{"id":"https://openalex.org/W2565629565","doi":"https://doi.org/10.1021/acs.jproteome.6b00875","title":"Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison","display_name":"Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison","publication_year":2016,"publication_date":"2016-12-19","ids":{"openalex":"https://openalex.org/W2565629565","doi":"https://doi.org/10.1021/acs.jproteome.6b00875","mag":"2565629565","pmid":"https://pubmed.ncbi.nlm.nih.gov/27992229"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jproteome.6b00875","doi":"https://doi.org/10.1021/acs.jproteome.6b00875","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.6b00875","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048295105","display_name":"Patrick Leuthold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Leuthold","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066057635","display_name":"Elke Schaeffeler","orcid":"https://orcid.org/0009-0005-2997-0355","observed_orcids":["https://orcid.org/0009-0005-2997-0355"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke Schaeffeler","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101400735","display_name":"Stefan Winter","orcid":"https://orcid.org/0000-0002-5267-0255","observed_orcids":["https://orcid.org/0000-0002-5267-0255"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Winter","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046654269","display_name":"Florian B\u00fcttner","orcid":"https://orcid.org/0000-0002-0657-9522","observed_orcids":["https://orcid.org/0000-0002-0657-9522"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian B\u00fcttner","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040542934","display_name":"Ute Hofmann","orcid":"https://orcid.org/0000-0003-0823-9027","observed_orcids":["https://orcid.org/0000-0003-0823-9027"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ute Hofmann","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044993303","display_name":"Thomas E. M\u00fcrdter","orcid":"https://orcid.org/0000-0002-8786-8122","observed_orcids":["https://orcid.org/0000-0002-8786-8122"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas E. M\u00fcrdter","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042022681","display_name":"Steffen Rausch","orcid":"https://orcid.org/0000-0002-6398-8701","observed_orcids":["https://orcid.org/0000-0002-6398-8701"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Rausch","raw_affiliation_strings":["Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043572864","display_name":"Denise Sonntag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146003","display_name":"Biocrates Life Sciences (Austria)","ror":"https://ror.org/05168x816","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210146003"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Denise Sonntag","raw_affiliation_strings":["Biocrates Life Sciences AG, 6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocrates Life Sciences AG, 6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I4210146003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081040105","display_name":"Judith Wahrheit","orcid":"https://orcid.org/0000-0002-9390-1806","observed_orcids":["https://orcid.org/0000-0002-9390-1806"]},"institutions":[{"id":"https://openalex.org/I4210146003","display_name":"Biocrates Life Sciences (Austria)","ror":"https://ror.org/05168x816","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210146003"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Judith Wahrheit","raw_affiliation_strings":["Biocrates Life Sciences AG, 6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocrates Life Sciences AG, 6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I4210146003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030552991","display_name":"Falko Fend","orcid":"https://orcid.org/0000-0002-5496-293X","observed_orcids":["https://orcid.org/0000-0002-5496-293X"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Falko Fend","raw_affiliation_strings":["Institute of Pathology and Neuropathology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and Neuropathology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034310234","display_name":"J\u00f6rg Hennenlotter","orcid":"https://orcid.org/0000-0003-3827-6996","observed_orcids":["https://orcid.org/0000-0003-3827-6996"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Hennenlotter","raw_affiliation_strings":["Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080116321","display_name":"Jens Bedke","orcid":"https://orcid.org/0000-0003-2778-3108","observed_orcids":["https://orcid.org/0000-0003-2778-3108"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Bedke","raw_affiliation_strings":["Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057183308","display_name":"Matthias Georg Schwab","orcid":"https://orcid.org/0000-0002-9984-075X","observed_orcids":["https://orcid.org/0000-0002-9984-075X","https://orcid.org/0000-0001-6999-1795"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Schwab","raw_affiliation_strings":["Department of Clinical Pharmacology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","Department of Pharmacy and Biochemistry, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"Department of Pharmacy and Biochemistry, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080035541","display_name":"Mathias Haag","orcid":"https://orcid.org/0000-0001-9017-9021","observed_orcids":["https://orcid.org/0000-0001-9017-9021"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mathias Haag","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9017-9021","affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of T\u00fcbingen, 72074 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080035541"],"corresponding_institution_ids":["https://openalex.org/I4210120009","https://openalex.org/I8087733"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0727,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.92725925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"2","first_page":"933","last_page":"944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-tissue","display_name":"kidney tissue","score":0.5669999718666077},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.953000009059906},{"id":"https://openalex.org/keywords/lc-qtof-ms","display_name":"LC-QTOF-MS","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hilic-separation","display_name":"HILIC separation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.7059999704360962},{"id":"https://openalex.org/keywords/human-kidney-tissue","display_name":"human kidney tissue","score":0.5889999866485596},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.9332003593444824},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6438173651695251},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.560013473033905},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.5338507890701294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49428558349609375},{"id":"https://openalex.org/C2994400308","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolite profiling","level":3,"score":0.4922892153263092},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4821871817111969},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.44715189933776855},{"id":"https://openalex.org/C3020395395","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Human kidney","level":3,"score":0.43832144141197205},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.42821845412254333},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.424908310174942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3481573462486267},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3210543394088745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2767665386199951},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2551667094230652},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11728698015213013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jproteome.6b00875","doi":"https://doi.org/10.1021/acs.jproteome.6b00875","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.6b00875","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:27992229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27992229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319558","display_name":"Bosch-Forschungsstiftung","ror":null},{"id":"https://openalex.org/F4320320869","display_name":"Robert Bosch Stiftung","ror":"https://ror.org/012kqkf58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W254079993","https://openalex.org/W617288073","https://openalex.org/W907174691","https://openalex.org/W1932887754","https://openalex.org/W1959301426","https://openalex.org/W1964166931","https://openalex.org/W1965734230","https://openalex.org/W1973529232","https://openalex.org/W1976327004","https://openalex.org/W1978370372","https://openalex.org/W1980010799","https://openalex.org/W1984882020","https://openalex.org/W1987277104","https://openalex.org/W1988211561","https://openalex.org/W1988661228","https://openalex.org/W1988802259","https://openalex.org/W2001378684","https://openalex.org/W2005327657","https://openalex.org/W2009453329","https://openalex.org/W2013233148","https://openalex.org/W2023091041","https://openalex.org/W2028897202","https://openalex.org/W2032058847","https://openalex.org/W2046248894","https://openalex.org/W2047475836","https://openalex.org/W2051366884","https://openalex.org/W2052094618","https://openalex.org/W2054507410","https://openalex.org/W2054554580","https://openalex.org/W2054843171","https://openalex.org/W2059327215","https://openalex.org/W2063028213","https://openalex.org/W2064072638","https://openalex.org/W2066896487","https://openalex.org/W2069334493","https://openalex.org/W2074614450","https://openalex.org/W2084375915","https://openalex.org/W2088225832","https://openalex.org/W2088687798","https://openalex.org/W2110065044","https://openalex.org/W2115381717","https://openalex.org/W2117881637","https://openalex.org/W2138150495","https://openalex.org/W2148303315","https://openalex.org/W2148430691","https://openalex.org/W2152943013","https://openalex.org/W2153615428","https://openalex.org/W2154474366","https://openalex.org/W2155319744","https://openalex.org/W2188690658","https://openalex.org/W2226268614","https://openalex.org/W2234445408","https://openalex.org/W2255019206","https://openalex.org/W2260473606","https://openalex.org/W2276765574","https://openalex.org/W2284518822","https://openalex.org/W2293718036","https://openalex.org/W2295933889","https://openalex.org/W2301389244","https://openalex.org/W2313223411","https://openalex.org/W2335012284","https://openalex.org/W2337831726","https://openalex.org/W2465490941","https://openalex.org/W2470530820","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W3134292496","https://openalex.org/W2112521228","https://openalex.org/W4411858273","https://openalex.org/W2885815189","https://openalex.org/W1542241217","https://openalex.org/W2906633482","https://openalex.org/W3041848531","https://openalex.org/W2803961630","https://openalex.org/W2061822559","https://openalex.org/W2093740554"],"abstract_inverted_index":{"Metabolite":[0],"profiling":[1],"of":[2,12,31,39,48,105,158,184],"tissue":[3,167],"samples":[4],"is":[5],"a":[6,45,111,169],"promising":[7],"approach":[8,114],"for":[9,28,96],"the":[10,106,129,142,160,182],"characterization":[11],"cancer":[13,174],"pathways":[14],"and":[15,54,66,79,86,175],"tumor":[16],"classification":[17],"based":[18],"on":[19,35,126,181],"metabolic":[20],"features.":[21],"Here,":[22],"we":[23],"present":[24],"an":[25],"analytical":[26],"method":[27,97,161],"nontargeted":[29,107,143],"metabolomics":[30,108,113],"kidney":[32,88,166,173],"tissue.":[33],"Capitalizing":[34],"different":[36],"chemical":[37],"properties":[38],"metabolites":[40,121],"allowed":[41],"us":[42],"to":[43,110,148,164],"extract":[44],"broad":[46],"range":[47],"molecules":[49,53],"covering":[50],"small":[51],"polar":[52,56],"less":[55],"lipid":[57],"classes":[58],"that":[59,122,138],"were":[60,91],"analyzed":[61,80],"by":[62],"LC-QTOF-MS":[63],"after":[64],"HILIC":[65],"RP":[67],"chromatographic":[68],"separation,":[69],"respectively.":[70],"More":[71],"than":[72],"1000":[73],"features":[74],"could":[75,123,178],"be":[76,124,179],"reproducibly":[77],"extracted":[78],"(CV":[81],"<":[82],"30%)":[83],"in":[84],"porcine":[85],"human":[87,165],"tissue,":[89],"which":[90],"used":[92],"as":[93,156],"surrogate":[94],"matrices":[95],"development.":[98],"To":[99],"further":[100],"assess":[101],"assay":[102,144],"performance,":[103],"cross-validation":[104],"platform":[109],"targeted":[112,153],"was":[115,162],"carried":[116],"out.":[117],"Strikingly,":[118],"from":[119,141,151],"102":[120],"detected":[125],"both":[127],"platforms,":[128],"majority":[130],"(>90%)":[131],"revealed":[132],"Spearman's":[133],"correlation":[134],"coefficients":[135],"\u22650.3,":[136],"indicating":[137],"quantitative":[139],"results":[140],"are":[145],"largely":[146],"comparable":[147],"data":[149],"derived":[150],"classical":[152],"assays.":[154],"Finally,":[155],"proof":[157],"concept,":[159],"applied":[163],"where":[168],"clear":[170],"differentiation":[171],"between":[172],"nontumorous":[176],"material":[177],"demonstrated":[180],"basis":[183],"unsupervised":[185],"statistical":[186],"analysis.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
