{"id":"https://openalex.org/W2567576867","doi":"https://doi.org/10.1002/pbc.26396","title":"Real-world outcomes of treatment for acute lymphoblastic leukemia during adolescence in a financially restricted environment: Results at a single center in Latin America","display_name":"Real-world outcomes of treatment for acute lymphoblastic leukemia during adolescence in a financially restricted environment: Results at a single center in Latin America","publication_year":2016,"publication_date":"2016-12-13","ids":{"openalex":"https://openalex.org/W2567576867","doi":"https://doi.org/10.1002/pbc.26396","mag":"2567576867","pmid":"https://pubmed.ncbi.nlm.nih.gov/27957789"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.26396","doi":"https://doi.org/10.1002/pbc.26396","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.26396","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.26396","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.26396","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071179664","display_name":"Jos\u00e9 Carlos Jaime\u2010P\u00e9rez","orcid":"https://orcid.org/0000-0001-6804-9095","observed_orcids":["https://orcid.org/0000-0001-6804-9095"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 C. Jaime-P\u00e9rez","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046829788","display_name":"Ra\u00fal Alberto Jim\u00e9nez\u2010Castillo","orcid":"https://orcid.org/0000-0002-8331-6291","observed_orcids":["https://orcid.org/0000-0002-8331-6291"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ra\u00fal A. Jim\u00e9nez-Castillo","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008013668","display_name":"M\u00f3nica Andrea Pinz\u00f3n-Uresti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00f3nica A. Pinz\u00f3n-Uresti","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002064575","display_name":"Olga Graciela Cant\u00fa\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0003-2134-3734","observed_orcids":["https://orcid.org/0000-0003-2134-3734"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Olga G. Cant\u00fa-Rodr\u00edguez","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086438877","display_name":"Jos\u00e9 Lu\u00eds Herrera-Garza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 L. Herrera-Garza","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057366396","display_name":"Luis Javier Marfil\u2010Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis J. Marfil-Rivera","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000360404","display_name":"David G\u00f3mez\u2010Almaguer","orcid":"https://orcid.org/0000-0002-0460-6427","observed_orcids":["https://orcid.org/0000-0002-0460-6427"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"David G\u00f3mez-Almaguer","raw_affiliation_strings":["Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Division; Department of Hematology; \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d University Hospital of the School of Medicine of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n; Monterrey M\u00e9xico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071179664"],"corresponding_institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":2.8121,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91230555,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"7","first_page":"e26396","last_page":"e26396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adolescent-leukemia","display_name":"adolescent leukemia","score":0.6819999814033508},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.890999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.8949999809265137},{"id":"https://openalex.org/keywords/low-and-middle-income-countries","display_name":"low- and middle-income countries","score":0.8500000238418579},{"id":"https://openalex.org/keywords/organomegaly","display_name":"organomegaly","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.9089999794960022},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9515539407730103},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.575354814529419},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5553454756736755},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5370010733604431},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.41186702251434326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3954656422138214},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23540008068084717},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.10696563124656677}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007843","descriptor_name":"Latin America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.26396","doi":"https://doi.org/10.1002/pbc.26396","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.26396","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.26396","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},{"id":"pmid:27957789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27957789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pbc.26396","doi":"https://doi.org/10.1002/pbc.26396","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.26396","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.26396","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2567576867.pdf","grobid_xml":"https://content.openalex.org/works/W2567576867.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W146900568","https://openalex.org/W148262973","https://openalex.org/W1558704041","https://openalex.org/W1582130462","https://openalex.org/W1595924202","https://openalex.org/W1693855124","https://openalex.org/W1968151924","https://openalex.org/W1977096590","https://openalex.org/W1977546984","https://openalex.org/W1979300931","https://openalex.org/W1984156820","https://openalex.org/W1987446594","https://openalex.org/W1990660436","https://openalex.org/W1995931600","https://openalex.org/W2001993817","https://openalex.org/W2010729137","https://openalex.org/W2015844812","https://openalex.org/W2016612934","https://openalex.org/W2022557886","https://openalex.org/W2024028905","https://openalex.org/W2030049579","https://openalex.org/W2043310237","https://openalex.org/W2046731267","https://openalex.org/W2049204537","https://openalex.org/W2052336881","https://openalex.org/W2056710396","https://openalex.org/W2059999488","https://openalex.org/W2067585473","https://openalex.org/W2072434377","https://openalex.org/W2074181164","https://openalex.org/W2094111340","https://openalex.org/W2099145120","https://openalex.org/W2114372395","https://openalex.org/W2134118606","https://openalex.org/W2134892517","https://openalex.org/W2137365058","https://openalex.org/W2145662640","https://openalex.org/W2146762986","https://openalex.org/W2146971143","https://openalex.org/W2151288624","https://openalex.org/W2154410907","https://openalex.org/W2157438100","https://openalex.org/W2187668060","https://openalex.org/W2203215848","https://openalex.org/W2461138639","https://openalex.org/W2564933750","https://openalex.org/W3041047318"],"related_works":["https://openalex.org/W2610466312","https://openalex.org/W3143693161","https://openalex.org/W2051610151","https://openalex.org/W2164469240","https://openalex.org/W2154832101","https://openalex.org/W4282556446","https://openalex.org/W2555467846","https://openalex.org/W7164751142","https://openalex.org/W2043310237","https://openalex.org/W4283749083"],"abstract_inverted_index":{"OBJECTIVE:":[0],"There":[1],"is":[2,16,38],"a":[3,64,73],"paucity":[4],"of":[5,8,51,90,136,140,197,211],"the":[6,59,85,97,115,132,167],"studies":[7],"adolescents":[9,52,108],"with":[10,41,56,63,147,191],"acute":[11],"lymphoblastic":[12],"leukemia":[13],"(ALL).":[14],"This":[15],"more":[17],"noticeable":[18],"in":[19,159,170,219],"low-":[20],"and":[21,30,80,92,104,111,127,143,153,163,186,209],"middle-income":[22,74],"countries.":[23],"The":[24],"international":[25,192],"5-year":[26,188],"event-free":[27],"survival":[28,32,217],"(EFS)":[29],"overall":[31],"(OS)":[33],"for":[34,106,145],"this":[35],"age":[36],"group":[37],"around":[39],"80%,":[40],"pediatric-inspired":[42],"protocols":[43],"offering":[44],"better":[45],"results.":[46],"METHODS:":[47],"A":[48],"retrospective":[49],"analysis":[50],"aged":[53],"16-20":[54],"diagnosed":[55],"ALL":[57],"during":[58],"period":[60],"2004-2015":[61],"treated":[62],"high-risk":[65],"pediatric":[66,199],"protocol":[67],"at":[68,149],"an":[69],"academic":[70],"center":[71],"from":[72],"country":[75],"was":[76,151,166,194],"performed.":[77],"Five-year":[78,102],"OS":[79,105],"EFS":[81,103,189],"were":[82,94,109,131],"estimated":[83,95],"by":[84,96],"Kaplan-Meier":[86],"analysis.":[87],"Hazard":[88,138],"ratios":[89],"relapse":[91,184],"death":[93,144],"Cox":[98],"regression":[99],"model.":[100],"RESULTS:":[101],"57":[107],"23.3%":[110],"48.9%,":[112],"respectively.":[113,155],"From":[114],"41":[116],"patients":[117,146,162,175],"who":[118],"achieved":[119],"complete":[120],"remission,":[121],"24":[122],"(58.5%)":[123],"relapsed.":[124],"Bone":[125],"marrow":[126],"central":[128],"nervous":[129],"system":[130],"most":[133,168],"frequent":[134,169],"sites":[135],"relapse.":[137],"ratio":[139],"treatment":[141],"failure":[142],"organomegaly":[148],"diagnosis":[150],"2.026":[152],"2.970,":[154],"Treatment-related":[156],"toxicity":[157],"developed":[158],"31":[160],"(54.4%)":[161],"febrile":[164],"neutropenia":[165],"14":[171],"(24.6%)":[172],"cases.":[173],"Twelve":[174],"(21.1%)":[176],"had":[177],"poor":[178],"adherence":[179,201],"to":[180,202,215],"treatment.":[181],"CONCLUSIONS:":[182],"High":[183],"rate":[185],"low":[187],"compared":[190],"standards,":[193],"documented.":[195],"Use":[196],"intensified":[198],"regimens,":[200],"proven":[203],"effective":[204],"medications,":[205],"improved":[206],"supportive":[207],"care,":[208],"prevention":[210],"abandonment":[212],"are":[213],"necessary":[214],"improve":[216],"rates":[218],"these":[220],"patients.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}