{"id":"https://openalex.org/W2567412474","doi":"https://doi.org/10.1016/j.ebiom.2016.12.012","title":"FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression","display_name":"FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression","publication_year":2016,"publication_date":"2016-12-24","ids":{"openalex":"https://openalex.org/W2567412474","doi":"https://doi.org/10.1016/j.ebiom.2016.12.012","mag":"2567412474","pmid":"https://pubmed.ncbi.nlm.nih.gov/28159572","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5474427"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2016.12.012","doi":"https://doi.org/10.1016/j.ebiom.2016.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2016.12.012","pdf_url":"http://www.ebiomedicine.com/article/S2352396416305916/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ebiomedicine.com/article/S2352396416305916/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063172780","display_name":"Timothy S. Heuer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timothy S. Heuer","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA. Electronic address: tim@celldesignlabs.com","3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA. Electronic address: tim@celldesignlabs.com","institution_ids":[]},{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025154671","display_name":"Richard Ventura","orcid":"https://orcid.org/0000-0001-9101-4595","observed_orcids":["https://orcid.org/0000-0001-9101-4595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Ventura","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086374199","display_name":"Kasia Mordec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kasia Mordec","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Julie Lai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Lai","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056879586","display_name":"Marina Fridlib","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Fridlib","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108694850","display_name":"DOUGLAS I. BUCKLEY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Buckley","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010601658","display_name":"George\u00a0W. Kemble","orcid":"https://orcid.org/0000-0003-4225-8774","observed_orcids":["https://orcid.org/0000-0003-4225-8774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kemble","raw_affiliation_strings":["3-V Biosciences, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3-V Biosciences, Menlo Park, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063172780"],"corresponding_institution_ids":[],"apc_list":{"value":5780,"currency":"USD","value_usd":5780},"apc_paid":{"value":5780,"currency":"USD","value_usd":5780},"fwci":2.9408,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.9131258,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":null,"first_page":"51","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fasn-inhibition","display_name":"FASN inhibition","score":0.9369999766349792},{"id":"https://openalex.org/keywords/microtubule-organization","display_name":"microtubule organization","score":0.9039999842643738},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9480000138282776},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/combination-cancer-therapy","display_name":"combination cancer therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8119999766349792},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.6679999828338623},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.8157730102539062},{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.7738252878189087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6006720066070557},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.49781012535095215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4852049648761749},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4676031172275543},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.42429038882255554},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.4210693836212158},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3879980444908142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3640170693397522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3359575867652893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22998753190040588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19954979419708252},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.18231913447380066},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15312302112579346},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001384","descriptor_name":"Azetidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001384","descriptor_name":"Azetidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054878","descriptor_name":"Lipoylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ebiom.2016.12.012","doi":"https://doi.org/10.1016/j.ebiom.2016.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2016.12.012","pdf_url":"http://www.ebiomedicine.com/article/S2352396416305916/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4329334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5474427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5474427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5474427","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Text"},{"id":"pmid:28159572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28159572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6f1c25fe440a4d5bb962bf5f6a378714","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f1c25fe440a4d5bb962bf5f6a378714","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2016.12.012","doi":"https://doi.org/10.1016/j.ebiom.2016.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2016.12.012","pdf_url":"http://www.ebiomedicine.com/article/S2352396416305916/pdf","source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2567412474.pdf","grobid_xml":"https://content.openalex.org/works/W2567412474.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1159211040","https://openalex.org/W1542077667","https://openalex.org/W1653018988","https://openalex.org/W1969460990","https://openalex.org/W1972462355","https://openalex.org/W1974374321","https://openalex.org/W1978442696","https://openalex.org/W1980036978","https://openalex.org/W1986234170","https://openalex.org/W1994215463","https://openalex.org/W1997243908","https://openalex.org/W2002573954","https://openalex.org/W2002723573","https://openalex.org/W2005089124","https://openalex.org/W2011491015","https://openalex.org/W2017093906","https://openalex.org/W2021882008","https://openalex.org/W2042553386","https://openalex.org/W2043002642","https://openalex.org/W2044515618","https://openalex.org/W2051555837","https://openalex.org/W2052543023","https://openalex.org/W2062785709","https://openalex.org/W2069116752","https://openalex.org/W2077181241","https://openalex.org/W2079725368","https://openalex.org/W2086038153","https://openalex.org/W2095707070","https://openalex.org/W2097259163","https://openalex.org/W2105460931","https://openalex.org/W2111275575","https://openalex.org/W2111724662","https://openalex.org/W2118408423","https://openalex.org/W2121369716","https://openalex.org/W2122304919","https://openalex.org/W2136429273","https://openalex.org/W2136558879","https://openalex.org/W2139126860","https://openalex.org/W2140584796","https://openalex.org/W2142080343","https://openalex.org/W2143030306","https://openalex.org/W2146033919","https://openalex.org/W2149840294","https://openalex.org/W2150684284","https://openalex.org/W2153178365","https://openalex.org/W2172052207","https://openalex.org/W2254239548","https://openalex.org/W2294090452","https://openalex.org/W2314067388","https://openalex.org/W2346299551","https://openalex.org/W2405951222","https://openalex.org/W2751111146","https://openalex.org/W6678086514"],"related_works":["https://openalex.org/W2504955763","https://openalex.org/W1489437124","https://openalex.org/W2095707070","https://openalex.org/W4388406467","https://openalex.org/W2395834915","https://openalex.org/W2563493392","https://openalex.org/W2596685101","https://openalex.org/W2403778795","https://openalex.org/W7100926355","https://openalex.org/W2058182609"],"abstract_inverted_index":{"Palmitate,":[0],"the":[1,139,181],"enzymatic":[2],"product":[3],"of":[4,58,69,114,134,138,148,153,164,178,186,199],"FASN,":[5],"and":[6,16,45,86,93,141,151,176,190],"palmitate-derived":[7],"lipids":[8],"support":[9,184],"cell":[10,73],"metabolism,":[11],"membrane":[12],"architecture,":[13],"protein":[14],"localization,":[15],"intracellular":[17],"signaling.":[18],"Tubulins":[19],"are":[20,25],"among":[21],"many":[22],"proteins":[23],"that":[24,34,145,171],"modified":[26],"post-translationally":[27],"by":[28],"acylation":[29],"with":[30,37,64,78,103],"palmitate.":[31],"We":[32],"show":[33],"FASN":[35,59,61,91,119,140,168,188],"inhibition":[36,62,68,92,120,147,177,189],"TVB-3166":[38],"or":[39,95],"TVB-3664":[40],"significantly":[41,104],"reduces":[42],"tubulin":[43,149],"palmitoylation":[44,150],"mRNA":[46],"expression.":[47],"Disrupted":[48],"microtubule":[49,154],"organization":[50,155],"in":[51,70,112,127,156],"tumor":[52,72,88,101,116,157,165],"cells":[53,166],"is":[54],"an":[55],"additional":[56],"consequence":[57],"inhibition.":[60],"combined":[63,187],"taxane":[65,125,142,191],"treatment":[66,77,192],"enhances":[67],"vitro":[71],"growth":[74,102],"compared":[75],"to":[76,98,167],"either":[79],"agent":[80],"alone.":[81],"In":[82],"lung,":[83],"ovarian,":[84],"prostate,":[85],"pancreatic":[87],"xenograft":[89,100,117],"studies,":[90],"paclitaxel":[94],"docetaxel":[96],"combine":[97],"inhibit":[99],"enhanced":[105,135],"anti-tumor":[106,136],"activity.":[107],"Tumor":[108],"regression":[109],"was":[110],"observed":[111],"3":[113],"6":[115],"models.":[118],"does":[121],"not":[122],"affect":[123],"cellular":[124],"concentration":[126],"vitro.":[128],"Our":[129],"data":[130],"suggest":[131],"a":[132,162,194,197],"mechanism":[133],"activity":[137],"drug":[143],"combination":[144],"includes":[146],"disruption":[152],"cells,":[158],"as":[159,161,193],"well":[160],"sensitization":[163],"inhibition-mediated":[169],"effects":[170],"include":[172],"gene":[173],"expression":[174],"changes":[175],"\u03b2-catenin.":[179],"Together,":[180],"results":[182],"strongly":[183],"investigation":[185],"therapy":[195],"for":[196],"variety":[198],"human":[200],"cancers.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
