{"id":"https://openalex.org/W2565624923","doi":"https://doi.org/10.1182/blood.v112.11.3033.3033","title":"Validation of Pharmacokinetic {PK} Simulation for Fondaparinux (FPX) Dosing by FPX-Specific Anti-Factor Xa Assay in Elderly Cancer Patients with Severe Renal Dysfunction","display_name":"Validation of Pharmacokinetic {PK} Simulation for Fondaparinux (FPX) Dosing by FPX-Specific Anti-Factor Xa Assay in Elderly Cancer Patients with Severe Renal Dysfunction","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2565624923","doi":"https://doi.org/10.1182/blood.v112.11.3033.3033","mag":"2565624923"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.3033.3033","doi":"https://doi.org/10.1182/blood.v112.11.3033.3033","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3033.3033","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067168280","display_name":"Chin Y Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin Y Liu","raw_affiliation_strings":["Pharmacy, Karmanos Cancer Institute, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Karmanos Cancer Institute, Detroit, MI, USA","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103344218","display_name":"Judith C. Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith C. Andersen","raw_affiliation_strings":["Wayne State University, Karmanos Cancer Institute, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University, Karmanos Cancer Institute, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42895943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"3033","last_page":"3033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fondaparinux","display_name":"fondaparinux","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacokinetic-simulation","display_name":"pharmacokinetic simulation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/anti-factor-xa-assay","display_name":"anti-factor Xa assay","score":0.8700000047683716},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/elderly-cancer-patients","display_name":"elderly cancer patients","score":0.8330000042915344},{"id":"https://openalex.org/keywords/peak-and-trough-drug-levels","display_name":"peak and trough drug levels","score":0.5910000205039978},{"id":"https://openalex.org/keywords/once-weekly-dosing","display_name":"weekly dosing","score":0.6290000081062317},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.6359999775886536},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.6420000195503235},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.44699999690055847},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.42899999022483826},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7089410424232483},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6605133414268494},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5659313797950745},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5269637703895569},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4814838171005249},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.46039289236068726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36709457635879517},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.36331063508987427},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3357844352722168},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.3033.3033","doi":"https://doi.org/10.1182/blood.v112.11.3033.3033","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3033.3033","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2325519925","https://openalex.org/W4205628472","https://openalex.org/W2065796379","https://openalex.org/W2750338953","https://openalex.org/W2114069548","https://openalex.org/W2160840488","https://openalex.org/W2318402710","https://openalex.org/W2065215506","https://openalex.org/W2104374249","https://openalex.org/W2267651841"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Fondaparinux":[2],"(FPX)":[3],"is":[4,30,36],"a":[5,76,153,434,446],"synthetic":[6],"pentasaccharide":[7],"inhibitor":[8],"of":[9,17,69,110,145,156,338,346,380,408,437],"factor":[10],"Xa":[11,121,450],"indicated":[12],"for":[13,32,44,87,169,181,198,366,411],"prophylaxis":[14,89,367,413],"and":[15,41,185,194,343,371,464],"treatment":[16],"venous":[18],"thromboembolism":[19],"(VTE).":[20],"It":[21],"has":[22,427],"an":[23,115,378],"18":[24,242],"hr":[25],"half-life":[26],"(T":[27],"1/2),":[28],"thus":[29],"suitable":[31],"once-daily":[33],"dosing,":[34],"but":[35],"cleared":[37],"by":[38,442],"the":[39,67,362,465],"kidney":[40],"not":[42],"recommended":[43],"patients":[45,84,101,136,159,329,415,423,441],"with":[46,102,114,137,160,207,335,416,424],"SRD":[47,165],"(creatinine":[48],"clearance":[49,345],"(CrCl)":[50],"<30":[51],"mL/min)":[52],"in":[53,71,75,82,100,152,213,332,361,414,422,433],"whom":[54],"drug":[55,131,381,454,466],"accumulation":[56,455],"could":[57,127],"increase":[58],"bleeding":[59,393],"risk.":[60],"No":[61,391],"published":[62],"clinical":[63],"trials":[64],"have":[65],"evaluated":[66],"use":[68],"FPX":[70,80,86,125,175,203,354,400,409,447],"this":[72,111,129,333],"population.":[73],"However,":[74],"pharmacokinetic":[77,147,404],"simulation,":[78],"serum":[79],"concentrations":[81],"such":[83],"receiving":[85],"VTE":[88,182,395,412],"every":[90,178],"other":[91],"day":[92],"were":[93,188,205,330,397],"predicted":[94],"to":[95,98,133,376,430],"be":[96,377,431],"similar":[97],"those":[99],"mild":[103,425],"renal":[104,139,418],"impairment":[105],"on":[106],"daily":[107],"dosing.":[108],"Validation":[109],"dosing":[112,410],"regimen":[113],"automated":[116],"assay":[117],"that":[118],"determines":[119],"anti-factor":[120],"activity":[122],"levels":[123,187,204],"using":[124,445],"calibrators":[126],"make":[128],"versatile":[130],"accessible":[132],"many":[134],"hypercoagulable":[135],"severe":[138,417],"dysfunction":[140,419,426],"Methods:":[141],"A":[142,403],"retrospective":[143],"analysis":[144],"institutional":[146],"protocol":[148],"outcomes":[149],"was":[150,356],"conducted":[151],"small":[154,435],"population":[155,436],"elderly":[157,439],"cancer":[158,440],"chronic":[161,164],"or":[162,394],"acute-on-":[163],"(CrCl":[166],"<":[167],"30ml/min":[168],">72":[170],"hrs)":[171,462],"who":[172],"received":[173],"subcutaneous":[174],"2.5":[176],"mg":[177],"48":[179],"hrs":[180],"prophylaxis.":[183],"Peak":[184,229],"trough":[186,373],"determined":[189],"at":[190,199,457],"3":[191,201,257],"hours":[192],"post-dose":[193],"1hr":[195],"pre-dose":[196],"respectively,":[197],"least":[200,458],"doses.":[202],"assayed":[206],"FPX-specific":[208],"calibrators.":[209],"Descriptive":[210],"data":[211,421],"appear":[212],"Table":[214],"1.":[215],"Pt":[216],"Age":[217],"Sex":[218],"Race":[219],"D":[220],"Height":[221],"(cm)":[222],"Weight":[223],"(kg)":[224],"Creatinine":[225],"(mg/dL)":[226],"CrCl":[227],"(ml/min)":[228],"(mcg/mL)":[230,232],"Trough":[231],"1":[233],"71":[234],"F":[235,305],"W":[236,260,271,283,295],"Bladder":[237,272],"CA":[238,250,273,285,308],"167.6":[239],"71.9":[240],"2.7":[241],"0.52":[243],"0.15":[244],"2":[245],"86":[246],"M":[247,259,270,282,294,317],"B":[248,306,318],"Lung":[249],"166.4":[251],"76.2":[252],"1.7":[253],"28":[254],"0.47":[255],"0.14":[256],"67":[258],"Giloma":[261],"180.3":[262],"75.0":[263],"3.2":[264],"24":[265],"0.27":[266,325],"0.12":[267,383],"4":[268],"83":[269],"175.3":[274],"90.0":[275],"1.9":[276],"29":[277],"0.33":[278],"0.08":[279],"5":[280],"75":[281],"Prostate":[284],"167":[286],"74.5":[287],"5.4":[288],"11":[289],"0.6":[290],"0.11":[291],"6":[292],"62":[293],"Lymphoma":[296],"172":[297],"61.5":[298],"3.1":[299],"22":[300],"0.28":[301],"0.03":[302],"7":[303],"59":[304],"Uterine":[307],"160":[309],"115.0":[310],"4.8":[311],"10":[312,324],"0.37":[313],"0.1":[314],"8":[315],"53":[316],"Multiple":[319],"myeloma":[320],"177.8":[321],"57.0":[322],"6.0":[323],"0.2":[326],"Results:":[327],"Eight":[328],"included":[331],"study":[334],"mean":[336,352,372],"age":[337],"69.5":[339],"\u00b1":[340,348,358,384],"11.5":[341],"years":[342],"creatinine":[344],"19":[347],"7.9":[349],"mL/min.":[350],"The":[351],"peak":[353],"concentration":[355],"0.39":[357],"0.13":[359],"mcg/mL,":[360],"lower":[363],"target":[364],"range":[365],"efficacy":[368],"(0.39\u20130.50":[369],"mcg/mL)":[370],"concentration,":[374],"thought":[375],"indicator":[379],"accumulation,":[382],"0.05":[385],"mcg/mL":[386],"(target":[387],"range:":[388],"0.14\u20130.19":[389],"mcg/mL).":[390],"major":[392],"events":[396],"noted":[398],"during":[399],"administration.":[401],"Conclusion:":[402],"simulation":[405],"permitting":[406],"extrapolation":[407],"from":[420],"been":[428],"shown":[429],"valid":[432],"sick":[438],"PK":[443],"monitoring":[444],"-specific":[448],"anti-Factor":[449],"assay,":[451],"showing":[452],"no":[453],"over":[456],"three":[459],"doses":[460],"(144":[461],"[cyl1]":[463],"clinically":[467],"safe":[468],"as":[469],"dosed.":[470]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}
