{"id":"https://openalex.org/W2566700772","doi":"https://doi.org/10.1016/s1525-0016(16)33299-3","title":"490. Electroporation-Mediated Gene Transfer of Caveolin-1 Protects from Bleomycin-Induced Pulmonary Fibrosis Through Regulating Activation of Inflammasome","display_name":"490. Electroporation-Mediated Gene Transfer of Caveolin-1 Protects from Bleomycin-Induced Pulmonary Fibrosis Through Regulating Activation of Inflammasome","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2566700772","doi":"https://doi.org/10.1016/s1525-0016(16)33299-3","mag":"2566700772"},"language":"en","primary_location":{"id":"doi:10.1016/s1525-0016(16)33299-3","doi":"https://doi.org/10.1016/s1525-0016(16)33299-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1525-0016(16)33299-3","pdf_url":"http://www.cell.com/article/S1525001616332993/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001616332993/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102999810","display_name":"Xin Lin","orcid":"https://orcid.org/0000-0003-1376-3456","observed_orcids":["https://orcid.org/0000-0003-1376-3456"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Lin","raw_affiliation_strings":["School of Medicine and Dentistry, University of Rochester, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Dentistry, University of Rochester, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055586514","display_name":"Michael Barravecchia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Barravecchia","raw_affiliation_strings":["School of Medicine and Dentistry, University of Rochester, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Dentistry, University of Rochester, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017939101","display_name":"David A. Dean","orcid":"https://orcid.org/0000-0001-7748-8073","observed_orcids":["https://orcid.org/0000-0001-7748-8073"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Dean","raw_affiliation_strings":["School of Medicine and Dentistry, University of Rochester, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Dentistry, University of Rochester, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23704081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"S194","last_page":"S194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.8629999756813049},{"id":"https://openalex.org/keywords/inflammasome-activation","display_name":"inflammasome activation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.8050000071525574},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7638708353042603},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.7468087673187256},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.580088198184967},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.568648099899292},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5663431882858276},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5393187403678894},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5153971910476685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4573918581008911},{"id":"https://openalex.org/C2780870201","wikidata":"https://www.wikidata.org/wiki/Q17855958","display_name":"Caveolin 1","level":2,"score":0.44661372900009155},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42663976550102234},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4181879758834839},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.4174475073814392},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4125252962112427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3882392644882202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33926647901535034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3166249096393585},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2903771996498108},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28093165159225464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1726948320865631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08255317807197571},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1525-0016(16)33299-3","doi":"https://doi.org/10.1016/s1525-0016(16)33299-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1525-0016(16)33299-3","pdf_url":"http://www.cell.com/article/S1525001616332993/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s1525-0016(16)33299-3","doi":"https://doi.org/10.1016/s1525-0016(16)33299-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1525-0016(16)33299-3","pdf_url":"http://www.cell.com/article/S1525001616332993/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2566700772.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2996402389","https://openalex.org/W2169928292","https://openalex.org/W1566699518","https://openalex.org/W4382751177","https://openalex.org/W2113443763","https://openalex.org/W2112871329","https://openalex.org/W2331228735","https://openalex.org/W2163348373","https://openalex.org/W1634403590","https://openalex.org/W2001080768"],"abstract_inverted_index":{"Pulmonary":[0],"fibrosis":[1],"(PF)":[2],"is":[3,17,49,55,71],"a":[4,56,61,72,229],"progressive":[5],"chronic":[6],"interstitial":[7],"lung":[8,34,64,144],"disease":[9],"associated":[10,194],"with":[11,187,195],"high":[12],"morbidity":[13],"and":[14,26,41,77,154,162,172,208,215],"mortality.":[15],"It":[16],"characterized":[18],"by":[19,113,127,151,201],"increased":[20],"deposition":[21],"of":[22,29,44,63,75,87,130,140,157,170,184,198,205,220,234],"extracellular":[23],"matrix":[24],"proteins":[25],"the":[27,33,42,85,114,143,155,199,203],"accumulation":[28,43],"scar":[30],"tissue":[31],"in":[32,84,176,211],"interstitium,":[35],"resulting":[36],"from":[37,103,147],"alveolar":[38],"epithelial":[39],"injury":[40],"inflammatory":[45],"cells.":[46],"Currently,":[47],"there":[48],"no":[50],"effective":[51],"therapy.":[52],"Gene":[53],"therapy":[54],"promising":[57],"approach":[58],"to":[59,142],"treat":[60],"variety":[62],"diseases,":[65],"including":[66],"pulmonary":[67,95,105,235],"fibrosis.":[68,96,236],"Caveolin-1":[69],"(Cav-1)":[70],"major":[73],"component":[74],"caveolae,":[76],"has":[78],"been":[79],"found":[80,135,167],"greatly":[81],"reduced":[82,196],"expression":[83,156,204],"lungs":[86],"PF":[88,119],"patients.":[89],"Moreover,":[90],"Cav-1-deficient":[91],"mice":[92],"develop":[93],"spontaneous":[94],"To":[97],"investigate":[98],"if":[99],"Cav-1":[100,111,141,185,226],"can":[101],"protect":[102],"bleomycin-induced":[104],"fibrosis,":[106],"we":[107],"delivered":[108],"plasmids":[109],"expressing":[110],"driven":[112],"ubiquitin":[115],"promoter":[116],"using":[117],"electroporation.":[118],"was":[120,193],"induced":[121],"2":[122],"days":[123],"after":[124,181,218],"gene":[125,138,182],"transfer":[126,139,183],"intratracheal":[128],"administration":[129],"bleomycin":[131],"(2":[132],"unit/kg).":[133],"We":[134,165],"that":[136,225],"electroporation-mediated":[137],"significantly":[145],"protected":[146],"subsequent":[148],"bleomycin-mediated":[149],"fibrogenesis":[150],"histological":[152],"analysis":[153],"alpha-smooth":[158],"muscle":[159],"actin":[160],"(alpha-SMA)":[161],"collagen":[163],"measurement.":[164],"also":[166],"attenuated":[168],"recruitment":[169],"neutrophils":[171],"monocytes":[173],"and/or":[174],"macrophages":[175],"bronchoalveolar":[177],"lavage":[178],"(BAL)":[179],"fluid":[180],"compared":[186],"vector":[188],"control.":[189],"The":[190],"underlying":[191],"mechanism":[192],"activation":[197],"inflammasome":[200],"determining":[202],"cleaved":[206],"caspase-1":[207],"IL-1":[209],"beta":[210],"both":[212],"mouse":[213],"models":[214],"cultured":[216],"cells":[217],"overexpression":[219],"Cav-1.":[221],"These":[222],"results":[223],"demonstrate":[224],"might":[227],"be":[228],"potential":[230],"target":[231],"for":[232],"treatment":[233]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-01-06T00:00:00"}
