":[101],"compared":[102],"venous":[104],"(HUVEC)":[106],"support":[108],"only":[109],"progenitors.":[111],"Furthermore,":[112],"HSC-supportive":[114],"HAECs":[115],"secreted":[116],"up":[117,168],"25":[119],"pg/mL":[120],"into":[122],"conditioned":[123,131],"media,":[124],"whereas":[125],"undetectable":[128],"media":[130,200],"HUVEC.":[133,172],"To":[134],"directly":[135],"test":[136],"role":[138],"regeneration,":[143],"we":[144],"supplemented":[145],"co-cultures":[146],"irradiated":[148,194],"primary":[153],"with":[155,179,201],"recombinant":[156],"HGF.":[157],"Addition":[158],"sufficient":[162],"augment":[164],"cell":[166],"20-fold":[170],"This":[173],"effect":[174],"abolished":[176],"treatment":[178],"Met-specific":[181],"small":[182],"molecular":[183],"inhibitor,":[184],"PF04217903.":[185],"Importantly,":[186],"neither":[187],"addition":[189],"alone":[192],"nor":[197],"spiking":[198],"HUVEC-conditioned":[199],"improved":[203],"absence":[208],"EC":[211],"monolayer.":[212],"Together,":[213],"results":[215],"indicate":[216],"activates":[219],"signaling":[221],"loop":[222],"supports":[226],"Disclosures":[229],"No":[230],"relevant":[231],"conflicts":[232],"interest":[234],"declare.":[236]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-13T00:00:00"}