{"id":"https://openalex.org/W2567526705","doi":"https://doi.org/10.1021/acssensors.6b00627","title":"Label-Free Nanopore Biosensor for Rapid and Highly Sensitive Cocaine Detection in Complex Biological Fluids","display_name":"Label-Free Nanopore Biosensor for Rapid and Highly Sensitive Cocaine Detection in Complex Biological Fluids","publication_year":2016,"publication_date":"2016-12-12","ids":{"openalex":"https://openalex.org/W2567526705","doi":"https://doi.org/10.1021/acssensors.6b00627","mag":"2567526705","pmid":"https://pubmed.ncbi.nlm.nih.gov/28723133"},"language":"en","primary_location":{"id":"doi:10.1021/acssensors.6b00627","doi":"https://doi.org/10.1021/acssensors.6b00627","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssensors.6b00627","pdf_url":null,"source":{"id":"https://openalex.org/S2764631046","display_name":"ACS Sensors","issn_l":"2379-3694","issn":["2379-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sensors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029709818","display_name":"Sana Rauf","orcid":"https://orcid.org/0000-0002-3866-5396","observed_orcids":["https://orcid.org/0000-0002-3866-5396"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sana Rauf","raw_affiliation_strings":["Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100622715","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0003-0650-4376","observed_orcids":["https://orcid.org/0000-0003-0650-4376"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110004122","display_name":"Asghar Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Asghar Ali","raw_affiliation_strings":["Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356054","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0003-0042-5183","observed_orcids":["https://orcid.org/0000-0003-0042-5183","https://orcid.org/0000-0001-6017-9821"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089448918","display_name":"Jinghong Li","orcid":"https://orcid.org/0000-0002-0750-7352","observed_orcids":["https://orcid.org/0000-0002-0750-7352","https://orcid.org/0000-0002-2716-4801"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinghong Li","raw_affiliation_strings":["Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China"],"raw_orcid":"https://orcid.org/0000-0002-0750-7352","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089448918"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3618,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.92850789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"2","issue":"2","first_page":"227","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-detection","display_name":"cocaine detection","score":0.9900000095367432},{"id":"https://openalex.org/keywords/alpha-hemolysin-nanopore","display_name":"\u03b1-hemolysin nanopore","score":0.8769999742507935},{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dna-translocation","display_name":"DNA translocation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.6489999890327454},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9139999747276306},{"id":"https://openalex.org/keywords/illicit-drug-detection","display_name":"illicit drug detection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/current-blockade","display_name":"current blockade","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.8926303386688232},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.8082734942436218},{"id":"https://openalex.org/C2909138979","wikidata":"https://www.wikidata.org/wiki/Q38523","display_name":"Drug detection","level":2,"score":0.7024487257003784},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6948907375335693},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.6197911500930786},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5153486132621765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5037049651145935},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5022351741790771},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.49000492691993713},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4252763092517853},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3547596037387848},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33444997668266296},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23085322976112366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18925228714942932},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.18539822101593018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16736653447151184}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acssensors.6b00627","doi":"https://doi.org/10.1021/acssensors.6b00627","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssensors.6b00627","pdf_url":null,"source":{"id":"https://openalex.org/S2764631046","display_name":"ACS Sensors","issn_l":"2379-3694","issn":["2379-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sensors","raw_type":"journal-article"},{"id":"pmid:28723133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28723133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS sensors","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1831686664","display_name":null,"funder_award_id":"2162100-3","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3221522796","display_name":null,"funder_award_id":"21327806","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7366342745","display_name":"\u77f3\u58a8\u70ef\u751f\u7269\u529f\u80fd\u754c\u9762\u7684\u6784\u5efa\u53ca\u751f\u7269\u4f20\u611f\u7814\u7a76","funder_award_id":"21235004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1492349014","https://openalex.org/W1964505154","https://openalex.org/W1968217555","https://openalex.org/W1974053573","https://openalex.org/W1989474885","https://openalex.org/W1994782728","https://openalex.org/W1997511581","https://openalex.org/W1997698671","https://openalex.org/W2008940612","https://openalex.org/W2014326137","https://openalex.org/W2023627819","https://openalex.org/W2024619744","https://openalex.org/W2025583382","https://openalex.org/W2029080751","https://openalex.org/W2029335522","https://openalex.org/W2030683115","https://openalex.org/W2040345323","https://openalex.org/W2044909322","https://openalex.org/W2045889911","https://openalex.org/W2052826004","https://openalex.org/W2053884127","https://openalex.org/W2055705536","https://openalex.org/W2060423946","https://openalex.org/W2061517332","https://openalex.org/W2062415820","https://openalex.org/W2072013830","https://openalex.org/W2077151519","https://openalex.org/W2081737898","https://openalex.org/W2089780165","https://openalex.org/W2090867369","https://openalex.org/W2090924278","https://openalex.org/W2091025649","https://openalex.org/W2105630356","https://openalex.org/W2110143127","https://openalex.org/W2111400509","https://openalex.org/W2112381014","https://openalex.org/W2123498041","https://openalex.org/W2133873308","https://openalex.org/W2143470297","https://openalex.org/W2143789454","https://openalex.org/W2148332776","https://openalex.org/W2154572268","https://openalex.org/W2161616467","https://openalex.org/W2208632078","https://openalex.org/W2306374249","https://openalex.org/W2316676858","https://openalex.org/W2317461078","https://openalex.org/W2320205033","https://openalex.org/W2324683134","https://openalex.org/W2336069139","https://openalex.org/W2419550432","https://openalex.org/W3146764412"],"related_works":["https://openalex.org/W2320205033","https://openalex.org/W1986082438","https://openalex.org/W2779780693","https://openalex.org/W2794185144","https://openalex.org/W2029335522","https://openalex.org/W2015450567","https://openalex.org/W2066244015","https://openalex.org/W4306849692","https://openalex.org/W1580445560","https://openalex.org/W281019272"],"abstract_inverted_index":{"Detection":[0],"of":[1,5,42,87,129,134,182],"very":[2],"low":[3,167],"amounts":[4],"illicit":[6],"drugs":[7],"such":[8],"as":[9],"cocaine":[10,43,62,72,109,150],"in":[11,23,44,101,118,152],"clinical":[12],"fluids":[13,155],"like":[14,156],"serum":[15,46,160],"continues":[16],"to":[17,71,126,137],"be":[18],"important":[19],"for":[20,36,61,149,179],"many":[21],"areas":[22],"the":[24,77,132,176,183],"fight":[25],"against":[26],"drug":[27],"trafficking.":[28],"Herein,":[29],"we":[30],"constructed":[31],"a":[32,66,104,119],"label-free":[33],"nanopore":[34,93],"biosensor":[35],"rapid":[37],"and":[38,47,85,111,159,171],"highly":[39],"sensitive":[40],"detection":[41,135,151,174],"human":[45,157],"saliva":[48,158],"samples":[49,161],"based":[50],"on":[51],"target-induced":[52],"strand":[53,80],"release":[54],"strategy.":[55],"In":[56,140],"this":[57,88,142],"bioassay,":[58],"an":[59],"aptamer":[60,84],"was":[63,81,116,146],"prehybridized":[64],"with":[65,75,131,162],"short":[67,78],"complementary":[68],"DNA.":[69],"Owing":[70],"specific":[73],"binding":[74],"aptamer,":[76],"DNA":[79,90,113],"displaced":[82],"from":[83,123],"translocation":[86],"output":[89,112],"through":[91],"\u03b1-hemolysin":[92],"generated":[94],"distinct":[95],"spike-like":[96],"current":[97],"blockages.":[98],"When":[99],"plotted":[100],"double-logarithmic":[102],"scale,":[103],"linear":[105],"relationship":[106],"between":[107],"target":[108],"concentration":[110,121],"event":[114],"frequency":[115],"obtained":[117],"wide":[120],"range":[122],"50":[124,138],"nM":[125],"100":[127],"\u03bcM":[128],"cocaine,":[130],"limit":[133],"down":[136],"nM.":[139],"addition,":[141],"aptamer-based":[143],"sensor":[144],"method":[145],"successfully":[147],"applied":[148],"complex":[153],"biological":[154],"great":[163],"selectivity.":[164],"Simple":[165],"preparation,":[166],"cost,":[168],"rapid,":[169],"label-free,":[170],"real":[172],"sample":[173],"are":[175],"motivating":[177],"factors":[178],"practical":[180],"application":[181],"proposed":[184],"biosensor.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
