{"id":"https://openalex.org/W2569614730","doi":"https://doi.org/10.1158/2159-8290.cd-16-0645","title":"APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability","display_name":"APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability","publication_year":2017,"publication_date":"2017-01-09","ids":{"openalex":"https://openalex.org/W2569614730","doi":"https://doi.org/10.1158/2159-8290.cd-16-0645","mag":"2569614730","pmid":"https://pubmed.ncbi.nlm.nih.gov/28069571"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-16-0645","doi":"https://doi.org/10.1158/2159-8290.cd-16-0645","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-16-0645","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090314471","display_name":"Laurent Sansregret","orcid":"https://orcid.org/0009-0007-6467-2251","observed_orcids":["https://orcid.org/0009-0007-6467-2251"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurent Sansregret","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048027649","display_name":"James Oliver Patterson","orcid":"https://orcid.org/0000-0003-1993-4500","observed_orcids":["https://orcid.org/0000-0003-1993-4500"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James O. Patterson","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107936849","display_name":"Sally M. Dewhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally Dewhurst","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017175813","display_name":"Carlos L\u00f3pez\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-9848-8216","observed_orcids":["https://orcid.org/0000-0001-9848-8216"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carlos L\u00f3pez-Garc\u00eda","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051520092","display_name":"Andr\u00e9 Koch","orcid":"https://orcid.org/0000-0003-3502-382X","observed_orcids":["https://orcid.org/0000-0003-3502-382X"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Koch","raw_affiliation_strings":["2The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056525592","display_name":"Nicholas McGranahan","orcid":"https://orcid.org/0000-0001-9537-4045","observed_orcids":["https://orcid.org/0000-0001-9537-4045"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I4210147892","display_name":"CRUK Lung Cancer Centre of Excellence","ror":"https://ror.org/04nm2mq63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210147892"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas McGranahan","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom","3CRUK UCL/Manchester Lung Cancer Centre of Excellence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"3CRUK UCL/Manchester Lung Cancer Centre of Excellence","institution_ids":["https://openalex.org/I4210147892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080913663","display_name":"William Chong Hang Chao","orcid":"https://orcid.org/0000-0003-4951-796X","observed_orcids":["https://orcid.org/0000-0003-4951-796X"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Chong Hang Chao","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041131742","display_name":"David J. Barry","orcid":"https://orcid.org/0000-0003-2763-5244","observed_orcids":["https://orcid.org/0000-0003-2763-5244"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Barry","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111857924","display_name":"Andrew Rowan","orcid":"https://orcid.org/0000-0003-1926-9707","observed_orcids":["https://orcid.org/0000-0003-1926-9707"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Rowan","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054337695","display_name":"Rachael Instrell","orcid":"https://orcid.org/0000-0002-4437-2952","observed_orcids":["https://orcid.org/0000-0002-4437-2952"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachael Instrell","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000879181","display_name":"Stuart D. Horswell","orcid":"https://orcid.org/0000-0003-2787-1933","observed_orcids":["https://orcid.org/0000-0003-2787-1933"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart Horswell","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005071379","display_name":"Michael Way","orcid":"https://orcid.org/0000-0001-7207-2722","observed_orcids":["https://orcid.org/0000-0001-7207-2722"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Way","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065145095","display_name":"Michael T. Howell","orcid":"https://orcid.org/0000-0003-0912-0079","observed_orcids":["https://orcid.org/0000-0003-0912-0079"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Howell","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055945260","display_name":"Martin R. Singleton","orcid":"https://orcid.org/0000-0001-5716-7715","observed_orcids":["https://orcid.org/0000-0001-5716-7715"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin R. Singleton","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074565662","display_name":"Ren\u00e9 H. Medema","orcid":"https://orcid.org/0000-0002-6754-0381","observed_orcids":["https://orcid.org/0000-0002-6754-0381","https://orcid.org/0009-0004-3701-7751"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 H. Medema","raw_affiliation_strings":["2The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019124036","display_name":"Paul Nurse","orcid":"https://orcid.org/0000-0002-9244-7787","observed_orcids":["https://orcid.org/0000-0002-9244-7787"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Nurse","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056893617","display_name":"Mark P. Petronczki","orcid":"https://orcid.org/0000-0003-0139-5692","observed_orcids":["https://orcid.org/0000-0003-0139-5692"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I4210119669","display_name":"Boehringer Ingelheim (Austria)","ror":"https://ror.org/026vtvm28","country_code":"AT","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210119669"]}],"countries":["AT","GB"],"is_corresponding":true,"raw_author_name":"Mark Petronczki","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom","4Boehringer Ingelheim, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"4Boehringer Ingelheim, Vienna, Austria","institution_ids":["https://openalex.org/I4210119669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016475369","display_name":"Charles Swanton","orcid":"https://orcid.org/0000-0002-4299-3018","observed_orcids":["https://orcid.org/0000-0002-4299-3018"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I4210147892","display_name":"CRUK Lung Cancer Centre of Excellence","ror":"https://ror.org/04nm2mq63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210147892"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Charles Swanton","raw_affiliation_strings":["1The Francis Crick Institute, London, United Kingdom","3CRUK UCL/Manchester Lung Cancer Centre of Excellence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"3CRUK UCL/Manchester Lung Cancer Centre of Excellence","institution_ids":["https://openalex.org/I4210147892"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016475369","https://openalex.org/A5056893617"],"corresponding_institution_ids":["https://openalex.org/I2801081054","https://openalex.org/I4210119669","https://openalex.org/I4210147892"],"apc_list":null,"apc_paid":null,"fwci":6.5894,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.97627936,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"218","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9049999713897705},{"id":"https://openalex.org/keywords/anaphase-promoting-complex","display_name":"anaphase-promoting complex","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cdc27","display_name":"CDC27","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mitotic-duration","display_name":"mitotic duration","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chromosome-segregation-errors","display_name":"chromosome segregation errors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lagging-chromosomes","display_name":"lagging chromosomes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tetraploidization","display_name":"tetraploidization","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6420000195503235},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cancer-driver-mutations","display_name":"cancer driver mutations","score":0.550000011920929},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.7395734190940857},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6875156760215759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6547226905822754},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6360935568809509},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5784367918968201},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5499035716056824},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4684928357601166},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4653087258338928},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4634172320365906},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3711419701576233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27218490839004517},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.11300620436668396},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064191","descriptor_name":"Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/2159-8290.cd-16-0645","doi":"https://doi.org/10.1158/2159-8290.cd-16-0645","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-16-0645","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"pmid:28069571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28069571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5300100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1545876","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1545876/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Discovery , 7 (2) pp. 218-233. (2017)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/13110050","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/APC_C_dysfunction_limits_excessive_cancer_chromosomal_instability/13110050","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5300100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[],"awards":[{"id":"https://openalex.org/G105866021","display_name":null,"funder_award_id":"10155","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G1528842596","display_name":null,"funder_award_id":"FC001121","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G182428912","display_name":null,"funder_award_id":"NNF15OC0016584","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G1872847433","display_name":null,"funder_award_id":"10169","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G2009050457","display_name":null,"funder_award_id":"FC001209","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2248652948","display_name":null,"funder_award_id":"19343","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2559657960","display_name":null,"funder_award_id":"10209","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G2646115653","display_name":null,"funder_award_id":"FC001169","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2979561664","display_name":null,"funder_award_id":"10008","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G4344689229","display_name":null,"funder_award_id":"10002","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G4598959000","display_name":null,"funder_award_id":"19310","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4744380510","display_name":null,"funder_award_id":"10121","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G4895684100","display_name":null,"funder_award_id":"FC001155","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5479116230","display_name":null,"funder_award_id":"15656","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8003459845","display_name":null,"funder_award_id":"FC001169","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1483245334","https://openalex.org/W1558701786","https://openalex.org/W1577353247","https://openalex.org/W1881319148","https://openalex.org/W1907376883","https://openalex.org/W1951480739","https://openalex.org/W1970442105","https://openalex.org/W1971013077","https://openalex.org/W1982586094","https://openalex.org/W1987369248","https://openalex.org/W1988852424","https://openalex.org/W1990085600","https://openalex.org/W1995051337","https://openalex.org/W1995147621","https://openalex.org/W2009502142","https://openalex.org/W2011982648","https://openalex.org/W2015360671","https://openalex.org/W2016661249","https://openalex.org/W2027680171","https://openalex.org/W2031211461","https://openalex.org/W2034086671","https://openalex.org/W2039517468","https://openalex.org/W2041353881","https://openalex.org/W2044433401","https://openalex.org/W2045897698","https://openalex.org/W2048938594","https://openalex.org/W2050953095","https://openalex.org/W2052948442","https://openalex.org/W2053300345","https://openalex.org/W2055375306","https://openalex.org/W2056338458","https://openalex.org/W2059145105","https://openalex.org/W2060082769","https://openalex.org/W2065461424","https://openalex.org/W2065629914","https://openalex.org/W2065849886","https://openalex.org/W2067708830","https://openalex.org/W2071110654","https://openalex.org/W2071359790","https://openalex.org/W2073868774","https://openalex.org/W2075447540","https://openalex.org/W2080125477","https://openalex.org/W2091902964","https://openalex.org/W2098088639","https://openalex.org/W2098964644","https://openalex.org/W2102502996","https://openalex.org/W2102922697","https://openalex.org/W2102960342","https://openalex.org/W2106735070","https://openalex.org/W2107190139","https://openalex.org/W2111326065","https://openalex.org/W2114031931","https://openalex.org/W2114843025","https://openalex.org/W2116737251","https://openalex.org/W2117015042","https://openalex.org/W2118562565","https://openalex.org/W2129731003","https://openalex.org/W2130758991","https://openalex.org/W2134590240","https://openalex.org/W2137220794","https://openalex.org/W2149304739","https://openalex.org/W2149441684","https://openalex.org/W2149953930","https://openalex.org/W2153472959","https://openalex.org/W2154974159","https://openalex.org/W2156393663","https://openalex.org/W2159940514","https://openalex.org/W2169016078","https://openalex.org/W2171175279","https://openalex.org/W2174225329","https://openalex.org/W2182664595","https://openalex.org/W2188223075","https://openalex.org/W2194986544","https://openalex.org/W2262414037","https://openalex.org/W2316375349","https://openalex.org/W2343854987","https://openalex.org/W2344511238","https://openalex.org/W2465420247"],"related_works":["https://openalex.org/W2084475506","https://openalex.org/W2352719856","https://openalex.org/W1995981964","https://openalex.org/W2073596489","https://openalex.org/W1506578365","https://openalex.org/W2134683317","https://openalex.org/W2048694704","https://openalex.org/W2152859477","https://openalex.org/W2147271975","https://openalex.org/W177476023"],"abstract_inverted_index":{"Intercellular":[0],"heterogeneity,":[1],"exacerbated":[2],"by":[3,143,180,226],"chromosomal":[4],"instability":[5],"(CIN),":[6],"fosters":[7],"tumor":[8,159],"heterogeneity":[9],"and":[10,51,76,228],"drug":[11],"resistance.":[12],"However,":[13],"extreme":[14],"CIN":[15,174],"correlates":[16],"with":[17,173],"improved":[18],"cancer":[19,83,112,119,152,211],"outcome,":[20],"suggesting":[21],"that":[22,213],"karyotypic":[23],"diversity":[24],"required":[25],"to":[26,28,54,93,101,154,210],"adapt":[27],"selection":[29],"pressures":[30],"might":[31],"be":[32,204],"balanced":[33],"in":[34,58,82,115,139,195,235],"tumors":[35],"against":[36,175],"the":[37,104,116,147,169,176,187,236],"risk":[38],"of":[39,111,129,149,189,198,208],"excessive":[40,181],"instability.":[41],"Here,":[42],"we":[43],"used":[44],"a":[45,97,164,205],"functional":[46],"genomics":[47],"screen,":[48],"genome":[49,182],"editing,":[50],"pharmacologic":[52],"approaches":[53],"identify":[55],"CIN-survival":[56],"factors":[57],"diploid":[59],"cells.":[60],"We":[61,162],"find":[62],"partial":[63],"anaphase-promoting":[64],"complex/cyclosome":[65],"(APC/C)":[66],"dysfunction":[67],"lengthens":[68],"mitosis,":[69],"suppresses":[70],"pharmacologically":[71],"induced":[72],"chromosome":[73,124,215],"segregation":[74,125,216],"errors,":[75,126],"reduces":[77,123],"naturally":[78],"occurring":[79],"lagging":[80],"chromosomes":[81],"cell":[84],"lines":[85],"or":[86],"following":[87],"tetraploidization.":[88],"APC/C":[89,117,131,144,191,201],"impairment":[90],"caused":[91,179],"adaptation":[92],"MPS1":[94],"inhibitors,":[95],"revealing":[96],"likely":[98],"resistance":[99,209],"mechanism":[100,165,207],"therapies":[102],"targeting":[103],"spindle":[105],"assembly":[106],"checkpoint.":[107],"Finally,":[108],"CRISPR-mediated":[109],"introduction":[110],"somatic":[113],"mutations":[114,194],"subunit":[118,132,192],"driver":[120,193],"gene":[121],"CDC27":[122,190],"whereas":[127],"reversal":[128],"an":[130],"nonsense":[133],"mutation":[134],"increases":[135],"CIN.":[136],"Subtle":[137],"variations":[138],"mitotic":[140],"duration,":[141],"determined":[142],"activity,":[145],"influence":[146],"extent":[148],"CIN,":[150],"allowing":[151],"cells":[153],"dynamically":[155],"optimize":[156],"fitness":[157,177],"during":[158],"evolution.":[160],"SIGNIFICANCE:":[161],"report":[163],"whereby":[166],"cancers":[167],"balance":[168],"evolutionary":[170],"advantages":[171],"associated":[172],"costs":[178],"instability,":[183],"providing":[184],"insight":[185],"into":[186],"consequence":[188],"cancer.":[196],"Lengthening":[197],"mitosis":[199],"through":[200],"modulation":[202],"may":[203],"common":[206],"therapeutics":[212],"increase":[214],"errors.":[217],"Cancer":[218],"Discov;":[219],"7(2);":[220],"218-33.":[221],"\u00a92017":[222],"AACR.See":[223],"related":[224],"commentary":[225],"Burkard":[227],"Weaver,":[229],"p.":[230,241],"134This":[231],"article":[232],"is":[233],"highlighted":[234],"In":[237],"This":[238],"Issue":[239],"feature,":[240],"115.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":10}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
