{"id":"https://openalex.org/W2566041655","doi":"https://doi.org/10.1158/1538-7445.am2015-3300","title":"Abstract 3300: Concerted epigenetic and signaling mechanisms regulate normal stem cell radiosensitivity","display_name":"Abstract 3300: Concerted epigenetic and signaling mechanisms regulate normal stem cell radiosensitivity","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2566041655","doi":"https://doi.org/10.1158/1538-7445.am2015-3300","mag":"2566041655"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-3300","doi":"https://doi.org/10.1158/1538-7445.am2015-3300","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3300","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008200566","display_name":"Keith M. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith M. Jacobs","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009449249","display_name":"Sandeep Misri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandeep Misri","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Barbara Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Meyer","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065709816","display_name":"Suyash Raj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suyash Raj","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058094959","display_name":"Cheri L. Zobel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheri L. Zobel","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000388529","display_name":"Barry P. Sleckman","orcid":"https://orcid.org/0000-0001-8295-4462","observed_orcids":["https://orcid.org/0000-0001-8295-4462"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry P. Sleckman","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008423688","display_name":"Dennis E. Hallahan","orcid":"https://orcid.org/0000-0002-1668-8159","observed_orcids":["https://orcid.org/0000-0002-1668-8159"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis E. Hallahan","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070695256","display_name":"Girdhar G. Sharma","orcid":"https://orcid.org/0000-0003-1420-5579","observed_orcids":["https://orcid.org/0000-0003-1420-5579"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girdhar G. Sharma","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"3300","last_page":"3300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.08460000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-stem-cells","display_name":"normal stem cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8080000281333923},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/histone-h3-lysine-56-acetylation","display_name":"histone H3 lysine 56 acetylation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/radiation-induced-apoptosis","display_name":"radiation-induced apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/normal-tissue-damage","display_name":"normal tissue damage","score":0.7099999785423279},{"id":"https://openalex.org/keywords/radiotherapy-complications","display_name":"radiotherapy complications","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7907568216323853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6536148190498352},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.5858725309371948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5518805980682373},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5342084169387817},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5048704743385315},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.48765408992767334},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.4713159203529358},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46753546595573425},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4661489725112915},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42160555720329285},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.41533878445625305},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30024686455726624},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2598300576210022},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.2473745346069336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19668123126029968},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.14977407455444336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12090277671813965},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.07913997769355774},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07756307721138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06336599588394165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-3300","doi":"https://doi.org/10.1158/1538-7445.am2015-3300","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3300","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W915545873","https://openalex.org/W2332766086","https://openalex.org/W2905410927","https://openalex.org/W2330971347","https://openalex.org/W2799389516","https://openalex.org/W2020374784","https://openalex.org/W2565850957","https://openalex.org/W2563021519","https://openalex.org/W2071007497","https://openalex.org/W2334878072"],"abstract_inverted_index":{"Abstract":[0],"Side":[1],"effects":[2],"resulting":[3],"from":[4],"ionizing":[5],"radiation":[6],"(IR)":[7],"during":[8],"cancer":[9],"radiotherapy":[10],"often":[11],"involve":[12],"normal":[13,35,67,94,140,204,261],"tissue":[14,19,26],"injury":[15],"including":[16],"depletion":[17],"of":[18,49,60,96,101,121,133,158,171,178,214,230,268,273],"regenerative":[20],"capacity.":[21],"Utilizing":[22],"multiple":[23],"in":[24,80,85,110,139,212],"vivo":[25,81],"niches":[27],"and":[28,46,87,175,191,197,216,226,257],"cell":[29,57,173,183,224,263],"culture":[30],"models,":[31],"we":[32],"demonstrate":[33],"that":[34,66,194],"stem":[36,50,68,111,127,141,172,182,205,223,262],"cells":[37,51,69,114,128,142],"are":[38,44,115],"highly":[39],"radiosensitive":[40],"while":[41],"differentiated":[42],"progeny":[43],"radioresistant,":[45],"IR-induced":[47,78,222],"apoptosis":[48],"is":[52,108,143],"observed":[53],"broadly":[54],"throughout":[55],"the":[56,73,203,228,269,274],"cycle":[58],"independent":[59],"proliferation":[61],"status.":[62],"Our":[63],"study":[64],"demonstrates":[65],"fail":[70],"to":[71,117,155,202,220],"activate":[72],"DDR,":[74],"do":[75],"not":[76],"display":[77],"foci":[79],"as":[82,84,168],"well":[83],"culture,":[86],"exhibit":[88],"severely":[89],"attenuated":[90],"DNA":[91,97,105],"repair.":[92],"Despite":[93],"sensing":[95],"breaks,":[98],"recruitment/":[99],"retention":[100,157],"repair":[102,134,159],"factors":[103],"at":[104],"break":[106,124],"sites":[107],"repressed":[109],"cells.":[112,206],"Stem":[113],"unable":[116],"eliminate":[118],"constitutive":[119],"phosphorylation":[120],"H2AX-Y142":[122],"around":[123],"sites,":[125],"abetting":[126],"toward":[129],"an":[130],"apoptotic":[131],"instead":[132],"pathway.":[135],"The":[136],"abrogated":[137],"DDR":[138],"associated":[144],"with":[145],"a":[146],"constitutively":[147],"enhanced":[148],"histone-3":[149],"lysine-56":[150],"acetylation,":[151],"which":[152],"epigenetically":[153],"contributes":[154],"muted":[156],"factors.":[160],"Reinforced":[161],"PP2A":[162],"phosphatase":[163,179],"expression":[164],"was":[165],"also":[166],"identified":[167],"substantial":[169],"regulators":[170],"radiosensitivity":[174],"transient":[176],"inhibition":[177],"activity":[180],"restores":[181],"survival.":[184],"We":[185],"thus":[186],"identify":[187],"pluralistic":[188],"interacting":[189],"molecular":[190],"epigenetic":[192,256],"mechanisms":[193,259],"collectively":[195],"control":[196],"impart":[198],"IR":[199],"hypersensitive":[200],"phenotype":[201],"These":[207],"insights":[208],"will":[209],"be":[210],"crucial":[211],"development":[213],"prevention":[215],"intervention":[217],"therapeutic":[218],"strategies":[219],"minimize":[221],"dropout":[225],"increase":[227],"efficacy":[229],"radiotherapy.":[231],"Citation":[232],"Format:":[233],"Keith":[234],"M.":[235],"Jacobs,":[236],"Sandeep":[237],"Misri,":[238],"Barbara":[239],"Meyer,":[240],"Suyash":[241],"Raj,":[242],"Cheri":[243],"L.":[244],"Zobel,":[245],"Barry":[246],"P.":[247],"Sleckman,":[248],"Dennis":[249],"E.":[250],"Hallahan,":[251],"Girdhar":[252],"G.":[253],"Sharma.":[254],"Concerted":[255],"signaling":[258],"regulate":[260],"radiosensitivity.":[264],"[abstract].":[265],"In:":[266],"Proceedings":[267],"106th":[270],"Annual":[271],"Meeting":[272],"American":[275],"Association":[276],"for":[277],"Cancer":[278,288],"Research;":[279],"2015":[280],"Apr":[281],"18-22;":[282],"Philadelphia,":[283],"PA.":[284],"Philadelphia":[285],"(PA):":[286],"AACR;":[287],"Res":[289],"2015;75(15":[290],"Suppl):Abstract":[291],"nr":[292],"3300.":[293],"doi:10.1158/1538-7445.AM2015-3300":[294]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2017-01-06T00:00:00"}
