{"id":"https://openalex.org/W2569467830","doi":"https://doi.org/10.1089/ten.tea.2016.0452","title":"Electrospun Template Architecture and Composition Regulate Neutrophil NETosis In Vitro and In Vivo","display_name":"Electrospun Template Architecture and Composition Regulate Neutrophil NETosis In Vitro and In Vivo","publication_year":2017,"publication_date":"2017-01-10","ids":{"openalex":"https://openalex.org/W2569467830","doi":"https://doi.org/10.1089/ten.tea.2016.0452","mag":"2569467830","pmid":"https://pubmed.ncbi.nlm.nih.gov/28068879"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2016.0452","doi":"https://doi.org/10.1089/ten.tea.2016.0452","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2016.0452","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052939786","display_name":"Allison E. Fetz","orcid":"https://orcid.org/0000-0002-1125-8926","observed_orcids":["https://orcid.org/0000-0002-1125-8926"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison E. Fetz","raw_affiliation_strings":["Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027357292","display_name":"Indira Neeli","orcid":"https://orcid.org/0000-0002-1446-2068","observed_orcids":["https://orcid.org/0000-0002-1446-2068"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indira Neeli","raw_affiliation_strings":["Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040920769","display_name":"Isaac A. Rodriguez","orcid":"https://orcid.org/0000-0002-4851-5623","observed_orcids":["https://orcid.org/0000-0002-4851-5623"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac A. Rodriguez","raw_affiliation_strings":["Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105348991","display_name":"Marko Z. Radic","orcid":"https://orcid.org/0000-0002-8004-282X","observed_orcids":["https://orcid.org/0000-0002-8004-282X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marko Z. Radic","raw_affiliation_strings":["Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074642385","display_name":"Gary L. Bowlin","orcid":"https://orcid.org/0000-0003-0917-8203","observed_orcids":["https://orcid.org/0000-0003-0917-8203"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary L. Bowlin","raw_affiliation_strings":["Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee","institution_ids":["https://openalex.org/I94658018"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074642385"],"corresponding_institution_ids":["https://openalex.org/I94658018"],"apc_list":null,"apc_paid":null,"fwci":1.4757,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.76966999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"19-20","first_page":"1054","last_page":"1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9419999718666077},{"id":"https://openalex.org/keywords/netosis","display_name":"NETosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/polydioxanone","display_name":"polydioxanone","score":0.9039999842643738},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fiber-diameter","display_name":"fiber diameter","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tissue-integration","display_name":"tissue integration","score":0.5770000219345093},{"id":"https://openalex.org/keywords/capsule-formation","display_name":"capsule formation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/in-situ-regeneration","display_name":"in situ regeneration","score":0.5950000286102295},{"id":"https://openalex.org/keywords/subcutaneous-implantation","display_name":"subcutaneous implantation","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7794123291969299},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.7494434118270874},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6185088753700256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48888224363327026},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4494207203388214},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43904706835746765},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4255998730659485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.404765248298645},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35747140645980835},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27353498339653015},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2596505284309387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.252864271402359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16135361790657043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11420345306396484},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016687","descriptor_name":"Polydioxanone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/ten.tea.2016.0452","doi":"https://doi.org/10.1089/ten.tea.2016.0452","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2016.0452","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmid:28068879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28068879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W191274304","https://openalex.org/W1536376329","https://openalex.org/W1572925458","https://openalex.org/W1675847437","https://openalex.org/W1883364178","https://openalex.org/W1913879859","https://openalex.org/W1925096404","https://openalex.org/W1980971337","https://openalex.org/W1986282241","https://openalex.org/W1990847801","https://openalex.org/W1993935178","https://openalex.org/W2001642739","https://openalex.org/W2002157461","https://openalex.org/W2002192590","https://openalex.org/W2013035214","https://openalex.org/W2018860370","https://openalex.org/W2019047698","https://openalex.org/W2025565664","https://openalex.org/W2029259783","https://openalex.org/W2030213790","https://openalex.org/W2032227357","https://openalex.org/W2049273306","https://openalex.org/W2051881849","https://openalex.org/W2051948180","https://openalex.org/W2064157289","https://openalex.org/W2064520471","https://openalex.org/W2067022007","https://openalex.org/W2070438219","https://openalex.org/W2078817520","https://openalex.org/W2093940946","https://openalex.org/W2095917499","https://openalex.org/W2098261445","https://openalex.org/W2104934425","https://openalex.org/W2108814966","https://openalex.org/W2118217258","https://openalex.org/W2138694950","https://openalex.org/W2139552156","https://openalex.org/W2140995313","https://openalex.org/W2143455089","https://openalex.org/W2166585891","https://openalex.org/W2168176302","https://openalex.org/W2257342069","https://openalex.org/W2368227213","https://openalex.org/W2405920214"],"related_works":["https://openalex.org/W2794645214","https://openalex.org/W2971171779","https://openalex.org/W3108805048","https://openalex.org/W3168955539","https://openalex.org/W4210410654","https://openalex.org/W3037892944","https://openalex.org/W3195240652","https://openalex.org/W2807245796","https://openalex.org/W2580188336","https://openalex.org/W4410359865"],"abstract_inverted_index":{"Mounting":[0],"evidence":[1],"indicates":[2],"that":[3,115],"neutrophils,":[4,81],"first":[5],"responders":[6],"to":[7,221,238],"an":[8,106],"implanted":[9],"biomaterial,":[10],"prime":[11],"the":[12,34,83,125,159,166,198,217,228,232],"microenvironment":[13],"for":[14,74,93,216],"recruited":[15],"immune":[16,219],"cells":[17],"by":[18,102,186],"secreting":[19],"factors":[20],"and":[21,40,52,63,76,82,95,105,202,211],"releasing":[22],"neutrophil":[23],"extracellular":[24],"traps":[25],"(NETs)":[26],"through":[27],"NETosis.":[28,44],"In":[29,164,223],"this":[30],"study,":[31],"we":[32],"investigated":[33],"role":[35],"of":[36,127,132,144,158,177,230,242],"electrospun":[37],"template":[38],"architecture":[39],"composition":[41],"in":[42,72,88,111,136,154,173,182,194,199,244],"regulating":[43],"Electrospun":[45],"polydioxanone":[46],"(PDO),":[47],"collagen":[48],"type":[49],"I":[50],"(COL),":[51],"blended":[53],"PDO-COL":[54],"templates":[55,85,149,160,240],"(PC)":[56],"were":[57,70,86,100,171,184],"fabricated":[58],"with":[59,79,236],"small-diameter":[60,167],"(0.25-0.35":[61],"\u03bcm)":[62,66],"large-diameter":[64,147],"(1.0-2.00":[65],"fibers.":[67],"Neutrophil-template":[68],"interactions":[69],"evaluated":[71],"vitro":[73,112,200],"3":[75],"24":[77,180],"h":[78,181],"human":[80],"PDO":[84,122,148,168],"studied":[87],"vivo":[89,137,195],"(rat":[90],"subcutaneous":[91],"model)":[92],"1":[94,151],"7":[96,162,190],"days.":[97,163,191],"Template-bound":[98],"NETs":[99,145,178],"quantified":[101],"fluorescent":[103],"microscopy":[104],"On-cell":[107],"Western":[108],"assay.":[109],"The":[110,135],"results":[113,138,196,226],"indicate":[114],"larger":[116],"fiber":[117,133],"diameters":[118],"reduced":[119],"NETosis":[120,130,204],"on":[121,146],"templates,":[123,169],"whereas":[124],"incorporation":[126],"COL":[128],"attenuated":[129],"independent":[131],"diameter.":[134],"similarly":[139],"revealed":[140],"a":[141,174,206,212],"lower":[142],"degree":[143],"at":[150,161,179,189],"day,":[152],"resulting":[153],"marginal":[155],"tissue":[156,188],"integration":[157],"contrast,":[165],"which":[170],"coated":[172],"large":[175],"amount":[176],"vivo,":[183],"surrounded":[185],"capsule-like":[187],"These":[192],"preliminary":[193],"validate":[197],"model":[201],"signify":[203],"as":[205],"potentially":[207],"significant":[208],"physiological":[209],"response":[210,220],"critical":[213],"preconditioning":[214],"event":[215],"innate":[218],"templates.":[222],"conclusion,":[224],"these":[225],"demonstrate":[227],"importance":[229],"characterizing":[231],"neutrophil's":[233],"acute":[234],"confrontation":[235],"biomaterials":[237],"engineer":[239],"capable":[241],"promoting":[243],"situ":[245],"regeneration.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-01-13T00:00:00"}