{"id":"https://openalex.org/W2568066932","doi":"https://doi.org/10.1055/s-2006-933838","title":"siRNA Transfektion der Lunge und des Bronchialkarzinomes im Mausmodell","display_name":"siRNA Transfektion der Lunge und des Bronchialkarzinomes im Mausmodell","publication_year":2006,"publication_date":"2006-04-20","ids":{"openalex":"https://openalex.org/W2568066932","doi":"https://doi.org/10.1055/s-2006-933838","mag":"2568066932"},"language":"de","primary_location":{"id":"doi:10.1055/s-2006-933838","doi":"https://doi.org/10.1055/s-2006-933838","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-933838","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113727263","display_name":"Florentine Kamlah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Kamlah","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033644774","display_name":"BG Eul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Eul","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020015230","display_name":"Leigh Matthew Marsh","orcid":"https://orcid.org/0000-0002-1754-9249","observed_orcids":["https://orcid.org/0000-0002-1754-9249"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Marsh","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016018148","display_name":"Gra\u017cyna Kwapiszewska","orcid":"https://orcid.org/0000-0003-0518-9079","observed_orcids":["https://orcid.org/0000-0003-0518-9079"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Kwapiszewska","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016511599","display_name":"Werner Seeger","orcid":"https://orcid.org/0000-0003-1946-0894","observed_orcids":["https://orcid.org/0000-0003-1946-0894"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Seeger","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084935661","display_name":"Friedrich Grimminger","orcid":"https://orcid.org/0000-0001-8725-6276","observed_orcids":["https://orcid.org/0000-0001-8725-6276"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Grimminger","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik V Innere Medizin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik V Innere Medizin","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002977333","display_name":"J\u00f6rg H\u00e4nze","orcid":"https://orcid.org/0000-0001-5424-7808","observed_orcids":["https://orcid.org/0000-0001-5424-7808"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J H\u00e4nze","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Medizinische Klinik II Innere Medizin / Pneumologie","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109987859","display_name":"Frank Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Rose","raw_affiliation_strings":["Universit\u00e4tsklinikum Gie\u00dfen und Marburg Klinik f\u00fcr Strahlentherapie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg Klinik f\u00fcr Strahlentherapie","institution_ids":["https://openalex.org/I268975460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I268975460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.26035324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"60","issue":"S 1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.781000018119812},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/transfection-reagents","display_name":"transfection reagents","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lipofectamine-2000","display_name":"Lipofectamine 2000","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intratracheal-administration","display_name":"intratracheal administration","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intraperitoneal-administration","display_name":"intraperitoneal administration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.4269999861717224},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6189219355583191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49746063351631165},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.36515355110168457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2897946834564209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13936927914619446}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2006-933838","doi":"https://doi.org/10.1055/s-2006-933838","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-933838","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6944979423","https://openalex.org/W3201251641","https://openalex.org/W2095241987","https://openalex.org/W2068519358","https://openalex.org/W824608950","https://openalex.org/W2025209129","https://openalex.org/W2620417991","https://openalex.org/W2316238388","https://openalex.org/W2163094978","https://openalex.org/W2744927102"],"abstract_inverted_index":{"RNA":[0],"interferenz":[1],"stellt":[2],"eine":[3,46,84,187],"sehr":[4],"effektive":[5],"Methode":[6],"zur":[7,98,240],"gezielten":[8],"Inhibition":[9,68],"der":[10,35,47,58,139,164,234],"Genexpression":[11],"dar.":[12],"Sie":[13],"wird":[14],"vermittelt":[15],"\u00fcber":[16,119],"siRNA,":[17],"welche":[18],"sequenzspezifisch":[19],"die":[20,33,72,77,103,207],"Ziel-mRNA":[21],"Degradierung":[22],"triggert.":[23],"Die":[24,41,132,229],"Transfektion":[25,104],"von":[26,69,136,151],"siRNA":[27,100,152,235],"in":[28,193,197,242],"vivo":[29],"ist":[30,52],"limitiert":[31],"durch":[32,38],"Erreichbarkeit":[34],"Zielzellen":[36],"und":[37,117,126,143,153,196],"ihre":[39],"Stabilit\u00e4t.":[40],"konventionelle":[42],"Behandlung":[43],"des":[44,50,79,105,189],"Bronchialkarzinoms,":[45],"h\u00e4ufigsten":[48],"Tumorerkrankung":[49],"Menschen,":[51],"trotz":[53],"neuwertiger":[54],"Strategien":[55],"gemessen":[56],"an":[57],"mittleren":[59],"5-Jahres-\u00dcberlebensrate":[60],"nicht":[61,227],"ausreichend.":[62],"Eine":[63],"antitumor\u00f6se":[64],"Gentherapie":[65],"mit":[66,173,213,215],"spezifischer":[67],"relevanten":[70],"Proteinen,":[71],"beispielsweise":[73],"das":[74,232],"Wachstum":[75],"oder":[76],"Angiogenese":[78],"Tumors":[80],"f\u00f6rdern,":[81],"w\u00e4re":[82],"daher":[83],"wesentliche":[85],"Verbesserung":[86],"aller":[87],"bisherigen":[88],"Therapieformen.":[89],"Ziel":[90],"dieser":[91],"Studie":[92],"war":[93],"es,":[94],"ein":[95],"geeignetes":[96],"Verfahren":[97],"effizienten":[99],"Verabreichung":[101],"f\u00fcr":[102],"Bronchialkarzinomes":[106],"zu":[107,159,176,219],"finden.":[108],"Mittels":[109],"Cy3-markierter":[110],"Nukleins\u00e4ure":[111],"wurden":[112,155],"zwei":[113],"verschiedene":[114],"Transfektionsreagenzien":[115],"(Lipofectamin2000":[116],"JetPEI)":[118],"einen":[120,123,127],"intratrachealen":[121],"(i.t.),":[122],"zentralven\u00f6sen":[124],"(i.v.)":[125],"intraperitonealen":[128],"(i.p.)":[129],"Zugangsweg":[130],"getestet.":[131],"Detektion":[133],"erfolgte":[134],"anhand":[135],"histologischen":[137],"Schnitten":[138],"Lunge,":[140],"Niere,":[141],"Milz":[142],"Leber":[144],"im":[145,180,202],"Fluoreszenzmikroskop.":[146],"Nach":[147],"i.":[148],"t.":[149],"Applikation":[150,170,212],"Lipofectamin2000":[154],"haupts\u00e4chlich":[156],"alveol\u00e4re":[157],"Makrophagen":[158],"ca.":[160],"50%":[161],"transfiziert.":[162,228],"In":[163],"gesunden":[165],"Lunge":[166],"sind":[167],"nach":[168],"i.v.":[169],"gro\u00dfe":[171],"Bereiche":[172],"beiden":[174],"Reagenzien":[175],"transfizieren,":[177],"w\u00e4hrend":[178],"sich":[179],"Lungentumormodell":[181],"(LLC)":[182],"bei":[183],"gleicher":[184],"Applikationsform":[185],"sogar":[186],"Akkumulation":[188],"Signals":[190],"vor":[191],"allem":[192],"gef\u00e4\u00dfnahen":[194],"Bereichen":[195],"kleineren":[198],"Tumoren":[199],"zeigte.":[200],"Auch":[201],"s.c.":[203],"Tumormodell":[204],"(A549)":[205],"waren":[206,225],"soliden":[208,243],"Tumore":[209],"mittels":[210],"i.p.":[211],"JetPEI":[214],"einer":[216],"guten":[217],"Effizienz":[218],"transfizieren.":[220],"Alle":[221],"anderen":[222],"untersuchten":[223],"Organe":[224],"fast":[226],"Ergebnisse":[230],"unterstreichen":[231],"Potential":[233],"Technik":[236],"als":[237],"therapeutischen":[238],"Ansatz":[239],"Geninhibition":[241],"Lungentumoren.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-13T00:00:00"}
