{"id":"https://openalex.org/W2568459288","doi":null,"title":"Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein","display_name":"Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2568459288","mag":"2568459288"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.uvm.edu:graddis-1688","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.uvm.edu/graddis/689","pdf_url":"https://scholarworks.uvm.edu/graddis/689","source":{"id":"https://openalex.org/S4377196529","display_name":"ScholarWorks -A service of University of Vermont Libraries (University of Vermont)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111236770","host_organization_name":"University of Vermont","host_organization_lineage":["https://openalex.org/I111236770"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate College Dissertations and Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.uvm.edu/graddis/689","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091698636","display_name":"Thomas E. Sladewski","orcid":"https://orcid.org/0000-0002-8584-5007","observed_orcids":["https://orcid.org/0000-0002-8584-5007"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas E. Sladewski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8584-5007","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091698636"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00493572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-localization","display_name":"mRNA localization","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mrna-transport","display_name":"mRNA transport","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myosin-v","display_name":"myosin V","score":0.871999979019165},{"id":"https://openalex.org/keywords/cytoplasmic-dynein","display_name":"cytoplasmic dynein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dynactin","display_name":"dynactin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/molecular-motors","display_name":"molecular motors","score":0.675000011920929},{"id":"https://openalex.org/keywords/processivity","display_name":"processivity","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.7290070056915283},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6927706599235535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.53725665807724},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5367506742477417},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.4702412486076355},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4375254213809967},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.42551571130752563},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.41569268703460693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40168988704681396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39561957120895386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28671836853027344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2365666925907135},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.2234470248222351},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17859363555908203},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.14212024211883545},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.08248364925384521},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.uvm.edu:graddis-1688","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.uvm.edu/graddis/689","pdf_url":"https://scholarworks.uvm.edu/graddis/689","source":{"id":"https://openalex.org/S4377196529","display_name":"ScholarWorks -A service of University of Vermont Libraries (University of Vermont)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111236770","host_organization_name":"University of Vermont","host_organization_lineage":["https://openalex.org/I111236770"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate College Dissertations and Theses","raw_type":"text"},{"id":"mag:2568459288","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.uvm.edu/cgi/viewcontent.cgi?article=1688&context=graddis","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.uvm.edu:graddis-1688","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.uvm.edu/graddis/689","pdf_url":"https://scholarworks.uvm.edu/graddis/689","source":{"id":"https://openalex.org/S4377196529","display_name":"ScholarWorks -A service of University of Vermont Libraries (University of Vermont)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111236770","host_organization_name":"University of Vermont","host_organization_lineage":["https://openalex.org/I111236770"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate College Dissertations and Theses","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3263424686","display_name":"Mutational Studies of Processive Myosin Motors","funder_award_id":"R01GM078097","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2568459288.pdf","grobid_xml":"https://content.openalex.org/works/W2568459288.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1936657395","https://openalex.org/W1963597564","https://openalex.org/W1972398314","https://openalex.org/W1984926639","https://openalex.org/W1997836836","https://openalex.org/W2004872614","https://openalex.org/W2022782971","https://openalex.org/W2030053673","https://openalex.org/W2033859483","https://openalex.org/W2034725792","https://openalex.org/W2040897146","https://openalex.org/W2047730219","https://openalex.org/W2063798177","https://openalex.org/W2064880862","https://openalex.org/W2065476928","https://openalex.org/W2068761333","https://openalex.org/W2072596507","https://openalex.org/W2081882866","https://openalex.org/W2093025565","https://openalex.org/W2107421715","https://openalex.org/W2124859239","https://openalex.org/W2130612942","https://openalex.org/W2132550454","https://openalex.org/W2142298504","https://openalex.org/W2144151547","https://openalex.org/W2160226734","https://openalex.org/W2162897213","https://openalex.org/W2163408061"],"related_works":["https://openalex.org/W2082350401","https://openalex.org/W2055053888","https://openalex.org/W1971730188","https://openalex.org/W4248434658","https://openalex.org/W2142298504","https://openalex.org/W2027720684","https://openalex.org/W2070735576","https://openalex.org/W2114440725","https://openalex.org/W2187421457","https://openalex.org/W2074258416"],"abstract_inverted_index":{"mRNA":[0,54,160,171,190,220,231,237,260,272,304,427,451,460],"localization":[1],"ensures":[2,243],"correct":[3],"spatial":[4],"and":[5,187,281,313,386,401,415,421,423,448,475],"temporal":[6],"control":[7],"of":[8,53,170,230,235,259,309,334,439,446,450,458,464],"protein":[9,144,155,295,320],"synthesis":[10],"in":[11,18,64,79,112,173,193,199,227,262,267,337,410,429,453,471],"the":[12,25,51,65,128,142,167,228,257,282,286,314,318,361,366,381,387,444,456],"cell.":[13],"Using":[14,196],"a":[15,46,68,95,148,179,188,211,340,349,407,424,468],"single":[16,69,197],"molecule":[17,198,369],"vitro":[19,113,200,411],"approach,":[20],"we":[21,176,202,404],"provide":[22],"insight":[23],"into":[24],"mechanisms":[26,52,169],"by":[27,33,67,111,162,219,278,378,398],"which":[28],"localizing":[29,57,189,289,426],"mRNAs":[30,58],"are":[31,59,82,249,265,291],"carried":[32],"molecular":[34,168],"motors":[35,76,248],"on":[36,61,275],"cytoskeletal":[37],"tracks":[38,63,277],"to":[39,115,123,141,146,159,254,288,371,478,486],"their":[40],"destination.":[41],"Budding":[42],"yeast":[43,108,264,474],"serves":[44],"as":[45,98],"model":[47],"system":[48],"for":[49,90,120,355,443,462],"studying":[50],"transport":[55,81,172,261,452],"because":[56,374],"moved":[60],"actin":[62],"cell":[66],"class":[70],"V":[71],"myosin":[72],"motor,":[73],"Myo4p.":[74],"Molecular":[75],"that":[77,86,127,204,216,242,244,284,330,352,433,480],"specialize":[78],"cargo":[80,161,246,305,389,400,461,487],"generally":[83],"double-headed":[84,213],"so":[85],"they":[87],"can":[88],"\"walk\"":[89],"many":[91],"microns":[92],"without":[93],"dissociating,":[94],"feature":[96],"known":[97],"processivity.":[99],"Thus,":[100,225,455],"is":[101,126,217,232,273,353,376,396,437,467,483],"was":[102,109,327],"surprising":[103],"when":[104],"Myo4p":[105,129,158,233],"purified":[106,185],"from":[107,184,412],"shown":[110,329],"assays":[114],"be":[116],"non-processive.":[117],"The":[118,152,293,307],"reason":[119],"its":[121],"inability":[122],"move":[124],"processively":[125],"heavy":[130],"chain":[131],"does":[132],"not":[133],"dimerize":[134],"with":[135,303,317,339],"itself,":[136],"but":[137],"instead":[138],"binds":[139,311],"tightly":[140,484],"adapter":[143,154,294],"She3p":[145],"form":[147],"single-headed":[149],"motor":[150,214,287,301,465,481],"complex.":[151],"mRNA-binding":[153,319],"She2p":[156,205],"links":[157],"binding":[163,384,390],"She3p.":[164],"To":[165,392],"understand":[166,255,393],"budding":[174,194,263,473],"yeast,":[175],"fully":[177,405],"reconstituted":[178,406],"messenger":[180],"ribonucleoprotein":[181],"(mRNP)":[182],"complex":[183,215,345,350,409],"proteins":[186],"(ASH1)":[191],"found":[192,428],"yeast.":[195],"assays,":[201],"find":[203,432],"recruits":[206],"two":[207],"Myo4p-She3p":[208],"complexes,":[209],"forming":[210],"processive":[212,357],"stabilized":[218],"at":[221],"physiological":[222],"ionic":[223],"strength.":[224],"only":[226,245,434],"presence":[229,457],"capable":[234,438],"continuous":[236],"transport,":[238],"an":[239,331,459],"elegant":[240],"mechanism":[241,470],"bound":[247],"motile.":[250],"We":[251,431],"next":[252],"wished":[253],"if":[256],"principles":[258],"conserved":[266,469],"higher":[268,476],"eukaryotes.":[269],"In":[270],"Drosophila,":[271],"transported":[274],"microtubule":[276],"cytoplasmic":[279],"dynein,":[280,312],"adapters":[283,419],"link":[285],"transcripts":[290],"well-defined.":[292],"bicaudal":[296],"D":[297],"(BicD)":[298],"coordinates":[299],"dynein":[300,324,383,395,414],"activity":[302,482],"binding.":[306],"N-terminus":[308],"BicD":[310,335,368,420,441],"C-terminus":[315],"interacts":[316],"Egalitarian.":[321],"Unlike":[322],"mammalian":[323],"alone,":[325],"it":[326,375],"recently":[328],"N-terminal":[332,382],"fragment":[333],"(BicD2CC1),":[336],"combination":[338],"large":[341],"1.2MDa":[342],"multi-subunit":[343],"accessory":[344],"called":[346],"dynactin,":[347,416],"forms":[348],"(DDBCC1)":[351],"activated":[354,363,397],"long":[356],"runs.":[358],"But":[359],"unlike":[360],"constitutively":[362],"BicD2CC1":[364],"fragment,":[365],"full-length":[367,402,418],"fails":[370],"recruit":[372],"dynein-dynactin":[373],"auto-inhibited":[377],"interactions":[379],"between":[380],"domain":[385],"C-terminal":[388],"domain.":[391],"how":[394],"native":[399],"adapters,":[403],"mRNP":[408],"tissue-purified":[413],"expressed":[417],"Egalitarian,":[422],"synthesized":[425],"Drosophila.":[430],"mRNA-bound":[435],"Egalitarian":[436],"relieving":[440],"auto-inhibition":[442],"recruitment":[445],"dynein-dynactin,":[447],"activation":[449,463],"vitro.":[454],"complexes":[466],"both":[472],"eukaryotes":[477],"ensure":[479],"coupled":[485],"selection.":[488]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-01-13T00:00:00"}
