{"id":"https://openalex.org/W2569578362","doi":"https://doi.org/10.1016/j.apjtb.2016.12.024","title":"Anti-angiogenic effect of Artocarpus heterophyllus seed methanolic extract in ex ovo chicken chorioallantoic membrane","display_name":"Anti-angiogenic effect of Artocarpus heterophyllus seed methanolic extract in ex ovo chicken chorioallantoic membrane","publication_year":2017,"publication_date":"2017-01-10","ids":{"openalex":"https://openalex.org/W2569578362","doi":"https://doi.org/10.1016/j.apjtb.2016.12.024","mag":"2569578362"},"language":"en","primary_location":{"id":"doi:10.1016/j.apjtb.2016.12.024","doi":"https://doi.org/10.1016/j.apjtb.2016.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2016.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2221169115310303/pdf","source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2221169115310303/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015972719","display_name":"Swastika Oktavia","orcid":"https://orcid.org/0000-0001-9198-4620","observed_orcids":["https://orcid.org/0000-0001-9198-4620"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]},{"id":"https://openalex.org/I4210164426","display_name":"Universitas Mathla'ul Anwar Banten","ror":"https://ror.org/05j2ycs33","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210164426"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Swastika Oktavia","raw_affiliation_strings":["Department of Biology, Science and Pharmacy Faculty, Mathla'ul Anwar University, Banten, Indonesia","Post Graduate Program, Biology Faculty, Universitas Gadjah Mada, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Pharmacy Faculty, Mathla'ul Anwar University, Banten, Indonesia","institution_ids":["https://openalex.org/I4210164426"]},{"raw_affiliation_string":"Post Graduate Program, Biology Faculty, Universitas Gadjah Mada, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033968542","display_name":"Nastiti Wijayanti","orcid":"https://orcid.org/0000-0001-6483-2816","observed_orcids":["https://orcid.org/0000-0001-6483-2816"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nastiti Wijayanti","raw_affiliation_strings":["Laboratory of Animal Physiology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077381814","display_name":"Bambang Retnoaji","orcid":"https://orcid.org/0000-0002-0290-9723","observed_orcids":["https://orcid.org/0000-0002-0290-9723"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Bambang Retnoaji","raw_affiliation_strings":["Laboratory of Animal Structure and Development, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Structure and Development, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077381814"],"corresponding_institution_ids":["https://openalex.org/I165230279"],"apc_list":null,"apc_paid":null,"fwci":1.3036,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79372943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"3","first_page":"240","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jackfruit","display_name":"Artocarpus heterophyllus","score":1.0},{"id":"https://openalex.org/keywords/jackfruit-seeds","display_name":"jackfruit seeds","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/methanolic-seed-extract","display_name":"methanolic seed extract","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chorioallantoic-membrane","display_name":"chorioallantoic membrane","score":0.8610000014305115},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2778765379","wikidata":"https://www.wikidata.org/wiki/Q17055931","display_name":"In ovo","level":3,"score":0.9610657691955566},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.9262838363647461},{"id":"https://openalex.org/C2777674797","wikidata":"https://www.wikidata.org/wiki/Q161085","display_name":"Artocarpus","level":2,"score":0.8326895236968994},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6364588141441345},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.4932629466056824},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.48644328117370605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4275180995464325},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.29897066950798035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2698401212692261},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2606913447380066},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.25281888246536255},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21480783820152283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20538362860679626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.09769859910011292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.apjtb.2016.12.024","doi":"https://doi.org/10.1016/j.apjtb.2016.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2016.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2221169115310303/pdf","source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ca526ba7a4ee4373a03d6b1d8859a596","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ca526ba7a4ee4373a03d6b1d8859a596","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 240-244 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apjtb.2016.12.024","doi":"https://doi.org/10.1016/j.apjtb.2016.12.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2016.12.024","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2221169115310303/pdf","source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324785","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55"},{"id":"https://openalex.org/F4320324828","display_name":"\u00c5bo Akademi","ror":null},{"id":"https://openalex.org/F4320327626","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638"},{"id":"https://openalex.org/F4320335079","display_name":"Direktorat Jenderal Pendidikan Tinggi","ror":"https://ror.org/03sxt1c89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2569578362.pdf","grobid_xml":"https://content.openalex.org/works/W2569578362.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1510386426","https://openalex.org/W1555986393","https://openalex.org/W1926681914","https://openalex.org/W1964417650","https://openalex.org/W1970929586","https://openalex.org/W1973595289","https://openalex.org/W2014177895","https://openalex.org/W2019226051","https://openalex.org/W2022192661","https://openalex.org/W2064116577","https://openalex.org/W2078251012","https://openalex.org/W2084074955","https://openalex.org/W2100650248","https://openalex.org/W2109531769","https://openalex.org/W2118394271","https://openalex.org/W2156831659","https://openalex.org/W2160034684","https://openalex.org/W2168631000","https://openalex.org/W2183431454","https://openalex.org/W2203232460","https://openalex.org/W2289478283","https://openalex.org/W2290535466","https://openalex.org/W2312843703","https://openalex.org/W4252851641","https://openalex.org/W4285719527","https://openalex.org/W6686297990","https://openalex.org/W6792572400"],"related_works":["https://openalex.org/W2290528575","https://openalex.org/W2889853797","https://openalex.org/W3127746434","https://openalex.org/W1982466788","https://openalex.org/W3122863401","https://openalex.org/W7008096202","https://openalex.org/W4318387360","https://openalex.org/W2340679566","https://openalex.org/W2911024886","https://openalex.org/W2978065733"],"abstract_inverted_index":{"To":[0],"examine":[1,26],"the":[2,27,45,112,124,132,137],"anti-angiogenic":[3,29,138],"potential":[4,28,150],"of":[5,31,48,81,84,87,115,126,140],"Artocarpus":[6],"heterophyllus":[7,33,89,146],"(A.":[8],"heterophyllus)":[9],"seed":[10,34],"extract":[11,86,121,142],"in":[12,100],"chicken":[13,20,101],"chorioallantoic":[14],"membrane":[15],"(CAM).":[16],"This":[17,106,130],"study":[18,134],"used":[19,42],"CAM":[21,52,102],"ex":[22,103],"ovo":[23,104],"culture":[24],"to":[25,43,135],"activity":[30],"A.":[32,88,145],"methanolic":[35,85,141],"extract.":[36,55],"Basic":[37],"fibroblast":[38,94],"growth":[39,95],"factor":[40],"was":[41,59],"induce":[44],"ectopic":[46],"formation":[47,125],"blood":[49,116,128],"vessels":[50],"on":[51,111],"treated":[53],"with":[54,108],"Blood":[56],"vessel":[57],"number":[58],"assessed":[60],"by":[61,98],"macroscopic":[62],"and":[63,66,68,73,148],"microscopic":[64,109],"observation,":[65],"compared":[67],"analyzed":[69],"for":[70,154],"all":[71],"treatments":[72],"controls.":[74],"Macroscopic":[75],"observation":[76],"revealed":[77],"that":[78,120],"a":[79,152],"dose":[80],"35":[82],"\u03bcg/mL":[83],"seeds":[90,147],"could":[91],"inhibit":[92],"basic":[93],"factor-induced":[96],"angiogenesis":[97],"61%":[99],"culture.":[105],"concurred":[107],"observations":[110],"histological":[113],"structure":[114],"vessels,":[117],"which":[118],"indicated":[119],"treatment":[122],"repressed":[123],"new":[127],"vessels.":[129],"is":[131],"first":[133],"report":[136],"effect":[139],"derived":[143],"from":[144],"its":[149],"as":[151],"candidate":[153],"future":[155],"anticancer":[156],"therapy.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-13T00:00:00"}
