{"id":"https://openalex.org/W2566624343","doi":"https://doi.org/10.1182/blood.v110.11.2019.2019","title":"Outcomes in the Recent Seattle Cord Blood Experience: Low TRM and Relapse; High Mild Acute GVHD and CMV Reactivation.","display_name":"Outcomes in the Recent Seattle Cord Blood Experience: Low TRM and Relapse; High Mild Acute GVHD and CMV Reactivation.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2566624343","doi":"https://doi.org/10.1182/blood.v110.11.2019.2019","mag":"2566624343"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.2019.2019","doi":"https://doi.org/10.1182/blood.v110.11.2019.2019","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2019.2019","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041615072","display_name":"Jonathan Aaron Gutman","orcid":"https://orcid.org/0000-0002-1470-0716","observed_orcids":["https://orcid.org/0000-0002-1470-0716"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Gutman","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045176208","display_name":"Ann E. Woolfrey","orcid":"https://orcid.org/0000-0001-7222-3607","observed_orcids":["https://orcid.org/0000-0001-7222-3607"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann E. Woolfrey","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056405520","display_name":"Frederick R. Appelbaum","orcid":"https://orcid.org/0000-0002-1839-5069","observed_orcids":["https://orcid.org/0000-0002-1839-5069"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick R. Appelbaum","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084915025","display_name":"Brenda M. Sandmaier","orcid":"https://orcid.org/0000-0002-9767-9739","observed_orcids":["https://orcid.org/0000-0002-9767-9739"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda M. Sandmaier","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103391116","display_name":"Jean E. Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean E. Sanders","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025632410","display_name":"Colleen S. Delaney","orcid":"https://orcid.org/0000-0002-1044-2801","observed_orcids":["https://orcid.org/0000-0002-1044-2801"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Delaney","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Medicine and Pediatrics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medicine and Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36367432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"2019","last_page":"2019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/double-cord-blood-transplantation","display_name":"double cord blood transplantation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/graft-versus-malignancy-effect","display_name":"graft-versus-malignancy effect","score":0.9079999923706055},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cytomegalovirus-reactivation","display_name":"cytomegalovirus reactivation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hla-matching","display_name":"HLA matching","score":0.6299999952316284},{"id":"https://openalex.org/keywords/total-nucleated-cell-dose","display_name":"total nucleated cell dose","score":0.7950000166893005},{"id":"https://openalex.org/keywords/reduced-intensity-conditioning","display_name":"reduced-intensity conditioning","score":0.8180000185966492},{"id":"https://openalex.org/keywords/myeloablative-conditioning","display_name":"myeloablative conditioning","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8323512673377991},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.7298897504806519},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.7173521518707275},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5959029793739319},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5085715055465698},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.5082547068595886},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5046252012252808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47983404994010925},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43513673543930054},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4340079426765442},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4250495135784149},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1976710557937622},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.2019.2019","doi":"https://doi.org/10.1182/blood.v110.11.2019.2019","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2019.2019","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417001856","https://openalex.org/W7127448803","https://openalex.org/W2553859648","https://openalex.org/W2574972294","https://openalex.org/W2660757502","https://openalex.org/W2563891917","https://openalex.org/W2007489685","https://openalex.org/W2558633850","https://openalex.org/W2514823367","https://openalex.org/W4389222122"],"abstract_inverted_index":{"Abstract":[0],"Studies":[1],"of":[2,5,64,67,103,110,134,229,324,356,370,378,415,432,447,466,478,517,530,536],"simultaneous":[3],"transplantation":[4,20,190],"two":[6,276,283,301,537],"cord":[7,18],"blood":[8,19],"units":[9,104,123,277,284,302,311,539,545],"have":[10,96,358,455,473,498],"suggested":[11],"that":[12,115],"as":[13,36,38,74,76,267],"compared":[14,69],"to":[15,70,100,237,317,402,406,421],"single":[16,71,116,269],"unit":[17,72,117,271,295],"(CBT),":[21],"increased":[22,65],"cell":[23,89,131],"dose":[24,90,133,548],"may":[25],"overcome":[26],"graft":[27,411],"rejection":[28],"and":[29,52,82,153,200,222,249,259,261,292,300,348,373,385,393,410,460,486,520,546,550],"improve":[30],"survival,":[31],"particularly":[32],"in":[33,79,88,105,166,239,376,468],"mismatched":[34],"CBT,":[35,73],"well":[37,75],"enhance":[39],"the":[40,62,86,227,240,512,528,534],"graft-versus-malignancy":[41],"effect.":[42],"Successful":[43],"double":[44,93,309],"CBT":[45,111,118,159,310],"has":[46],"been":[47],"reported":[48,482],"following":[49,191,217],"both":[50],"myeloablative":[51,189,346],"reduced":[53],"intensity":[54],"(RIT)":[55],"conditioning.":[56],"However,":[57],"several":[58],"concerns":[59],"remain,":[60],"including":[61],"possibility":[63],"incidence":[66,465,477],"GVHD":[68,245,480,492],"persistent":[77],"delays":[78],"hematopoietic":[80],"recovery":[81],"immune":[83],"reconstitution":[84],"despite":[85],"increase":[87],"achieved":[91],"by":[92,427],"CBT.":[94],"We":[95,472],"used":[97],"an":[98],"algorithm":[99,532],"guide":[101],"selection":[102],"our":[106,531],"most":[107],"recent":[108],"cohort":[109],"patients":[112,506],"(pts),":[113],"such":[114],"is":[119,335,339,366],"allowed":[120],"only":[121],"for":[122,125,141,160,257,264,272,279,286,296,304,418,490,514,533,540],"matched":[124,140,316,544],"5/6":[126,270,285,294,549],"HLA":[127,143,543],"with":[128,144,171,176,193,226,345],"total":[129,201],"nucleated":[130],"(TNC)":[132],"at":[135,146,313,429,483],"least":[136,147,314],"4.0":[137],"\u00d7107/kg":[138],"or":[139],"6/6":[142,303,551],"TNC":[145],"3.0":[148],"\u00d7107/kg.":[149],"Between":[150],"February":[151],"2006":[152],"June":[154],"2007,":[155],"22":[156,379,433],"pts":[157,181,208,274,281,288,298,329,343,357,380,398,416,440],"underwent":[158,188,215],"high":[161,262],"risk":[162],"hematologic":[163],"malignancies":[164],"(21":[165],"complete":[167],"morphologic":[168],"remission,":[169],"8":[170],"minimal":[172],"residual":[173],"disease,":[174],"1":[175],"active":[177],"mycosis":[178],"fungoides).":[179],"Fourteen":[180],"median":[182,209,322,431],"age":[183,210],"20.5":[184],"years":[185,212],"(range":[186,213,330,435],"0.6\u201342)":[187],"conditioning":[192,347],"fludarabine":[194],"(FLU)":[195],"75mg/m2,":[196],"cyclophosphamide":[197],"(CY)":[198],"120mg/kg,":[199],"body":[202],"irradiation":[203],"(TBI)":[204],"13.2":[205],"GY.":[206],"Eight":[207],"52.5":[211],"24\u201368)":[214],"RIT":[216,352],"FLU":[218],"200mg/m2,":[219],"CY":[220],"50mg/kg,":[221],"TBI":[223],"2":[224],"GY":[225],"addition":[228],"ATG":[230],"90mg/kg":[231],"if":[232],"there":[233],"was":[234,247,266,444],"no":[235],"exposure":[236],"chemotherapy":[238],"three":[241,273,287,297],"months":[242],"preceding":[243],"transplant.":[244],"prophylaxis":[246],"cyclosporine":[248],"MMF.":[250],"Donor-recipient":[251],"matching":[252],"based":[253],"on":[254],"intermediate":[255],"resolution":[256,263],"HLA-A":[258],"B":[260],"HLA-DRB1":[265],"follows:":[268],"(14%),":[275,289,299],"4/6":[278,291,315,542],"12":[280],"(55%),":[282],"one":[290,293,305,445],"patient":[306],"(5%).":[307],"All":[308],"were":[312],"each":[318],"other.":[319],"At":[320],"a":[321,430,461,469,475,479],"follow-up":[323],"243":[325],"days":[326,434],"among":[327,342,351],"surviving":[328],"71\u2013451),":[331],"overall":[332],"survival":[333],"(OS)":[334],"77%":[336],"(17/22).":[337],"OS":[338],"93%":[340],"(13/14)":[341],"treated":[344],"50%":[349],"(4/8)":[350],"pts.":[353],"14%":[354],"(3/22)":[355],"relapsed.":[359],"Day":[360],"100":[361],"transplant":[362,422],"related":[363],"mortality":[364],"(TRM)":[365],"5%":[367],"(1/22).":[368],"Incidence":[369],"grade":[371],"II\u2013IV":[372],"III\u2013IV":[374],"aGVHD":[375],"19":[377],"who":[381],"had":[382],"sustained":[383],"engraftment":[384],"survived":[386],"past":[387],"day":[388],"30":[389],"are":[390,399],"89%":[391],"(17/19)":[392],"26%":[394],"(5/19)":[395],"respectively.":[396],"Three":[397],"non-evaluable":[400],"due":[401],"septic":[403],"death":[404],"prior":[405,420],"engraftment,":[407],"early":[408,458,509],"relapse,":[409],"failure.":[412],"100%":[413],"(11/11)":[414],"seropositive":[417,505],"CMV":[419,424,449,508,518],"developed":[423,441],"reactivation":[425,519],"measured":[426],"PCR":[428],"3\u201339).":[436],"No":[437],"(0/11)":[438],"seronegative":[439],"CMV.":[442],"There":[443],"case":[446],"non-fatal":[448],"pneumonitis.":[450],"Using":[451],"this":[452],"strategy,":[453],"we":[454,497],"observed":[456,499],"limited":[457],"TRM":[459],"lower":[462],"than":[463,481],"expected":[464],"relapse":[467],"high-risk":[470],"population.":[471],"seen":[474],"higher":[476],"other":[484],"centers,":[485],"long":[487],"term":[488],"monitoring":[489,516],"chronic":[491],"will":[493,526],"be":[494],"important.":[495],"Though":[496],"few":[500],"significant":[501],"infectious":[502],"complications,":[503],"all":[504,541],"reactivated":[507],"post-transplant,":[510],"emphasizing":[511],"need":[513],"close":[515],"improved":[521],"treatment":[522],"strategies.":[523],"Ongoing":[524],"experience":[525],"confirm":[527],"efficacy":[529],"use":[535],"CB":[538],"low":[547],"units.":[552]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-01-06T00:00:00"}
