{"id":"https://openalex.org/W2567662999","doi":"https://doi.org/10.1136/gut.2009.208942r","title":"PWE-022 Can fibre improve bowel function in inflammatory conditions of the rectum? A pilot study in prostate cancer patients receiving radiotherapy","display_name":"PWE-022 Can fibre improve bowel function in inflammatory conditions of the rectum? A pilot study in prostate cancer patients receiving radiotherapy","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2567662999","doi":"https://doi.org/10.1136/gut.2009.208942r","mag":"2567662999"},"language":"en","primary_location":{"id":"doi:10.1136/gut.2009.208942r","doi":"https://doi.org/10.1136/gut.2009.208942r","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gut.2009.208942r","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004176174","display_name":"Linda J. Wedlake","orcid":"https://orcid.org/0000-0001-6644-0947","observed_orcids":["https://orcid.org/0000-0001-6644-0947"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L Wedlake","raw_affiliation_strings":["GI Unit, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Unit, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035228430","display_name":"Helen A. McNair","orcid":"https://orcid.org/0000-0001-7389-5587","observed_orcids":["https://orcid.org/0000-0001-7389-5587"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H McNair","raw_affiliation_strings":["Department of Radiotherapy, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004686249","display_name":"Gordon J. Mcvie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G McVie","raw_affiliation_strings":["Department of Radiotherapy, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033672260","display_name":"Karen Thomas","orcid":"https://orcid.org/0000-0001-7548-4466","observed_orcids":["https://orcid.org/0000-0001-7548-4466"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K Thomas","raw_affiliation_strings":["Department of Computing, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025921361","display_name":"David Paul Dearnaley","orcid":"https://orcid.org/0000-0002-3954-2806","observed_orcids":["https://orcid.org/0000-0002-3954-2806"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Dearnaley","raw_affiliation_strings":["Department of Radiotherapy, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029255628","display_name":"Jervoise N. Andreyev","orcid":"https://orcid.org/0000-0002-7165-6352","observed_orcids":["https://orcid.org/0000-0002-7165-6352"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Andreyev","raw_affiliation_strings":["GI Unit, Royal Marsden Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Unit, Royal Marsden Hospital, London, UK","institution_ids":["https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121186"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"Suppl 1","first_page":"A93.2","last_page":"A94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.972000002861023},{"id":"https://openalex.org/keywords/prostate-cancer-radiotherapy","display_name":"prostate cancer radiotherapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/proctitis","display_name":"proctitis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/bowel-function","display_name":"bowel function","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fecal-consistency","display_name":"stool consistency","score":0.7419999837875366},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.6880000233650208},{"id":"https://openalex.org/keywords/rectal-distension","display_name":"rectal distension","score":0.8399999737739563},{"id":"https://openalex.org/keywords/rectal-gas","display_name":"rectal gas","score":0.7829999923706055},{"id":"https://openalex.org/keywords/non-starch-polysaccharides","display_name":"non-starch polysaccharides","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fluid-intake","display_name":"fluid intake","score":0.6460000276565552},{"id":"https://openalex.org/keywords/bristol-stool-form","display_name":"Bristol stool form","score":0.4300000071525574},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8961980938911438},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.8231152296066284},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.766159176826477},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5454472303390503},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5340347290039062},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5035318732261658},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4712028205394745},{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.46837764978408813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4511069059371948},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4217076301574707},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4137931168079376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.377913236618042},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26031965017318726},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22485744953155518}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/gut.2009.208942r","doi":"https://doi.org/10.1136/gut.2009.208942r","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gut.2009.208942r","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2310618425","https://openalex.org/W2303991146","https://openalex.org/W2136338948","https://openalex.org/W2990855456","https://openalex.org/W2724783613","https://openalex.org/W2017606885","https://openalex.org/W3178378280","https://openalex.org/W48680474","https://openalex.org/W7202395368","https://openalex.org/W4281778363"],"abstract_inverted_index":{"Introduction":[0],"The":[1,44,290,316],"anti-inflammatory":[2],"role":[3],"of":[4,32,80,116,121,150,190],"dietary":[5],"fibre,":[6],"its":[7],"impact":[8],"on":[9,124,378,422],"bowel":[10,106,151,202],"frequency":[11,149,170,280,427],"and":[12,66,100,110,129,136,143,158,171,186,200,208,247,256,262,269,307,392,415],"stool":[13,130,169,426],"consistency":[14,131],"is":[15,386,395],"inadequately":[16],"studied.":[17],"Therapeutic":[18],"radiotherapy":[19,64,73],"for":[20,112,381],"prostate":[21,52],"cancer":[22],"provides":[23],"a":[24,67,98,193,387],"unique":[25],"opportunity":[26],"to":[27,89,104,147,153,233,285,331,364,373,389,397,410],"assess":[28],"the":[29,36,63,77,83,87,113,119,122,175,305,326],"potential":[30],"efficacy":[31],"fibre":[33,101,252,277,309,328,353,375,402],"in":[34,56,214,293,303,319,325,352],"protecting":[35],"rectum":[37,45],"from":[38,224,282,359,413],"cumulative,":[39],"radiation-therapy":[40],"induced,":[41],"inflammatory":[42,69],"insults.":[43],"inevitably":[46],"receives":[47],"some":[48],"radiation":[49],"dose":[50,391],"during":[51,72,76],"irradiation.":[53],"Rectal":[54,204,337],"function":[55],"most":[57],"men,":[58],"will":[59],"be":[60],"normal":[61],"before":[62,109],"starts":[65],"predictable":[68],"response":[70],"occurs":[71],"which":[74,300],"peaks":[75],"second":[78],"week":[79],"treatment,":[81],"causing":[82],"worst":[84],"symptoms":[85,414],"by":[86],"fourth":[88],"fifth":[90],"weeks.":[91],"We":[92],"investigated":[93],"whether":[94],"patients":[95,230,250,267,271],"could":[96],"follow":[97,374],"fluid":[99,137,161],"prescription":[102],"designed":[103],"regularise":[105,148],"habit":[107],"commencing":[108],"continuing":[111],"6\u20139":[114],"weeks":[115],"radiotherapy.":[117],"Additionally,":[118],"effect":[120,421],"diet":[123],"gastrointestinal":[125],"symptoms,":[126],"rectal":[127,218,343,356,423],"distension":[128,209,338],"was":[132,139,164,168,297,301,322,339,347],"examined.":[133],"Methods":[134],"Fibre":[135],"intake":[138,253,259,403],"assessed":[140,183],"at":[141,154,184,187,288,362,367],"baseline":[142,185,246,363],"individualised":[144],"prescriptions":[145,376],"given":[146],"motion":[152],"least":[155],"1":[156],"motion/day":[157],"ensure":[159],"adequate":[160],"intake.":[162,278,354],"Compliance":[163],"measured":[165,221],"daily":[166],"as":[167,217],"type":[172],"(consistency)":[173],"using":[174,192],"Bristol":[176],"Stool":[177,279],"Form":[178],"7-point":[179],"scale.":[180],"Symptoms":[181],"were":[182,220,231],"end-RT":[188],"(end":[189],"radiotherapy)":[191],"modified":[194],"IBDQ":[195,320],"(Inflammatory":[196],"Bowel":[197],"Disease":[198],"Questionnaire)":[199],"IBDQ-B,":[201],"subset.":[203],"gas":[205,344],"(5-point":[206],"scale)":[207],"(rectal":[210],"Cross":[211],"Sectional":[212],"Area":[213],"cm2)":[215],"defined":[216],"volume/length":[219],"throughout":[222],"treatment":[223],"serial":[225],"CT":[226],"scans.":[227],"Result":[228],"22":[229],"invited":[232],"participate.":[234],"21":[235],"(median:":[236],"71":[237],"years;":[238],"range:":[239],"59\u201382":[240],"years)":[241],"provided":[242],"evaluable":[243],"data.":[244],"Between":[245],"end-RT,":[248],"14":[249],"increased":[251,281],"(NSP:":[254],"Englyst)":[255],"seven":[257],"decreased":[258,358],"(5":[260],"g/day":[261],"-2":[263],"g/day,":[264],"respectively).":[265,315,336],"13":[266],"exceeded":[268],"eight":[270],"did":[272,416],"not":[273,348,417],"meet":[274],"their":[275],"prescribed":[276],"mean":[283,291,317],"1.9":[284],"2.4":[286],"motions/day":[287],"end-RT.":[289,368],"fall":[292,318],"IBDQ-B":[294],"scores":[295,321],"(n=21)":[296],"10.8":[298],"points":[299],"similar":[302],"both":[304],"increasing":[306,332],"decreasing":[308,327],"groups":[310],"(10.3":[311],"vs":[312,334],"11.6":[313],"points,":[314],"twofold":[323],"greater":[324],"group":[329],"compared":[330],"(34.6":[333],"17.6,":[335],"significantly":[340],"correlated":[341],"with":[342,350],"(p=0.04)":[345],"but":[346,384],"associated":[349],"change":[351],"Mean":[355],"CSAcm2":[357],"7.5":[360],"cm2":[361,366],"6.8":[365],"Conclusion":[369],"Patients":[370],"are":[371],"able":[372],"based":[377],"normally-consumed":[379],"foods":[380],"prolonged":[382],"periods":[383],"there":[385],"tendency":[388],"exceed":[390],"therefore":[393],"it":[394],"important":[396],"set":[398],"upper":[399],"limits.":[400],"Increased":[401],"(25%":[404],"more":[405],"than":[406],"habitually":[407],"consumed)":[408],"appeared":[409],"offer":[411],"protection":[412],"have":[418],"an":[419],"adverse":[420],"gas,":[424],"distension,":[425],"or":[428],"consistency.":[429]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-06T00:00:00"}