{"id":"https://openalex.org/W2566055064","doi":"https://doi.org/10.1158/1538-7445.panca16-b80","title":"Abstract B80: Stroma in pancreatic cancer: Automated quantification and its prognostic significance","display_name":"Abstract B80: Stroma in pancreatic cancer: Automated quantification and its prognostic significance","publication_year":2016,"publication_date":"2016-12-14","ids":{"openalex":"https://openalex.org/W2566055064","doi":"https://doi.org/10.1158/1538-7445.panca16-b80","mag":"2566055064"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca16-b80","doi":"https://doi.org/10.1158/1538-7445.panca16-b80","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca16-b80","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009029114","display_name":"Robert J. Torphy","orcid":"https://orcid.org/0000-0003-3941-0886","observed_orcids":["https://orcid.org/0000-0003-3941-0886"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Torphy","raw_affiliation_strings":["1University of Colorado, Denver, CO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Colorado, Denver, CO,","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073378127","display_name":"Naim U. Rashid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashid Naim","raw_affiliation_strings":["2University of North Carolina, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074052706","display_name":"Bentley R. Midkiff","orcid":"https://orcid.org/0000-0002-6565-9055","observed_orcids":["https://orcid.org/0000-0002-6565-9055"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bentley Midkiff","raw_affiliation_strings":["2University of North Carolina, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051390078","display_name":"Keith A. Volmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Volmar","raw_affiliation_strings":["2University of North Carolina, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035793503","display_name":"Eric Andrew Collisson","orcid":"https://orcid.org/0000-0001-8037-9388","observed_orcids":["https://orcid.org/0000-0001-8037-9388","https://orcid.org/0000-0002-2829-355X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Collisson","raw_affiliation_strings":["3University of California, San Franscisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of California, San Franscisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065098287","display_name":"Jen Jen Yeh","orcid":"https://orcid.org/0000-0003-2542-6211","observed_orcids":["https://orcid.org/0000-0003-2542-6211"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen Jen Yeh","raw_affiliation_strings":["2University of North Carolina, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"24_Supplement","first_page":"B80","last_page":"B80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/automated-image-analysis","display_name":"automated image analysis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8240000009536743},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.968999981880188},{"id":"https://openalex.org/keywords/pancreaticoduodenectomy","display_name":"pancreaticoduodenectomy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/h-e-staining","display_name":"H&E staining","score":0.6359999775886536},{"id":"https://openalex.org/keywords/inflammatory-cell-infiltration","display_name":"inflammatory cell infiltration","score":0.5559999942779541},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.421999990940094},{"id":"https://openalex.org/keywords/treatment-goals","display_name":"treatment goals","score":0.33899998664855957},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.4390000104904175},{"id":"https://openalex.org/keywords/image-segmentation-algorithm","display_name":"image segmentation algorithm","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.7251724004745483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6580241918563843},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5918681621551514},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5302445888519287},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.5236272811889648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.511508584022522},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5108699202537537},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4852478504180908},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.47533416748046875},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4419211447238922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4385024607181549},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4231034517288208},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2714998722076416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15170472860336304},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca16-b80","doi":"https://doi.org/10.1158/1538-7445.panca16-b80","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca16-b80","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2601705175","https://openalex.org/W4320081516","https://openalex.org/W7124830069","https://openalex.org/W2783150380","https://openalex.org/W3059263535","https://openalex.org/W7171936880","https://openalex.org/W2590000420","https://openalex.org/W4386352178","https://openalex.org/W4398162673","https://openalex.org/W4386444496"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"stroma":[2,164,393],"(TS)":[3],"is":[4,22,388],"a":[5,52,274,284,293,346,359],"cardinal":[6],"component":[7],"of":[8,18,31,46,69,76,108,205,278,308,318,342,348,375,378,397,428],"pancreatic":[9,417],"ductal":[10],"adenocarcinoma":[11],"(PDAC);":[12],"it":[13],"comprises":[14],"60":[15],"to":[16,50,64,88,118,130,149,177,357,390],"90%":[17],"tumor":[19,78,109,138,163,168,193,382],"volume":[20],"and":[21,40,63,90,99,106,141,182,197,202,223,233,238,249,253,298,315,421,439],"an":[23,126,265],"emerging":[24],"treatment":[25,396],"target.":[26],"There":[27],"are":[28],"conflicting":[29],"reports":[30],"the":[32,66,132,145,151,227,243,376,395,429],"role":[33],"that":[34],"TS":[35,60,379],"plays":[36],"in":[37,71,155,326,336,364,367,380,394,416,437],"disease":[38],"progression":[39,383],"its":[41,422],"prognostic":[42,67,362,423],"significance.":[43,424],"The":[44,323],"objective":[45,316],"this":[47,258],"study":[48,328],"was":[49,110,128,147,160,175,213,217,235,251,291,334],"develop":[51],"high-throughput,":[53],"operator":[54],"independent":[55,361],"method":[56],"for":[57,84,190,306,311],"objectively":[58],"quantifying":[59],"density":[61],"(TSD)":[62],"evaluate":[65],"significance":[68],"TSD":[70,159,188,212,216,229,245,277,297,309,325,347,356],"resected":[72,365],"tumors.":[73],"Tissue":[74],"sections":[75],"primary":[77],"from":[79,86],"126":[80],"patients":[81,261,368],"undergoing":[82],"pancreaticoduodenectomy":[83],"PDAC":[85,321,343],"1979":[87],"2008":[89],"followed":[91],"by":[92],"observation":[93],"only":[94],"were":[95,103,116,262],"stained":[96,320],"with":[97,220,264,283,338],"hematoxylin":[98],"eosin":[100],"(H&E).":[101],"Sections":[102],"digitally":[104],"uploaded":[105],"location":[107],"annotated":[111],"using":[112,330],"ImageScope.":[113],"Annotated":[114],"images":[115],"imported":[117],"Definiens":[119],"Architect.":[120],"By":[121],"training":[122],"on":[123,433],"representative":[124],"areas,":[125],"algorithm":[127,146,305,333],"created":[129],"segment":[131],"tissue":[133,157],"into":[134],"different":[135],"regions-of-interest":[136],"(ROI):":[137],"epithelium,":[139],"TS,":[140],"inflammatory":[142],"infiltrate.":[143],"Next,":[144],"used":[148,176],"quantify":[150],"above":[152],"described":[153],"ROIs":[154],"each":[156],"section.":[158],"calculated":[161],"as":[162],"area":[165],"over":[166],"total":[167],"area.":[169],"A":[170],"cox":[171],"proportional":[172],"hazards":[173],"model":[174],"compare":[178],"overall":[179,198],"survival":[180,185,285],"(OS)":[181],"recurrence":[183],"free":[184],"(RFS)":[186],"vs":[187,384],"controlling":[189],"age,":[191],"sex,":[192],"grade,":[194],"T,":[195],"N,":[196],"stage,":[199],"smoking":[200],"status,":[201],"American":[203],"Society":[204],"Anesthesia":[206],"(ASA)":[207],"physical":[208],"classification":[209],"score.":[210],"Median":[211],"0.637.":[214],"High":[215],"significantly":[218],"associated":[219],"RFS":[221,232,248],"(p=0.043)":[222],"OS":[224,234,250,266,300],"(p=0.037).":[225],"In":[226,242,257],"low":[228],"group,":[230,246],"median":[231,247,276,324],"8.9":[236],"months":[237],"11.5":[239],"months,":[240,255],"respectively.":[241,256],"high":[244,296,312,355],"13.9":[252],"18.3":[254],"cohort,":[259],"18":[260],"identified":[263],"greater":[267,286,349],"than":[268,287,350],"5":[269,288],"years.":[270],"This":[271],"cohort":[272],"had":[273],"higher":[275],"0.71.":[279],"After":[280],"excluding":[281],"those":[282],"years,":[289],"there":[290],"still":[292],"trend":[294],"toward":[295],"worse":[299],"(p=0.052).":[301],"Our":[302],"novel":[303,332],"automated":[304],"quantification":[307,420],"allows":[310],"throughput,":[313],"reproducible,":[314],"analysis":[317],"H&E":[319],"slides.":[322],"our":[327,331],"obtained":[329],"0.637,":[335],"agreement":[337],"prior":[339],"manual":[340],"descriptions":[341],"tumors":[344,366],"having":[345],"60%.":[351],"We":[352],"also":[353],"found":[354],"be":[358],"positive":[360],"variable":[363],"not":[369],"receiving":[370],"adjuvant":[371],"therapy.":[372],"Further":[373],"understanding":[374],"balance":[377],"restraining":[381],"impeding":[385],"chemotherapeutic":[386],"delivery":[387],"needed":[389],"successfully":[391],"manipulate":[392],"PDAC.":[398],"Citation":[399],"Format:":[400],"Robert":[401],"J.":[402],"Torphy,":[403],"Rashid":[404],"Naim,":[405],"Bentley":[406],"Midkiff,":[407],"Keith":[408],"Volmar,":[409],"Eric":[410],"Collisson,":[411],"Jen":[412,413],"Yeh.{Authors}.":[414],"Stroma":[415],"cancer:":[418],"Automated":[419],"[abstract].":[425],"In:":[426],"Proceedings":[427],"AACR":[430],"Special":[431],"Conference":[432],"Pancreatic":[434],"Cancer:":[435],"Advances":[436],"Science":[438],"Clinical":[440],"Care;":[441],"2016":[442],"May":[443],"12-15;":[444],"Orlando,":[445],"FL.":[446],"Philadelphia":[447],"(PA):":[448],"AACR;":[449],"Cancer":[450],"Res":[451],"2016;76(24":[452],"Suppl):Abstract":[453],"nr":[454],"B80.":[455]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-01-06T00:00:00"}