{"id":"https://openalex.org/W2565885331","doi":"https://doi.org/10.1182/blood.v126.23.2617.2617","title":"Non-Functional (\"haploinsufficient\"), but Not Dominant Negative Clonal IKZF1 Deletions Confer an Adverse Prognosis in Adult BCR-ABL-Negative Acute Lymphoblastic Leukemia","display_name":"Non-Functional (\"haploinsufficient\"), but Not Dominant Negative Clonal IKZF1 Deletions Confer an Adverse Prognosis in Adult BCR-ABL-Negative Acute Lymphoblastic Leukemia","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2565885331","doi":"https://doi.org/10.1182/blood.v126.23.2617.2617","mag":"2565885331"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.2617.2617","doi":"https://doi.org/10.1182/blood.v126.23.2617.2617","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.2617.2617","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004037716","display_name":"Benjamin Kobitzsch","orcid":"https://orcid.org/0000-0001-7327-2785","observed_orcids":["https://orcid.org/0000-0001-7327-2785"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benjamin Kobitzsch","raw_affiliation_strings":["Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067318724","display_name":"Nicola G\u00f6kbuget","orcid":"https://orcid.org/0000-0003-2291-8245","observed_orcids":["https://orcid.org/0000-0003-2291-8245"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicola G\u00f6kbuget","raw_affiliation_strings":["Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039023052","display_name":"Stefan Schwartz","orcid":"https://orcid.org/0000-0001-8833-5793","observed_orcids":["https://orcid.org/0000-0001-8833-5793"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Schwartz","raw_affiliation_strings":["Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048553869","display_name":"Richard Reinhardt","orcid":"https://orcid.org/0000-0001-9376-2132","observed_orcids":["https://orcid.org/0000-0001-9376-2132"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard Reinhardt","raw_affiliation_strings":["Max Planck Genome Center Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Genome Center Cologne, Cologne, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075073484","display_name":"Monika Br\u00fcggemann","orcid":"https://orcid.org/0000-0001-5514-5010","observed_orcids":["https://orcid.org/0000-0001-5514-5010"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Monika Brueggemann","raw_affiliation_strings":["Department of Hematology, University Hospital Schleswig-Holstein, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital Schleswig-Holstein, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067716137","display_name":"Andreas Viardot","orcid":"https://orcid.org/0000-0001-9593-6327","observed_orcids":["https://orcid.org/0000-0001-9593-6327"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Viardot","raw_affiliation_strings":["Med. Dept. III (Hematology, Oncology), Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Med. Dept. III (Hematology, Oncology), Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088238455","display_name":"Ralph W\u00e4sch","orcid":"https://orcid.org/0000-0002-0813-3444","observed_orcids":["https://orcid.org/0000-0002-0813-3444"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralph W\u00e4sch","raw_affiliation_strings":["Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058842632","display_name":"Michael Starck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091445","display_name":"M\u00fcnchen Klinik Schwabing","ror":"https://ror.org/002bjfj29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210091445","https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Starck","raw_affiliation_strings":["Dept. of Hematology, Klinikum M\u00fcnchen-Schwabing, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Hematology, Klinikum M\u00fcnchen-Schwabing, Munich, Germany","institution_ids":["https://openalex.org/I4210091445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112247416","display_name":"Eckhard Thiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eckhard Thiel","raw_affiliation_strings":["Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103446353","display_name":"Dieter F. Hoelzer","orcid":"https://orcid.org/0000-0001-5970-1205","observed_orcids":["https://orcid.org/0000-0001-5970-1205"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Hoelzer","raw_affiliation_strings":["Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029065407","display_name":"Thomas Burmeister","orcid":"https://orcid.org/0000-0003-4843-2876","observed_orcids":["https://orcid.org/0000-0003-4843-2876"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Burmeister","raw_affiliation_strings":["Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Tumor Immunology, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004037716","https://openalex.org/A5029065407","https://openalex.org/A5039023052","https://openalex.org/A5048553869","https://openalex.org/A5058842632","https://openalex.org/A5067716137","https://openalex.org/A5075073484","https://openalex.org/A5088238455"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I196349391","https://openalex.org/I2801240073","https://openalex.org/I4210091445","https://openalex.org/I4210112713","https://openalex.org/I7877124"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32211866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"23","first_page":"2617","last_page":"2617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.7480000257492065},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dominant-negative-isoform","display_name":"dominant-negative isoform","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intragenic-deletion","display_name":"intragenic deletion","score":0.8429999947547913},{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/adult-acute-lymphoblastic-leukemia","display_name":"adult acute lymphoblastic leukemia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chromosome-breakpoints","display_name":"chromosomal breakpoints","score":0.5239999890327454},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.42899999022483826},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.5490000247955322},{"id":"https://openalex.org/keywords/tcf3-pbx1","display_name":"TCF3-PBX1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/etv6-runx1","display_name":"ETV6-RUNX1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mll-af4","display_name":"MLL-AF4","score":0.6290000081062317},{"id":"https://openalex.org/keywords/mll-enl","display_name":"MLL-ENL","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mll-af9","display_name":"MLL-AF9","score":0.9829999804496765},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.7742462158203125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.574684739112854},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.43996304273605347},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42033839225769043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4023485481739044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33079981803894043},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.22809788584709167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1791979968547821},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.2617.2617","doi":"https://doi.org/10.1182/blood.v126.23.2617.2617","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.2617.2617","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310120276","https://openalex.org/W2740576382","https://openalex.org/W2588214878","https://openalex.org/W4386001899","https://openalex.org/W2548991597","https://openalex.org/W2602140352","https://openalex.org/W7066732503","https://openalex.org/W2940560299","https://openalex.org/W2979414116","https://openalex.org/W7019736970"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"IKAROS":[2,26],"(IKZF1)":[3],"is":[4,101,120],"a":[5,19,112,380,407,412,485,581],"key":[6],"transcription":[7,49,77],"factor":[8,600,641],"for":[9,162,196,501,629],"B-cell":[10],"development.":[11],"The":[12,115,299],"IKZF1":[13,30,97,140,164,185,198,222,323,337,409,483,589,595,620,635],"protein":[14],"exerts":[15],"its":[16],"functions":[17],"as":[18,36,208,506,597],"dimer":[20],"(homodimer":[21],"or":[22,53,617],"heterodimer":[23],"with":[24,325,344,347,350,353,357,385,406,480,503],"other":[25],"family":[27],"members).":[28],"Various":[29],"intragenic":[31,588],"deletions":[32,590,596,636],"have":[33,90,127],"been":[34],"identified":[35,557,592],"recurrent":[37],"aberrations":[38,199,223,239,281],"in":[39,45,87,111,117,131,149,266,423,558,572,601,642],"acute":[40],"lymphoblastic":[41],"leukemia:":[42],"those":[43,64,491],"resulting":[44],"the":[46,58,67,72,76,92,133,150,153,181,197,216,267,286,302,392,397,466,548,559,564,568,573,613],"loss":[47,56],"of":[48,50,57,75,96,136,139,152,183,315,341,382,388,399,567,575,587],"one":[51,322,331],"allele":[52],"at":[54,272,320,417,437,457],"least":[55,321],"dimerization":[59,73],"domain":[60,69,74],"(\"haploinsufficient\",":[61],"\"non-functional\")":[62],"and":[63,123,171,188,237,261,275,312,355,359,401,583,591,603],"involving":[65],"only":[66,368],"DNA-binding":[68],"but":[70],"retaining":[71],"factor,":[78],"leading":[79],"to":[80,166,179,285,442,462,490,522,538,612],"so-called":[81],"\"dominant":[82],"negative\"":[83],"isoforms.":[84],"Several":[85],"studies":[86,126,161],"pediatric":[88],"ALL":[89,119,156,256,608],"confirmed":[91],"negative":[93,619],"prognostic":[94,134,169,393,599,624,640],"impact":[95,135],"alterations":[98,165],"although":[99],"there":[100,334],"still":[102],"no":[103,432,471,623],"consensus":[104],"if":[105],"they":[106],"are":[107],"independent":[108,639],"risk":[109,505,510,518,644],"factors":[110],"multivariate":[113],"analysis.":[114,268],"situation":[116],"adult":[118,602],"less":[121],"clear":[122],"few":[124],"larger":[125],"addressed":[128],"this":[129],"issue,":[130],"particular":[132],"different":[137,163],"types":[138,387],"alterations.":[141],"Objectives:":[142],"We":[143,176,579],"investigated":[144,190],"archived":[145],"patient":[146],"samples":[147],"obtained":[148,271],"context":[151],"German":[154,648],"Multicenter":[155],"Study":[157],"Group":[158],"(GMALL)":[159],"therapy":[160],"assess":[167],"their":[168,172],"implications":[170],"molecular":[173,280,539,585],"pattern.":[174],"Methods:":[175],"used":[177],"RT-PCR":[178],"determine":[180],"presence":[182],"aberrant":[184],"transcript":[186,205],"variants":[187],"additionally":[189],"all":[191],"patients":[192,257,318,327,365,384,479,502,519,609],"by":[193,219,508],"DNA-based":[194],"PCRs":[195],"D4-7,":[200,342],"D2-7,":[201,345],"D4-8,":[202,348],"D2-8.":[203],"Rare":[204],"variants,":[206],"such":[207,234],"D2-3,":[209,351],"D2,":[210],"D5-7":[211,358],"were":[212,224,246,264,270,282,301,335,545,556],"molecularly":[213,247],"characterized":[214],"on":[215,434,473],"DNA":[217],"level":[218],"specific":[220],"PCRs.":[221],"quantified":[225],"using":[226],"gel":[227],"densitometry":[228],"and/or":[229],"quantitative":[230],"real":[231],"time":[232],"PCR":[233],"that":[235],"clonal":[236,481,593,633],"subclonal":[238,449],"could":[240],"be":[241],"distinguished.":[242],"All":[243],"chromosomal":[244,542],"breakpoints":[245],"characterized.":[248,546],"Results:":[249],"In":[250,465,547],"total,":[251],"482":[252,316],"B":[253,605],"cell":[254,606],"precursor":[255,607],"aged":[258],"between":[259],"15":[260],"65":[262],"years":[263],"included":[265],"Samples":[269],"primary":[273],"diagnosis":[274],"tested":[276,283],"BCR-ABL":[277],"-negative.":[278],"Other":[279],"according":[284,611],"GMALL":[287,509,614],"standards:":[288],"39":[289],"MLL-AF4-positive,":[290],"4":[291],"MLL-ENL,":[292],"1":[293,356],"MLL-AF9,":[294],"30":[295],"TCF3-PBX1,":[296],"3":[297],"ETV6-RUNX1.":[298],"immunophenotypes":[300],"following:":[303],"424":[304],"pre":[305],"B/common,":[306],"58":[307],"pro":[308],"B.":[309],"One":[310],"hundred":[311],"twenty-eight":[313],"out":[314],"(27%)":[317],"carried":[319,367],"deletion,":[324],"37":[326],"carrying":[328],"more":[329],"than":[330],"deletion.":[332],"Altogether":[333],"175":[336],"deletions,":[338],"71":[339],"cases":[340],"47":[343],"26":[346],"19":[349],"10":[352],"D2-8,":[354],"D2":[360],"each.":[361],"Taken":[362,477],"together":[363],"56":[364],"(12%)":[366],"non-functional":[369,400,408,450,482,594,634],"mutations":[370,376,389,403,430,451,621],"while":[371,428],"50":[372],"(10%)":[373],"had":[374,411,431,470,484,622],"dominant-negative":[375,402,429,467],"only.":[377],"There":[378],"was":[379,499],"group":[381],"22":[383],"both":[386],"(5%).":[390],"Evaluating":[391],"impact,":[394],"we":[395],"considered":[396],"effect":[398,433],"separately.":[404],"Patients":[405],"mutation":[410],"reduced":[413],"overall":[414],"survival":[415,455],"(OS":[416,436,456],"5":[418,438,458],"ys":[419,439,459],"37%":[420],"vs":[421,494,513,532],"59%":[422,460],"IKZF1-unmutated":[424],"patients,":[425],"N=78/404,":[426],"p=0.001)":[427],"OS":[435,474,488],"54%":[440],"compared":[441,461,489],"56%,":[443],"N=72/410,":[444],"p=0.95).":[445],"However,":[446],"solely":[447],"present":[448],"did":[452,527],"not":[453,528],"affect":[454],"59%,":[463],"N=23/404).":[464],"group,":[468],"clonality":[469],"influence":[472],"(p=0.56,":[475],"N=45/73/351).":[476],"together,":[478],"significantly":[486],"worse":[487],"without":[492],"(0.28":[493],"0.59,":[495],"N=53/427,":[496],"p<.0001).":[497],"This":[498],"true":[500],"standard":[504],"defined":[507],"stratification":[511],"(0.37":[512],"0.68,":[514],"N=24/243,":[515],"p.0002).":[516],"High":[517],"also":[520],"tended":[521],"do":[523],"worse,":[524],"which":[525],"however":[526],"reach":[529],"significance":[530],"(0.26":[531],"0.46,":[533],"N=30/184,":[534],"p=.06).":[535],"With":[536],"regard":[537],"analysis":[540,586,631],"193":[541],"fusion":[543],"sites":[544,555],"great":[549],"majority":[550],"(>95%)":[551],"putative":[552],"cryptic":[553],"recombination":[554,570],"near":[560],"vicinity":[561],"thus":[562],"underlining":[563],"causal":[565],"role":[566],"VDJ":[569],"machinery":[571],"generation":[574],"these":[576],"aberrations.":[577],"Conclusions:":[578],"conducted":[580],"detailed":[582],"large-scale":[584],"adverse":[598],"adolescent":[604],"treated":[610],"protocols.":[615],"Subclonal,":[616],"dominant":[618],"effect.":[625],"It":[626],"remains":[627],"open":[628],"further":[630],"whether":[632],"represent":[637],"an":[638],"MRD-based":[643],"stratification.":[645],"Disclosures":[646],"W\u00e4sch:":[647],"Cancer":[649,654],"Aid:":[650],"Research":[651,657,660,663],"Funding;":[652,658,661],"Comprehensiv":[653],"Center":[655],"Freiburg:":[656],"Janssen-Cilag:":[659],"MSD:":[662],"Funding.":[664]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}