{"id":"https://openalex.org/W2565734680","doi":"https://doi.org/10.1182/blood.v106.11.2054.2054","title":"Incompatible Inhibitory KIR Ligands Contribute To Lower Survival Rates in Leukemia Patients Receiving T-Replete Hematopoietic Cell Transplants (HCTs).","display_name":"Incompatible Inhibitory KIR Ligands Contribute To Lower Survival Rates in Leukemia Patients Receiving T-Replete Hematopoietic Cell Transplants (HCTs).","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2565734680","doi":"https://doi.org/10.1182/blood.v106.11.2054.2054","mag":"2565734680"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.2054.2054","doi":"https://doi.org/10.1182/blood.v106.11.2054.2054","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.2054.2054","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J.Y. Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.Y. Sun","raw_affiliation_strings":["Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043320174","display_name":"Andrew Dagis","orcid":"https://orcid.org/0000-0003-2649-0186","observed_orcids":["https://orcid.org/0000-0003-2649-0186"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Dagis","raw_affiliation_strings":["Divisons of Information Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisons of Information Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059488703","display_name":"Marcia M. Miller","orcid":"https://orcid.org/0000-0001-8721-6338","observed_orcids":["https://orcid.org/0000-0001-8721-6338"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.M. Miller","raw_affiliation_strings":["Molecular Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064172508","display_name":"Jeff Longmate","orcid":"https://orcid.org/0000-0002-0869-7928","observed_orcids":["https://orcid.org/0000-0002-0869-7928"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Longmate","raw_affiliation_strings":["Divisons of Information Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisons of Information Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011455409","display_name":"R. Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-6851-4222","observed_orcids":["https://orcid.org/0000-0002-6851-4222"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Rodriguez","raw_affiliation_strings":["Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033527431","display_name":"Laima Gaidulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. Gaidulis","raw_affiliation_strings":["Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039374832","display_name":"Stephen J. Forman","orcid":"https://orcid.org/0000-0002-2803-4152","observed_orcids":["https://orcid.org/0000-0002-2803-4152"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.J. Forman","raw_affiliation_strings":["Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112534159","display_name":"Donald S. David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. David","raw_affiliation_strings":["Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033527431","https://openalex.org/A5043320174","https://openalex.org/A5059488703","https://openalex.org/A5064172508","https://openalex.org/A5112534159"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30433021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"2054","last_page":"2054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/killer-cell-immunoglobulin-like-receptors","display_name":"killer cell immunoglobulin-like receptors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nk-cell-alloreactivity","display_name":"NK cell alloreactivity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hla-mismatch","display_name":"HLA mismatch","score":0.7289999723434448},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.44200000166893005},{"id":"https://openalex.org/keywords/unrelated-donor","display_name":"unrelated donor","score":0.5189999938011169},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.699999988079071},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hla-typing","display_name":"HLA typing","score":0.48899999260902405},{"id":"https://openalex.org/keywords/donor-selection","display_name":"donor selection","score":0.5770000219345093},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5779215693473816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5697619318962097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48830294609069824},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4728715121746063},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.44506311416625977},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.42327505350112915},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4219948947429657},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4210954010486603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3539217710494995},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3153252899646759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29585596919059753},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2942754030227661},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12423717975616455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10932603478431702}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.2054.2054","doi":"https://doi.org/10.1182/blood.v106.11.2054.2054","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.2054.2054","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066236891","https://openalex.org/W2048849656","https://openalex.org/W1968369411","https://openalex.org/W2980580784","https://openalex.org/W2059164379","https://openalex.org/W1993761061","https://openalex.org/W2557465148","https://openalex.org/W1993396723","https://openalex.org/W4310108043","https://openalex.org/W2018492618"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"killer":[2],"(NK)":[3],"cells":[4,112],"are":[5,21,358],"becoming":[6],"increasingly":[7],"recognized":[8],"as":[9],"an":[10],"important":[11],"part":[12],"of":[13,25,133,167,193,251,304,348],"the":[14,22,84,153,164,202,207,212,219,230,234,239,254,260,265,271,278,283,290,296,302,310,321,343],"immune":[15],"system.":[16],"Killer":[17],"Ig-like":[18],"receptors":[19,26],"(KIRs)":[20],"major":[23],"form":[24],"used":[27],"by":[28,140,152],"human":[29],"NK":[30,40,70,350],"cells.":[31,55],"KIRs":[32,45],"transmit":[33],"either":[34,91],"inhibitory":[35,44,59],"or":[36,50,96,108,334],"activating":[37],"signals":[38],"regulating":[39],"cell":[41,71,351],"activity.":[42],"Some":[43],"specifically":[46],"recognize":[47],"HLA-A,":[48,168],"B":[49],"-Cw":[51],"allotypes":[52],"on":[53],"target":[54],"Thus":[56],"differences":[57],"in":[58,69,76,307,353],"ligand":[60],"(iKIRL)":[61],"phenotypes":[62],"between":[63,201,229,253],"donors":[64,136],"and":[65,135,155,172,180,211,238,264,313],"patients":[66,89,100,134,308,322],"could":[67],"result":[68],"alloreactivity":[72,352],"that":[73],"further":[74],"results":[75],"different":[77,190,248],"HCT":[78],"outcomes.":[79],"To":[80],"test":[81],"this":[82],"hypothesis,":[83],"present":[85],"study":[86],"evaluated":[87],"362":[88],"with":[90,104,120,160,176,182,282,342],"ALL":[92],"(99),":[93],"AML/MDS":[94],"(141),":[95],"CML":[97],"(122).":[98],"The":[99,130,145,286],"were":[101,137],"transplanted":[102],"(1996~2003)":[103],"T-replete":[105],"bone":[106],"marrow,":[107],"peripheral":[109],"blood":[110],"stem":[111],"from":[113],"unrelated":[114],"donors.":[115],"High":[116],"resolution":[117],"HLA":[118,154,162,178],"typing":[119],"DNA-based":[121],"methods":[122],"had":[123],"been":[124],"prospectively":[125],"performed":[126],"for":[127],"donor":[128],"selection.":[129],"KIR":[131,156],"genes":[132],"retrospectively":[138],"typed":[139],"a":[141,223,247,315],"multiplex":[142],"PCR-SSP":[143],"method.":[144],"cohort":[146],"was":[147,199,227],"divided":[148],"into":[149],"three":[150],"groups":[151],"profiles:":[157],"247":[158],"cases":[159],"matched":[161],"at":[163],"antigen":[165],"level":[166],"B,":[169],"Cw,":[170],"DRB1,":[171],"DQB1":[173],"(MH),":[174],"64":[175],"mismatched":[177,185],"(mMH)":[179],"51":[181],"mMH":[183,208,235,261,279],"plus":[184],"iKIRL":[186,306,330],"(mMH+miKIRL).":[187],"A":[188],"significantly":[189],"rate":[191,249],"(P=0.009)":[192],"estimated":[194],"one":[195,329],"year":[196],"overall":[197],"survival":[198,317],"found":[200,314],"MH":[203,231,255,272,311],"(61%,":[204],"95%CI":[205],"55\u201367%),":[206],"(46%,":[209],"34\u201359%),":[210],"mMH+miKIRL":[213,240,266,287],"(29%,":[214],"18\u201343%)":[215],"groups.":[216,243,269],"When":[217],"analyzing":[218],"event":[220],"free":[221],"survival,":[222],"similar":[224],"difference":[225,318],"(P=0.003)":[226],"observed":[228],"(57%,":[232],"51\u201363%),":[233],"(43%,":[236],"32\u201356%)":[237],"(25%,":[241],"15\u201339%)":[242],"Further":[244],"analysis":[245],"demonstrated":[246],"(P=0.02)":[250],"relapse":[252],"(two-year":[256],"estimation:":[257],"21%,":[258],"16\u201328%),":[259],"(16%,":[262],"7\u201331%),":[263],"(36%":[267],"18\u201358%)":[268],"That":[270],"group":[273,288],"experienced":[274,289],"more":[275],"relapses":[276,292],"than":[277],"is":[280],"consistent":[281],"GvL":[284,297],"effect.":[285,298],"most":[291],"implied":[293],"miKIRL":[294],"undermine":[295],"We":[299],"also":[300],"tested":[301],"influence":[303],"lacking":[305,323],"within":[309],"group,":[312],"significant":[316],"(P=0.05)":[319],"among":[320],"two":[324],"iKIRLs":[325],"(n=67,":[326],"54%":[327],"42%\u201365%),":[328],"(n=104,":[331],"59%":[332],"49%\u201368%),":[333],"none":[335],"(n=76,":[336],"70%":[337],"58%\u201379%).":[338],"This":[339],"finding":[340],"contrasts":[341],"previously":[344],"reported":[345],"beneficial":[346],"role":[347],"potential":[349],"T-depleted":[354],"HCT.":[355],"Additional":[356],"studies":[357],"required":[359],"to":[360],"resolve":[361],"these":[362],"issues.":[363]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-01-06T00:00:00"}